{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:02:38Z","timestamp":1792641758142,"version":"4.5.0"},"reference-count":137,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Ulcerative colitis (UC) is a prevalent inflammatory bowel disease primarily impacting the mucosa of the colon. It is characterized by recurring and incurable symptoms and causes immense suffering and significant economic burden due to limited treatment options. Typical symptoms of UC include diarrhea, alterations in bowel patterns, bleeding from the rectum, rectal pain or urgency, anemia, and tiredness. Therefore, developing novel and effective treatment strategies for UC is imperative.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>This review aimed to explain how macrophage polarization contributes to UC development and compiled information on natural compounds with promising therapeutic potential that can target the macrophage phenotype and shed light on its potential mode of action.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The phenotypic alteration of macrophages profoundly affects the development of UC, and these cells are essential for preserving intestinal immunological homeostasis. Evidence from research suggests that one effective method for UC prevention and therapy is to guide macrophage polarization toward the M2 phenotype. Phytochemicals, which are compounds extracted from plants, possess a wide array of biological activities. For example: Ginsenoside Rg1 emerges as a crucial regulator of macrophage polarization, promoting the M2 phenotype while inhibiting the M1 phenotype. Notably, their low toxicity and high effectiveness render them promising candidates for therapeutic interventions. These compounds have demonstrated encouraging protective effects against inflammation in the colon.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Exploring phytochemicals as a therapeutic avenue targeting macrophage polarization presents an innovative approach to treating UC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/crocol\/otae070","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T16:35:42Z","timestamp":1732811742000},"source":"Crossref","is-referenced-by-count":5,"title":["A Future Avenue of Treatment Ulcerative Colitis Targeting Macrophage Polarization: A Phytochemical Application"],"prefix":"10.1093","volume":"6","author":[{"given":"Nishant Kumar","family":"Saurabh","sequence":"first","affiliation":[{"name":"Division of Molecular Biology, National Institute of Cancer Prevention & Research (ICMR-NICPR) , I-7, Sector-39, Noida 201301 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3721-8731","authenticated-orcid":false,"given":"Mohd Mabood","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Robinson Research Building, Vanderbilt University Medical Centre , Nashville, TN 37232-6602 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-9359","authenticated-orcid":false,"given":"Annet","family":"Kirabo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Robinson Research Building, Vanderbilt University Medical Centre , Nashville, TN 37232-6602 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"issue":"28","key":"2024121208355129600_CIT0001","doi-asserted-by":"publisher","first-page":"9458","DOI":"10.3748\/wjg.v20.i28.9458","article-title":"Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis","volume":"20","author":"da Silva","year":"2014","journal-title":"World J Gastroenterol."},{"issue":"9","key":"2024121208355129600_CIT0002","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1093\/ecco-jcc\/jjab048","article-title":"Results of the Seventh Scientific Workshop of ECCO: precision medicine in IBD-prediction and prevention of inflammatory bowel disease","volume":"15","author":"Torres","year":"2021","journal-title":"J Crohns Colitis."},{"issue":"1","key":"2024121208355129600_CIT0003","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology."},{"issue":"11","key":"2024121208355129600_CIT0004","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1016\/j.mayocp.2014.07.002","article-title":"Ulcerative colitis: epidemiology, diagnosis, and management","volume":"89","author":"Feuerstein","year":"2014","journal-title":"Mayo Clin Proc."},{"issue":"1","key":"2024121208355129600_CIT0005","doi-asserted-by":"publisher","first-page":"1426954","DOI":"10.1155\/2019\/1426954","article-title":"Application of proteomics to inflammatory bowel disease research: current status and future perspectives","volume":"2019","author":"Assadsangabi","year":"2019","journal-title":"Gastroenterol Res Pract."},{"issue":"12","key":"2024121208355129600_CIT0006","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1136\/gut.2009.199679","article-title":"New IBD genetics: common pathways with other diseases","volume":"60","author":"Lees","year":"2011","journal-title":"Gut."},{"issue":"1","key":"2024121208355129600_CIT0007","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.mayocp.2018.09.013","article-title":"Mechanisms of disease: inflammatory bowel diseases","volume":"94","author":"Ramos","year":"2019","journal-title":"Mayo Clin Proc."},{"issue":"1","key":"2024121208355129600_CIT0008","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12328-017-0813-5","article-title":"Gut microbiota in the pathogenesis of inflammatory bowel disease","volume":"11","author":"Nishida","year":"2018","journal-title":"Clin J Gastroenterol."},{"issue":"1","key":"2024121208355129600_CIT0009","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nrgastro.2015.186","article-title":"Immunopathogenesis of IBD: current state of the art","volume":"13","author":"de Souza","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol."},{"issue":"1","key":"2024121208355129600_CIT0010","first-page":"31","article-title":"The effect of intracolonic Matricaria recutita L. aqueous extract on acetic acid-induced ulcerative colitis in adult male rats","volume":"19","author":"Nejad","year":"2014","journal-title":"Govaresh."