{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T18:11:36Z","timestamp":1793988696363,"version":"4.8.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016469","name":"Takeda Pharmaceuticals International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016469","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Crohn\u2019s perianal fistula is a disabling manifestation of Crohn\u2019s disease. However, the additional burden of perianal fistula on patients with only Crohn\u2019s disease remains to be addressed. This patient-reported survey considered outcomes of two domains: \u201cdiagnosis\u201d (eg, symptoms) and \u201cliving with the disease\u201d (eg, quality of life, well-being, and relationships).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with perianal fistula and Crohn\u2019s disease completed an online, self-selective, anonymous, 46-item survey available in 11 languages hosted on the European Federation of Crohn\u2019s &amp; Ulcerative Colitis Associations and national patient association websites. The survey was conducted between July and December 2019 in Europe and other regions. Likert scales and closed questions were used to assess outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 820 respondents with Crohn\u2019s disease (67.2% women; median age, 40.0 years), 532 (64.9%) reported the presence of perianal fistula. Patients with perianal fistula reported a greater impact on overall quality of life (P\u2005&amp;lt;\u2005.001), well-being (P\u2005&amp;lt;\u2005.001), relationships (P\u2005&amp;lt;\u2005.001), social life (P\u2005=\u2005.001), and work life (P\u2005=\u2005.012) than patients with only Crohn\u2019s disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Perianal fistulas impact several domains of the life of patients with Crohn\u2019s disease. These results may help healthcare practitioners plan therapeutic strategies that address the symptomatic and psychological burden experienced by patients with perianal fistulizing Crohn\u2019s disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/crocol\/otad036","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T16:45:12Z","timestamp":1690303512000},"source":"Crossref","is-referenced-by-count":47,"title":["The Impact of Crohn\u2019s Perianal Fistula on Quality of Life: Results of an International Patient Survey"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1493-1768","authenticated-orcid":false,"given":"Antonino","family":"Spinelli","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University , Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Milan , Italy"},{"name":"Division of Colon and Rectal Surgery, IRCCS Humanitas Research Hospital , Via Manzoni 56, 20089 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