{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:14:26Z","timestamp":1791000866071,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"University of Bonn [BONFOR","award":["2017-6-08"],"award-info":[{"award-number":["2017-6-08"]}]},{"name":"University of Bonn [BONFOR","award":["2018-1A-07"],"award-info":[{"award-number":["2018-1A-07"]}]},{"name":"University of Bonn [BONFOR","award":["2020-2A-05 to"],"award-info":[{"award-number":["2020-2A-05 to"]}]},{"DOI":"10.13039\/501100010578","name":"German Cardiac Society","doi-asserted-by":"publisher","award":["DGK16\/2018"],"award-info":[{"award-number":["DGK16\/2018"]}],"id":[{"id":"10.13039\/501100010578","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ernst und Bertha Grimmke Foundation","award":["13\/19"],"award-info":[{"award-number":["13\/19"]}]},{"DOI":"10.13039\/501100004543","name":"Chinese Scholarship Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation","award":["4139\/8-1"],"award-info":[{"award-number":["4139\/8-1"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation","award":["2351\/2-1"],"award-info":[{"award-number":["2351\/2-1"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation","award":["397484323 \u2013 TRR 259"],"award-info":[{"award-number":["397484323 \u2013 TRR 259"]}]},{"DOI":"10.13039\/100016021","name":"Corona-Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016021","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) is an independent risk factor for the development of coronary artery disease (CAD). For both, CKD and CAD, the intercellular transfer of microRNAs (miRs) through extracellular vesicles (EVs) is an important factor of disease development. Whether the combination of CAD and CKD affects endothelial function through cellular crosstalk of EV-incorporated miRs is still unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Out of 172 screened CAD patients, 31 patients with CAD + CKD were identified and matched with 31 CAD patients without CKD. Additionally, 13 controls without CAD and CKD were included. Large EVs from CAD + CKD patients contained significantly lower levels of the vasculo-protective miR-130a-3p and miR-126-3p compared to CAD patients and controls. Flow cytometric analysis of plasma-derived EVs revealed significantly higher numbers of endothelial cell-derived EVs in CAD and CAD + CKD patients compared to controls. EVs from CAD + CKD patients impaired target human coronary artery endothelial cell (HCAEC) proliferation upon incubation in vitro. Consistent with the clinical data, treatment with the uraemia toxin indoxyl sulfate (IS)-reduced miR-130a-3p levels in HCAEC-derived EVs. EVs from IS-treated donor HCAECs-reduced proliferation and re-endothelialization in EV-recipient cells and induced an anti-angiogenic gene expression profile. In a mouse-experiment, intravenous treatment with EVs from IS-treated endothelial cells significantly impaired endothelial regeneration. On the molecular level, we found that IS leads to an up-regulation of the heterogenous nuclear ribonucleoprotein U (hnRNPU), which retains miR-130a-3p in the cell leading to reduced vesicular miR-130a-3p export and impaired EV-recipient cell proliferation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that EV-miR-mediated vascular intercellular communication is altered in patients with CAD and CKD, promoting CKD-induced endothelial dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvaa322","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T15:12:16Z","timestamp":1603465936000},"page":"316-333","source":"Crossref","is-referenced-by-count":35,"title":["MicroRNA-mediated vascular intercellular communication is altered in chronic kidney disease"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5759-7627","authenticated-orcid":false,"given":"Andreas","family":"Zietzer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2247-8158","authenticated-orcid":false,"given":"Eva","family":"Steffen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8095-5824","authenticated-orcid":false,"given":"Sven","family":"Niepmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"D\u00fcsing","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Rabiul","family":"Hosen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-0088","authenticated-orcid":false,"given":"Paul","family":"Jamme","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baravan","family":"Al-Kassou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1485-4221","authenticated-orcid":false,"given":"Philipp Roger","family":"Goody","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-2088","authenticated-orcid":false,"given":"Sebastian","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5908-8823","authenticated-orcid":false,"given":"Katrin S","family":"Reiners","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Pfeifer","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Medical Department III, Faculty of Medicine, Saarland University Medical Center, Saarland University, Kirrberger Stra\u00dfe 100, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"},{"name":"Medical Department II, Krankenhaus der Barmherzigen Br\u00fcder Trier, Nordallee 1, 54292 Trier, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"2022011201335048500_cvaa322-B1","first-page":"2154","article-title":"Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research","volume":"108","author":"Sarnak","year":"2003","journal-title":"Clin Cardiol Epidemiol Prev Circul"},{"key":"2022011201335048500_cvaa322-B2","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0140-6736(12)60572-8","article-title":"Risk of coronary events in people with chronic kidney disease compared with those with diabetes: a population-level cohort