},{"issue":"1","key":"2024121208355129600_CIT0011","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1159\/000452364","article-title":"Changes in intestinal motility and gut microbiota composition in a rat stress model","volume":"95","author":"Murakami","year":"2017","journal-title":"Digestion."},{"issue":"37","key":"2024121208355129600_CIT0012","doi-asserted-by":"publisher","first-page":"5151","DOI":"10.3748\/wjg.v18.i37.5151","article-title":"Irritable bowel syndrome: diagnosis and pathogenesis","volume":"18","author":"El-Salhy","year":"2012","journal-title":"World J Gastroenterol."},{"issue":"9400","key":"2024121208355129600_CIT0013","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1016\/S0140-6736(03)15024-6","article-title":"Crohn\u2019s disease: the cold chain hypothesis","volume":"362","author":"Hugot","year":"2003","journal-title":"Lancet."},{"issue":"26","key":"2024121208355129600_CIT0014","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1056\/nejm198712243172603","article-title":"Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis","volume":"317","author":"Schroeder","year":"1987","journal-title":"N Engl J Med."},{"issue":"10","key":"2024121208355129600_CIT0015","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.crohns.2012.09.003","article-title":"Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 1: definitions and diagnosis","volume":"6","author":"Dignass","year":"2012","journal-title":"J Crohns Colitis."},{"issue":"6","key":"2024121208355129600_CIT0016","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.cgh.2012.01.010","article-title":"Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies","volume":"10","author":"Jess","year":"2012","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"4","key":"2024121208355129600_CIT0017","doi-asserted-by":"publisher","first-page":"203","DOI":"10.4103\/2225-4110.139111","article-title":"Dietary agents and phytochemicals in the prevention and treatment of experimental ulcerative colitis","volume":"4","author":"Saxena","year":"2014","journal-title":"J Tradit Complement Med."},{"key":"2024121208355129600_CIT0018","doi-asserted-by":"publisher","first-page":"343","DOI":"10.2147\/CEG.S237653","article-title":"Patient preference and adherence to aminosalicylates for the treatment of ulcerative colitis","volume":"14","author":"Tripathi","year":"2021","journal-title":"Clin Exp Gastroenterol."},{"issue":"11","key":"2024121208355129600_CIT0019","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1080\/03007995.2021.1968813","article-title":"Efficacy and safety of oral Pentasa (prolonged-release mesalazine) in mild-to-moderate ulcerative colitis: a systematic review and meta-analysis","volume":"37","author":"Paridaens","year":"2021","journal-title":"Curr Med Res Opin."},{"key":"2024121208355129600_CIT0020","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2147\/CEG.S225675","article-title":"Protective effect of asacol in combination with pantoprazole in ulcerative colitis patients who defecate asacol tablets intactly: a clinical trial study","volume":"13","author":"Bashiri","year":"2020","journal-title":"Clin Exp Gastroenterol."},{"issue":"1","key":"2024121208355129600_CIT0021","doi-asserted-by":"publisher","first-page":"e00302","DOI":"10.14309\/crj.0000000000000302","article-title":"Balsalazide-induced pneumonitis causing dyspnea in a patient with inflammatory bowel disease","volume":"7","author":"Sobecki","year":"2020","journal-title":"ACG Case Rep J."},{"key":"2024121208355129600_CIT0022","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.biomaterials.2018.09.005","article-title":"Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease","volume":"185","author":"Date","year":"2018","journal-title":"Biomaterials."},{"issue":"11-12","key":"2024121208355129600_CIT0023","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1111\/apt.16137","article-title":"NUDT15 C415T variant compared with TPMT genotyping in predicting azathioprine-induced leucopenia: prospective analysis of 1014 inflammatory bowel disease patients in India","volume":"52","author":"Banerjee","year":"2020","journal-title":"Aliment Pharmacol Ther."},{"issue":"4","key":"2024121208355129600_CIT0024","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1053\/j.gastro.2018.06.046","article-title":"Methotrexate is not superior to placebo in maintaining steroid-free response or remission in ulcerative colitis","volume":"155","author":"Herfarth","year":"2018","journal-title":"Gastroenterology."},{"key":"2024121208355129600_CIT0025","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.ejpb.2017.07.004","article-title":"Targeted delivery of Cyclosporine A by polymeric nanocarriers improves the therapy of inflammatory bowel disease in a relevant mouse model","volume":"119","author":"Melero","year":"2017","journal-title":"Eur J Pharm Biopharm."},{"issue":"5","key":"2024121208355129600_CIT0026","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1093\/ecco-jcc\/jjz195","article-title":"Predictors of primary response to biologic treatment [Anti-TNF, Vedolizumab, and Ustekinumab] in patients with inflammatory bowel disease: from basic science to clinical practice","volume":"14","author":"Gisbert","year":"2020","journal-title":"J Crohns Colitis."},{"issue":"3","key":"2024121208355129600_CIT0027","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/ptr.5271","article-title":"Phytochemicals and their potential usefulness in inflammatory bowel disease","volume":"29","author":"Somani","year":"2015","journal-title":"Phytother Res."},{"issue":"28","key":"2024121208355129600_CIT0028","doi-asserted-by":"publisher","first-page":"5097","DOI":"10.3748\/wjg.v23.i28.5097","article-title":"Therapeutic potential of flavonoids in inflammatory bowel disease: a comprehensive review","volume":"23","author":"Salaritabar","year":"2017","journal-title":"World J Gastroenterol."