{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:33:46Z","timestamp":1793025226232,"version":"4.5.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National institutes of Health","doi-asserted-by":"publisher","award":["R01 HL R0110737"],"award-info":[{"award-number":["R01 HL R0110737"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Sex differences impact the occurrence, presentation, prognosis, and response to therapy in heart disease. Particularly, the phenotypic presentation of patients with non-ischaemic dilated cardiomyopathy (NIDCM) differs between men and women. However, whether the response to mesenchymal stem cell (MSC) therapy is influenced by sex remains unknown. We hypothesize that males and females with NIDCM respond similarly to MSC therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Male (n\u2009=\u200924) and female (n\u2009=\u200910) patients from the POSEIDON-DCM trial who received MSCs via transendocardial injections were evaluated over 12\u2009months. Endothelial function was measured at baseline and 3\u2009months post-transendocardial stem cell injection (TESI). At baseline, ejection fraction (EF) was lower (P\u2009=\u20090.004) and end-diastolic volume (EDV; P\u2009=\u20090.0002) and end-systolic volume (ESV; P\u2009=\u20090.0002) were higher in males vs. females. In contrast, baseline demographic characteristics, Minnesota Living with Heart Failure Questionnaire (MLHFQ), and 6-min walk test (6MWT) were similar between groups. EF improved in males by 6.2 units (P\u2009=\u20090.04) and in females by 8.6 units (P\u2009=\u20090.04; males vs. females, P\u2009=\u20090.57). EDV and ESV were unchanged over time. The MLHFQ score, New York Heart Association (NYHA) class, endothelial progenitor cell-colony forming units, and serum tumour necrosis factor alpha improved similarly in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite major differences in phenotypic presentation of NIDCM in males and females, this study is the first of its kind to demonstrate that MSC therapy improves a variety of parameters in NIDCM irrespective of patient sex. These findings have important clinical and pathophysiologic implications regarding the impact of sex on responses to cell-based therapy for NIDCM.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cvr\/cvaa004","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T12:09:15Z","timestamp":1580990955000},"page":"2131-2141","source":"Crossref","is-referenced-by-count":18,"title":["The impact of patient sex on the response to intramyocardial mesenchymal stem cell administration in patients with non-ischaemic dilated cardiomyopathy"],"prefix":"10.1093","volume":"116","author":[{"given":"Victoria","family":"Florea","sequence":"first","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Biomedical Research Building - 9th Floor 1501 NW 10th Ave, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela C","family":"Rieger","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Biomedical Research Building - 9th Floor 1501 NW 10th Ave, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4800-7274","authenticated-orcid":false,"given":"Makoto","family":"Natsumeda","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Biomedical Research Building - 9th Floor 1501 NW 10th Ave, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5437-0400","authenticated-orcid":false,"given":"Bryon A","family":"Tompkins","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Biomedical Research Building - 9th Floor 1501 NW 10th Ave, Miami, FL 33136, USA"},{"name":"Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monisha N","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Biomedical Research Building - 9th Floor 1501 NW 10th Ave, Miami, FL 33136, USA"},{"name":"Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2814-2321","authenticated-orcid":false,"given":"Ivonne H","family":"Schulman","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Biomedical Research Building - 9th Floor 1501 NW 10th Ave, Miami, FL 33136, USA"},{"name":"Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6175-0049","authenticated-orcid":false,"given":"Courtney","family":"Premer","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Biomedical Research Building - 9th Floor 1501 NW 10th Ave, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Khan","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Biomedical Research Building - 9th Floor 1501 NW 10th Ave, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystalenia","family":"Valasaki","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Biomedical Research Building - 9th Floor 1501 NW 10th Ave, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Heidecker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Charite