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These sex disparities are seen across the spectrum of cardiovascular care, but, are especially pronounced in acute cardiovascular care. The spectrum of acute cardiovascular care encompasses critically ill or tenuous patients with cardiovascular conditions that require urgent or emergent decision-making and interventions. In this narrative review, the disparities in the clinical course, management, and outcomes of six commonly encountered acute cardiovascular conditions, some with a known sex-predilection will be discussed within the basis of underlying sex differences in physiology, anatomy, and pharmacology with the goal of identifying areas where improvement in clinical approaches are needed.<\/jats:p>","DOI":"10.1093\/cvr\/cvab063","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T20:18:21Z","timestamp":1614802701000},"page":"667-685","source":"Crossref","is-referenced-by-count":39,"title":["Sex differences in acute cardiovascular care: a review and needs assessment"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-8238","authenticated-orcid":false,"given":"Saraschandra","family":"Vallabhajosyula","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA"},{"name":"Center for Clinical and Translational Science, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA"},{"name":"Section of Interventional Cardiology, Division of Cardiovascular Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1904-7397","authenticated-orcid":false,"given":"Dhiran","family":"Verghese","sequence":"additional","affiliation":[{"name":"Department of Medicine, Amita Health Saint Joseph Hospital, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7134-7042","authenticated-orcid":false,"given":"Viral K","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pranathi R","family":"Sundaragiri","sequence":"additional","affiliation":[{"name":"Division of Hospital Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia M","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"},{"name":"Department of Surgery, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"2022022108500511300_cvab063-B1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1136\/heartjnl-2011-300038","article-title":"Age- and gender-specific differences in the prognostic value of CT coronary 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