{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:30:18Z","timestamp":1764052218331,"version":"3.41.2"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5K23DK117054-02"],"award-info":[{"award-number":["5K23DK117054-02"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Global Studies in IBD and University of Miami Sylvester Cancer Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Inflammatory bowel disease (IBD) is an emerging disease in Hispanics. In this study, we examine the prevalence of IBD-related colon dysplasia (IBD-dys) in Hispanics versus non-Hispanic whites (NHWs) and compare differences in established clinical and environmental risk factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a cross-sectional analysis on adult Hispanics and NHWs with IBD who met criteria for colorectal cancer surveillance and were followed at our center between 2008 and 2018. Clinical variables and IBD phenotype were recorded. Lifestyle IBD-dys risk factors were examined, including smoking and lack of physical activity. Using multivariable regression, we compared the prevalence of IBD-dys in Hispanics versus NHW, using relevant covariates. Receiver operating characteristic and area under the curve were performed to find the best fitting model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 445 IBD patients were included (148 Hispanics and 297 NHWs). IBD phenotype was similar between groups, except that Hispanics had shorter disease duration, a lower frequency of Crohn\u2019s disease-related complications, and lower reported use of steroids. Frequency of surveillance colonoscopies was similar between Hispanics and NHW. There were no differences in median body mass index between Hispanics and NHW [26.5 (IQR 6.0) vs 25.0 (IQR 6.0), P = 0.40]. Hispanics were less likely than NHW to consume alcohol but smoking history was similar between groups. Three out of 148 Hispanic patients had IBD-dys (2.02%) compared to 29 out of 297 NHWs (9.76%). Adjusting for disease duration, primary sclerosing cholangitis, family history of colon cancer, and smoking, Hispanics had a lower prevalence of IBD-dys compared to NHW [ORadjusted = 0.207 (95% CI 0.046\u20130.938), P = 0.008].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Hispanics with IBD undergoing surveillance had a lower prevalence of IBD-dys than their NHW counterparts, despite similar risk factors. Future studies should examine dietary and microbial factors that may explain differences in risk.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/crocol\/otab016","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T04:15:40Z","timestamp":1616472940000},"source":"Crossref","is-referenced-by-count":2,"title":["Ethnicity Influences Risk of Inflammatory Bowel Disease (IBD)-Associated Colon Cancer: A Cross-sectional Analysis of Dysplasia Prevalence and Risk Factors in Hispanics and Non-Hispanic Whites With IBD"],"prefix":"10.1093","volume":"3","author":[{"given":"Oriana M","family":"Damas","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine , Miami, Florida , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Raffa","sequence":"additional","affiliation":[{"name":"Internal Medicine, Jackson Memorial Hospital\/University of Miami Miller School of Medicine , Miami, Florida , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Estes","sequence":"additional","affiliation":[{"name":"Internal Medicine, Jackson Memorial Hospital\/University of Miami Miller School of Medicine , Miami, Florida , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grechen","family":"Mills","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine , Miami, Florida , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kerman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine , Miami, Florida , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Palacio","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Miami Miller School of Medicine , Miami, Florida , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth J","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Miami Miller School of Medicine , Miami, Florida , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar R","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine , Miami, Florida , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T","family":"Abreu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine , Miami, Florida , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"2022111812300263700_CIT0001","doi-asserted-by":"crossref","first-page":"108771","DOI":"10.18632\/oncotarget.21938","article-title":"Trends in colorectal cancer mortality in Hispanics: a SEER analysis","volume":"8","author":"Barzi","year":"2017","journal-title":"Oncotarget."