{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T22:18:16Z","timestamp":1773526696052,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL091799"],"award-info":[{"award-number":["P01 HL091799"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R37 HL061690"],"award-info":[{"award-number":["NIH R37 HL061690"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH P01 HL075443"],"award-info":[{"award-number":["NIH P01 HL075443"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01 HL139522"],"award-info":[{"award-number":["NIH R01 HL139522"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH F31 HL154814"],"award-info":[{"award-number":["NIH F31 HL154814"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Merit Award","award":["18MERIT33900036"],"award-info":[{"award-number":["18MERIT33900036"]}]},{"name":"Scientific Development","award":["17SDG33400114"],"award-info":[{"award-number":["17SDG33400114"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims\u2003<\/jats:title>\n                  <jats:p>Myocardial infarction (MI) is the most common cause of heart failure (HF) worldwide. G protein-coupled receptor kinase 5 (GRK5) is upregulated in failing human myocardium and promotes maladaptive cardiac hypertrophy in animal models. However, the role of GRK5 in ischemic heart disease is still unknown. In this study, we evaluated whether myocardial GRK5 plays a critical role post-MI in mice and included the examination of specific cardiac immune and inflammatory responses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results\u2003<\/jats:title>\n                  <jats:p>Cardiomyocyte-specific GRK5 overexpressing transgenic mice (TgGRK5) and non-transgenic littermate control (NLC) mice as well as cardiomyocyte-specific GRK5 knockout mice (GRK5cKO) and wild type (WT) were subjected to MI and, functional as well as structural changes together with outcomes were studied. TgGRK5 post-MI mice showed decreased cardiac function, augmented left ventricular dimension and decreased survival rate compared to NLC post-MI mice. Cardiac hypertrophy and fibrosis as well as fetal gene expression were increased post-MI in TgGRK5 compared to NLC mice. In TgGRK5 mice, GRK5 elevation produced immuno-regulators that contributed to the elevated and long-lasting leukocyte recruitment into the injured heart and ultimately to chronic cardiac inflammation. We found an increased presence of pro-inflammatory neutrophils and macrophages as well as neutrophils, macrophages and T-lymphocytes at 4-days and 8-weeks respectively post-MI in TgGRK5 hearts. Conversely, GRK5cKO mice were protected from ischemic injury and showed reduced early immune cell recruitment (predominantly monocytes) to the heart, improved contractility and reduced mortality compared to WT post-MI mice. Interestingly, cardiomyocyte-specific GRK2 transgenic mice did not share the same phenotype of TgGRK5 mice and did not have increased cardiac leukocyte migration and cytokine or chemokine production post-MI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions\u2003<\/jats:title>\n                  <jats:p>Our study shows that myocyte GRK5 has a crucial and GRK-selective role on the regulation of leucocyte infiltration into the heart, cardiac function and survival in a murine model of post-ischemic HF, supporting GRK5 inhibition as a therapeutic target for HF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvab044","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T12:12:59Z","timestamp":1612613579000},"page":"169-183","source":"Crossref","is-referenced-by-count":41,"title":["G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4346-111X","authenticated-orcid":false,"given":"Claudio","family":"de Lucia","sequence":"first","affiliation":[{"name":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurel A","family":"Grisanti","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Borghetti","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4932-4378","authenticated-orcid":false,"given":"Michela","family":"Piedepalumbo","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"},{"name":"Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5237-6489","authenticated-orcid":false,"given":"Jessica","family":"Ibetti","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Lucchese","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric W","family":"Barr","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajika","family":"Roy","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4723-9495","authenticated-orcid":false,"given":"Ama Dedo","family":"Okyere","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haley Christine","family":"Murphy","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erhe","family":"Gao","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9701-0437","authenticated-orcid":false,"given":"Giuseppe","family":"Rengo","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, Division of Geriatrics, Federico II University, Via S. Pansini, 5, Naples, Italy"},{"name":"Laboratory of neurovegetative system pathophysiology, Istituti Clinici Scientifici ICS Maugeri, IRCCS Istituto Scientifico di Telese