{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:39:05Z","timestamp":1788586745074,"version":"build-2803163510"},"reference-count":180,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["DFG-BR2107\/4-1"],"award-info":[{"award-number":["DFG-BR2107\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["DFG-OD86\/6-1"],"award-info":[{"award-number":["DFG-OD86\/6-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["DFG-OD86\/7-1"],"award-info":[{"award-number":["DFG-OD86\/7-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Leducq Foundation for Cardiovascular Research","award":["18CVD05"],"award-info":[{"award-number":["18CVD05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cardiomyocytes express a surprisingly large number of potassium channel types. The primary physiological functions of the currents conducted by these channels are to maintain the resting membrane potential and mediate action potential repolarization under basal conditions and in response to changes in the concentrations of intracellular sodium, calcium, and ATP\/ADP. Here, we review the diversity and functional roles of cardiac potassium channels under normal conditions and how heritable mutations in the genes encoding these channels can lead to distinct arrhythmias. We briefly review atrial fibrillation and J-wave syndromes. For long and short QT syndromes, we describe their genetic basis, clinical manifestation, risk stratification, traditional and novel therapeutic approaches, as well as insights into disease mechanisms provided by animal and cellular models.<\/jats:p>","DOI":"10.1093\/cvr\/cvaa068","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T20:12:39Z","timestamp":1585253559000},"page":"1542-1556","source":"Crossref","is-referenced-by-count":42,"title":["Heritable arrhythmias associated with abnormal function of cardiac potassium channels"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8739-6527","authenticated-orcid":false,"given":"Lia","family":"Crotti","sequence":"first","affiliation":[{"name":"Center for Cardiac Arrhythmias of Genetic Origin, Istituto Auxologico Italiano, IRCCS, Milan, Italy"},{"name":"Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano, IRCCS, Milan, Italy"},{"name":"Department of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, San Luca Hospital, Milan, Italy"},{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja E","family":"Odening","sequence":"first","affiliation":[{"name":"Department of Cardiology and Angiology I, Heart Center University of Freiburg, Medical Faculty, Freiburg, Germany"},{"name":"Institute of Experimental Cardiovascular Medicine, Heart Center University of Freiburg, Medical Faculty, Freiburg, Germany"},{"name":"Department of Cardiology, Translational Cardiology, Inselspital, Bern University Hospital, and Institute of Physiology, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-0969","authenticated-orcid":false,"given":"Michael C","family":"Sanguinetti","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"2020070907341565800_cvaa068-B1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1152\/physrev.00022.2013","article-title":"Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia","volume":"94","author":"Schmitt","year":"2014","journal-title":"Physiol Rev"},{"key":"2020070907341565800_cvaa068-B2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/384078a0","article-title":"KvLQT1 and IsK (minK) proteins associate to form the IKs cardiac potassium 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