},{"issue":"1","key":"2024121208355129600_CIT0029","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/jbcpp-2018-0036","article-title":"Immune response and inflammatory pathway of ulcerative colitis","volume":"30","author":"Tatiya-Aphiradee","year":"2018","journal-title":"J Basic Clin Physiol Pharmacol."},{"key":"2024121208355129600_CIT0030","doi-asserted-by":"publisher","first-page":"118129","DOI":"10.1016\/j.lfs.2020.118129","article-title":"Ulcerative colitis: gut microbiota, immunopathogenesis and application of natural products in animal models","volume":"258","author":"Nascimento","year":"2020","journal-title":"Life Sci."},{"issue":"1","key":"2024121208355129600_CIT0031","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.advms.2016.09.001","article-title":"Cells of the innate and adaptive immunity and their interactions in inflammatory bowel disease","volume":"62","author":"Kmie\u0107","year":"2017","journal-title":"Adv Med Sci."},{"key":"2024121208355129600_CIT0032","doi-asserted-by":"publisher","first-page":"893803","DOI":"10.3389\/fimmu.2022.893803","article-title":"Identification of a disease-associated network of intestinal immune cells in treatment-naive inflammatory bowel disease","volume":"13","author":"van Unen","year":"2022","journal-title":"Front Immunol."},{"issue":"2","key":"2024121208355129600_CIT0033","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1053\/j.gastro.2015.04.017","article-title":"Interleukin 6 increases production of cytokines by colonic innate lymphoid cells in mice and patients with chronic intestinal inflammation","volume":"149","author":"Powell","year":"2015","journal-title":"Gastroenterology."},{"key":"2024121208355129600_CIT0034","doi-asserted-by":"publisher","first-page":"918241","DOI":"10.3389\/fimmu.2022.918241","article-title":"DMGV is a rheostat of T cell survival and a potential therapeutic for inflammatory diseases and cancers","volume":"13","author":"Yang","year":"2022","journal-title":"Front Immunol."},{"issue":"1","key":"2024121208355129600_CIT0035","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.clnu.2008.11.002","article-title":"Butyrate modulates oxidative stress in the colonic mucosa of healthy humans","volume":"28","author":"Hamer","year":"2009","journal-title":"Clin Nutr."},{"key":"2024121208355129600_CIT0036","doi-asserted-by":"publisher","first-page":"102441","DOI":"10.1016\/j.redox.2022.102441","article-title":"Mo(3)Se(4) nanoparticle with ROS scavenging and multi-enzyme activity for the treatment of DSS-induced colitis in mice","volume":"56","author":"Guo","year":"2022","journal-title":"Redox Biol."},{"key":"2024121208355129600_CIT0037","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12950-017-0172-5","article-title":"Hyperoside attenuates dextran sulfate sodium-induced colitis in mice possibly via activation of the Nrf2 signalling pathway","volume":"14","author":"Yang","year":"2017","journal-title":"J Inflamm (Lond)."},{"issue":"9","key":"2024121208355129600_CIT0038","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1021\/acs.jafc.0c06755","article-title":"Troxerutin improves dextran sulfate sodium-induced ulcerative colitis in mice","volume":"69","author":"Wang","year":"2021","journal-title":"J Agric Food Chem."},{"key":"2024121208355129600_CIT0039","doi-asserted-by":"publisher","first-page":"893231","DOI":"10.3389\/fphar.2022.893231","article-title":"Chang qing formula ameliorates colitis-associated colorectal cancer via suppressing IL-17\/NF-\u03baB\/STAT3 pathway in mice as revealed by network pharmacology study","volume":"13","author":"Luo","year":"2022","journal-title":"Front Pharmacol."},{"issue":"8","key":"2024121208355129600_CIT0040","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1038\/s41419-018-0810-8","article-title":"Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer","volume":"9","author":"Pal","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"2024121208355129600_CIT0041","doi-asserted-by":"publisher","first-page":"1512969","DOI":"10.1155\/2019\/1512969","article-title":"Functions of macrophages in the maintenance of intestinal homeostasis","volume":"2019","author":"Wang","year":"2019","journal-title":"J Immunol Res."},{"key":"2024121208355129600_CIT0042","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3389\/fimmu.2015.00613","article-title":"Diversity of intestinal macrophages in inflammatory bowel diseases","volume":"6","author":"K\u00fchl","year":"2015","journal-title":"Front Immunol."},{"issue":"2","key":"2024121208355129600_CIT0043","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/path.4133","article-title":"Macrophage plasticity and polarization in tissue repair and remodelling","volume":"229","author":"Mantovani","year":"2013","journal-title":"J Pathol."},{"issue":"2","key":"2024121208355129600_CIT0044","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s00005-020-00576-4","article-title":"Current status of M1 and M2 macrophages pathway as drug targets for inflammatory bowel disease","volume":"68","author":"Seyedizade","year":"2020","journal-title":"Arch Immunol Ther Exp (Warsz)."},{"issue":"12","key":"2024121208355129600_CIT0045","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat Rev Immunol."},{"issue":"3","key":"2024121208355129600_CIT0046","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1084\/jem.116.3.381","article-title":"Cellular resistance to infection","volume":"116","author":"Mackaness","year":"1962","journal-title":"J Exp Med."},{"issue":"1","key":"2024121208355129600_CIT0047","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat Rev Immunol."},{"issue":"12","key":"2024121208355129600_CIT0048","doi-asserted-by":"publisher","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"J Immunol."