study","volume":"380","author":"Tonelli","year":"2012","journal-title":"Lancet"},{"key":"2022011201335048500_cvaa322-B3","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1046\/j.1523-1755.2003.00784.x","article-title":"Grade of chronic renal failure, and acute and long-term outcome after percutaneous coronary interventions","volume":"63","author":"Reinecke","year":"2003","journal-title":"Kidney Int"},{"key":"2022011201335048500_cvaa322-B4","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1161\/01.CIR.0000027560.41358.B3","article-title":"Prognostic implications of abnormalities in renal function in patients with acute coronary syndromes","volume":"106","author":"Al Suwaidi","year":"2002","journal-title":"Circulation"},{"key":"2022011201335048500_cvaa322-B5","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1159\/000191468","article-title":"Indoxyl sulfate inhibits nitric oxide production and cell viability by inducing oxidative stress in vascular endothelial cells","volume":"29","author":"Tumur","year":"2009","journal-title":"Am J Nephrol"},{"key":"2022011201335048500_cvaa322-B6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1523-1755.2004.00399.x","article-title":"The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair","volume":"65","author":"Dou","year":"2004","journal-title":"Kidney Int"},{"key":"2022011201335048500_cvaa322-B7","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1161\/CIRCULATIONAHA.108.838268","article-title":"Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community","volume":"119","author":"B\u00f6Ger","year":"2009","journal-title":"Circulation"},{"key":"2022011201335048500_cvaa322-B8","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005022","article-title":"Indoxyl sulfate: a novel cardiovascular risk factor in chronic kidney disease","volume":"6","author":"Hung","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2022011201335048500_cvaa322-B9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/ncb2441","article-title":"Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs","volume":"14","author":"Hergenreider","year":"2012","journal-title":"Nat Cell Biol"},{"key":"2022011201335048500_cvaa322-B10","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1007\/s00018-011-0689-3","article-title":"Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles","volume":"68","author":"Gy\u00f6rgy","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"2022011201335048500_cvaa322-B11","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1182\/blood-2014-11-611046","article-title":"Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs","volume":"125","author":"Njock","year":"2015","journal-title":"Blood"},{"key":"2022011201335048500_cvaa322-B12","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat Cell Biol"},{"key":"2022011201335048500_cvaa322-B13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/CIRCRESAHA.118.314010","article-title":"Atherosclerotic conditions promote the packaging of functional microRNA-92a-3p into endothelial microvesicles","volume":"124","author":"Liu","year":"2019","journal-title":"Circ Res"},{"key":"2022011201335048500_cvaa322-B14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1161\/01.ATV.0000191634.13057.15","article-title":"Circulating CD31+\/annexin V+ apoptotic microparticles correlate with coronary endothelial function in patients with coronary artery disease","volume":"26","author":"Werner","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2022011201335048500_cvaa322-B15","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1161\/01.ATV.0000243941.72375.15","article-title":"Increased ratio of CD31+\/CD42-microparticles to endothelial progenitors as a novel marker of atherosclerosis in hypercholesterolemia","volume":"26","author":"Pirro","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2022011201335048500_cvaa322-B16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/ajh\/hpz112","article-title":"Secreted monocyte miR-27a, via mesenteric arterial mas receptor-eNOS pathway, causes hypertension","volume":"33","author":"Zou","year":"2020","journal-title":"Am J Hypertens"},{"key":"2022011201335048500_cvaa322-B17","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1161\/CIRCULATIONAHA.113.001720","article-title":"Endothelial microparticle-mediated transfer of MicroRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles","volume":"128","author":"Jansen","year":"2013","journal-title":"Circulation"},{"key":"2022011201335048500_cvaa322-B18","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1538-7836.2005.01780.x","article-title":"Elevation of circulating endothelial microparticles in patients with chronic renal failure","volume":"4","author":"Faure","year":"2006","journal-title":"J Thromb Haemost"},{"key":"2022011201335048500_cvaa322-B19","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1681\/ASN.2005050535","article-title":"Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure","volume":"16","author":"Amabile","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"2022011201335048500_cvaa322-B20","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.00666","article-title":"Microvesicles derived from indoxyl sulfate treated endothelial cells induce endothelial progenitor cells dysfunction","volume":"8","author":"Carmona","year":"2017","journal-title":"Front Physiol"},{"key":"2022011201335048500_cvaa322-B21","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/1471-2164-13-357","article-title":"Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types","volume":"13","author":"Guduric-Fuchs","year":"2012","journal-title":"BMC Genomics"},{"key":"2022011201335048500_cvaa322-B22","doi-asserted-by":"crossref","first-page":"12855","DOI":"10.1038\/srep12855","article-title":"Reduced expression of argonaute 1, argonaute 2, and TRBP changes levels and intracellular distribution of RNAi