{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:06:50Z","timestamp":1791634010092,"version":"4.3.4"},"reference-count":236,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"British Heart Foundation Intermediate Research Fellowship"},{"name":"Canadian Institute of Health Research (CIHR) post-doc fellowship"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT 166105"],"award-info":[{"award-number":["PJT 166105"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP142486"],"award-info":[{"award-number":["MOP142486"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Heart and Stroke Foundation of Canada","award":["G-18-0022148"],"award-info":[{"award-number":["G-18-0022148"]}]},{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"publisher","award":["148401"],"award-info":[{"award-number":["148401"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004411","name":"HSFC","doi-asserted-by":"publisher","award":["18-0022032"],"award-info":[{"award-number":["18-0022032"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hormones are potent endo-, para-, and autocrine endogenous regulators of the function of multiple organs, including the heart. Endocrine dysfunction promotes a number of cardiovascular diseases, including atrial fibrillation (AF). While the heart is a target for endocrine regulation, it is also an active endocrine organ itself, secreting a number of important bioactive hormones that convey significant endocrine effects, but also through para-\/autocrine actions, actively participate in cardiac self-regulation. The hormones regulating heart-function work in concert to support myocardial performance. AF is a serious clinical problem associated with increased morbidity and mortality, mainly due to stroke and heart failure. Current therapies for AF remain inadequate. AF is characterized by altered atrial function and structure, including electrical and profibrotic remodelling in the atria and ventricles, which facilitates AF progression and hampers its treatment. Although features of this remodelling are well-established and its mechanisms are partly understood, important pathways pertinent to AF arrhythmogenesis are still unidentified. The discovery of these missing pathways has the potential to lead to therapeutic breakthroughs. Endocrine dysfunction is well-recognized to lead to AF. In this review, we discuss endocrine and cardiocrine signalling systems that directly, or as a consequence of an underlying cardiac pathology, contribute to AF pathogenesis. More specifically, we consider the roles of products from the hypothalamic-pituitary axis, the adrenal glands, adipose tissue, the renin\u2013angiotensin system, atrial cardiomyocytes, and the thyroid gland in controlling atrial electrical and structural properties. The influence of endocrine\/paracrine dysfunction on AF risk and mechanisms is evaluated and discussed. We focus on the most recent findings and reflect on the potential of translating them into clinical application.<\/jats:p>","DOI":"10.1093\/cvr\/cvab080","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T15:10:10Z","timestamp":1615475410000},"page":"1645-1661","source":"Crossref","is-referenced-by-count":42,"title":["New aspects of endocrine control of atrial fibrillation and possibilities for clinical translation"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1622-9876","authenticated-orcid":false,"given":"Martin","family":"Aguilar","sequence":"first","affiliation":[{"name":"Department of Medicine and Research Center, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"},{"name":"Department of Pharmacology and Physiology\/Institute of Biomedical Engineering, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9880-3482","authenticated-orcid":false,"given":"Robert A","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Cardiac Sciences, Department of Physiology and Pharmacology, Libin Cardiovascular Institute, Cumming School of Medicine, Health Research Innovation Center, University of Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Takawale","sequence":"additional","affiliation":[{"name":"Department of Medicine and Research Center, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"},{"name":"Department of Pharmacology and Physiology\/Institute of Biomedical Engineering, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"},{"name":"Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Nattel","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada"},{"name":"Faculty of Medicine, Department of Pharmacology and Physiology, and Research Centre, Montreal Heart Institute and University of Montreal, Montreal, QC, Canada"},{"name":"Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Germany"},{"name":"IHU LIRYC and Fondation Bordeaux Universit\u00e9, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-1239","authenticated-orcid":false,"given":"Svetlana","family":"Reilly","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"2021122415330310500_cvab080-B1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0889-8529(18)30412-2","article-title":"Diagnostic evaluation of Cushing's syndrome","volume":"17","author":"Carpenter","year":"1988","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2021122415330310500_cvab080-B2","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1001\/archinte.166.9.1016","article-title":"Corticosteroids and the risk of atrial fibrillation","volume":"166","author":"van der Hooft","year":"2006","journal-title":"Arch Intern Med"},{"key":"2021122415330310500_cvab080-B3","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgaa270","article-title":"Prevalence and incidence of atrial