},{"key":"2022111812300263700_CIT0002","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/ajg.2009.190","article-title":"Distribution and manifestations of inflammatory bowel disease in Asians, Hispanics, and African Americans: a systematic review","volume":"104","author":"Hou","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"2022111812300263700_CIT0003","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0140-6736(19)32545-0","article-title":"Colorectal cancer in ulcerative colitis: a Scandinavian population-based cohort study","volume":"395","author":"Ol\u00e9n","year":"2020","journal-title":"Lancet"},{"key":"2022111812300263700_CIT0004","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1158\/1940-6207.CAPR-16-0124","article-title":"Colorectal cancer and dysplasia in inflammatory bowel disease: a review of disease epidemiology, pathophysiology, and management","volume":"9","author":"Dulai","year":"2016","journal-title":"Cancer Prev Res (Phila)"},{"key":"2022111812300263700_CIT0005","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/ajg.2012.393","article-title":"Phenotypic manifestations of inflammatory bowel disease differ between Hispanics and non-Hispanic whites: results of a large cohort study","volume":"108","author":"Damas","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"2022111812300263700_CIT0006","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.jada.2008.05.009","article-title":"A systematic review of the relationship between acculturation and diet among Latinos in the United States: implications for future research","volume":"108","author":"Ayala","year":"2008","journal-title":"J Am Diet Assoc."},{"key":"2022111812300263700_CIT0007","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41430-018-0234-7","article-title":"Dietary patterns derived from principal component analysis (PCA) and risk of colorectal cancer: a systematic review and meta-analysis","volume":"73","author":"Garcia-Larsen","year":"2019","journal-title":"Eur J Clin Nutr"},{"key":"2022111812300263700_CIT0008","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.amepre.2013.10.023","article-title":"Understanding current racial\/ethnic disparities in colorectal cancer screening in the United States: the contribution of socioeconomic status and access to care","volume":"46","author":"Liss","year":"2014","journal-title":"Am J Prev Med."},{"key":"2022111812300263700_CIT0009","first-page":"S32","article-title":"Health disparities in colorectal cancer among racial and ethnic minorities in the United States","volume":"7","author":"Jackson","year":"2016","journal-title":"J Gastrointest Oncol."},{"key":"2022111812300263700_CIT0010","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1111\/j.1365-2036.2012.05119.x","article-title":"Risk of colorectal adenomas and advanced neoplasia in Hispanic, black and white patients undergoing screening colonoscopy","volume":"35","author":"Lebwohl","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"2022111812300263700_CIT0011","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int J Cancer."},{"key":"2022111812300263700_CIT0012","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1158\/1055-9965.EPI-09-0329","article-title":"Cancer incidence in first generation U.S. Hispanics: Cubans, Mexicans, Puerto Ricans, and new Latinos","volume":"18","author":"Pinheiro","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"2022111812300263700_CIT0013","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1158\/1055-9965.EPI-16-0684","article-title":"Cancer mortality in Hispanic ethnic groups","volume":"26","author":"Pinheiro","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2022111812300263700_CIT0014","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10552-015-0691-4","article-title":"Disparities in colorectal cancer incidence among Latino subpopulations in California defined by country of origin","volume":"27","author":"Stern","year":"2016","journal-title":"Cancer Causes Control"},{"key":"2022111812300263700_CIT0015","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/carcin\/bgw046","article-title":"Genome-wide association study of colorectal cancer in Hispanics","volume":"37","author":"Schmit","year":"2016","journal-title":"Carcinogenesis."},{"key":"2022111812300263700_CIT0016","doi-asserted-by":"crossref","first-page":"265","DOI":"10.21873\/cgp.20084","article-title":"Frequency of mismatch repair protein deficiency in a Puerto Rican population with colonic adenoma and adenocarcinoma","volume":"15","author":"Reveron","year":"2018","journal-title":"Cancer Genomics Proteomics"},{"key":"2022111812300263700_CIT0017","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/ecco-jcc\/jjv197","article-title":"IBD genetic risk profile in healthy first-degree relatives of Crohn\u2019s disease patients","volume":"10","author":"Kevans","year":"2016","journal-title":"J Crohns Colitis"},{"key":"2022111812300263700_CIT0018","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1158\/1055-9965.EPI-19-1328","article-title":"A systematic analysis of interactions between environmental risk factors and genetic variation in susceptibility to colorectal cancer","volume":"29","author":"Yang","year":"2020","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2022111812300263700_CIT0019","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1053\/j.gastro.2009.12.035","article-title":"AGA technical review on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease","volume":"138","author":"Farraye","year":"2010","journal-title":"Gastroenterology."