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In this review, we provide an overview of the pathogenic role of CMD in the setting of diabetes mellitus, obesity, hypertensive pregnancy disorders, chronic inflammatory and autoimmune rheumatic disorders, chronic kidney disease, hypertrophic cardiomyopathy, and aortic valve stenosis. In these various conditions, CMD results from different structural, functional, and\/or dynamic alterations in the coronary microcirculation associated with the primary disease process. CMD is often detectable very early in the course of the primary disease, before clinical symptoms or signs of myocardial ischaemia are present, and it portrays an increased risk for cardiovascular events.<\/jats:p>","DOI":"10.1093\/cvr\/cvaa009","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T20:09:11Z","timestamp":1579637351000},"page":"817-828","source":"Crossref","is-referenced-by-count":85,"title":["The pathogenic role of coronary microvascular dysfunction in the setting of other cardiac or systemic conditions"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7139-5949","authenticated-orcid":false,"given":"Regina E","family":"Konst","sequence":"first","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz J","family":"Guzik","sequence":"additional","affiliation":[{"name":"Institute 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