{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:26:35Z","timestamp":1780496795650,"version":"3.54.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Veni","award":["09150161810155"],"award-info":[{"award-number":["09150161810155"]}]},{"name":"Dutch Organization for Scientific Research"},{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The definition of periprocedural myocardial infarction (PMI) after coronary artery bypass grafting (CABG) remains debated, particularly regarding the use of cardiac troponins vs creatine kinase MB isoform (CK-MB), and biomarker thresholds seem outdated [10\u00d7, 35\u00d7, or 70\u00d7 multiples of upper reference limits (URL)]. We studied high-sensitivity cardiac troponin T (hs-cTnT) and I (hs-cTnI), and CK-MB, following CABG patients with an emphasis on those with an uncomplicated course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing isolated on-pump CABG and minimally invasive direct CABG (MIDCAB) were prospectively included. Blood was collected preoperatively and then postoperatively at intensive care unit (ICU) arrival, 5\u2005h and 8\u2005h subsequently, and postoperative days 1 and 3. hs-cTnT (Roche), hs-cTnI (Abbott), and CK-MB (Roche) were measured and normalized using URLs according to package inserts or the Universal Sample Bank.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-one on-pump CABG and 22 MIDCAB patients were included. On-pump CABG patients showed a median (interquartile range) hs-cTnT peak of 610 (466\u2013879)\u2005ng\/L, hs-cTnI 3918 (2154\u20136713)\u2005ng\/L, and CK-MB 22.0 (14.9\u201334.8)\u2005\u00b5g\/L 5\u2005h after ICU arrival. When normalized according to package inserts, this corresponds to 44\u00d7 (33\u00d7\u201363\u00d7) URL, 150\u00d7 (82\u00d7\u2013256\u00d7) URL, 4.5 \u00d7 (3.0\u00d7\u20137.1\u00d7) URL, respectively. These values slightly differ when sex-specific or other URL definitions are used (P &amp;gt; 0.05). In subgroup analyses, MIDCAB patients had reduced biomarker concentrations, and significant differences were observed between cardioplegia regimens (P &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The postoperative kinetics of hs-cTnT, hs-cTnI, and CK-MB in CABG patients with an uncomplicated course illustrate that hs-cTn, in particular, surpasses current diagnostic cutoffs for PMI. This varies in time, across hs-cTn assays, surgical approaches, and cardioplegia regimens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/clinchem\/hvag012","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:48:00Z","timestamp":1769690880000},"page":"692-702","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac Biomarker Kinetics in Patients after Coronary Artery Bypass Grafting with an Uncomplicated Course"],"prefix":"10.1093","volume":"72","author":[{"given":"Ellen J S","family":"Denessen","sequence":"first","affiliation":[{"name":"Central Diagnostic Laboratory, Maastricht University Medical Center+ , Maastricht ,","place":["the Netherlands"]},{"name":"Cardiovascular Research Institute Maastricht, Maastricht University , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Swinnen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht, Maastricht University , Maastricht ,","place":["the Netherlands"]},{"name":"Department of Cardiothoracic Surgery, Maastricht University Medical Center+ , Maastricht ,","place":["the Netherlands"]},{"name":"Department of Radiology and Nuclear Medicine, Maastricht University Medical Center+ , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sacha K","family":"Lamers","sequence":"additional","affiliation":[{"name":"Central Diagnostic Laboratory, Maastricht University Medical Center+ , Maastricht ,","place":["the Netherlands"]},{"name":"Cardiovascular Research Institute Maastricht, Maastricht University , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thijs S R","family":"Delnoij","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Maastricht University Medical Center+ , Maastricht ,","place":["the Netherlands"]},{"name":"Department of Cardiology, Maastricht University Medical Center+ , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P T M","family":"van Doorn","sequence":"additional","affiliation":[{"name":"Central Diagnostic Laboratory, Maastricht University Medical Center+ , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Bekers","sequence":"additional","affiliation":[{"name":"Central Diagnostic Laboratory, Maastricht University Medical Center+ , Maastricht ,","place":["the Netherlands"]},{"name":"Cardiovascular Research Institute Maastricht, Maastricht University , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7414-3712","authenticated-orcid":false,"given":"Patrique","family":"Segers","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Maastricht University Medical Center+ , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos G","family":"Maessen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht, Maastricht University , Maastricht ,","place":["the Netherlands"]},{"name":"Department of Cardiothoracic Surgery, Maastricht University Medical Center+ , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwan C C","family":"van der Horst","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht, Maastricht University , Maastricht ,","place":["the Netherlands"]},{"name":"Board of Directors, Albert Schweitzer Hospital , Dordrecht ,","place":["the 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