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The present review is primarily focused on the findings to indicate the role of ACE2 in the relationship of coronaviruses and influenza viruses to CV disease. It is postulated that the risk of coronavirus or influenza virus infection is high, at least partly due to high ACE2 expression in populations with a high CV risk. Coronavirus and influenza virus vaccine usage in high CV risk populations could be a potential strategy to prevent both CV disease and coronavirus\/influenza virus infections.<\/jats:p>","DOI":"10.1093\/cvr\/cvaa093","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T19:10:26Z","timestamp":1585768226000},"page":"1932-1936","source":"Crossref","is-referenced-by-count":53,"title":["The role of angiotensin-converting enzyme 2 in coronaviruses\/influenza viruses and cardiovascular disease"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2454-4849","authenticated-orcid":false,"given":"Li","family":"Chen","sequence":"first","affiliation":[{"name":"Georgia Prevention Institute, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3780-0223","authenticated-orcid":false,"given":"Guang","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"2020100807442086600_cvaa093-B1","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1161\/ATVBAHA.118.311282","article-title":"Renin\u2013angiotensin system and cardiovascular functions","volume":"38","author":"Wu","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2020100807442086600_cvaa093-B2","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/hr.2016.17","article-title":"Structure and functions of angiotensinogen","volume":"39","author":"Lu","year":"2016","journal-title":"Hypertens Res"},{"key":"2020100807442086600_cvaa093-B3","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/01.RES.85.7.643","article-title":"The cardiac renin\u2013angiotensin system: conceptual, or a regulator of cardiac function?","volume":"85","author":"Dostal","year":"1999","journal-title":"Circ Res"},{"key":"2020100807442086600_cvaa093-B4","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/01.RES.0000217340.40936.53","article-title":"Signaling by the angiotensin-converting enzyme","volume":"98","author":"Fleming","year":"2006","journal-title":"Circ Res"},{"key":"2020100807442086600_cvaa093-B5","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/01.RES.87.5.e1","article-title":"A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9","volume":"87","author":"Donoghue","year":"2000","journal-title":"Circ Res"},{"key":"2020100807442086600_cvaa093-B6","doi-asserted-by":"crossref","first-page":"33238","DOI":"10.1074\/jbc.M002615200","article-title":"A human homolog of angiotensin-converting enzyme. 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