{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:57:35Z","timestamp":1790261855863,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"St Vincent\u2019s Hospital (Melbourne) Research Endowment Fund"},{"name":"Stafford Fox Medical Research Foundation"},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["CS\/14\/3\/31002"],"award-info":[{"award-number":["CS\/14\/3\/31002"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Health Research University College London Hospitals Biomedical Research Centre"},{"name":"Duke-National University Singapore Medical School"},{"name":"Singapore Ministry of Health\u2019s National Medical Research Council"},{"name":"Clinician Scientist-Senior Investigator scheme","award":["NMRC\/CSA-SI\/0011\/2017"],"award-info":[{"award-number":["NMRC\/CSA-SI\/0011\/2017"]}]},{"name":"Collaborative Centre Grant scheme","award":["NMRC\/CGAug16C006"],"award-info":[{"award-number":["NMRC\/CGAug16C006"]}]},{"name":"Singapore Ministry of Education Academic Research Fund Tier 2","award":["MOE2016-T2-2-021"],"award-info":[{"award-number":["MOE2016-T2-2-021"]}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["#1057741"],"award-info":[{"award-number":["#1057741"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["#1139489"],"award-info":[{"award-number":["#1139489"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Helen Amelia Hanis Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To establish pre-clinical proof of concept that sustained subcutaneous delivery of the secretome of human cardiac stem cells (CSCs) can be achieved in vivo to produce significant cardioreparative outcomes in the setting of myocardial infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Rats were subjected to permanent ligation of left anterior descending coronary artery and randomized to receive subcutaneous implantation of TheraCyte devices containing either culture media as control or 1 \u00d7 106 human W8B2+ CSCs, immediately following myocardial ischaemia. At 4\u2009weeks following myocardial infarction, rats treated with W8B2+ CSCs encapsulated within the TheraCyte device showed preserved left ventricular ejection fraction. The preservation of cardiac function was accompanied by reduced fibrotic scar tissue, interstitial fibrosis, cardiomyocyte hypertrophy, as well as increased myocardial vascular density. Histological analysis of the TheraCyte devices harvested at 4\u2009weeks post-implantation demonstrated survival of human W8B2+ CSCs within the devices, and the outer membrane was highly vascularized by host blood vessels. Using CSCs expressing plasma membrane reporters, extracellular vesicles of W8B2+ CSCs were found to be transferred to the heart and other organs at 4\u2009weeks post-implantation. Furthermore, mass spectrometry-based proteomic profiling of extracellular vesicles of W8B2+ CSCs identified proteins implicated in inflammation, immunoregulation, cell survival, angiogenesis, as well as tissue remodelling and fibrosis that could mediate the cardioreparative effects of secretome of human W8B2+ CSCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Subcutaneous implantation of TheraCyte devices encapsulating human W8B2+ CSCs attenuated adverse cardiac remodelling and preserved cardiac function following myocardial infarction. The TheraCyte device can be employed to deliver stem cells in a minimally invasive manner for effective secretome-based cardiac therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvaa088","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T07:16:40Z","timestamp":1585725400000},"page":"918-929","source":"Crossref","is-referenced-by-count":68,"title":["Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1002-2302","authenticated-orcid":false,"given":"Andrew R","family":"Kompa","sequence":"first","affiliation":[{"name":"Departments of Medicine and Surgery, University of Melbourne, Melbourne, VIC, Australia"},{"name":"Department of Epidemiology and Preventive Medicine, Centre of Cardiovascular Research and Education in Therapeutics, Monash University, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7516-485X","authenticated-orcid":false,"given":"David W","family":"Greening","sequence":"additional","affiliation":[{"name":"Molecular Proteomics, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia"},{"name":"Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M","family":"Kong","sequence":"additional","affiliation":[{"name":"O\u2019Brien Institute Department, St Vincent\u2019s Institute of Medical Research, 9 Princes Street, Fitzroy, VIC 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-1175","authenticated-orcid":false,"given":"Paul J","family":"McMillan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E","family":"Newcomb","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, St Vincent\u2019s Hospital Melbourne, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7062-0684","authenticated-orcid":false,"given":"Bakhos A","family":"Tannous","sequence":"additional","affiliation":[{"name":"Department of Neurology and Pathology, Massachusetts General Hospital, Charlestown, MA, USA"},{"name":"Program in Neuroscience, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6242-5990","authenticated-orcid":false,"given":"Cameron","family":"Kos","sequence":"additional","affiliation":[{"name":"O'Brien Institute Department & Immunology & Diabetes Unit, St Vincent\u2019s Institute of Medical Research, VIC, 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