{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:12:40Z","timestamp":1791943960581,"version":"4.3.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"am","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aims<\/jats:title>\n                    <jats:p>Patients with Crohn\u2019s disease (CD) are at an increased risk of urolithiasis, particularly after ileocolic (IC) resection. This study aimed to investigate the prevalence of hyperoxaluria, hypocitraturia, and hypomagnesuria in CD patients with and without IC resection, compared to healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included three groups: CD patients who had undergone IC resection (group 1), CD patients with IC involvement but without active inflammation and without resection (group 2), and healthy controls (group 3). Each participant collected a 24-hour urine sample for analysis of oxalate, citrate, and magnesium excretion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 107 participants were enrolled (34 in group 1, 42 in group 2, and 31 in group 3). The prevalence of hyperoxaluria was 26.5% in group 1, 35.7% in group 2, and 29.0% in group 3, with no significant differences between groups (p\u2009=\u20090.664). Hypocitraturia was more common in CD groups: 35.3% in group 1, 31.0% in group 2, compared to 9.7% in controls, with a significant difference from controls (p\u2009=\u20090.034). A significant difference in hypomagnesuria was found in group 1 compared to groups 2 and 3 (p\u2009=\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While hyperoxaluria prevalence was similar across groups, hypocitraturia and hypomagnesuria were more frequent in CD patients, particularly those with IC resection. Monitoring these biomarkers may help identify at-risk individuals and guide prevention of urolithiasis in CD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/crocol\/otag033","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T11:22:52Z","timestamp":1776684172000},"source":"Crossref","is-referenced-by-count":1,"title":["Urinary Biomarkers of Urolithiasis Risk in Crohn\u2019s Disease: Hyperoxaluria, Hypocitraturia, and Hypomagnesuria in Patients with and without Ileocolic Resection"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9323-1996","authenticated-orcid":false,"given":"Vit","family":"Navratil","sequence":"first","affiliation":[{"name":"University Hospital Olomouc Department of Internal Medicine\u2014Gastroenterology and Geriatrics, , Faculty of Medicine and Dentistry, , Olomouc,","place":["Czech Republic"]},{"name":"Palacky University Olomouc Department of Internal Medicine\u2014Gastroenterology and Geriatrics, , Faculty of Medicine and Dentistry, , Olomouc,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8845","authenticated-orcid":false,"given":"Barbora","family":"Pipek","sequence":"additional","affiliation":[{"name":"University Hospital Olomouc Department of Internal Medicine\u2014Gastroenterology and Geriatrics, , Faculty of Medicine and Dentistry, , Olomouc,","place":["Czech Republic"]},{"name":"Palacky University Olomouc Department of Internal Medicine\u2014Gastroenterology and Geriatrics, , Faculty of Medicine and Dentistry, , Olomouc,","place":["Czech Republic"]},{"name":"AGEL Ostrava-V\u00edtkovice Hospital Digestive Diseases Center, , Ostrava,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8843-4716","authenticated-orcid":false,"given":"Premysl","family":"Falt","sequence":"additional","affiliation":[{"name":"University Hospital Olomouc Department of Internal Medicine\u2014Gastroenterology and Geriatrics, , Faculty of Medicine and Dentistry, , Olomouc,","place":["Czech Republic"]},{"name":"Palacky University Olomouc Department of Internal Medicine\u2014Gastroenterology and Geriatrics, , Faculty of Medicine and Dentistry, , Olomouc,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9694-2486","authenticated-orcid":false,"given":"Jana","family":"Zapletalova","sequence":"additional","affiliation":[{"name":"Palacky University Olomouc Department of Medical Biophysics, Faculty of Medicine and Dentistry, , Olomouc,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2705-1357","authenticated-orcid":false,"given":"Jan","family":"Krivinka","sequence":"additional","affiliation":[{"name":"University Hospital Olomouc Department of Internal Medicine\u2014Gastroenterology and Geriatrics, , Faculty of Medicine and Dentistry, , Olomouc,","place":["Czech Republic"]},{"name":"Palacky University Olomouc Department of Internal Medicine\u2014Gastroenterology and Geriatrics, , Faculty of Medicine and Dentistry, , Olomouc,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2935-6778","authenticated-orcid":false,"given":"Virginia","family":"Solitano","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale San Raffaele Division of Gastroenterology and Gastrointestinal Endoscopy, , , Milan,","place":["Italy"]},{"name":"University Vita-Salute San Raffaele Division of Gastroenterology and Gastrointestinal Endoscopy, , , Milan,","place":["Italy"]},{"name":"Western University Department of Medicine, Division of Gastroenterology, , London, Canada. Departments of Medicine, Epidemiology and Biostatistics, , London,","place":["Canada"]},{"name":"Western University Department of Medicine, Division of Gastroenterology, , London, Canada. Departments of Medicine, Epidemiology and Biostatistics, , London,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-8759","authenticated-orcid":false,"given":"Lumir","family":"Kunovsky","sequence":"additional","affiliation":[{"name":"University Hospital Olomouc Department of Internal Medicine\u2014Gastroenterology and Geriatrics, , Faculty of Medicine and Dentistry, , Olomouc,","place":["Czech Republic"]},{"name":"Palacky University Olomouc Department of Internal Medicine\u2014Gastroenterology and Geriatrics, , Faculty of Medicine and Dentistry, , Olomouc,","place":["Czech Republic"]},{"name":"University Hospital Brno Department of Surgery, , Faculty of Medicine, , Brno,","place":["Czech Republic"]},{"name":"Masaryk University Department of Surgery, , Faculty of Medicine, , Brno,","place":["Czech Republic"]},{"name":"Masaryk Memorial Cancer Institute Department of Gastroenterology and Digestive Endoscopy, , Brno,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,22]]},"container-title":["Crohn's &amp; Colitis 360"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/advance-article-pdf\/doi\/10.1093\/crocol\/otag033\/68143767\/otag033.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/advance-article-pdf\/doi\/10.1093\/crocol\/otag033\/68143767\/otag033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T17:00:11Z","timestamp":1776963611000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/advance-article\/doi\/10.1093\/crocol\/otag033\/8661461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/crocol\/otag033","relation":{},"ISSN":["2631-827X"],"issn-type":[{"value":"2631-827X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]},"article-number":"otag033"}}