fibrillation in a large cohort of adrenal incidentalomas: a long-term study","volume":"105","author":"Di Dalmazi","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122415330310500_cvab080-B4","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1210\/jc.2012-3754","article-title":"Hypercortisolism is associated with increased coronary arterial atherosclerosis: analysis of noninvasive coronary angiography using multidetector computerized tomography","volume":"98","author":"Neary","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122415330310500_cvab080-B5","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1365-2265.2004.02168.x","article-title":"High cardiovascular risk in patients with Cushing's syndrome according to 1999 WHO\/ISH guidelines","volume":"61","author":"Mancini","year":"2004","journal-title":"Clin Endocrinol"},{"key":"2021122415330310500_cvab080-B6","doi-asserted-by":"crossref","first-page":"e011484","DOI":"10.1161\/JAHA.118.011484","article-title":"Glucocorticoid receptor-binding and transcriptome signature in cardiomyocytes","volume":"8","author":"Severinova","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2021122415330310500_cvab080-B7","doi-asserted-by":"crossref","first-page":"110488","DOI":"10.1016\/j.mce.2019.110488","article-title":"The acute effects of hydrocortisone on cardiac electrocardiography, action potentials, intracellular calcium, and contraction: the role of protein kinase C","volume":"494","author":"Park","year":"2019","journal-title":"Mol Cell Endocrinol"},{"key":"2021122415330310500_cvab080-B8","doi-asserted-by":"crossref","first-page":"H325","DOI":"10.1152\/ajpheart.2001.281.1.H325","article-title":"Glucocorticoid modulation of protein phosphorylation and sarcoplasmic reticulum function in rat myocardium","volume":"281","author":"Rao","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2021122415330310500_cvab080-B9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1096\/fj.12-218230","article-title":"Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1","volume":"27","author":"Lang","year":"2013","journal-title":"FASEB J"},{"key":"2021122415330310500_cvab080-B10","doi-asserted-by":"crossref","first-page":"15075","DOI":"10.1074\/jbc.M113.453670","article-title":"The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11","volume":"288","author":"Lamothe","year":"2013","journal-title":"J Biol Chem"},{"key":"2021122415330310500_cvab080-B11","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00380-015-0660-6","article-title":"Adrenal insufficiency causes life-threatening arrhythmia with prolongation of QT interval","volume":"31","author":"Komuro","year":"2016","journal-title":"Heart Vessels"},{"key":"2021122415330310500_cvab080-B12","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.ajem.2008.12.001","article-title":"Lethal arrhythmia and corticosteroid insufficiency","volume":"27","author":"Nishizawa","year":"2009","journal-title":"Am J Emerg Med"},{"key":"2021122415330310500_cvab080-B13","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3389\/fphar.2019.00308","article-title":"Glucocorticoid-Induced leucine zipper: a novel anti-inflammatory molecule","volume":"10","author":"Bereshchenko","year":"2019","journal-title":"Front Pharmacol"},{"key":"2021122415330310500_cvab080-B14","first-page":"1021","article-title":"R. The cardiovascular system in growth hormone excess and growth hormone deficiency","volume":"35","author":"Lombardi","year":"2012","journal-title":"J Endocrinol Invest"},{"key":"2021122415330310500_cvab080-B15","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1016\/S0140-6736(16)30053-8","article-title":"Hypopituitarism","volume":"388","author":"Higham","year":"2016","journal-title":"Lancet"},{"key":"2021122415330310500_cvab080-B16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1365-2265.1994.tb03789.x","article-title":"Determinants of clinical outcome and survival in acromegaly","volume":"41","author":"Rajasoorya","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2021122415330310500_cvab080-B17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2174\/157340309788970306","article-title":"The GH\/IGF-1 axis and heart failure","volume":"5","author":"Castellano","year":"2009","journal-title":"Curr Cardiol Rev"},{"key":"2021122415330310500_cvab080-B18","doi-asserted-by":"crossref","first-page":"22892","DOI":"10.1074\/jbc.M011647200","article-title":"Demonstration of direct effects of growth hormone on neonatal cardiomyocytes","volume":"276","author":"Lu","year":"2001","journal-title":"J Biol Chem"},{"key":"2021122415330310500_cvab080-B19","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cjca.2014.03.032","article-title":"Sex differences in cardiac electrophysiology and clinical arrhythmias: epidemiology, therapeutics, and mechanisms","volume":"30","author":"Tadros","year":"2014","journal-title":"Can J Cardiol"},{"key":"2021122415330310500_cvab080-B20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41569-019-0211-4","article-title":"Testosterone replacement therapy and cardiovascular risk","volume":"16","author":"Gagliano-Juc\u00e1","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"2021122415330310500_cvab080-B21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1161\/CIRCEP.113.001322","article-title":"Association of sex hormones, aging, and atrial fibrillation in men: the Framingham Heart Study","volume":"7","author":"Magnani","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2021122415330310500_cvab080-B22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/14779072.2019.1606713","article-title":"Cardiac arrhythmias secondary to hormone therapy