{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:53:26Z","timestamp":1782975206995,"version":"3.54.5"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":250,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006788","name":"Great Lakes Fishery Commission","doi-asserted-by":"publisher","award":["2016_WIL_54050"],"award-info":[{"award-number":["2016_WIL_54050"]}],"id":[{"id":"10.13039\/100006788","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The pesticide 3-trifluoromethyl-4-nitrophenol (TFM) is applied to rivers and streams draining into the Laurentian Great Lakes to control populations of invasive sea lamprey (Petromyzon marinus), which are ongoing threats to fisheries during the lamprey\u2019s hematophagous, parasitic juvenile life stage. While TFM targets larval sea lamprey during treatments, threatened populations of juvenile lake sturgeon (Acipenser fulvescens), particularly young-of-the-year (&amp;lt;100\u00a0mm in length), may be adversely affected by TFM when their habitats overlap with larval sea lamprey. Exposure to TFM causes marked reductions in tissue glycogen and high energy phosphagens in lamprey and rainbow trout (Oncorhynchus mykiss) by interfering with oxidative ATP production in the mitochondria. To test that environmentally relevant concentrations of TFM would similarly affect juvenile lake sturgeon, we exposed them to the larval sea lamprey minimum lethal concentration (9-h LC99.9), which mimicked concentrations of a typical lampricide application and quantified energy stores and metabolites in the carcass, liver and brain. Exposure to TFM reduced brain ATP, PCr and glycogen by 50\u201360%, while lactate increased by 45\u201350% at 6 and 9\u00a0h. A rapid and sustained depletion of liver glucose and glycogen of more than 50% was also observed, whereas the respective concentrations of ATP and glycogen were reduced by 60% and 80% after 9\u00a0h, along with higher lactate and a slight metabolic acidosis (~0.1 pH unit). We conclude that exposure to environmentally relevant concentrations of TFM causes metabolic disturbances in lake sturgeon that can lead to impaired physiological performance and, in some cases, mortality. Our observations support practices such as delaying TFM treatments to late summer\/fall or using alternative TFM application strategies to mitigate non-target effects in waters where lake sturgeon are present. These actions would help to conserve this historically and culturally significant species in the Great Lakes.<\/jats:p>","DOI":"10.1093\/conphys\/coab069","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:45:54Z","timestamp":1631101554000},"source":"Crossref","is-referenced-by-count":6,"title":["The lampricide 3-trifluoromethyl-4-nitrophenol causes temporary metabolic disturbances in juvenile lake sturgeon (<i>Acipenser fulvescens<\/i>): implications for sea lamprey control and fish conservation"],"prefix":"10.1093","volume":"9","author":[{"given":"R Adrian","family":"Ionescu","sequence":"first","affiliation":[{"name":"Department of Biology and Laurier Institute for Water Science, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L J","family":"Hepditch","sequence":"additional","affiliation":[{"name":"Department of Biology and Laurier Institute for Water Science, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5, Canada"},{"name":"Current Address: Centre Eau Terre Environment, Institut National de la Recherche Scientifique, Qu\u00e9bec, Qu\u00e9bec City G1K 9A9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Wilkie","sequence":"additional","affiliation":[{"name":"Department of Biology and Laurier Institute for Water Science, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"2021090909060807700_ref1","first-page":"1","author":"APHA","year":"2007"},{"key":"2021090909060807700_ref2","first-page":"1","author":"Applegate","year":"1966"},{"key":"2021090909060807700_ref3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1577\/1548-8659(1962)91[342:CTOTTT]2.0.CO;2","article-title":"Comparative toxicity of 3-trifluoromethyl-4-nitrophenol (TFM) to 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