Terme, Benevento, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R","family":"Houser","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9681-3377","authenticated-orcid":false,"given":"Douglas G","family":"Tilley","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8522-530X","authenticated-orcid":false,"given":"Walter J","family":"Koch","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"2022011201345592600_cvab044-B1","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart disease and stroke statistics-2020 update: a report from the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"2022011201345592600_cvab044-B2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"2022011201345592600_cvab044-B3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ Res"},{"key":"2022011201345592600_cvab044-B4","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3389\/fphar.2018.00904","article-title":"New insights in cardiac \u03b2-adrenergic signaling during heart failure and aging","volume":"9","author":"de Lucia","year":"2018","journal-title":"Front Pharmacol"},{"key":"2022011201345592600_cvab044-B5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejphar.2004.03.015","article-title":"Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases","volume":"489","author":"Dzimiri","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"2022011201345592600_cvab044-B6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cardfail.2011.10.008","article-title":"Myocardial G protein receptor-coupled kinase expression correlates with functional parameters and clinical severity in advanced heart failure","volume":"18","author":"Ag\u00fcero","year":"2012","journal-title":"J Card Fail"},{"key":"2022011201345592600_cvab044-B7","doi-asserted-by":"crossref","first-page":"H368","DOI":"10.1152\/ajpheart.01061.2011","article-title":"Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables","volume":"303","author":"Mont\u00f3","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2022011201345592600_cvab044-B8","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1161\/CIRCULATIONAHA.119.041161","article-title":"Genome-wide analysis of left ventricular image-derived phenotypes identifies fourteen loci associated with cardiac morphogenesis and heart failure development","volume":"140","author":"Aung","year":"2019","journal-title":"Circulation"},{"key":"2022011201345592600_cvab044-B9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.yjmcc.2016.01.027","article-title":"Canonical and non-canonical actions of GRK5 in the heart","volume":"92","author":"Traynham","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"2022011201345592600_cvab044-B10","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1161\/CIRCRESAHA.116.304475","article-title":"GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity","volume":"115","author":"Hullmann","year":"2014","journal-title":"Circ Res"},{"key":"2022011201345592600_cvab044-B11","doi-asserted-by":"crossref","first-page":"12457","DOI":"10.1073\/pnas.0803153105","article-title":"Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes","volume":"105","author":"Martini","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022011201345592600_cvab044-B12","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1161\/CIRCRESAHA.112.273367","article-title":"Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication","volume":"111","author":"Gold","year":"2012","journal-title":"Circ Res"},{"key":"2022011201345592600_cvab044-B13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cellimm.2011.10.019","article-title":"Overlapping and distinct roles of GRK5 in TLR2-, and TLR3-induced inflammatory response in vivo","volume":"272","author":"Packiriswamy","year":"2012","journal-title":"Cell Immunol"},{"key":"2022011201345592600_cvab044-B14","doi-asserted-by":"crossref","first-page":"9954","DOI":"10.1073\/pnas.93.18.9954","article-title":"Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice","volume":"93","author":"Rockman","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022011201345592600_cvab044-B15","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.7761854","article-title":"Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor","volume":"268","author":"Koch","year":"1995","journal-title":"Science"},{"key":"2022011201345592600_cvab044-B16","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1161\/CIRCRESAHA.110.223925","article-title":"A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse","volume":"107","author":"Gao","year":"2010","journal-title":"Circ Res"},{"key":"2022011201345592600_cvab044-B17","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/gerona\/gly139","article-title":"Echocardiographic strain analysis for the early detection of left ventricular systolic\/diastolic dysfunction and dyssynchrony in a mouse model of physiological aging","volume":"74","author":"de Lucia","year":"2019","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2022011201345592600_cvab044-B18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1126\/scitranslmed.aaa0154","article-title":"Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction","volume":"7","author":"Schumacher","year":"2015","journal-title":"Sci