in trans women","volume":"17","author":"Wamboldt","year":"2019","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"2021122415330310500_cvab080-B23","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.jsxm.2017.06.015","article-title":"Low plasma testosterone is associated with elevated cardiovascular disease biomarkers","volume":"14","author":"Pastuszak","year":"2017","journal-title":"J Sex Med"},{"key":"2021122415330310500_cvab080-B24","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1111\/j.1540-8167.2009.01474.x","article-title":"Deficiency of testosterone associates with the substrate of atrial fibrillation in the rat model","volume":"20","author":"Tsuneda","year":"2009","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2021122415330310500_cvab080-B25","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.hrthm.2017.01.046","article-title":"Increment of late sodium currents in the left atrial myocytes and its potential contribution to increased susceptibility of atrial fibrillation in castrated male mice","volume":"14","author":"Zhang","year":"2017","journal-title":"Heart Rhythm"},{"key":"2021122415330310500_cvab080-B26","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1210\/en.2012-2265","article-title":"Ablation of the androgen receptor gene modulates atrial electrophysiology and arrhythmogenesis with calcium protein dysregulation","volume":"154","author":"Tsai","year":"2013","journal-title":"Endocrinology"},{"key":"2021122415330310500_cvab080-B27","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrneph.2010.30","article-title":"Aldosterone: effects on the kidney and cardiovascular system","volume":"6","author":"Briet","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"2021122415330310500_cvab080-B28","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.jacc.2006.07.059","article-title":"A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients","volume":"48","author":"Rossi","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"2021122415330310500_cvab080-B29","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.jacc.2005.01.015","article-title":"Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism","volume":"45","author":"Milliez","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"2021122415330310500_cvab080-B30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1161\/HYPERTENSIONAHA.117.10596","article-title":"Adrenalectomy lowers incident atrial fibrillation in primary aldosteronism patients at long term","volume":"71","author":"Rossi","year":"2018","journal-title":"Hypertension"},{"key":"2021122415330310500_cvab080-B31","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.jacc.2011.11.063","article-title":"Eplerenone and atrial fibrillation in mild systolic heart failure: results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) study","volume":"59","author":"Swedberg","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2021122415330310500_cvab080-B32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0008-6363(97)00097-7","article-title":"Fibrosis of atria and great vessels in response to angiotensin II or aldosterone infusion","volume":"35","author":"Sun","year":"1997","journal-title":"Cardiovasc Res"},{"key":"2021122415330310500_cvab080-B33","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/01.HYP.37.2.787","article-title":"Mineralocorticoid receptor affects AP-1 and nuclear factor-kappab activation in angiotensin II-induced cardiac injury","volume":"37","author":"Fiebeler","year":"2001","journal-title":"Hypertension"},{"key":"2021122415330310500_cvab080-B34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1291\/hypres.28.447","article-title":"Excess aldosterone under normal salt diet induces cardiac hypertrophy and infiltration via oxidative stress","volume":"28","author":"Yoshida","year":"2005","journal-title":"Hypertens Res"},{"key":"2021122415330310500_cvab080-B35","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1161\/01.CIR.0000097000.51723.6F","article-title":"Aldosterone and not plasminogen activator inhibitor-1 is a critical mediator of early angiotensin II\/NG-nitro-L-arginine methyl ester-induced myocardial injury","volume":"108","author":"Oestreicher","year":"2003","journal-title":"Circulation"},{"key":"2021122415330310500_cvab080-B36","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1210\/en.2016-1040","article-title":"Cardiac tissue injury and remodeling is dependent upon MR regulation of activation pathways in cardiac tissue macrophages","volume":"157","author":"Shen","year":"2016","journal-title":"Endocrinology"},{"key":"2021122415330310500_cvab080-B37","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1161\/01.CIR.0000127949.05756.9D","article-title":"Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone","volume":"109","author":"Keidar","year":"2004","journal-title":"Circulation"},{"key":"2021122415330310500_cvab080-B38","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.12659\/MSM.915542","article-title":"Inhibitory effects of oxymatrine on transdifferentiation of neonatal rat cardiac fibroblasts to myofibroblasts induced by aldosterone via keap1\/nrf2 signaling pathways in vitro","volume":"25","author":"Yang","year":"2019","journal-title":"Med Sci Monit"},{"key":"2021122415330310500_cvab080-B39","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1093\/eurheartj\/ehr266","article-title":"Aldosterone promotes atrial fibrillation","volume":"33","author":"Reil","year":"2012","journal-title":"Eur Heart J"},{"key":"2021122415330310500_cvab080-B40","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1159\/000178483","article-title":"Spironolactone