factors","volume":"5","author":"Matsui","year":"2015","journal-title":"Sci Rep"},{"key":"2022011201335048500_cvaa322-B23","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.celrep.2016.09.031","article-title":"The RNA-binding protein SYNCRIP is a component of the hepatocyte exosomal machinery controlling microRNA sorting","volume":"17","author":"Santangelo","year":"2016","journal-title":"Cell Rep"},{"key":"2022011201335048500_cvaa322-B24","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1038\/ncomms3980","article-title":"Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs","volume":"4","author":"Villarroya-Beltri","year":"2013","journal-title":"Nat Commun"},{"key":"2022011201335048500_cvaa322-B25","doi-asserted-by":"crossref","first-page":"1786967","DOI":"10.1080\/20013078.2020.1786967","article-title":"The RNA-binding protein hnRNPU regulates the sorting of microRNA-30c-5p into large extracellular vesicles","volume":"9","author":"Zietzer","year":"2020","journal-title":"J Extracell Vesicles"},{"key":"2022011201335048500_cvaa322-B26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Intern Med"},{"key":"2022011201335048500_cvaa322-B27","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1161\/01.CIR.99.17.2345","article-title":"ACC\/AHA guidelines for coronary angiography: executive summary and recommendations. A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Committee on Coronary Angiography) developed in collaboration with the Society for Cardiac Angiography and Interventions","volume":"99","author":"Scanlon","year":"1999","journal-title":"Circulation"},{"key":"2022011201335048500_cvaa322-B28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/eurheartj\/ehy394","article-title":"2018 ESC\/EACTS Guidelines on myocardial revascularization","volume":"40","author":"Neumann","year":"2019","journal-title":"Eur Heart J"},{"key":"2022011201335048500_cvaa322-B29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.yjmcc.2017.09.004","article-title":"Endothelial microparticle-promoted inhibition of vascular remodeling is abrogated under hyperglycaemic conditions","volume":"112","author":"Jansen","year":"2017","journal-title":"J Mol Cell Cardiol"},{"key":"2022011201335048500_cvaa322-B30","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/CIRCRESAHA.109.215566","article-title":"Circulating microRNAs in patients with coronary artery disease","volume":"107","author":"Fichtlscherer","year":"2010","journal-title":"Circ Res"},{"key":"2022011201335048500_cvaa322-B31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00395-020-0774-6","article-title":"Murine sca1\/flk1-positive cells are not endothelial progenitor cells, but B2 lymphocytes","volume":"115","author":"Steffen","year":"2020","journal-title":"Basic Res Cardiol"},{"key":"2022011201335048500_cvaa322-B32","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal Information for Studies of Extracellular Vesicles 2018 (MISEV 2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV 2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"Int Soc Extracell Vesicl"},{"key":"2022011201335048500_cvaa322-B33","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1161\/CIRCRESAHA.117.309417","article-title":"Methodological guidelines to study extracellular vesicles","volume":"120","author":"Coumans","year":"2017","journal-title":"Circ Res"},{"key":"2022011201335048500_cvaa322-B34","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.devcel.2008.07.002","article-title":"The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis","volume":"15","author":"Wang","year":"2008","journal-title":"Dev Cell"},{"key":"2022011201335048500_cvaa322-B35","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1177\/0003319716638242","article-title":"Circulating miR-130a, miR-27b, and miR-210 in patients with peripheral artery disease and their potential relationship with oxidative stress","volume":"67","author":"Signorelli","year":"2016","journal-title":"Angiology"},{"key":"2022011201335048500_cvaa322-B36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cca.2010.09.029","article-title":"Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans","volume":"412","author":"Li","year":"2011","journal-title":"Clin Chim Acta"},{"key":"2022011201335048500_cvaa322-B37","doi-asserted-by":"crossref","first-page":"e80345","DOI":"10.1371\/journal.pone.0080345","article-title":"Diagnostic potential of plasmatic microRNA signatures in stable and unstable angina","volume":"8","author":"D'Alessandra","year":"2013","journal-title":"PLoS One"},{"key":"2022011201335048500_cvaa322-B38","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1161\/CIRCRESAHA.108.193102","article-title":"Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes","volume":"104","author":"Rane","year":"2009","journal-title":"Circ Res"},{"key":"2022011201335048500_cvaa322-B39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.biopha.2018.03.129","article-title":"MicroRNA-20a protects human aortic endothelial cells from Ox-LDL-induced inflammation through targeting TLR4 and TXNIP signaling","volume":"103","author":"Chen","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"2022011201335048500_cvaa322-B40","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1111\/jcmm.12607","article-title":"Endothelial microparticles reduce ICAM-1 expression in a microRNA-222-dependent mechanism","volume":"19","author":"Jansen","year":"2015","journal-title":"J Cell Mol Med"},{"key":"2022011201335048500_cvaa322-B41","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1182\/blood-2011-08-373886","article-title":"MicroRNA-27a\/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A","volume":"119","author":"Urbich","year":"2012","journal-title":"Blood"},{"key":"2022011201335048500_cvaa322-B42","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1253\/circj.CJ-10-0393","article-title":"Vascular