{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:40:37Z","timestamp":1792593637352,"version":"4.5.0"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T32DK067872"],"award-info":[{"award-number":["T32DK067872"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ulcerative colitis is monitored through clinical, laboratory, endoscopic, and histologic measures. Persistence of histologic inflammation despite clinical and endoscopic remission is associated with disease flare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared the identification of clinically significant histologic inflammation by general and IBD-specialized gastroenterologists (GI) using a simplified binary scoring system and looked at associations with disease relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both general and IBD-specialized GIs identified significant inflammation associated with relapse, though IBD-specialized GIs scoring had stronger correlations with relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest simple histologic assessment can inform risk stratification, and further work is needed to optimize monitoring patients with histologic inflammation despite endoscopic remission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/crocol\/otag112","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:56:37Z","timestamp":1792540597000},"source":"Crossref","is-referenced-by-count":0,"title":["Assessing inflammation and predicting relapse in ulcerative colitis is more accurate when performed by IBD specialized gastroenterologists"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5650-3393","authenticated-orcid":false,"given":"Madeline","family":"Alizadeh","sequence":"first","affiliation":[{"name":"Institute for Genome Sciences, University of Maryland School of Medicine , Baltimore, MD,","place":["United States"]},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine , Baltimore, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A","family":"George","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, MedStar Washington Hospital Center , Washington, DC,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameer","family":"Abutaleb","sequence":"additional","affiliation":[{"name":"Department of Medicine, George Washington School of Medicine and Health Sciences , Washington, DC,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pathology, NYU Grossman School of Medicine, NYC , NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D","family":"Greenwald","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine , Baltimore, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harris T","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beth Israel Deaconess Medical Center , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shien","family":"Hu","sequence":"additional","affiliation":[{"name":"Frederick Gastroenterology Associates , Frederick, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hudesman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, NYU Grossman School of Medicine, NYC , NY,","place":["United 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Posner Institute for Digestive Health & Liver Disease at Mercy Medical Center , Baltimore, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"2026102109561383600_otag112-B1","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1053\/j.gastro.2023.07.003","article-title":"Incidence, prevalence, and racial and ethnic distribution of inflammatory bowel disease in the United States","volume":"165","author":"Lewis","year":"2023","journal-title":"Gastroenterology"},{"key":"2026102109561383600_otag112-B2","doi-asserted-by":"publisher","first-page":"jjaf106","DOI":"10.1093\/ecco-jcc\/jjaf106","article-title":"ECCO-ESGAR-ESP-IBUS guideline on diagnostics and monitoring of patients with inflammatory bowel disease: Part 1: initial diagnosis, monitoring of known inflammatory bowel disease, detection of complications","volume":"19","author":"Kucharzik","year":"2025","journal-title":"J Crohns Colitis"},{"issue":"Suppl 2","key":"2026102109561383600_otag112-B3","doi-asserted-by":"publisher","first-page":"S164","DOI":"10.1002\/ibd.20586","article-title":"What are the critical histologic features in the diagnosis of ulcerative colitis?","volume":"14","author":"Appleman","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"2026102109561383600_otag112-B4","doi-asserted-by":"publisher","first-page":"otad059","DOI":"10.1093\/crocol\/otad059","article-title":"Histologic inflammation can predict future clinical relapse in ulcerative colitis patients in endoscopic remission","volume":"5","author":"George","year":"2023","journal-title":"Crohns Colitis 360"},{"key":"2026102109561383600_otag112-B5","doi-asserted-by":"publisher","first-page":"202","DOI":"10.5217\/ir.2016.14.3.202","article-title":"Histological inflammation increases the risk of colorectal neoplasia in ulcerative colitis: a systematic review","volume":"14","author":"Colman","year":"2016","journal-title":"Intest Res"},{"key":"2026102109561383600_otag112-B6","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1093\/ecco-jcc\/jjaa110","article-title":"ECCO position paper: Harmonization of the approach to ulcerative colitis histopathology","volume":"14","author":"Magro","year":"2020","journal-title":"J Crohns Colitis"},{"key":"2026102109561383600_otag112-B7","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1016\/j.cgh.2015.05.038","article-title":"Level of fecal calprotectin correlates with endoscopic and histologic inflammation and identifies patients with mucosal healing in ulcerative colitis","volume":"13","author":"Theede","year":"2015","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["Crohn\u2019s &amp; Colitis 360"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/article-pdf\/8\/4\/otag112\/71730842\/otag112.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/article-pdf\/8\/4\/otag112\/71730842\/otag112.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:56:17Z","timestamp":1792590977000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/crohnscolitis360\/article\/doi\/10.1093\/crocol\/otag112\/8888363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10,5]]}},"URL":"https:\/\/doi.org\/10.1093\/crocol\/otag112","relation":{},"ISSN":["2631-827X"],"issn-type":[{"value":"2631-827X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,10]]},"article-number":"otag112"}}