{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:46:34Z","timestamp":1753875994610,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":72,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pyostomatitis vegetans (PV) is a rare inflammatory stomatitis often associated with inflammatory bowel diseases (IBD). Treatment of PV depends on the presence of coexisting IBD. To date, there have been no reports on the use of ustekinumab for PV. There have been recent cases on the use of ustekinumab for treatment of pyoderma gangrenosum and uveitis. We report the case of a 26-year-old female with moderately severe Crohn\u2019s disease (CD) and PV who was successfully treated with ustekinumab monotherapy. Since initiation of ustekinumab, she has been in clinical and biochemical remission from a CD and PV standpoint for the last 12 months.<\/jats:p>","DOI":"10.1093\/crocol\/otaa014","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T20:25:32Z","timestamp":1583958332000},"source":"Crossref","is-referenced-by-count":1,"title":["Ustekinumab Successfully Treats and Maintains Remission of Pyostomatitis Vegetans Associated with Crohn\u2019s Disease"],"prefix":"10.1093","volume":"2","author":[{"given":"Sarah","family":"Abi Doumeth","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, American University of Beirut , Beirut, Lebanon"},{"name":"Department of Internal Medicine, American University of Beirut , Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ossama","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Dermatology, American University of Beirut , Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana G","family":"Hashash","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, American University of Beirut , Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"key":"2022111812280108500_CIT0001","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/sj.bdj.2017.37","article-title":"Gastrointestinal diseases and their oro-dental manifestations: part 2: ulcerative colitis","volume":"222","author":"Tan","year":"2017","journal-title":"Br Dent J."},{"key":"2022111812280108500_CIT0002","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1046\/j.1365-2036.2003.01782.x","article-title":"Review article: oral ulceration\u2013aetiopathogenesis, clinical diagnosis and management in the gastrointestinal clinic","volume":"18","author":"Field","year":"2003","journal-title":"Aliment Pharmacol Ther."},{"key":"2022111812280108500_CIT0003","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1600-0714.2012.01152.x","article-title":"Pyostomatitis vegetans and its relation to inflammatory bowel disease, pyoderma gangrenosum, pyodermatitis vegetans, and pemphigus","volume":"41","author":"Nico","year":"2012","journal-title":"J Oral Pathol Med."},{"key":"2022111812280108500_CIT0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2230.2004.01438.x","article-title":"Pyostomatitis vegetans","volume":"29","author":"Hegarty","year":"2004","journal-title":"Clin Exp Dermatol."},{"key":"2022111812280108500_CIT0005","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.tripleo.2003.08.022","article-title":"Pyostomatitis vegetans. Report of two cases and review of the literature","volume":"99","author":"Ruiz-Roca","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"2022111812280108500_CIT0006","first-page":"E114","article-title":"Pyostomatitis vegetans: a review of the literature","volume":"14","author":"Femiano","year":"2009","journal-title":"Med Oral Patol Oral Cir Bucal."},{"key":"2022111812280108500_CIT0007","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1046\/j.1365-2133.2003.05385.x","article-title":"Successful treatment with infliximab and methotrexate of pyostomatitis vegetans associated with Crohn\u2019s disease","volume":"149","author":"Bens","year":"2003","journal-title":"Br J Dermatol."},{"key":"2022111812280108500_CIT0008","first-page":"2050313X19845206","article-title":"Ustekinumab for the treatment of recalcitrant pyoderma gangrenosum: a case report","volume":"7","author":"Vallerand","year":"2019","journal-title":"SAGE Open Med Case Rep."},{"key":"2022111812280108500_CIT0009","article-title":"Two cases of successful ustekinumab treatment for non-infectious uveitis associated with Crohn\u2019s disease","author":"Chateau","year":"2019","journal-title":"J Crohns Colitis."},{"key":"2022111812280108500_CIT0010","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/pde.13123","article-title":"Asymptomatic upper lip swelling in an 8-year-old boy","volume":"34","author":"Karouni","year":"2017","journal-title":"Pediatr Dermatol."},{"key":"2022111812280108500_CIT0011","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1001\/archdermatol.2011.168","article-title":"Interleukin 23 expression in pyoderma gangrenosum and targeted therapy with ustekinumab","volume":"147","author":"Guenova","year":"2011","journal-title":"Arch Dermatol."}],"container-title":["Crohn's &amp; Colitis 360"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/crohnscolitis360\/advance-article-pdf\/doi\/10.1093\/crocol\/otaa014\/32901407\/otaa014.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/article-pdf\/2\/1\/otaa014\/47118027\/otaa014.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/article-pdf\/2\/1\/otaa014\/47118027\/otaa014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T12:28:39Z","timestamp":1668774519000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/article\/doi\/10.1093\/crocol\/otaa014\/5804698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/crocol\/otaa014","relation":{},"ISSN":["2631-827X"],"issn-type":[{"type":"electronic","value":"2631-827X"}],"subject":[],"published-other":{"date-parts":[[2020,1]]},"published":{"date-parts":[[2020,1,1]]},"article-number":"otaa014"}}