smooth muscle cell proliferation is influenced by let-7d microRNA and its interaction with KRAS","volume":"75","author":"Yu","year":"2011","journal-title":"Circ J"},{"key":"2022011201335048500_cvaa322-B43","doi-asserted-by":"crossref","first-page":"7823","DOI":"10.1038\/s41598-018-25690-4","article-title":"MicroRNA expression profile of human advanced coronary atherosclerotic plaques","volume":"8","author":"Parahuleva","year":"2018","journal-title":"Sci Rep"},{"key":"2022011201335048500_cvaa322-B44","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nm.3487","article-title":"MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1","volume":"20","author":"Schober","year":"2014","journal-title":"Nat Med"},{"key":"2022011201335048500_cvaa322-B45","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1681\/ASN.2016111215","article-title":"MicroRNA-92a mediates endothelial dysfunction in CKD","volume":"28","author":"Shang","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"2022011201335048500_cvaa322-B46","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1093\/ndt\/gfx029","article-title":"Microbiome perturbation by oral vancomycin reduces plasma concentration of two gut-derived uremic solutes, indoxyl sulfate and p-cresyl sulfate, in end-stage renal disease","volume":"32","author":"Nazzal","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"2022011201335048500_cvaa322-B47","doi-asserted-by":"crossref","first-page":"F906","DOI":"10.1152\/ajprenal.00178.2017","article-title":"HIF-1-mediated production of exosomes during hypoxia is protective in renal tubular cells","volume":"313","author":"Zhang","year":"2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"2022011201335048500_cvaa322-B48","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1093\/eurheartj\/ehu153","article-title":"Association of circulating endothelial microparticles with cardiometabolic risk factors in the Framingham Heart Study","volume":"35","author":"Amabile","year":"2014","journal-title":"Eur Heart J"},{"key":"2022011201335048500_cvaa322-B49","doi-asserted-by":"crossref","first-page":"247","DOI":"10.5551\/jat.26658","article-title":"Levels of circulating microparticles in patients with chronic cardiorenal disease","volume":"22","author":"Chen","year":"2015","journal-title":"J Atheroscler Thromb"},{"key":"2022011201335048500_cvaa322-B50","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1161\/01.HYP.0000259667.22309.df","article-title":"In vivo shear stress determines circulating levels of endothelial microparticles in end-stage renal disease","volume":"49","author":"Boulanger","year":"2007","journal-title":"Hypertension"},{"key":"2022011201335048500_cvaa322-B51","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007818","article-title":"Endothelial microparticles and systemic complement activation in patients with chronic kidney disease","volume":"7","author":"Jalal","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2022011201335048500_cvaa322-B52","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1038\/s41598-019-41101-8","article-title":"Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients","volume":"9","author":"Fourdinier","year":"2019","journal-title":"Sci Rep"},{"key":"2022011201335048500_cvaa322-B53","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/ckj\/sfx068","article-title":"Serum microRNAs are altered in various stages of chronic kidney disease: a preliminary study","volume":"10","author":"Brigant","year":"2017","journal-title":"Clin Kidney J"},{"key":"2022011201335048500_cvaa322-B54","doi-asserted-by":"crossref","first-page":"F982","DOI":"10.1152\/ajprenal.00569.2016","article-title":"Extracellular microRNA signature in chronic kidney disease","volume":"312","author":"Muralidharan","year":"2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"2022011201335048500_cvaa322-B55","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/ndt\/gfr573","article-title":"Predictive value of circulating endothelial microparticles for cardiovascular mortality in end-stage renal failure: a pilot study","volume":"27","author":"Amabile","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"2022011201335048500_cvaa322-B56","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20020338","article-title":"Acute exposure to indoxyl sulfate impairs endothelium-dependent vasorelaxation in rat aorta","volume":"20","author":"Matsumoto","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2022011201335048500_cvaa322-B57","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1084\/jem.20182313","article-title":"Caveolin-1 selectively regulates microRNA sorting into microvesicles after noxious stimuli","volume":"216","author":"Lee","year":"2019","journal-title":"J Exp Med"},{"key":"2022011201335048500_cvaa322-B58","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1161\/CIRCULATIONAHA.112.093906","article-title":"Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chronic heart failure: role for impaired in vivo neovascularization and cardiac repair capacity","volume":"126","author":"Jakob","year":"2012","journal-title":"Circulation"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvaa322\/35065156\/cvaa322.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/118\/1\/316\/42108028\/cvaa322.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/118\/1\/316\/42108028\/cvaa322.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T20:55:02Z","timestamp":1641934502000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/118\/1\/316\/5949089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,2]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,11,2]]},"published-print":{"date-parts":[[2022,1,7]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvaa322","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2020,11,2]]}}}