{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T08:14:09Z","timestamp":1793434449869,"version":"4.5.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This retrospective study gathered medical\/pharmacy claims data on patients with inflammatory bowel disease (IBD) between January 01, 2000 and March 31, 2019 from the IBM MarketScan commercial claims database to assess the real-world impact of fatigue on healthcare costs in patients newly diagnosed with IBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible participants were \u226518 years, newly diagnosed with IBD (\u22652 separate claims), and had \u226512 months of continuous database enrollment before and after fatigue diagnosis. The date of fatigue diagnosis was the index date; participants were followed for 12 months post-index. Patients with (cases) or without (controls) fatigue were matched 1:1 by propensity score matching. Patients with evidence of prior IBD diagnosis\/treatment, or those with a chronic disease other than IBD wherein fatigue is the primary symptom, were excluded. Healthcare resource utilization (HCRU), including hospitalizations, inpatient and outpatient visits, and associated costs were compared between cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Matched IBD cohorts (21 321 cases\/21 321 controls) were identified (42% Crohn\u2019s disease [CD] and 58% ulcerative colitis [UC]) with similar baseline characteristics (average age: 46 years; 60% female). Cases versus controls had significantly more all-cause outpatient visits (incidence rate ratio [IRR], 95% confidence intervals [95% CI]: 1.64 [1.61, 1.67], P &amp;lt; .001) and all-cause hospitalizations (IRR [95% CI]: 1.92 [1.81, 2.04], P &amp;lt; .001); as well as significantly higher all-cause total direct healthcare costs (mean: $24 620 vs. $15 324; P &amp;lt; .001). Similar findings were observed for IBD-related outcomes, as well as in CD- and UC-specific subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Presence of fatigue is associated with an increase in HCRU and total medical costs among patients newly diagnosed with IBD.<\/jats:p><\/jats:sec>","DOI":"10.1093\/crocol\/otad020","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T16:37:59Z","timestamp":1682008679000},"source":"Crossref","is-referenced-by-count":17,"title":["Economic Burden of Fatigue in Inflammatory Bowel Disease"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9436-1821","authenticated-orcid":false,"given":"Ashwin N","family":"Ananthakrishnan","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Massachusetts General Hospital and Harvard medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes & Policy, University of Florida , Gainesville, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Heath Economics and Outcomes Research, AbbVie Inc. , North Chicago, IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Griffith","sequence":"additional","affiliation":[{"name":"Heath Economics and Outcomes Research, AbbVie Inc. , North Chicago, IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naijun","family":"Chen","sequence":"additional","affiliation":[{"name":"Heath Economics and Outcomes Research, AbbVie Inc. , North Chicago, IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Edward V","family":"Loftus","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science , Rochester, MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"issue":"2","key":"2023083115543924400_CIT0001","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/apt.13255","article-title":"Assessing fatigue in inflammatory bowel disease: comparison of three fatigue scales","volume":"42","author":"Norton","year":"2015","journal-title":"Aliment Pharmacol Ther."},{"issue":"1","key":"2023083115543924400_CIT0002","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/apt.16145","article-title":"Fatigue in inflammatory bowel disease and its impact on daily activities","volume":"53","author":"Schreiner","year":"2021","journal-title":"Aliment Pharmacol Ther."},{"issue":"4","key":"2023083115543924400_CIT0003","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41575-018-0091-9","article-title":"Fatigue in IBD: epidemiology, pathophysiology and management","volume":"16","author":"Borren","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol."},{"issue":"1","key":"2023083115543924400_CIT0004","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12325-019-01151-w","article-title":"Fatigue in inflammatory bowel diseases: etiologies and management","volume":"37","author":"Nocerino","year":"2020","journal-title":"Adv Ther."},{"issue":"9","key":"2023083115543924400_CIT0005","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/ecco-jcc\/jjv091","article-title":"Fatigue in newly diagnosed inflammatory bowel disease","volume":"9","author":"Grimstad","year":"2015","journal-title":"J Crohns Colitis"},{"issue":"4","key":"2023083115543924400_CIT0006","first-page":"CD012005","article-title":"Interventions for fatigue in inflammatory bowel disease","volume":"4","author":"Farrell","year":"2020","journal-title":"Cochrane Database Syst Rev."},{"issue":"12","key":"2023083115543924400_CIT0007","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1002\/ibd.21285","article-title":"Fatigue and health-related quality of life in inflammatory bowel disease: results from a population-based study in the Netherlands: the IBD-South Limburg cohort","volume":"16","author":"Romberg-Camps","year":"2010","journal-title":"Inflamm Bowel Dis."},{"key":"2023083115543924400_CIT0008","volume-title":"Health Care Utilization Among U.S. Adults With Inflammatory Bowel Disease, 2015\u20132016","author":"Terlizzi","year":"2021"},{"issue":"1","key":"2023083115543924400_CIT0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.jom.0000249782.60321.2a","article-title":"Fatigue in the U.S. workforce: prevalence and implications for lost productive work 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study","volume":"27","author":"Borren","year":"2021","journal-title":"Inflamm Bowel Dis."},{"issue":"2","key":"2023083115543924400_CIT0013","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11894-020-0746-x","article-title":"Sleep and Fatigue in IBD: an unrecognized but important extra-intestinal manifestation","volume":"22","author":"Canakis","year":"2020","journal-title":"Curr Gastroenterol Rep."},{"issue":"8","key":"2023083115543924400_CIT0014","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.cgh.2013.01.021","article-title":"Sleep disturbance and risk of active disease in patients with Crohn's disease and ulcerative colitis","volume":"11","author":"Ananthakrishnan","year":"2013","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"11\u201312","key":"2023083115543924400_CIT0015","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1111\/j.1365-2036.2011.04871.x","article-title":"Validation of the functional assessment of chronic illness therapy-fatigue (FACIT-F) in patients with inflammatory bowel disease","volume":"34","author":"Tinsley","year":"2011","journal-title":"Aliment Pharmacol Ther."}],"container-title":["Crohn's &amp; Colitis 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