{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T21:45:29Z","timestamp":1780782329390,"version":"3.54.1"},"reference-count":88,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":225,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"American Association of Zoo Veterinarians\u2019 Wild Animal Health Fund and the Florida Save Our Seas Specialty License Plate Fund"},{"name":"Sea Turtle Conservancy Florida Sea Turtle License Plate Grants Program","award":["17-036R"],"award-info":[{"award-number":["17-036R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sea turtle health assessments can be strengthened by developing conserved biomarkers that discriminate between healthy and diseased states. Serum amyloid A, myeloid-related protein 126 and cardiac troponin C (CTNC) were explored as potential biomarkers of sea turtle health. Plasma concentrations initially quantified using a targeted SPARCL\u2122 assay significantly differed between moribund (n\u2009=\u200915) and recovered (n\u2009=\u20095) loggerhead turtles (Caretta caretta). There was a negative correlation between myeloid-related protein 126 and packed cell volume (r\u2009=\u2009\u22120.612, P\u2009=\u20090.005) and total solids (r\u2009=\u2009\u22120.497, P\u2009=\u20090.03) and between and Fulton\u2019s body condition index (r\u2009=\u2009\u22120.684, P\u2009=\u20090.001). Serum amyloid A showed a relatively high interquartile range (IQR) in moribund turtles and no significant correlations with clinical parameters. Myeloid-related protein 126 and cardiac troponin C were further evaluated by an enzyme-linked immunosorbent assay in a larger dataset of loggerhead, Kemp\u2019s ridley (Lepidochelys kempii) and green (Chelonia mydas) turtles. Plasma myeloid-related protein 126 was significantly lower in captive healthy (n\u2009=\u20097) and recovered (n\u2009=\u200923) turtles than in moribund (n\u2009=\u200925) and nesting green (n\u2009=\u200958) turtles. Green turtles with fibropapillomatosis (n\u2009=\u200910) were not significantly different from any group. Discriminating values between healthy\/recovered and moribund turtles were 1.89\u00a0and 1.97\u00a0ng\/ml by receiver operating characteristic and logistic regression analyses, respectively. Myeloid-related protein 126 decreased in successfully rehabilitated turtles (n\u2009=\u200918 turtles; n\u2009=\u200967 blood samples) and was negatively correlated with body condition score (r\u2009=\u2009\u22120.672, P\u2009&amp;lt;\u20090.001) and packed cell volume (r\u2009=\u2009\u22120.443, P\u2009=\u20090.009). Cardiac troponin C was significantly higher (P\u2009=\u20090.049) in moribund turtles (n\u2009=\u200916) compared to healthy\/recovered turtles (n\u2009=\u20097) and in moribund samples (n\u2009=\u200911) compared to recovered samples (n\u2009=\u200911) in serially sampled turtles (P\u2009=\u20090.015), but was not predictive of health status. Myeloid-related protein 126 represents a strong biomarker candidate in sea turtles. Cardiac troponin C warrants further evaluation in a larger dataset and serum amyloid A requires examination of variables affecting pathophysiologic responses in sea turtles.<\/jats:p>","DOI":"10.1093\/conphys\/coaf061","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T11:43:18Z","timestamp":1753443798000},"source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of myeloid-related protein 126, cardiac troponin C and serum amyloid A as potential plasma biomarkers of health and disease in sea turtles"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4751-4001","authenticated-orcid":false,"given":"David P","family":"Marancik","sequence":"first","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, St. George's University , True Blue, Grenada ,","place":["West Indies"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C","family":"Chadwick","sequence":"additional","affiliation":[{"name":"Life Diagnostics, Inc. , 124 Turner Lane, West Chester, PA, 19380 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fields","sequence":"additional","affiliation":[{"name":"Windward Islands Research and Education Foundation , St. George ,","place":["Grenada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A","family":"Manire","sequence":"additional","affiliation":[{"name":"Loggerhead Marinelife Center , 14200 U.S. Highway One, Juno Beach, FL, 33408 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3044-5468","authenticated-orcid":false,"given":"Terry M","family":"Norton","sequence":"additional","affiliation":[{"name":"Georgia Sea Turtle Center, Jekyll Island Authority , 214 Stable Road, Jekyll Island, GA, 31527 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5046-6701","authenticated-orcid":false,"given":"Justin R","family":"Perrault","sequence":"additional","affiliation":[{"name":"Loggerhead Marinelife Center , 14200 U.S. Highway One, Juno Beach, FL, 33408 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Cray","sequence":"additional","affiliation":[{"name":"Division of Comparative Pathology, Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine , 1600 NW 10th Avenue, Miami, FL 33136 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"2025081401211132300_ref1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s00227-020-03747-1","article-title":"Nontargeted lipidomics in nesting females of three sea turtle species in 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