{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:46:17Z","timestamp":1753875977763,"version":"3.41.2"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Crohn\u2019s disease (CD) and ulcerative colitis (UC) involve an inflammatory state where sleep dysregulation is common. Little is known about implications, if any, of inflammatory bowel disease (IBD) on the development of obstructive sleep apnea (OSA). This study aims to investigate if IBD patients are at higher risk for OSA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective multivariate analysis utilized a commercial database named Explorys (IBM Watson). We identified patients from 1\/2015 to 1\/2020 with UC and CD. Cohorts of these patients with and without OSA were then created and prevalence values were obtained. A multivariate analysis was used to correct for several potential confounding variables.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The overall prevalence of OSA was 7.8% in UC and 7.2% in CD, as compared with a prevalence of 4.3% in non-IBD patients (odds ratio [OR] for UC: 1.9 [95% CI 1.86\u20131.94, P &amp;lt; .0001], OR for CD: 1.72 [95% CI 1.69\u20131.76, P &amp;lt; .0001]). In multivariate analysis, age above 65, Caucasian race, male sex, obesity, smoking, hypertension, and diabetes were all independent risk factors for the development of OSA, with obesity being the most significant. After controlling for the listed variables in the multivariate analysis, IBD was an independent risk factor associated with OSA (OR 1.46, 95% CI 1.43\u20131.48).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this large population-based study, IBD was independently associated with increased prevalence of OSA. This has implications for screening for OSA in IBD, as well as management of other risk factors for OSA in IBD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/crocol\/otac026","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T22:37:05Z","timestamp":1657147025000},"source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of Obstructive Sleep Apnea Is Increased in Patients With Inflammatory Bowel Disease: A Large, Multi-Network Study"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1520-4925","authenticated-orcid":false,"given":"Kyle","family":"Hoffman","sequence":"first","affiliation":[{"name":"Case Western Reserve University\/University Hospitals Cleveland Medical Center, Department of Medicine , Cleveland, Ohio , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad","family":"Mansoor","sequence":"additional","affiliation":[{"name":"Cleveland Louis Stokes VA Medical Center, Division of Gastroenterology and Liver Disease , Cleveland, Ohio , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Siyab","family":"Panhwar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tulane University Medical Center, Section of Cardiology , New Orleans, Louisiana , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7681-8111","authenticated-orcid":false,"given":"Miguel","family":"Regueiro","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation, Department of Gastroenterology , Cleveland, Ohio , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Cooper","sequence":"additional","affiliation":[{"name":"Case Western Reserve University\/University Hospitals Cleveland Medical Center, Division of Gastroenterology , Cleveland, Ohio , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taha","family":"Qazi","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation, Department of Gastroenterology , Cleveland, Ohio , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"issue":"6","key":"2022111812325287300_CIT0001","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1152\/japplphysiol.00772.2005","article-title":"Pathogenesis of obstructive sleep apnea","volume":"99","author":"Ryan","year":"2005","journal-title":"J Appl Physiol."},{"key":"2022111812325287300_CIT0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5772\/64313","article-title":"Inflammatory bowel disease: epidemiology.","volume-title":"New Insights into Inflammatory Bowel Disease","author":"Arora","year":"2016"},{"issue":"1","key":"2022111812325287300_CIT0003","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1128\/CMR.15.1.79-94.2002","article-title":"Clinical aspects and pathophysiology of inflammatory bowel disease","volume":"15","author":"Hendrickson","year":"2002","journal-title":"Clin Microbiol Rev."},{"issue":"30","key":"2022111812325287300_CIT0004","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.3748\/wjg.v12.i30.4819","article-title":"Extraintestinal manifestations and complications in inflammatory bowel diseases","volume":"12","author":"Rothfuss","year":"2006","journal-title":"World J Gastroenterol."},{"issue":"6","key":"2022111812325287300_CIT0005","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1093\/ibd\/izy354","article-title":"Risk of myocardial infarction in inflammatory bowel disease: a population-based national study","volume":"25","author":"Panhwar","year":"2019","journal-title":"Inflamm Bowel 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cases","volume":"38","author":"El-Assaad","year":"2017","journal-title":"Pediatr Cardiol."},{"issue":"10","key":"2022111812325287300_CIT0010","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1007\/s10620-016-4204-4","article-title":"The 2010\u20132015 prevalence of eosinophilic esophagitis in the USA: a population-based study","volume":"61","author":"Mansoor","year":"2016","journal-title":"Dig Dis Sci."},{"issue":"16","key":"2022111812325287300_CIT0011","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1001\/jama.291.16.2013","article-title":"Risk factors for obstructive sleep apnea in adults","volume":"291","author":"Young","year":"2004","journal-title":"JAMA."},{"issue":"19","key":"2022111812325287300_CIT0012","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1001\/archinte.1994.00420190121014","article-title":"Smoking as a risk factor for sleep-disordered breathing","volume":"154","author":"Wetter","year":"1994","journal-title":"Arch Intern Med."},{"issue":"10","key":"2022111812325287300_CIT0013","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.5665\/sleep.4082","article-title":"Heritability of craniofacial structures in normal subjects and patients with sleep apnea","volume":"37","author":"Chi","year":"2014","journal-title":"Sleep."},{"issue":"9","key":"2022111812325287300_CIT0014","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.3899\/jrheum.081335","article-title":"Do rheumatoid arthritis patients have a higher risk for sleep apnea?","volume":"36","author":"Reading","year":"2009","journal-title":"J Rheumatol."},{"issue":"1","key":"2022111812325287300_CIT0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/rheumatology\/kes210","article-title":"Obstructive sleep apnoea in relation to rheumatic disease","volume":"52","author":"Taylor-Gjevre","year":"2013","journal-title":"Rheumatology."},{"issue":"40","key":"2022111812325287300_CIT0016","doi-asserted-by":"crossref","first-page":"11304","DOI":"10.3748\/wjg.v21.i40.11304","article-title":"Arterial structure and function in inflammatory bowel disease","volume":"21","author":"Zanoli","year":"2015","journal-title":"World J Gastroenterol."}],"container-title":["Crohn's &amp; Colitis 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