Transl Med"},{"key":"2022011201345592600_cvab044-B19","doi-asserted-by":"crossref","first-page":"H1938","DOI":"10.1152\/ajpheart.2001.281.5.H1938","article-title":"Effects of avertin versus xylazine-ketamine anesthesia on cardiac function in normal mice","volume":"281","author":"Hart","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2022011201345592600_cvab044-B20","doi-asserted-by":"crossref","first-page":"H1525","DOI":"10.1152\/ajpheart.00890.2014","article-title":"Best anesthetics for assessing left ventricular systolic function by echocardiography in mice","volume":"308","author":"Pachon","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2022011201345592600_cvab044-B21","doi-asserted-by":"crossref","first-page":"eaau0144","DOI":"10.1126\/scisignal.aau0144","article-title":"Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation","volume":"11","author":"Sato","year":"2018","journal-title":"Sci Signal"},{"key":"2022011201345592600_cvab044-B22","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2022011201345592600_cvab044-B23","doi-asserted-by":"crossref","first-page":"e99485","DOI":"10.1172\/jci.insight.99485","article-title":"Prior \u03b2-blocker treatment decreases leukocyte responsiveness to injury","volume":"4","author":"Grisanti","year":"2019","journal-title":"JCI Insight"},{"key":"2022011201345592600_cvab044-B24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.trsl.2017.10.001","article-title":"Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction","volume":"191","author":"Ma","year":"2018","journal-title":"Transl Res"},{"key":"2022011201345592600_cvab044-B25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41420-019-0152-z","article-title":"The whole transcriptome and proteome changes in the early stage of myocardial infarction","volume":"5","author":"Li","year":"2019","journal-title":"Cell Death Discov"},{"key":"2022011201345592600_cvab044-B26","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1152\/physrev.00015.2014","article-title":"The evolving impact of g protein-coupled receptor kinases in cardiac health and disease","volume":"95","author":"Sato","year":"2015","journal-title":"Physiol Rev"},{"key":"2022011201345592600_cvab044-B27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/cvr\/cvw024","article-title":"Temporal neutrophil polarization following myocardial infarction","volume":"110","author":"Ma","year":"2016","journal-title":"Cardiovasc Res"},{"key":"2022011201345592600_cvab044-B28","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/cvr\/cvz336","article-title":"Cardiac monocytes and macrophages after myocardial infarction","volume":"116","author":"Peet","year":"2020","journal-title":"Cardiovasc Res"},{"key":"2022011201345592600_cvab044-B29","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nm1750","article-title":"A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure","volume":"14","author":"Liggett","year":"2008","journal-title":"Nat Med"},{"key":"2022011201345592600_cvab044-B30","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/ncb2866","article-title":"Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure","volume":"15","author":"Dirkx","year":"2013","journal-title":"Nat Cell Biol"},{"key":"2022011201345592600_cvab044-B31","doi-asserted-by":"crossref","first-page":"8056","DOI":"10.1074\/jbc.M117.809913","article-title":"PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) regulates G-protein-coupled receptor kinase 5 (GRK5)-induced cardiac hypertrophy","volume":"293","author":"Yeh","year":"2018","journal-title":"J Biol Chem"},{"key":"2022011201345592600_cvab044-B32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.hrthm.2009.11.032","article-title":"S38G single-nucleotide polymorphism at the KCNE1 locus is associated with heart failure","volume":"7","author":"Fatini","year":"2010","journal-title":"Heart Rhythm"},{"key":"2022011201345592600_cvab044-B33","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ijcard.2013.11.010","article-title":"Substance P in heart failure: the good and the bad","volume":"170","author":"Dehlin","year":"2014","journal-title":"Int J Cardiol"},{"key":"2022011201345592600_cvab044-B34","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1113\/jphysiol.2010.202366","article-title":"Intramyocardial administration of chimeric ephrinA1-Fc promotes tissue salvage following myocardial infarction in mice","volume":"589","author":"Dries","year":"2011","journal-title":"J Physiol"},{"key":"2022011201345592600_cvab044-B35","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.healun.2017.02.012","article-title":"The ubiquitin-proteasome system: a potential therapeutic target for heart failure","volume":"36","author":"Barac","year":"2017","journal-title":"J Heart Lung Transplant"},{"key":"2022011201345592600_cvab044-B36","doi-asserted-by":"crossref","first-page":"8467","DOI":"10.1128\/MCB.24.19.8467-8476.2004","article-title":"Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development","volume":"24","author":"Chang","year":"2004","journal-title":"MCB"},{"key":"2022011201345592600_cvab044-B37","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.lfs.2003.09.042","article-title":"Temporal