{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T12:27:13Z","timestamp":1766579233475,"version":"3.41.2"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Oral extraintestinal manifestations (OEIMs) of inflammatory bowel disease (IBD) may impact IBD treatment. The aims of this study were to: (1) determine which OEIMs are most prevalent among patients with IBD, (2) investigate the presence of a temporal association between GI luminal disease activity and OEIMs, and (3) determine how often changes in therapeutic management of IBD are needed in the presence of OEIMs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>A retrospective cohort study was performed for adult patients with IBD evaluated between January 2017 and November 2021 with at least 1 oral complaint. Demographic data were collected from the charts of these patients. Kruskal-Wallis test for continuous measures and Fisher\u2019s Exact test for categorical measures were used.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 116 patients with IBD who had presented with at least 1 oral finding during the study time period were identified. Aphthous ulcers were the most common oral presentation in both Crohn\u2019s disease (CD) (85.1%) and ulcerative colitis (UC) (75.0%). OEIMs were associated with CD activity in the small intestine (P\u2005=\u2005.004) and colon (P\u2005&amp;lt;\u2005.001). UC pancolitis was associated with OEIMs (P\u2005=\u2005.002). In 32.7% of patients, OEIMs led to either an increase in dose or frequency of IBD therapy. In an additional 16.4% of patients, new systemic agents were started because of the OEIMs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study provides evidence that patients with IBD may develop OEIMs synchronous with IBD flares and may require escalation of IBD therapy when OEIMs occur.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/crocol\/otaf027","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:45:16Z","timestamp":1743381916000},"source":"Crossref","is-referenced-by-count":1,"title":["Oral Extraintestinal Manifestations of Inflammatory Bowel Disease: The Temporal Relationship Between Oral and Intestinal Symptoms"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9999-6113","authenticated-orcid":false,"given":"Lauren","family":"Loeb","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Mayo Clinic , 4500 San Pablo Road, Jacksonville, FL 32224 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marketa","family":"Janovska","sequence":"additional","affiliation":[{"name":"Institute of Dental Medicine, First Faculty of Medicine and General University Hospital in Prague, Charles University, Department of Oral Medicine , Karlovo namesti 32, Prague 2, 128 00, Prague ,","place":["Czech Republic"]},{"name":"Research Trainee in the Department of Dermatology, Mayo Clinic , Jacksonville, FL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaohua","family":"Ma","sequence":"additional","affiliation":[{"name":"Clinical Trials and Biostatistics, Mayo Clinic , 4500 San Pablo Road, Jacksonville, FL 32224 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Dermatology [Emeritus], Mayo Clinic , 13400 E Shea Blvd, Scottsdale, AZ 85259 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-2441","authenticated-orcid":false,"given":"Francis A","family":"Farraye","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center, Division of Gastroenterology and Hepatology, Mayo Clinic , 4500 San Pablo Road, Jacksonville, FL 32224 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Bruce","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic , 4500 San Pablo Road, Jacksonville, FL 32224 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8548-9228","authenticated-orcid":false,"given":"Victor","family":"Chedid","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center, Division of Gastroenterology and Hepatology, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center, Division of Gastroenterology and Hepatology, Mayo Clinic , Scottsdale, AZ ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Bodiford","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic , 4500 San Pablo Road, Jacksonville, FL 32224 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8305-9742","authenticated-orcid":false,"given":"Jana G","family":"Hashash","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center, Division of Gastroenterology and Hepatology, Mayo Clinic , 4500 San Pablo Road, Jacksonville, FL 32224 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