},{"key":"2024121208355129600_CIT0049","doi-asserted-by":"publisher","first-page":"999179","DOI":"10.3389\/fphar.2022.999179","article-title":"A potential therapeutic target in traditional Chinese medicine for ulcerative colitis: macrophage polarization","volume":"13","author":"Yang","year":"2022","journal-title":"Front Pharmacol."},{"key":"2024121208355129600_CIT0050","doi-asserted-by":"publisher","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep."},{"issue":"1","key":"2024121208355129600_CIT0051","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity."},{"issue":"2","key":"2024121208355129600_CIT0052","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.immuni.2014.01.006","article-title":"Transcriptome-based network analysis reveals a spectrum model of human macrophage activation","volume":"40","author":"Xue","year":"2014","journal-title":"Immunity."},{"key":"2024121208355129600_CIT0053","article-title":"Ginsenoside RB1 influences macrophage-DPSC interactions in inflammatory conditions","author":"Li","year":"2024","journal-title":"Int Dent J."},{"issue":"7","key":"2024121208355129600_CIT0054","doi-asserted-by":"publisher","first-page":"3854","DOI":"10.3390\/ijms25073854","article-title":"The role of macrophage efferocytosis in the pathogenesis of apical periodontitis","volume":"25","author":"Guan","year":"2024","journal-title":"Int J Mol Sci."},{"issue":"5","key":"2024121208355129600_CIT0055","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1002\/ptr.8146","article-title":"Cucurbitacin B modulates M2 macrophage differentiation and attenuates osteosarcoma progression via PI3K\/AKT pathway","volume":"38","author":"Wu","year":"2024","journal-title":"Phytother Res."},{"key":"2024121208355129600_CIT0056","doi-asserted-by":"publisher","first-page":"175229","DOI":"10.1016\/j.ejphar.2022.175229","article-title":"Macrophage phenotype-switching in cancer","volume":"931","author":"Zhang","year":"2022","journal-title":"Eur J Pharmacol."},{"issue":"9","key":"2024121208355129600_CIT0057","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol."},{"issue":"3","key":"2024121208355129600_CIT0058","doi-asserted-by":"publisher","first-page":"281","DOI":"10.2174\/1568010054022024","article-title":"Macrophages in inflammation","volume":"4","author":"Fujiwara","year":"2005","journal-title":"Curr Drug Targets Inflamm Allergy."},{"issue":"3","key":"2024121208355129600_CIT0059","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1080\/14728222.2021.1901079","article-title":"Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease","volume":"25","author":"Du","year":"2021","journal-title":"Expert Opin Ther Targets."},{"key":"2024121208355129600_CIT0060","doi-asserted-by":"publisher","first-page":"173090","DOI":"10.1016\/j.ejphar.2020.173090","article-title":"Macrophage M1\/M2 polarization","volume":"877","author":"Yunna","year":"2020","journal-title":"Eur J Pharmacol."},{"issue":"3","key":"2024121208355129600_CIT0061","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/mi.2012.89","article-title":"Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors","volume":"6","author":"Bain","year":"2013","journal-title":"Mucosal Immunol."},{"issue":"5","key":"2024121208355129600_CIT0062","doi-asserted-by":"publisher","first-page":"e338","DOI":"10.1038\/emm.2017.20","article-title":"Roles of intestinal epithelial cells in the maintenance of gut homeostasis","volume":"49","author":"Okumura","year":"2017","journal-title":"Exp Mol Med."},{"issue":"9","key":"2024121208355129600_CIT0063","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/s41575-019-0172-4","article-title":"Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD","volume":"16","author":"Na","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"2024121208355129600_CIT0064","doi-asserted-by":"publisher","first-page":"625423","DOI":"10.3389\/fcell.2021.625423","article-title":"Roles of macrophages in the development and treatment of gut inflammation","volume":"9","author":"Han","year":"2021","journal-title":"Front Cell Dev Biol."},{"issue":"6","key":"2024121208355129600_CIT0065","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1097\/MIB.0000000000000384","article-title":"Monocyte and M1 macrophage-induced barrier defect contributes to chronic intestinal inflammation in IBD","volume":"21","author":"Lissner","year":"2015","journal-title":"Inflamm Bowel Dis."},{"issue":"4","key":"2024121208355129600_CIT0066","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/j.1440-1746.1995.tb01589.x","article-title":"Direct evidence of monocyte recruitment to inflammatory bowel disease mucosa","volume":"10","author":"Grimm","year":"1995","journal-title":"J Gastroenterol Hepatol."},{"key":"2024121208355129600_CIT0067","doi-asserted-by":"publisher","first-page":"174742","DOI":"10.1016\/j.ejphar.2022.174742","article-title":"Ginsenoside Rg1 ameliorated experimental colitis by regulating the balance of M1\/M2 macrophage polarization and the homeostasis of intestinal flora","volume":"917","author":"Long","year":"2022","journal-title":"Eur J Pharmacol."},{"key":"2024121208355129600_CIT0068","doi-asserted-by":"publisher","first-page":"108176","DOI":"10.1016\/j.pharmthera.2022.108176","article-title":"Macrophage immunometabolism in inflammatory bowel diseases: from pathogenesis to therapy","volume":"238","author":"Pan","year":"2022","journal-title":"Pharmacol Ther."},{"issue":"1","key":"2024121208355129600_CIT0069","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12865-019-0322-z","article-title":"Subsets of mononuclear phagocytes are enriched in the inflamed colons of patients with IBD","volume":"20","author":"Liu","year":"2019","journal-title":"BMC Immunol."},{"issue":"9","key":"2024121208355129600_CIT0070","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1093\/ecco-jcc\/jjab031","article-title":"Restored macrophage function ameliorates disease pathophysiology in a mouse model for IL10 receptor-deficient very early onset inflammatory bowel disease","volume":"15","author":"Ackermann","year":"2021","journal-title":"J Crohns Colitis."