Berlin University of Medicine, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8462-9487","authenticated-orcid":false,"given":"Alejandro","family":"Mantero","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0405-0489","authenticated-orcid":false,"given":"Wayne","family":"Balkan","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Biomedical Research Building - 9th Floor 1501 NW 10th Ave, Miami, FL 33136, USA"},{"name":"Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul D","family":"Mitrani","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Biomedical Research Building - 9th Floor 1501 NW 10th Ave, Miami, FL 33136, USA"},{"name":"Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5656-8381","authenticated-orcid":false,"given":"Joshua M","family":"Hare","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Biomedical Research Building - 9th Floor 1501 NW 10th Ave, Miami, FL 33136, USA"},{"name":"Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"2020102411105470600_cvaa004-B1","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1161\/CIRCRESAHA.116.307547","article-title":"Cardiovascular disease in women: clinical perspectives","volume":"118","author":"Garcia","year":"2016","journal-title":"Circ Res"},{"key":"2020102411105470600_cvaa004-B2","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1093\/eurheartj\/ehp549","article-title":"The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences","volume":"31","author":"Heidecker","year":"2010","journal-title":"Eur Heart J"},{"key":"2020102411105470600_cvaa004-B3","volume-title":"The Dilated, Restrictive and Infiltrative Cardiomyopathies","author":"Hare","year":"1581","edition":"9th ed."},{"key":"2020102411105470600_cvaa004-B4","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/heartjnl-2015-308769","article-title":"Sex differences in cardiovascular ageing","volume":"102","author":"Merz","year":"2016","journal-title":"Heart"},{"key":"2020102411105470600_cvaa004-B5","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s11906-012-0260-0","article-title":"Hypertension in postmenopausal women","volume":"14","author":"Lima","year":"2012","journal-title":"Curr Hypertens Rep"},{"key":"2020102411105470600_cvaa004-B6","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1006\/jmcc.2001.1394","article-title":"Gender influences on sarcoplasmic reticulum Ca2+-handling in failing human myocardium","volume":"33","author":"Dash","year":"2001","journal-title":"J Mol Cell Cardiol"},{"key":"2020102411105470600_cvaa004-B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00021.2015","article-title":"Mechanistic pathways of sex differences in cardiovascular disease","volume":"97","author":"Regitz-Zagrosek","year":"2017","journal-title":"Physiol Rev"},{"key":"2020102411105470600_cvaa004-B8","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/01.RES.85.9.856","article-title":"Myocyte death in the failing human heart is gender dependent","volume":"85","author":"Guerra","year":"1999","journal-title":"Circ Res"},{"key":"2020102411105470600_cvaa004-B9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cpcardiol.2012.07.003","article-title":"Sex and gender differences in myocarditis and dilated cardiomyopathy","volume":"38","author":"Fairweather","year":"2013","journal-title":"Curr Probl Cardiol"},{"key":"2020102411105470600_cvaa004-B10","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1161\/ATVBAHA.107.159558","article-title":"Gender differences in endothelial progenitor cells and cardiovascular risk profile: the role of female estrogens","volume":"28","author":"Fadini","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2020102411105470600_cvaa004-B11","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.yjmcc.2006.09.016","article-title":"Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: role of the 55 kDa TNF receptor (TNFR1)","volume":"42","author":"Crisostomo","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"2020102411105470600_cvaa004-B12","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1152\/physrev.00019.2015","article-title":"Rebuilding the damaged heart: mesenchymal stem cells, cell-based therapy, and engineered heart tissue","volume":"96","author":"Golpanian","year":"2016","journal-title":"Physiol Rev"},{"key":"2020102411105470600_cvaa004-B13","doi-asserted-by":"crossref","first-page":"11474","DOI":"10.1073\/pnas.0504388102","article-title":"Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction","volume":"102","author":"Amado","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020102411105470600_cvaa004-B14","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/jwh.2009.1695","article-title":"Proceedings from the scientific symposium: sex differences in