{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:38:40Z","timestamp":1790829520987,"version":"4.1.0"},"reference-count":95,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T00:00:00Z","timestamp":1584144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Institutes of Health, National Heart, Lung and Blood Institute","award":["R01 HL143881"],"award-info":[{"award-number":["R01 HL143881"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heterogeneous macrophage lineages are present in the aortic and mitral valves of the heart during development and disease. These populations include resident macrophages of embryonic origins and recruited monocyte-derived macrophages prevalent in disease. Soon after birth, macrophages from haematopoietic lineages are recruited to the heart valves, and bone marrow transplantation studies in mice demonstrate that haematopoietic-derived macrophages continue to invest adult valves. During myxomatous heart valve disease, monocyte-derived macrophages are recruited to the heart valves and they contribute to valve degeneration in a mouse model of Marfan syndrome. Here, we review recent studies of macrophage lineages in heart valve development and disease with discussion of clinical significance and therapeutic applications.<\/jats:p>","DOI":"10.1093\/cvr\/cvaa062","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T20:25:29Z","timestamp":1583958329000},"page":"663-673","source":"Crossref","is-referenced-by-count":60,"title":["Macrophage lineages in heart valve development and disease"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4923-6343","authenticated-orcid":false,"given":"Andrew J","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Molecular Cardiovascular Biology, The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, 240 Albert Sabin Way, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Molecular Cardiovascular Biology, The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, 240 Albert Sabin Way, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1444-7124","authenticated-orcid":false,"given":"Katherine E","family":"Yutzey","sequence":"additional","affiliation":[{"name":"Division of Molecular Cardiovascular Biology, The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, 240 Albert Sabin Way, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,14]]},"reference":[{"key":"2021092111231699300_cvaa062-B1","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.jacc.2018.08.2149","article-title":"The macrophage in cardiac homeostasis and disease: JACC macrophage in CVD series (part 4)","volume":"72","author":"Lavine","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2021092111231699300_cvaa062-B2","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"key":"2021092111231699300_cvaa062-B3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.atherosclerosis.2007.09.008","article-title":"Ethnic differences between extra-coronary measures on cardiac computed tomography: multi-ethnic study of 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