},{"issue":"4","key":"2024121208355129600_CIT0071","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1053\/j.gastro.2009.12.041","article-title":"In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice","volume":"138","author":"Hunter","year":"2010","journal-title":"Gastroenterology."},{"issue":"5","key":"2024121208355129600_CIT0072","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.4049\/jimmunol.0804012","article-title":"Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset","volume":"184","author":"Takada","year":"2010","journal-title":"J Immunol."},{"issue":"4","key":"2024121208355129600_CIT0073","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1097\/MIB.0b013e318280292b","article-title":"Reduction of CD68+ macrophages and decreased IL-17 expression in intestinal mucosa of patients with inflammatory bowel disease strongly correlate with endoscopic response and mucosal healing following infliximab therapy","volume":"19","author":"Caprioli","year":"2013","journal-title":"Inflamm Bowel Dis."},{"key":"2024121208355129600_CIT0074","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.bcp.2017.08.013","article-title":"Chromofungin (CHR: CHGA(47-66)) is downregulated in persons with active ulcerative colitis and suppresses pro-inflammatory macrophage function through the inhibition of NF-\u03baB signaling","volume":"145","author":"Eissa","year":"2017","journal-title":"Biochem Pharmacol."},{"key":"2024121208355129600_CIT0075","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.3389\/fimmu.2017.01131","article-title":"Chromofungin ameliorates the progression of colitis by regulating alternatively activated macrophages","volume":"8","author":"Eissa","year":"2017","journal-title":"Front Immunol."},{"key":"2024121208355129600_CIT0076","doi-asserted-by":"publisher","first-page":"106456","DOI":"10.1016\/j.intimp.2020.106456","article-title":"Follistatin like protein-1 modulates macrophage polarization and aggravates dextran sodium sulfate-induced colitis","volume":"83","author":"Li","year":"2020","journal-title":"Int Immunopharmacol."},{"key":"2024121208355129600_CIT0077","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.intimp.2019.04.020","article-title":"Extracellular vesicles derived from bone marrow mesenchymal stem cells attenuate dextran sodium sulfate-induced ulcerative colitis by promoting M2 macrophage polarization","volume":"72","author":"Cao","year":"2019","journal-title":"Int Immunopharmacol."},{"issue":"9","key":"2024121208355129600_CIT0078","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1097\/MIB.0b013e3182920108","article-title":"Are there any differences in the efficacy and safety of different formulations of Oral 5-ASA used for induction and maintenance of remission in ulcerative colitis? evidence from Cochrane reviews","volume":"19","author":"Feagan","year":"2013","journal-title":"Inflamm Bowel Dis."},{"issue":"3","key":"2024121208355129600_CIT0079","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/ajg.2009.727","article-title":"Ulcerative colitis practice guidelines in adults: American College of Gastroenterology, Practice Parameters Committee","volume":"105","author":"Kornbluth","year":"2010","journal-title":"Am J Gastroenterol."},{"issue":"8","key":"2024121208355129600_CIT0080","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/s41574-020-0341-0","article-title":"Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment","volume":"16","author":"Chotiyarnwong","year":"2020","journal-title":"Nat Rev Endocrinol."},{"issue":"1","key":"2024121208355129600_CIT0081","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative colitis","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Nat Rev Dis Primers."},{"key":"2024121208355129600_CIT0082","doi-asserted-by":"publisher","first-page":"1051952","DOI":"10.3389\/fphar.2022.1051952","article-title":"The therapeutic potential of natural products for treating pancreatic cancer","volume":"13","author":"He","year":"2022","journal-title":"Front Pharmacol."},{"key":"2024121208355129600_CIT0083","doi-asserted-by":"publisher","first-page":"105613","DOI":"10.1016\/j.phrs.2021.105613","article-title":"Didymin switches M1-like toward M2-like macrophage to ameliorate ulcerative colitis via fatty acid oxidation","volume":"169","author":"Lv","year":"2021","journal-title":"Pharmacol Res."},{"issue":"11","key":"2024121208355129600_CIT0084","doi-asserted-by":"publisher","first-page":"5995","DOI":"10.21873\/anticanres.12046","article-title":"Anticancer activity of artemisinin and its derivatives","volume":"37","author":"Slezakova","year":"2017","journal-title":"Anticancer Res."},{"issue":"10","key":"2024121208355129600_CIT0085","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.3390\/molecules23102547","article-title":"Recent trends in potential therapeutic applications of the dietary flavonoid didymin","volume":"23","author":"Yao","year":"2018","journal-title":"Molecules."},{"issue":"1","key":"2024121208355129600_CIT0086","doi-asserted-by":"publisher","first-page":"2162158","DOI":"10.1080\/10717544.2022.2162158","article-title":"Development of phospholipon\u00ae 90H complex nanocarrier with enhanced oral bioavailability and anti-inflammatory potential of genistein","volume":"30","author":"Shete","year":"2023","journal-title":"Drug Deliv."},{"issue":"1","key":"2024121208355129600_CIT0087","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3390\/cancers15010249","article-title":"Multifaceted pharmacological potentials of curcumin, genistein, and tanshinone IIA through proteomic approaches: an in-depth review","volume":"15","author":"Khan","year":"2022","journal-title":"Cancers (Basel)."