{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:17:45Z","timestamp":1787008665054,"version":"build-2736575974"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972909"],"award-info":[{"award-number":["31972909"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31830039"],"award-info":[{"award-number":["31830039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Luzhou-Southwest Medical University","award":["2018-8"],"award-info":[{"award-number":["2018-8"]}]},{"name":"International Cooperative Initiatives from Science and Technology Department"},{"name":"Sichuan Science and Technology Program","award":["2019YFH0174"],"award-info":[{"award-number":["2019YFH0174"]}]},{"name":"Sichuan Province"},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/14\/6\/31144"],"award-info":[{"award-number":["RG\/14\/6\/31144"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Hypertension is a major risk factor for cardiovascular diseases. However, vascular remodelling, a hallmark of hypertension, has not been systematically characterized yet. We described systematic vascular remodelling, especially the artery type- and cell type-specific changes, in hypertension using spontaneously hypertensive rats (SHRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Single-cell RNA sequencing was used to depict the cell atlas of mesenteric artery (MA) and aortic artery (AA) from SHRs. More than 20\u2009000 cells were included in the analysis. The number of immune cells more than doubled in aortic aorta in SHRs compared to Wistar Kyoto controls, whereas an expansion of MA mesenchymal stromal cells (MSCs) was observed in SHRs. Comparison of corresponding artery types and cell types identified in integrated datasets unravels dysregulated genes specific for artery types and cell types. Intersection of dysregulated genes with curated gene sets including cytokines, growth factors, extracellular matrix (ECM), receptors, etc. revealed vascular remodelling events involving cell\u2013cell interaction and ECM re-organization. Particularly, AA remodelling encompasses upregulated cytokine genes in smooth muscle cells, endothelial cells, and especially MSCs, whereas in MA, change of genes involving the contractile machinery and downregulation of ECM-related genes were more prominent. Macrophages and T cells within the aorta demonstrated significant dysregulation of cellular interaction with vascular cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings provide the first cell landscape of resistant and conductive arteries in hypertensive animal models. Moreover, it also offers a systematic characterization of the dysregulated gene profiles with unbiased, artery type-specific and cell type-specific manners during hypertensive vascular remodelling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvaa164","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T07:10:18Z","timestamp":1592464218000},"page":"1202-1216","source":"Crossref","is-referenced-by-count":51,"title":["Single-cell RNA sequencing reveals cell type- and artery type-specific vascular remodelling in male spontaneously hypertensive rats"],"prefix":"10.1093","volume":"117","author":[{"given":"Jun","family":"Cheng","sequence":"first","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, 319 Zhongshan Road, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3859-3150","authenticated-orcid":false,"given":"Wenduo","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London BHF Centre, 125 Coldharbour Lane, London SE5 9NU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5736-3177","authenticated-orcid":false,"given":"Ting","family":"Lan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, 319 Zhongshan Road, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London BHF Centre, 125 Coldharbour Lane, London SE5 9NU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Ni","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London BHF Centre, 125 Coldharbour Lane, London SE5 9NU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London BHF Centre, 125 Coldharbour Lane, London SE5 9NU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London BHF Centre, 125 Coldharbour Lane, London SE5 9NU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6104-7596","authenticated-orcid":false,"given":"Xiaolei","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, 319 Zhongshan Road, Luzhou 646000, China"},{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London BHF Centre, 125 Coldharbour Lane, London SE5 9NU, UK"},{"name":"Vascular Surgery Department, Affiliated Hospital of Southwest Medical University, 25 Taiping Street, Luzhou 646000, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, 319 Zhongshan Road, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-8155","authenticated-orcid":false,"given":"Qingbo","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, 319 Zhongshan Road, Luzhou 