{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:36:40Z","timestamp":1774975000847,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"am","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune-mediated extraintestinal manifestations (IM-EIMs) are common in paediatric inflammatory bowel disease (pIBD). This systematic review and meta-analysis aimed to summarise the incidence and prevalence of IM-EIMs in pIBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEDLINE, EMBASE, CENTRAL and clinicaltrials.gov were searched up to May 6, 2024, for studies that included pIBD (2-17\u2009years) patients diagnosed with IM-EIMs. Primary outcomes included the incidence and prevalence of IM-EIMs among pIBD. Meta-analysis included pooled proportions of prevalence with DerSimonian-Laird random-effects analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The pooled proportion of IM-EIMs among pIBD overall was 10% (95% CI, 8-12%; I2=97.2%) among 65 studies (35,343 patients). The pooled proportion of IM-EIMs was 10% (95% CI, 7-13%; I2=94.8%) among 37 Crohn\u2019s disease (CD) studies (7657 patients), compared to 11% (95% CI, 7-15%; I2=93.3%) among 39 ulcerative colitis (UC) studies (4698 patients). Enthesitis was the highest reported individual IM-EIM (23%, 95% CI, 4-50%; I2=94.7%) in pIBD. Arthritis was the second highest reported individual IM-EIM (8%, 95% CI, 6-10%; I2=96%) in pIBD, followed by primary sclerosing cholangitis (PSC) in UC (5%, 95% CI, 4-7%; I2=81%). Uveitis, pyoderma gangrenosum, autoimmune hepatitis and PSC in CD were the lowest reported IM-EIMs at 1% or less. The largest difference in proportions between IBD phenotypes was PSC, which was 4% higher in UC than CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While musculoskeletal manifestations are common, fewer than 5% of pIBD patients experience ophthalmological, dermatological, and liver IM-EIMs. The small number of studies resulted in significant methodological and statistical heterogeneity. Multicentre collaborative efforts are needed to systematically describe the epidemiology of IM-EIMs in pIBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/crocol\/otag024","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:29:21Z","timestamp":1774870161000},"source":"Crossref","is-referenced-by-count":0,"title":["Incidence and prevalence of immune-mediated extraintestinal manifestations in paediatric inflammatory bowel disease: a systematic review and meta-analysis"],"prefix":"10.1093","author":[{"given":"Ruben J","family":"Colman","sequence":"first","affiliation":[{"name":"Stanford University School of Medicine Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, , Stanford, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudheer K","family":"Vuyyuru","sequence":"additional","affiliation":[{"name":"Western University Department of Medicine, Division of Gastroenterology, Schulich School of Medicine, , London, Ontario,","place":["Canada"]},{"name":"Alimentiv Inc ., London, Ontario,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Solitano","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Vita-Salute San Raffaele Division of Gastroenterology and Gastrointestinal Endoscopy, IRCCS Ospedale San Raffaele, , Milan,","place":["Italy"]},{"name":"Western University Department of Epidemiology and Biostatistics, , London, Ontario,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John K","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Alimentiv Inc ., London, Ontario,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Le","sequence":"additional","affiliation":[{"name":"Alimentiv Inc ., London, Ontario,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Ricciuto","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children Division of Gastroenterology, Hepatology and Nutrition, SickKids Inflammatory Bowel Disease Centre, , Toronto, Ontario,","place":["Canada"]},{"name":"University of Toronto Department of Paediatrics, , Toronto, Ontario,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Berard","sequence":"additional","affiliation":[{"name":"London Health Sciences Center Division of Rheumatology, Department of Pediatrics, , London, Ontario,","place":["Canada"]},{"name":"Children\u2019s Health Research Institute, London Health Sciences Centre , London, Ontario,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javed A","family":"Mohammed","sequence":"additional","affiliation":[{"name":"London Health Sciences Center Pediatric Dermatology, Department of Pediatrics, Children\u2019s Hospital, , London, Ontario,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Ma","sequence":"additional","affiliation":[{"name":"Alimentiv Inc ., London, Ontario,","place":["Canada"]},{"name":"University of Calgary Department of Community Health Sciences, Cumming School of Medicine, , Calgary, Alberta,","place":["Canada"]},{"name":"University of Calgary Division of Gastroenterology and Hepatology, Department of Medicine, , Calgary, Alberta,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vipul","family":"Jairath","sequence":"additional","affiliation":[{"name":"Western University Department of Medicine, Division of Gastroenterology, Schulich School of Medicine, , London, Ontario,","place":["Canada"]},{"name":"Alimentiv Inc ., London, Ontario,","place":["Canada"]},{"name":"Western University Department of Epidemiology and Biostatistics, , London, Ontario,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Crowley","sequence":"additional","affiliation":[{"name":"Alimentiv Inc ., London, Ontario,","place":["Canada"]},{"name":"Children\u2019s Hospital Western Ontario, Western University, London Health Sciences Centre Division of Paediatric Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, , London, Ontario,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,30]]},"container-title":["Crohn's &amp; Colitis 360"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/advance-article-pdf\/doi\/10.1093\/crocol\/otag024\/67695138\/otag024.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/advance-article-pdf\/doi\/10.1093\/crocol\/otag024\/67695138\/otag024.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:56:35Z","timestamp":1774968995000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/advance-article\/doi\/10.1093\/crocol\/otag024\/8566377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/crocol\/otag024","relation":{},"ISSN":["2631-827X"],"issn-type":[{"value":"2631-827X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]},"article-number":"otag024"}}