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Studies of gain- and loss-of-function animal models of mTOR signalling revealed that mTORC1\/2 elicits both adaptive and maladaptive functions in the cardiovascular system. Both mTORC1 and mTORC2 are indispensable for driving cardiac development and cardiac adaption to stress, such as pressure overload. However, persistent and deregulated mTORC1 activation in the heart is detrimental during stress and contributes to the development and progression of cardiac remodelling and genetic and metabolic cardiomyopathies. In this review, we discuss the latest findings regarding the role of mTOR in the cardiovascular system, both under basal conditions and during stress, such as pressure overload, ischemia, and metabolic stress. Current data suggest that mTOR modulation may represent a potential therapeutic strategy for the treatment of cardiac diseases.<\/jats:p>","DOI":"10.1093\/cvr\/cvab033","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T15:11:13Z","timestamp":1611673873000},"page":"424-439","source":"Crossref","is-referenced-by-count":64,"title":["The complex network of mTOR signalling in the heart"],"prefix":"10.1093","volume":"118","author":[{"given":"Sebastiano","family":"Sciarretta","sequence":"first","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 \u00a0Latina,","place":["Italy"]},{"name":"IRCCS Neuromed Pozzilli, Via Atinense, 18, 86077 Pozzilli","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Forte","sequence":"additional","affiliation":[{"name":"IRCCS Neuromed Pozzilli, Via Atinense, 18, 86077 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