646000, China"},{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London BHF Centre, 125 Coldharbour Lane, London SE5 9NU, UK"},{"name":"Department of Cardiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"2021032208553127900_cvaa164-B1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/jama.2016.19043","article-title":"Global burden of hypertension and systolic blood pressure of at least 110 to 115 mm Hg, 1990-2015","volume":"317","author":"Forouzanfar","year":"2017","journal-title":"JAMA"},{"key":"2021032208553127900_cvaa164-B2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1161\/HYPERTENSIONAHA.117.08929","article-title":"Resistant hypertension: an update of experimental and clinical findings","volume":"70","author":"Cai","year":"2017","journal-title":"Hypertension"},{"key":"2021032208553127900_cvaa164-B3","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1161\/ATVBAHA.118.311229","article-title":"Vascular smooth muscle remodeling in conductive and resistance arteries in hypertension","volume":"38","author":"Brown","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021032208553127900_cvaa164-B4","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1172\/JCI19628","article-title":"Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice","volume":"113","author":"Hu","year":"2004","journal-title":"J Clin Invest"},{"key":"2021032208553127900_cvaa164-B5","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1161\/CIRCULATIONAHA.116.023171","article-title":"Metabolic reprogramming regulates the proliferative and inflammatory phenotype of adventitial fibroblasts in pulmonary hypertension through the transcriptional corepressor C-terminal binding protein-1","volume":"134","author":"Li","year":"2016","journal-title":"Circulation"},{"key":"2021032208553127900_cvaa164-B6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s41577-019-0160-5","article-title":"Immune mechanisms of hypertension","volume":"19","author":"Drummond","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"2021032208553127900_cvaa164-B7","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1161\/CIRCRESAHA.117.312513","article-title":"Atlas of the immune cell repertoire in mouse atherosclerosis defined by single-cell RNA-sequencing and mass cytometry","volume":"122","author":"Winkels","year":"2018","journal-title":"Circ Res"},{"key":"2021032208553127900_cvaa164-B8","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1161\/ATVBAHA.119.312399","article-title":"Adventitial cell atlas of wt (wild type) and ApoE (apolipoprotein E)-deficient mice defined by single-cell RNA sequencing","volume":"39","author":"Gu","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021032208553127900_cvaa164-B9","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"2021032208553127900_cvaa164-B10","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","article-title":"UniProt: a worldwide hub of protein knowledge","volume":"47","author":"UniProt","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2021032208553127900_cvaa164-B11","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/s41588-018-0205-x","article-title":"Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits","volume":"50","author":"Evangelou","year":"2018","journal-title":"Nat Genet"},{"key":"2021032208553127900_cvaa164-B12","doi-asserted-by":"crossref","first-page":"D33","DOI":"10.1093\/nar\/gky822","article-title":"AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors","volume":"47","author":"Hu","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2021032208553127900_cvaa164-B13","doi-asserted-by":"crossref","first-page":"E10988","DOI":"10.1073\/pnas.1808790115","article-title":"The in silico human surfaceome","volume":"115","author":"Bausch-Fluck","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021032208553127900_cvaa164-B14","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.014647","article-title":"The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices","volume":"11","author":"Naba","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"2021032208553127900_cvaa164-B15","doi-asserted-by":"crossref","first-page":"D1091","DOI":"10.1093\/nar\/gkx1121","article-title":"The IUPHAR\/BPS guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY","volume":"46","author":"Harding","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2021032208553127900_cvaa164-B16","doi-asserted-by":"crossref","first-page":"D619","DOI":"10.1093\/nar\/gkw1033","article-title":"Genenames.org: the HGNC and VGNC resources in 2017","volume":"45","author":"Yates","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2021032208553127900_cvaa164-B17","doi-asserted-by":"crossref","first-page":"7866","DOI":"10.1038\/ncomms8866","article-title":"A draft network of ligand\u2013receptor-mediated multicellular signalling in human","volume":"6","author":"Ramilowski","year":"2015","journal-title":"Nat