},{"issue":"1","key":"2024121208355129600_CIT0088","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1080\/13880209.2022.2136206","article-title":"Therapeutic potential of plant iridoids in depression: a review","volume":"60","author":"Kou","year":"2022","journal-title":"Pharm Biol."},{"key":"2024121208355129600_CIT0089","doi-asserted-by":"publisher","first-page":"105796","DOI":"10.1016\/j.phrs.2021.105796","article-title":"Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization","volume":"172","author":"Wu","year":"2021","journal-title":"Pharmacol Res."},{"key":"2024121208355129600_CIT0090","doi-asserted-by":"publisher","first-page":"106240","DOI":"10.1016\/j.intimp.2020.106240","article-title":"Protective effects of iridoid glycosides on acute colitis via inhibition of the inflammatory response mediated by the STAT3\/NF-\u043aB pathway","volume":"81","author":"Yuan","year":"2020","journal-title":"Int Immunopharmacol."},{"issue":"12","key":"2024121208355129600_CIT0091","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.1016\/j.bbagen.2014.08.008","article-title":"Tiliroside, a dietary glycosidic flavonoid, inhibits TRAF-6\/NF-\u03baB\/p38-mediated neuroinflammation in activated BV2 microglia","volume":"1840","author":"Velagapudi","year":"2014","journal-title":"Biochim Biophys Acta."},{"issue":"1","key":"2024121208355129600_CIT0092","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.fshw.2021.07.014","article-title":"Sulforaphane attenuates dextran sodium sulphate induced intestinal inflammation via IL-10\/STAT3 signaling mediated macrophage phenotype switching","volume":"11","author":"Sun","year":"2022","journal-title":"Food Sci Hum Wellness."},{"key":"2024121208355129600_CIT0093","doi-asserted-by":"publisher","first-page":"108133","DOI":"10.1016\/j.intimp.2021.108133","article-title":"Ginsenoside Rg1 relieves experimental colitis by regulating balanced differentiation of Tfh\/Treg cells","volume":"100","author":"Jin","year":"2021","journal-title":"Int Immunopharmacol."},{"key":"2024121208355129600_CIT0094","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.intimp.2017.06.002","article-title":"Ginsenoside Rg1 attenuates the inflammatory response in DSS-induced mice colitis","volume":"50","author":"Zhu","year":"2017","journal-title":"Int Immunopharmacol."},{"key":"2024121208355129600_CIT0095","doi-asserted-by":"publisher","first-page":"114749","DOI":"10.1016\/j.jep.2021.114749","article-title":"Therapeutic effect of baicalin on inflammatory bowel disease: a review","volume":"283","author":"Wang","year":"2022","journal-title":"J Ethnopharmacol."},{"key":"2024121208355129600_CIT0096","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.intimp.2019.04.052","article-title":"Regulating effect of baicalin on IKK\/IKB\/NF-kB signaling pathway and apoptosis-related proteins in rats with ulcerative colitis","volume":"73","author":"Shen","year":"2019","journal-title":"Int Immunopharmacol."},{"key":"2024121208355129600_CIT0097","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.intimp.2016.03.030","article-title":"Baicalin ameliorates experimental inflammatory bowel disease through polarization of macrophages to an M2 phenotype","volume":"35","author":"Zhu","year":"2016","journal-title":"Int Immunopharmacol."},{"key":"2024121208355129600_CIT0098","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.molimm.2018.12.023","article-title":"Electroacupuncture at ST-36 ameliorates DSS-induced acute colitis via regulating macrophage polarization induced by suppressing NLRP3\/IL-1\u03b2 and promoting Nrf2\/HO-1","volume":"106","author":"Song","year":"2019","journal-title":"Mol Immunol."},{"issue":"1","key":"2024121208355129600_CIT0099","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.pharmthera.2013.12.001","article-title":"Artemisinins: pharmacological actions beyond anti-malarial","volume":"142","author":"Ho","year":"2014","journal-title":"Pharmacol Ther."},{"key":"2024121208355129600_CIT0100","doi-asserted-by":"publisher","first-page":"107284","DOI":"10.1016\/j.intimp.2020.107284","article-title":"Artemisinin ameliorates intestinal inflammation by skewing macrophages to the M2 phenotype and inhibiting epithelial-mesenchymal transition","volume":"91","author":"Huai","year":"2021","journal-title":"Int Immunopharmacol."},{"key":"2024121208355129600_CIT0101","doi-asserted-by":"publisher","first-page":"649463","DOI":"10.3389\/fimmu.2021.649463","article-title":"Tiliroside ameliorates ulcerative colitis by restoring the M1\/M2 macrophage balance via the HIF-1\u03b1\/glycolysis pathway","volume":"12","author":"Zhuang","year":"2021","journal-title":"Front Immunol."},{"key":"2024121208355129600_CIT0102","doi-asserted-by":"publisher","first-page":"107621","DOI":"10.1016\/j.intimp.2021.107621","article-title":"Suppression of NLRP3 inflammasome by Platycodin D via the TLR4\/MyD88\/NF-\u03baB pathway contributes to attenuation of lipopolysaccharide induced acute lung injury in rats","volume":"96","author":"Wu","year":"2021","journal-title":"Int Immunopharmacol."},{"key":"2024121208355129600_CIT0103","doi-asserted-by":"publisher","first-page":"107474","DOI":"10.1016\/j.intimp.2021.107474","article-title":"Anti-inflammatory effects of Platycodin D on dextran sulfate sodium (DSS) induced colitis and E. coli Lipopolysaccharide (LPS) induced inflammation","volume":"94","author":"Guo","year":"2021","journal-title":"Int Immunopharmacol."},{"key":"2024121208355129600_CIT0104","doi-asserted-by":"publisher","first-page":"108978","DOI":"10.1016\/j.jnutbio.2022.108978","article-title":"Sulforaphane reduces pro-inflammatory response to palmitic acid in monocytes and adipose tissue macrophages","volume":"104","author":"Williams","year":"2022","journal-title":"J Nutr Biochem."},{"issue":"1","key":"2024121208355129600_CIT0105","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s13568-020-01053-z","article-title":"Sulforaphane alter the microbiota and mitigate colitis severity on mice ulcerative colitis induced by DSS","volume":"10","author":"Zhang","year":"2020","journal-title":"AMB Express."