{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:42:14Z","timestamp":1785148934829,"version":"3.55.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There are currently no standardized guidelines for optimizing 5-aminosalicylic acid (5-ASA) maintenance treatment, particularly in patients with ulcerative colitis (UC) who have achieved clinical remission (CR). Therefore, this study examined the perspectives of patients and physicians regarding 5-ASA dose reduction and medication adherence to optimize maintenance treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This cross-sectional study was conducted from February 2023 to May 2023 at 19 institutions and included patients with UC and physicians. The participants\u2019 perspectives were assessed using an anonymous questionnaire.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>This study included 369 patients with UC (female, 43.1%; age,\u2005&amp;gt;\u200560 years, 29.3%; CR, 88.9%). Preference to reduce the 5-ASA dose and low medication adherence were observed in 46.1% and 16.0% of patients, respectively. Low medication adherence (odds ratio [OR]: 3.43, 95% confidence interval [CI]: 1.67\u20137.03) was associated with the preference to reduce the 5-ASA dose. Multivariate analysis for factors associated with low medication adherence revealed age\u2005&amp;lt;\u200560 years (OR: 10.25, 95% CI: 3.58\u201329.38), no intractable disease subsidy (OR: 2.63, 95% CI: 1.09\u20136.35), dosing frequency\u2005\u2265\u20052 times\/day (OR: 9.04, 95% CI: 3.67\u201322.25), and preference to reduce the 5-ASA dose (OR: 2.57, 95% CI: 1.16\u20135.70) as significant. Among 153 physicians, 62.7% had\u2005&amp;gt;\u200510 years of experience, and 51.0% regularly verified adherence, with experience being a significant factor (OR: 2.01, 95% CI: 1.10\u20133.68).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Factors influencing medication adherence with 5-ASA included patients\u2019 desire for dose reduction and physicians\u2019 lack of experience. Improving communication with patients and enhancing education for physicians could help optimize treatment with 5-ASA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/crocol\/otaf038","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T12:14:52Z","timestamp":1748607292000},"source":"Crossref","is-referenced-by-count":5,"title":["Optimizing 5-Aminosalicylic Acid Maintenance Treatment in Ulcerative Colitis from the Patient and Physician Perspective: A Cross-sectional Multicenter Study"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0489-7519","authenticated-orcid":false,"given":"Takahiro","family":"Amano","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine , Suita ,","place":["Japan"]},{"name":"Department of Gastroenterology, Ikeda Municipal Hospital , Ikeda 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