changes in matrix metalloproteinase expression and inflammatory response associated with cardiac rupture after myocardial infarction in mice","volume":"74","author":"Tao","year":"2004","journal-title":"Life Sci"},{"key":"2022011201345592600_cvab044-B38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/bs.pmbts.2017.02.001","article-title":"Matrix metalloproteinases in myocardial infarction and heart failure","volume":"147","author":"DeLeon-Pennell","year":"2017","journal-title":"Prog Mol Biol Transl Sci"},{"key":"2022011201345592600_cvab044-B39","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cardiores.2005.08.023","article-title":"Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility","volume":"69","author":"Wang","year":"2006","journal-title":"Cardiovasc Res"},{"key":"2022011201345592600_cvab044-B40","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1161\/CIRCRESAHA.110.221010","article-title":"Level of G protein-coupled receptor kinase-2 determines myocardial ischemia\/reperfusion injury via pro- and anti-apoptotic mechanisms","volume":"107","author":"Brinks","year":"2010","journal-title":"Circ Res"},{"key":"2022011201345592600_cvab044-B41","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1038\/s41467-017-02005-1","article-title":"BEX1 is an RNA-dependent mediator of cardiomyopathy","volume":"8","author":"Accornero","year":"2017","journal-title":"Nat Commun"},{"key":"2022011201345592600_cvab044-B42","doi-asserted-by":"crossref","first-page":"21395","DOI":"10.18632\/oncotarget.4095","article-title":"BEX1 acts as a tumor suppressor in acute myeloid leukemia","volume":"6","author":"Lindblad","year":"2015","journal-title":"Oncotarget"},{"key":"2022011201345592600_cvab044-B43","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13046-016-0355-6","article-title":"Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma","volume":"35","author":"Gao","year":"2016","journal-title":"J Exp Clin Cancer Res"},{"key":"2022011201345592600_cvab044-B44","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1042\/CS20150666","article-title":"Emerging importance of chemokine receptor CXCR3 and its ligands in cardiovascular diseases","volume":"130","author":"Altara","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"2022011201345592600_cvab044-B45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/5902947","article-title":"Chemokines and heart disease: a network connecting cardiovascular biology to immune and autonomic nervous systems","volume":"2016","author":"Dusi","year":"2016","journal-title":"Mediators Inflamm"},{"key":"2022011201345592600_cvab044-B46","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/FJC.0000000000000764","article-title":"Administration of interleukin-15 peptide improves cardiac function in a mouse model of myocardial infarction","volume":"75","author":"Ameri","year":"2020","journal-title":"J Cardiovasc Pharmacol"},{"key":"2022011201345592600_cvab044-B47","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1093\/eurheartj\/ehz835","article-title":"Sex differences in heart failure","volume":"40","author":"Lam","year":"2019","journal-title":"Eur Heart J"},{"key":"2022011201345592600_cvab044-B48","doi-asserted-by":"crossref","first-page":"20649","DOI":"10.1074\/jbc.M115.647370","article-title":"Crystal structure of G protein-coupled receptor kinase 5 in complex with a rationally designed inhibitor","volume":"290","author":"Homan","year":"2015","journal-title":"J Biol Chem"},{"key":"2022011201345592600_cvab044-B49","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1021\/acsmedchemlett.9b00365","article-title":"Structure-based design of selective, covalent G protein-coupled receptor kinase 5 inhibitors","volume":"10","author":"Rowlands","year":"2019","journal-title":"ACS Med Chem Lett"},{"key":"2022011201345592600_cvab044-B50","doi-asserted-by":"crossref","first-page":"482","DOI":"10.4062\/biomolther.2020.129","article-title":"KR-39038, a novel GRK5 inhibitor, attenuates cardiac hypertrophy and improves cardiac function in heart failure","volume":"28","author":"Lee","year":"2020","journal-title":"Biomol Ther (Seoul)"},{"key":"2022011201345592600_cvab044-B51","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.bmcl.2018.03.082","article-title":"Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors","volume":"28","author":"Waldschmidt","year":"2018","journal-title":"Bioorg Med Chem Lett"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvab044\/36219440\/cvab044.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/118\/1\/169\/42107922\/cvab044.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/118\/1\/169\/42107922\/cvab044.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T01:57:38Z","timestamp":1641952658000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/118\/1\/169\/6131786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,9]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,2,9]]},"published-print":{"date-parts":[[2022,1,7]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvab044","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2021,2,9]]}}}