cardiovascular disease and implications for therapies","volume":"19","author":"Bairey Merz","year":"2010","journal-title":"J Womens Health (Larchmt)"},{"key":"2020102411105470600_cvaa004-B15","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.jacc.2016.11.009","article-title":"Randomized comparison of allogeneic versus autologous mesenchymal stem cells for nonischemic dilated cardiomyopathy: POSEIDON-DCM trial","volume":"69","author":"Hare","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2020102411105470600_cvaa004-B16","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s12265-014-9594-0","article-title":"Rationale and design of the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis in Dilated Cardiomyopathy (the POSEIDON-DCM study): a phase I\/II, randomized pilot study of the comparative safety and efficacy of transendocardial injection of autologous mesenchymal stem cell vs. allogeneic mesenchymal stem cells in patients with non-ischemic dilated cardiomyopathy","volume":"7","author":"Mushtaq","year":"2014","journal-title":"J Cardiovasc Transl Res"},{"key":"2020102411105470600_cvaa004-B17","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.ahj.2003.09.020","article-title":"Endomyocardial biopsy plays a role in diagnosing patients with unexplained cardiomyopathy","volume":"147","author":"Ardehali","year":"2004","journal-title":"Am Heart J"},{"key":"2020102411105470600_cvaa004-B18","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1161\/CIRCRESAHA.111.242610","article-title":"Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodeling","volume":"108","author":"Williams","year":"2011","journal-title":"Circ Res"},{"key":"2020102411105470600_cvaa004-B19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-62703-505-7_8","article-title":"Cell-based therapies for myocardial repair: emerging role for bone marrow-derived mesenchymal stem cells (MSCs) in the treatment of the chronically injured heart","volume":"1037","author":"Da Silva","year":"2013","journal-title":"Methods Mol Biol"},{"key":"2020102411105470600_cvaa004-B20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ebiom.2015.03.020","article-title":"Mesenchymal stem cells restore endothelial function in heart failure by stimulating endothelial progenitor cells","volume":"2","author":"Premer","year":"2015","journal-title":"EBioMedicine"},{"key":"2020102411105470600_cvaa004-B21","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.amjmed.2011.10.025","article-title":"Endothelial progenitor cells are suppressed in anemic patients with acute coronary syndrome","volume":"125","author":"Solomon","year":"2012","journal-title":"Am J Med"},{"key":"2020102411105470600_cvaa004-B22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/eurjhf\/hfs026","article-title":"Gender and survival in patients with heart failure: interactions with diabetes and aetiology. Results from the MAGGIC individual patient meta-analysis","volume":"14","author":"Mart\u00ednez-Sell\u00e9s","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"2020102411105470600_cvaa004-B23","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jacc.2009.02.066","article-title":"Heart failure in women: a need for prospective data","volume":"54","author":"Hsich","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2020102411105470600_cvaa004-B24","doi-asserted-by":"crossref","first-page":"15225","DOI":"10.3390\/ijms150915225","article-title":"Adult stem cell transplantation: is gender a factor in stemness?","volume":"15","author":"Tajiri","year":"2014","journal-title":"Int J Mol Sci"},{"key":"2020102411105470600_cvaa004-B25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12265-009-9149-y","article-title":"Gender dimorphisms in progenitor and stem cell function in cardiovascular disease","volume":"3","author":"Herrmann","year":"2010","journal-title":"J Cardiovasc Transl Res"},{"key":"2020102411105470600_cvaa004-B26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12265-013-9514-8","article-title":"Should there be sex-specific criteria for the diagnosis and treatment of heart failure?","volume":"7","author":"Greiten","year":"2014","journal-title":"J Cardiovasc Transl Res"},{"key":"2020102411105470600_cvaa004-B27","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S0008-6363(01)00510-7","article-title":"Gender-specific differences of cardiac remodeling in subjects with left ventricular dysfunction: a population-based study","volume":"53","author":"Luchner","year":"2002","journal-title":"Cardiovasc Res"},{"key":"2020102411105470600_cvaa004-B28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.pcad.2006.08.011","article-title":"Role of gender in heart failure with normal left ventricular ejection fraction","volume":"49","author":"Regitz-Zagrosek","year":"2007","journal-title":"Prog