Commun"},{"key":"2021032208553127900_cvaa164-B18","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1152\/physrev.00035.2016","article-title":"Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans","volume":"97","author":"Padmanabhan","year":"2017","journal-title":"Physiol Rev"},{"key":"2021032208553127900_cvaa164-B19","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1161\/CIRCRESAHA.112.300387","article-title":"Advances in blood pressure genomics","volume":"112","author":"Munroe","year":"2013","journal-title":"Circ Res"},{"key":"2021032208553127900_cvaa164-B20","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1161\/HYP.0000000000000090","article-title":"Animal models of hypertension: a scientific statement from the American Heart Association","volume":"73","author":"Lerman","year":"2019","journal-title":"Hypertension"},{"key":"2021032208553127900_cvaa164-B21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/84777","article-title":"Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats","volume":"27","author":"Pravenec","year":"2001","journal-title":"Nat Genet"},{"key":"2021032208553127900_cvaa164-B22","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1161\/HYPERTENSIONAHA.114.03618","article-title":"Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis","volume":"65","author":"Wang","year":"2015","journal-title":"Hypertension"},{"key":"2021032208553127900_cvaa164-B23","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/cvr\/cvy023","article-title":"Vascular smooth muscle contraction in hypertension","volume":"114","author":"Touyz","year":"2018","journal-title":"Cardiovasc Res"},{"key":"2021032208553127900_cvaa164-B24","doi-asserted-by":"crossref","first-page":"13583","DOI":"10.1038\/ncomms13583","article-title":"PEP-19 modulates calcium binding to calmodulin by electrostatic steering","volume":"7","author":"Wang","year":"2016","journal-title":"Nat Commun"},{"key":"2021032208553127900_cvaa164-B25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/CIRCRESAHA.108.188409","article-title":"Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells","volume":"104","author":"Alexis","year":"2009","journal-title":"Circ Res"},{"key":"2021032208553127900_cvaa164-B26","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1161\/CIRCRESAHA.110.219071","article-title":"Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification","volume":"107","author":"Yao","year":"2010","journal-title":"Circ Res"},{"key":"2021032208553127900_cvaa164-B27","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s00223-016-0167-x","article-title":"Osteonectin (SPARC) expression in vascular calcification: in vitro and ex vivo studies","volume":"99","author":"Ciceri","year":"2016","journal-title":"Calcif Tissue Int"},{"key":"2021032208553127900_cvaa164-B28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00109-014-1229-z","article-title":"BMP-2 and TGF-beta1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells","volume":"93","author":"Song","year":"2015","journal-title":"J Mol Med"},{"key":"2021032208553127900_cvaa164-B29","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1111\/bph.14200","article-title":"Heat shock protein-27 and sex-selective regulation of muscarinic and proteinase-activated receptor 2-mediated vasodilatation: differential sensitivity to endothelial NOS inhibition","volume":"175","author":"Pulakazhi Venu","year":"2018","journal-title":"Br J Pharmacol"},{"key":"2021032208553127900_cvaa164-B30","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1111\/bph.14334","article-title":"The role of autoimmune reactivity induced by heat shock protein 70 in the pathogenesis of essential hypertension","volume":"176","author":"Rodriguez-Iturbe","year":"2019","journal-title":"Br J Pharmacol"},{"key":"2021032208553127900_cvaa164-B31","doi-asserted-by":"crossref","first-page":"18014","DOI":"10.1038\/nrdp.2018.14","article-title":"Hypertension","volume":"4","author":"Oparil","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"2021032208553127900_cvaa164-B32","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/ars.2016.6642","article-title":"Lysyl oxidase induces vascular oxidative stress and contributes to arterial stiffness and abnormal elastin structure in hypertension: role of p38MAPK","volume":"27","author":"Mart\u00ednez-Revelles","year":"2017","journal-title":"Antioxid Redox Signal"},{"key":"2021032208553127900_cvaa164-B33","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1161\/01.HYP.0000084603.93510.28","article-title":"Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension","volume":"42","author":"Widlansky","year":"2003","journal-title":"Hypertension"},{"key":"2021032208553127900_cvaa164-B34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00018-010-0518-0","article-title":"Endothelin","volume":"68","author":"Kawanabe","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"2021032208553127900_cvaa164-B35","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1161\/01.CIR.0000022690.55143.56","article-title":"Beta(2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension","volume":"106","author":"Iaccarino","year":"2002","journal-title":"Circulation"},{"key":"2021032208553127900_cvaa164-B36","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1016\/j.celrep.2019.04.102","article-title":"Single-cell