},{"key":"2022111812300263700_CIT0020","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1007\/s10620-015-3979-z","article-title":"Colorectal cancer screening in inflammatory bowel disease","volume":"61","author":"Sengupta","year":"2016","journal-title":"Dig Dis Sci"},{"key":"2022111812300263700_CIT0021","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.clcc.2016.02.002","article-title":"Colorectal cancer in patients with inflammatory bowel disease: the need for a real surveillance program","volume":"15","author":"Fornaro","year":"2016","journal-title":"Clin Colorectal Cancer"},{"key":"2022111812300263700_CIT0022","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.cgh.2015.04.183","article-title":"Incidence of interval colorectal cancer among inflammatory bowel disease patients undergoing regular colonoscopic surveillance","volume":"13","author":"Mooiweer","year":"2015","journal-title":"Clin Gastroenterol Hepatol."},{"key":"2022111812300263700_CIT0023","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.jacr.2018.12.025","article-title":"Relationships between health care disparities and coverage policies for breast, colon, and lung cancer screening","volume":"16","author":"Berland","year":"2019","journal-title":"J Am Coll Radiol."},{"key":"2022111812300263700_CIT0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21767\/2572-309X.100003","article-title":"Health disparities in colorectal cancer among African and Hispanic Americans in the United States","volume":"1","author":"Jackson","year":"2016","journal-title":"J Adenocarcinoma"},{"key":"2022111812300263700_CIT0025","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1097\/MCG.0000000000001204","article-title":"Race\/ethnicity-specific disparities in in-hospital mortality and hospital charges among inflammatory bowel disease-related hospitalizations in the United States","volume":"54","author":"Galoosian","year":"2019","journal-title":"J Clin Gastroenterol."},{"key":"2022111812300263700_CIT0026","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1053\/j.gastro.2020.03.054","article-title":"Risk factor profiles differ for cancers of different regions of the colorectum","volume":"159","author":"Wang","year":"2020","journal-title":"Gastroenterology."},{"key":"2022111812300263700_CIT0027","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1093\/annonc\/mdx171","article-title":"Foods and beverages and colorectal cancer risk: a systematic review and meta-analysis of cohort studies, an update of the evidence of the WCRF-AICR Continuous Update Project","volume":"28","author":"Vieira","year":"2017","journal-title":"Ann Oncol"},{"key":"2022111812300263700_CIT0028","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1053\/j.gastro.2006.12.038","article-title":"A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis","volume":"132","author":"D\u2019Haens","year":"2007","journal-title":"Gastroenterology."},{"key":"2022111812300263700_CIT0029","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1177\/2050640616666942","article-title":"Ethnic variations in the occurrence of colonic neoplasms","volume":"5","author":"Sonnenberg","year":"2017","journal-title":"United European Gastroenterol J."},{"key":"2022111812300263700_CIT0030","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3322\/caac.21395","article-title":"Colorectal cancer statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"2022111812300263700_CIT0031","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3322\/caac.21153","article-title":"Cancer statistics for Hispanics\/Latinos, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J Clin."},{"key":"2022111812300263700_CIT0032","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/s10552-013-0201-5","article-title":"Meta-analyses of colorectal cancer risk factors","volume":"24","author":"Johnson","year":"2013","journal-title":"Cancer Causes Control."},{"key":"2022111812300263700_CIT0033","doi-asserted-by":"crossref","first-page":"773","DOI":"10.4251\/wjgo.v11.i10.773","article-title":"Race, the microbiome and colorectal cancer","volume":"11","author":"Royston","year":"2019","journal-title":"World J Gastrointest Oncol"},{"key":"2022111812300263700_CIT0034","first-page":"51","article-title":"Acculturation erodes the diet quality of US Hispanics","volume":"23","author":"Variyam","year":"2000","journal-title":"Food Rev\/Natl Food Rev."},{"key":"2022111812300263700_CIT0035","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/ecco-jcc\/jjaa040","article-title":"Reappraising risk factors for inflammatory bowel disease-associated neoplasia: implications for colonoscopic surveillance in IBD","volume":"14","author":"Shah","year":"2020","journal-title":"J Crohns Colitis."},{"year":"2019","author":"Krogstad","key":"2022111812300263700_CIT0036"}],"container-title":["Crohn's &amp; Colitis 360"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/crohnscolitis360\/advance-article-pdf\/doi\/10.1093\/crocol\/otab016\/37789469\/otab016.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/article-pdf\/3\/2\/otab016\/47118209\/otab016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/article-pdf\/3\/2\/otab016\/47118209\/otab016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T12:31:23Z","timestamp":1668774683000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/article\/doi\/10.1093\/crocol\/otab016\/6263789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/crocol\/otab016","relation":{},"ISSN":["2631-827X"],"issn-type":[{"type":"electronic","value":"2631-827X"}],"subject":[],"published-other":{"date-parts":[[2021,4,1]]},"published":{"date-parts":[[2021,4,1]]},"article-number":"otab016"}}