Cardiovasc Dis"},{"key":"2020102411105470600_cvaa004-B29","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1161\/CIRCULATIONAHA.113.006855","article-title":"Heart failure with recovered ejection fraction: clinical description, biomarkers, and outcomes","volume":"129","author":"Basuray","year":"2014","journal-title":"Circulation"},{"key":"2020102411105470600_cvaa004-B30","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1001\/jamacardio.2016.1325","article-title":"Characteristics and outcomes of adult outpatients with heart failure and improved or recovered ejection fraction","volume":"1","author":"Kalogeropoulos","year":"2016","journal-title":"JAMA Cardiol"},{"key":"2020102411105470600_cvaa004-B31","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.amjcard.2005.05.037","article-title":"Reliability of ventricular remodeling as a surrogate for use in conjunction with clinical outcomes in heart failure","volume":"96","author":"Konstam","year":"2005","journal-title":"Am J Cardiol"},{"key":"2020102411105470600_cvaa004-B32","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.genm.2009.09.007","article-title":"Symptoms of a first acute myocardial infarction in women and men","volume":"6","author":"Berg","year":"2009","journal-title":"Gend Med"},{"key":"2020102411105470600_cvaa004-B33","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/0735-1097(92)90243-G","article-title":"Ischemic cardiomyopathy: endomyocardial biopsy and ventriculographic evaluation of patients with congestive heart failure, dilated cardiomyopathy and coronary artery disease","volume":"20","author":"Hare","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"2020102411105470600_cvaa004-B34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10354-011-0892-8","article-title":"Sex and gender differences in myocardial hypertrophy and heart failure","volume":"161","author":"Regitz-Zagrosek","year":"2011","journal-title":"Wien Med Wochenschr"},{"key":"2020102411105470600_cvaa004-B35","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S1016-8478(23)14021-0","article-title":"Estrogen receptor-alpha mediates the effects of estradiol on telomerase activity in human mesenchymal stem cells","volume":"26","author":"Cha","year":"2008","journal-title":"Mol Cells"},{"key":"2020102411105470600_cvaa004-B36","doi-asserted-by":"crossref","first-page":"C317","DOI":"10.1152\/ajpcell.00415.2008","article-title":"Role of HIF-1alpha and VEGF in human mesenchymal stem cell proliferation by 17beta-estradiol: involvement of PKC, PI3K\/Akt, and MAPKs","volume":"296","author":"Yun","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"2020102411105470600_cvaa004-B37","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.jacc.2003.05.012","article-title":"Gender differences in advanced heart failure: insights from the BEST study","volume":"42","author":"Ghali","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2020102411105470600_cvaa004-B38","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1161\/01.CIR.0000146819.43235.A9","article-title":"Mortality and morbidity reduction with Candesartan in patients with chronic heart failure and left ventricular systolic dysfunction: results of the CHARM low-left ventricular ejection fraction trials","volume":"110","author":"Young","year":"2004","journal-title":"Circulation"},{"key":"2020102411105470600_cvaa004-B39","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1056\/NEJMoa010713","article-title":"A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure","volume":"345","author":"Cohn","year":"2001","journal-title":"N Engl J Med"},{"key":"2020102411105470600_cvaa004-B40","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure","volume":"341","author":"Pitt","year":"1999","journal-title":"N Engl J Med"},{"key":"2020102411105470600_cvaa004-B41","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction","volume":"348","author":"Pitt","year":"2003","journal-title":"N Engl J Med"},{"key":"2020102411105470600_cvaa004-B42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1009492","article-title":"Eplerenone in patients with systolic heart failure and mild symptoms","volume":"364","author":"Zannad","year":"2011","journal-title":"N Engl J Med"},{"key":"2020102411105470600_cvaa004-B43","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ebiom.2019.09.043","article-title":"Genetic determinants of responsiveness to mesenchymal stem cell injections in non-ischemic dilated cardiomyopathy","volume":"48","author":"Rieger","year":"2019","journal-title":"EBioMedicine"},{"key":"2020102411105470600_cvaa004-B44","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41536-019-0083-6","article-title":"Mesenchymal stem cell perspective: cell biology to