transcriptional profiling of aortic endothelium identifies a hierarchy from endovascular progenitors to differentiated cells","volume":"27","author":"Lukowski","year":"2019","journal-title":"Cell Rep"},{"key":"2021032208553127900_cvaa164-B37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1161\/CIRCULATIONAHA.118.038362","article-title":"Single-cell analysis of the normal mouse aorta reveals functionally distinct endothelial cell populations","volume":"140","author":"Kalluri","year":"2019","journal-title":"Circulation"},{"key":"2021032208553127900_cvaa164-B38","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/cr.2016.85","article-title":"Identification of blood vascular endothelial stem cells by the expression of protein C receptor","volume":"26","author":"Yu","year":"2016","journal-title":"Cell Res"},{"key":"2021032208553127900_cvaa164-B39","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nature07391","article-title":"Sox18 induces development of the lymphatic vasculature in mice","volume":"456","author":"Fran\u00e7ois","year":"2008","journal-title":"Nature"},{"key":"2021032208553127900_cvaa164-B40","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.stem.2009.05.003","article-title":"Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6","volume":"5","author":"Lee","year":"2009","journal-title":"Cell Stem Cell"},{"key":"2021032208553127900_cvaa164-B41","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.yjmcc.2018.02.006","article-title":"Cartilage intermediate layer protein-1 alleviates pressure overload-induced cardiac fibrosis via interfering TGF-beta1 signaling","volume":"116","author":"Zhang","year":"2018","journal-title":"J Mol Cell Cardiol"},{"key":"2021032208553127900_cvaa164-B42","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nm.3777","article-title":"Orphan nuclear receptor NR4A1 regulates transforming growth factor-beta signaling and fibrosis","volume":"21","author":"Palumbo-Zerr","year":"2015","journal-title":"Nat Med"},{"key":"2021032208553127900_cvaa164-B43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41419-018-1284-4","article-title":"CYTL1 regulates bone homeostasis in mice by modulating osteogenesis of mesenchymal stem cells and osteoclastogenesis of bone marrow-derived macrophages","volume":"10","author":"Shin","year":"2019","journal-title":"Cell Death Dis"},{"key":"2021032208553127900_cvaa164-B44","doi-asserted-by":"crossref","first-page":"25198","DOI":"10.1038\/srep25198","article-title":"sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss","volume":"6","author":"Haraguchi","year":"2016","journal-title":"Sci Rep"},{"key":"2021032208553127900_cvaa164-B45","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1177\/0003319713513492","article-title":"Endocan\u2014a novel inflammatory indicator in newly diagnosed patients with hypertension: a pilot study","volume":"65","author":"Balta","year":"2014","journal-title":"Angiology"},{"key":"2021032208553127900_cvaa164-B46","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1161\/01.RES.0000207919.83894.9d","article-title":"GDF15, a cardioprotective TGF-beta superfamily protein","volume":"98","author":"Ago","year":"2006","journal-title":"Circ Res"},{"key":"2021032208553127900_cvaa164-B47","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1038\/s41467-018-06376-x","article-title":"Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway","volume":"9","author":"Dai","year":"2018","journal-title":"Nat Commun"},{"key":"2021032208553127900_cvaa164-B48","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/sj.jhh.1002304","article-title":"Endothelial progenitor cells are reduced in refractory hypertension","volume":"22","author":"Oliveras","year":"2008","journal-title":"J Hum Hypertens"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvaa164\/33675833\/cvaa164.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/117\/4\/1202\/36650346\/cvaa164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/117\/4\/1202\/36650346\/cvaa164.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T04:57:08Z","timestamp":1616389028000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/117\/4\/1202\/5863264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,26]]},"references-count":48,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,6,26]]},"published-print":{"date-parts":[[2021,3,21]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvaa164","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,4,1]]},"published":{"date-parts":[[2020,6,26]]}}}