},{"key":"2024121208355129600_CIT0106","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.intimp.2019.03.030","article-title":"Rhein protects against barrier disruption and inhibits inflammation in intestinal epithelial cells","volume":"71","author":"Zhuang","year":"2019","journal-title":"Int Immunopharmacol."},{"issue":"9","key":"2024121208355129600_CIT0107","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1111\/bph.15773","article-title":"Rhein regulates redox-mediated activation of NLRP3 inflammasomes in intestinal inflammation through macrophage-activated crosstalk","volume":"179","author":"Zhou","year":"2022","journal-title":"Br J Pharmacol."},{"key":"2024121208355129600_CIT0108","doi-asserted-by":"publisher","first-page":"102008","DOI":"10.1016\/j.jchemneu.2021.102008","article-title":"Rosmarinic acid attenuates lipopolysaccharide-induced neuroinflammation and cognitive impairment in rats","volume":"117","author":"Hassanzadeh-Taheri","year":"2021","journal-title":"J Chem Neuroanat."},{"issue":"6","key":"2024121208355129600_CIT0109","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.neo.2021.05.002","article-title":"Rosmarinic acid represses colitis-associated colon cancer: a pivotal involvement of the TLR4-mediated NF-\u03baB-STAT3 axis","volume":"23","author":"Jin","year":"2021","journal-title":"Neoplasia."},{"key":"2024121208355129600_CIT0110","doi-asserted-by":"publisher","first-page":"205873922095991","DOI":"10.1177\/2058739220959916","article-title":"Rosmarinic acid protects against ulcerative colitis by regulating macrophage polarization depending on heme oxygenase-1 in mice","volume":"18","author":"Mai","year":"2020","journal-title":"Eur J Inflamm."},{"issue":"8","key":"2024121208355129600_CIT0111","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.scib.2022.01.011","article-title":"Long-term exposure to genistein inhibits the proliferation of gallbladder cancer by downregulating the MCM complex","volume":"67","author":"Geng","year":"2022","journal-title":"Sci Bull (Beijing)."},{"key":"2024121208355129600_CIT0112","doi-asserted-by":"publisher","first-page":"1072044","DOI":"10.3389\/fnut.2022.1072044","article-title":"Genistein protects against hyperglycemia and fatty liver disease in diet-induced prediabetes mice via activating hepatic insulin signaling pathway","volume":"9","author":"Zhang","year":"2022","journal-title":"Front Nutr."},{"issue":"7","key":"2024121208355129600_CIT0113","doi-asserted-by":"publisher","first-page":"e0199631","DOI":"10.1371\/journal.pone.0199631","article-title":"Genistein induces macrophage polarization and systemic cytokine to ameliorate experimental colitis","volume":"13","author":"Abron","year":"2018","journal-title":"PLoS One."},{"issue":"1","key":"2024121208355129600_CIT0114","doi-asserted-by":"publisher","first-page":"40","DOI":"10.4062\/biomolther.2022.077","article-title":"Loganin prevents hepatic steatosis by blocking NLRP3 inflammasome activation","volume":"31","author":"Jang","year":"2023","journal-title":"Biomol Ther (Seoul)."},{"issue":"1","key":"2024121208355129600_CIT0115","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1080\/21655979.2020.1774992","article-title":"Loganin inhibits macrophage M1 polarization and modulates sirt1\/NF-\u03baB signaling pathway to attenuate ulcerative colitis","volume":"11","author":"Liu","year":"2020","journal-title":"Bioengineered."},{"key":"2024121208355129600_CIT0116","doi-asserted-by":"publisher","first-page":"154559","DOI":"10.1016\/j.phymed.2022.154559","article-title":"Dioscin induces M1 macrophage polarization through Connexin-43 channels in tumor-associated-macrophages-mediated melanoma metastasis","volume":"109","author":"Kou","year":"2023","journal-title":"Phytomedicine."},{"issue":"6","key":"2024121208355129600_CIT0117","doi-asserted-by":"publisher","first-page":"e24455","DOI":"10.1002\/jcla.24455","article-title":"Dioscin ameliorates inflammatory bowel disease by up-regulating miR-125a-5p to regulate macrophage polarization","volume":"36","author":"Shi","year":"2022","journal-title":"J Clin Lab Anal."},{"key":"2024121208355129600_CIT0118","doi-asserted-by":"publisher","first-page":"154012","DOI":"10.1016\/j.phymed.2022.154012","article-title":"Molecular pharmacology and therapeutic advances of the pentacyclic triterpene lupeol","volume":"99","author":"Sohag","year":"2022","journal-title":"Phytomedicine."},{"key":"2024121208355129600_CIT0119","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.intimp.2015.11.031","article-title":"The pentacyclic triterpene Lupeol switches M1 macrophages to M2 and ameliorates experimental inflammatory bowel disease","volume":"30","author":"Zhu","year":"2016","journal-title":"Int Immunopharmacol."},{"key":"2024121208355129600_CIT0120","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.lfs.2016.01.001","article-title":"Lupeol inhibits LPS-induced NF-kappa B signaling in intestinal epithelial cells and macrophages, and attenuates acute and chronic murine colitis","volume":"146","author":"Lee","year":"2016","journal-title":"Life Sci."},{"key":"2024121208355129600_CIT0121","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.phrs.2016.02.010","article-title":"Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in C57BL\/6 mice by suppressing Th17 responses","volume":"110","author":"Li","year":"2016","journal-title":"Pharmacol Res."},{"issue":"6","key":"2024121208355129600_CIT0122","doi-asserted-by":"publisher","first-page":"e0320722","DOI":"10.1128\/spectrum.03207-22","article-title":"Berberine depresses inflammation and adjusts smooth muscle to ameliorate ulcerative colitis of cats by regulating gut microbiota","volume":"10","author":"Li","year":"2022","journal-title":"Microbiol Spectr."