clinical progress","volume":"4","author":"Pittenger","year":"2019","journal-title":"NPJ Regen Med"},{"key":"2020102411105470600_cvaa004-B45","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jacc.2014.10.040","article-title":"Effect of aging on human mesenchymal stem cell therapy in ischemic cardiomyopathy patients","volume":"65","author":"Golpanian","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2020102411105470600_cvaa004-B46","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1191\/026921501680425216","article-title":"Psychometric properties of the Minnesota Living with Heart Failure Questionnaire (MLHF-Q)","volume":"15","author":"Middel","year":"2001","journal-title":"Clin Rehabil"},{"key":"2020102411105470600_cvaa004-B47","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1161\/CIRCULATIONAHA.106.184461","article-title":"Assessment of functional capacity in clinical and research settings: a scientific statement from the American Heart Association Committee on Exercise, Rehabilitation, and Prevention of the Council on Clinical Cardiology and the Council on Cardiovascular Nursing","volume":"116","author":"Arena","year":"2007","journal-title":"Circulation"},{"key":"2020102411105470600_cvaa004-B48","first-page":"166","article-title":"Prognostic value of 6-minute walk test in stable outpatients with heart failure","volume":"34","author":"Arslan","year":"2007","journal-title":"Tex Heart Inst J"},{"key":"2020102411105470600_cvaa004-B49","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.jacc.2015.09.010","article-title":"Mechanisms contributing to the progression of ischemic and nonischemic dilated cardiomyopathy: possible modulating effects of paracrine activities of stem cells","volume":"66","author":"Kelkar","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2020102411105470600_cvaa004-B50","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1056\/NEJMoa022287","article-title":"Circulating endothelial progenitor cells, vascular function, and cardiovascular risk","volume":"348","author":"Hill","year":"2003","journal-title":"N Engl J Med"},{"key":"2020102411105470600_cvaa004-B51","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004106","article-title":"Progenitor cells and clinical outcomes in patients with heart failure","volume":"10","author":"Samman Tahhan","year":"2017","journal-title":"Circ Heart Fail"},{"key":"2020102411105470600_cvaa004-B52","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/CIRCRESAHA.116.304187","article-title":"Circulating CD34+ progenitor cells and risk of mortality in a population with coronary artery disease","volume":"116","author":"Patel","year":"2015","journal-title":"Circ Res"},{"key":"2020102411105470600_cvaa004-B53","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/CIRCRESAHA.116.308802","article-title":"Circulating progenitor cells identify peripheral arterial disease in patients with coronary artery disease","volume":"119","author":"Hayek","year":"2016","journal-title":"Circ Res"},{"key":"2020102411105470600_cvaa004-B54","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1634\/stemcells.2005-0589","article-title":"Intracoronary infusion of CD133+ and CD133-CD34+ selected autologous bone marrow progenitor cells in patients with chronic ischemic cardiomyopathy: cell isolation, adherence to the infarcted area, and body distribution","volume":"24","author":"Goussetis","year":"2006","journal-title":"Stem Cells"},{"key":"2020102411105470600_cvaa004-B55","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/CIRCRESAHA.110.222703","article-title":"Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation","volume":"107","author":"Hatzistergos","year":"2010","journal-title":"Circ Res"},{"key":"2020102411105470600_cvaa004-B56","doi-asserted-by":"crossref","first-page":"e1886","DOI":"10.1371\/journal.pone.0001886","article-title":"Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing","volume":"3","author":"Chen","year":"2008","journal-title":"PLoS One"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvaa004\/32450369\/cvaa004.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/116\/13\/2131\/34011822\/cvaa004.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/116\/13\/2131\/34011822\/cvaa004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T03:56:44Z","timestamp":1722398204000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/116\/13\/2131\/5735457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,13]]},"references-count":56,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2020,2,13]]},"published-print":{"date-parts":[[2020,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvaa004","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,11,1]]},"published":{"date-parts":[[2020,2,13]]}}}