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CRMs include natural and synthetic compounds able to inhibit protein acetyltransferases, to interfere with acetyl coenzyme A biosynthesis, or to activate (de)acetyltransferase proteins. These modifications mimic the effects of caloric restriction, which is associated with the activation of autophagy. Previous evidence demonstrated the ability of CRMs to ameliorate cardiac function and reduce cardiac hypertrophy and maladaptive remodelling in animal models of ageing, mechanical overload, chronic myocardial ischaemia, and in genetic and metabolic cardiomyopathies. In addition, CRMs were found to reduce acute ischaemia\u2013reperfusion injury. In many cases, these beneficial effects of CRMs appeared to be mediated by autophagy activation. In the present review, we discuss the relevant literature about the role of different CRMs in animal models of cardiac diseases, emphasizing the molecular mechanisms underlying the beneficial effects of these compounds and their potential future clinical application.<\/jats:p>","DOI":"10.1093\/cvr\/cvaa297","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T11:13:22Z","timestamp":1602242002000},"page":"1434-1449","source":"Crossref","is-referenced-by-count":36,"title":["Caloric restriction mimetics for the treatment of cardiovascular diseases"],"prefix":"10.1093","volume":"117","author":[{"given":"Sebastiano","family":"Sciarretta","sequence":"first","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 40100 Latina, Italy"},{"name":"Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli (IS), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Forte","sequence":"additional","affiliation":[{"name":"Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli (IS), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1365-3863","authenticated-orcid":false,"given":"Francesca","family":"Castoldi","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, Team \u201cMetabolism, Cancer & Immunity\u201d, INSERM UMRS1138, Universit\u00e9 de Paris, Sorbonne Universit\u00e9, 75006 Paris, France"},{"name":"Cell Biology and Metabolomics platforms, Gustave Roussy Cancer Campus, 94805 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2703-3761","authenticated-orcid":false,"given":"Giacomo","family":"Frati","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 40100 Latina, Italy"},{"name":"Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli (IS), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2413-6693","authenticated-orcid":false,"given":"Francesco","family":"Versaci","sequence":"additional","affiliation":[{"name":"Division of Cardiology, S. 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