},{"issue":"4","key":"2024121208355129600_CIT0123","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.7150\/ijbs.65476","article-title":"Berberine ameliorates DSS-induced intestinal mucosal barrier dysfunction through microbiota-dependence and Wnt\/\u03b2-catenin pathway","volume":"18","author":"Dong","year":"2022","journal-title":"Int J Biol Sci."},{"issue":"5","key":"2024121208355129600_CIT0124","doi-asserted-by":"publisher","first-page":"G504","DOI":"10.1152\/ajpgi.00312.2011","article-title":"Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice","volume":"302","author":"Yan","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"2024121208355129600_CIT0125","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.intimp.2018.01.049","article-title":"Berberine inhibits macrophage M1 polarization via AKT1\/SOCS1\/NF-\u03baB signaling pathway to protect against DSS-induced colitis","volume":"57","author":"Liu","year":"2018","journal-title":"Int Immunopharmacol."},{"issue":"1-2","key":"2024121208355129600_CIT0126","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ijbiomac.2012.05.001","article-title":"Chemical analysis and antioxidant activity in vitro of a \u03b2-d-glucan isolated from Dictyophora indusiata","volume":"51","author":"Deng","year":"2012","journal-title":"Int J Biol Macromol."},{"key":"2024121208355129600_CIT0127","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.ijbiomac.2019.01.022","article-title":"Mechanism of the anti-inflammatory activity by a polysaccharide from Dictyophora indusiata in lipopolysaccharide-stimulated macrophages","volume":"126","author":"Wang","year":"2019","journal-title":"Int J Biol Macromol."},{"key":"2024121208355129600_CIT0128","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.ijbiomac.2019.08.198","article-title":"Protective effect and mechanism of polysaccharide from Dictyophora indusiata on dextran sodium sulfate-induced colitis in C57BL\/6 mice","volume":"140","author":"Wang","year":"2019","journal-title":"Int J Biol Macromol."},{"issue":"8","key":"2024121208355129600_CIT0129","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.3390\/nu10081003","article-title":"A polysaccharide isolated from Dictyophora indusiata promotes recovery from antibiotic-driven intestinal dysbiosis and improves gut epithelial barrier function in a mouse model","volume":"10","author":"Kanwal","year":"2018","journal-title":"Nutrients"},{"key":"2024121208355129600_CIT0130","doi-asserted-by":"publisher","first-page":"103641","DOI":"10.1016\/j.jff.2019.103641","article-title":"Attenuation of DSS induced colitis by Dictyophora indusiata polysaccharide (DIP) via modulation of gut microbiota and inflammatory related signaling pathways","volume":"64","author":"Kanwal","year":"2020","journal-title":"J Funct Foods."},{"issue":"10","key":"2024121208355129600_CIT0131","doi-asserted-by":"publisher","first-page":"2929","DOI":"10.1111\/j.1572-0241.2001.04683.x","article-title":"Prevalence of nonadherence with maintenance mesalamine in quiescent ulcerative colitis","volume":"96","author":"Kane","year":"2001","journal-title":"Am J Gastroenterol."},{"issue":"10","key":"2024121208355129600_CIT0132","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1002\/ibd.20189","article-title":"Nonadherence in inflammatory bowel disease: results of factor analysis","volume":"13","author":"Cerven\u00fd","year":"2007","journal-title":"Inflamm Bowel Dis."},{"issue":"4","key":"2024121208355129600_CIT0133","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1177\/146642400012000412","article-title":"Dietary fibre, physicochemical properties and their relationship to health","volume":"120","author":"Blackwood","year":"2000","journal-title":"J R Soc Promot Health."},{"issue":"7","key":"2024121208355129600_CIT0134","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1002\/pds.3621","article-title":"Risk of malignancies in patients with inflammatory bowel disease treated with thiopurines or anti-TNF alpha antibodies","volume":"23","author":"Beigel","year":"2014","journal-title":"Pharmacoepidemiol Drug Saf."},{"issue":"9","key":"2024121208355129600_CIT0135","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s00535-013-0873-3","article-title":"Hematologic malignancies in the Japanese patients with inflammatory bowel disease","volume":"49","author":"Fukata","year":"2014","journal-title":"J Gastroenterol."},{"issue":"5","key":"2024121208355129600_CIT0136","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1080\/17460441.2021.1851185","article-title":"Select animal models of colitis and their value in predicting clinical efficacy of biological therapies in ulcerative colitis","volume":"16","author":"Bilsborough","year":"2021","journal-title":"Expert Opin Drug Discov."},{"key":"2024121208355129600_CIT0137","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.intimp.2019.02.050","article-title":"M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds","volume":"70","author":"Wang","year":"2019","journal-title":"Int Immunopharmacol."}],"container-title":["Crohn's &amp; Colitis 360"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/advance-article-pdf\/doi\/10.1093\/crocol\/otae070\/60885150\/otae070.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/article-pdf\/6\/4\/otae070\/61080481\/otae070.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/article-pdf\/6\/4\/otae070\/61080481\/otae070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T08:36:13Z","timestamp":1733992573000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/article\/doi\/10.1093\/crocol\/otae070\/7912125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":137,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/crocol\/otae070","relation":{},"ISSN":["2631-827X"],"issn-type":[{"value":"2631-827X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,10,1]]},"article-number":"otae070"}}