prevents aldosterone induced increased duration of atrial fibrillation in rat","volume":"29","author":"Lammers","year":"2012","journal-title":"Cell Physiol Biochem"},{"key":"2021122415330310500_cvab080-B41","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1161\/CIRCULATIONAHA.104.503706","article-title":"Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias","volume":"111","author":"Ouvrard-Pascaud","year":"2005","journal-title":"Circulation"},{"key":"2021122415330310500_cvab080-B42","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1161\/01.RES.85.12.1139","article-title":"Aldosterone upregulates Ca(2+) current in adult rat cardiomyocytes","volume":"85","author":"Benitah","year":"1999","journal-title":"Circ Res"},{"key":"2021122415330310500_cvab080-B43","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1113\/jphysiol.2005.092692","article-title":"A direct relationship between plasma aldosterone and cardiac L-type Ca2+ current in mice","volume":"569","author":"Perrier","year":"2005","journal-title":"J Physiol"},{"key":"2021122415330310500_cvab080-B44","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1161\/CIRCULATIONAHA.108.805804","article-title":"Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins","volume":"119","author":"Gomez","year":"2009","journal-title":"Circulation"},{"key":"2021122415330310500_cvab080-B45","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1074\/jbc.M113.519256","article-title":"The mineralocorticoid receptor promotes fibrotic remodeling in atrial fibrillation","volume":"289","author":"Lavall","year":"2014","journal-title":"J Biol Chem"},{"key":"2021122415330310500_cvab080-B46","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.jacc.2009.09.045","article-title":"Increased expression of mineralocorticoid receptor in human atrial fibrillation and a cellular model of atrial fibrillation","volume":"55","author":"Tsai","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2021122415330310500_cvab080-B47","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1097\/HJH.0b013e32834a4ce9","article-title":"Cardiovascular manifestations of phaeochromocytoma","volume":"29","author":"Prejbisz","year":"2011","journal-title":"J Hypertens"},{"key":"2021122415330310500_cvab080-B48","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jacc.2020.04.080","article-title":"Pathophysiology and acute management of tachyarrhythmias in pheochromocytoma: JACC review topic of the week","volume":"76","author":"Nazari","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2021122415330310500_cvab080-B49","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41574-019-0230-6","article-title":"The endocrine function of adipose tissues in health and cardiometabolic disease","volume":"15","author":"Scheja","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"2021122415330310500_cvab080-B50","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cjca.2014.10.027","article-title":"The implications of obesity for cardiac arrhythmia mechanisms and management","volume":"31","author":"Pathak","year":"2015","journal-title":"Can J Cardiol"},{"key":"2021122415330310500_cvab080-B51","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1016\/j.jacc.2017.03.566","article-title":"Atrial fibrillation and body composition: is it fat or lean that ultimately determines the risk?","volume":"69","author":"Nattel","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2021122415330310500_cvab080-B52","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1016\/j.jacc.2017.03.558","article-title":"Lean body mass is the predominant anthropometric risk factor for atrial fibrillation","volume":"69","author":"Fenger-Gr\u00f8n","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2021122415330310500_cvab080-B53","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cjca.2018.11.020","article-title":"MD1 deficiency promotes inflammatory atrial remodelling induced by high-fat diets","volume":"35","author":"Shuai","year":"2019","journal-title":"Can J Cardiol"},{"key":"2021122415330310500_cvab080-B54","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1161\/CIRCULATIONAHA.118.035202","article-title":"Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation","volume":"138","author":"Yao","year":"2018","journal-title":"Circulation"},{"key":"2021122415330310500_cvab080-B55","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1161\/01.CIR.0000142055.53122.FA","article-title":"Circulating mononuclear cells in the obese are in a proinflammatory state","volume":"110","author":"Ghanim","year":"2004","journal-title":"Circulation"},{"key":"2021122415330310500_cvab080-B56","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/epirev\/mxm005","article-title":"Biomarkers of obesity and subsequent cardiovascular events","volume":"29","author":"Musaad","year":"2007","journal-title":"Epidemiol Rev"},{"key":"2021122415330310500_cvab080-B57","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.hrthm.2012.08.043","article-title":"Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation","volume":"10","author":"Abed","year":"2013","journal-title":"Heart Rhythm"},{"key":"2021122415330310500_cvab080-B58","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.jacc.2020.07.017","article-title":"Epicardial adipose tissue accumulation confers atrial conduction abnormality","volume":"76","author":"Nalliah","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2021122415330310500_cvab080-B59","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/cvr\/cvw001","article-title":"Cardiac adipose tissue and atrial fibrillation: the perils of adiposity","volume":"109","author":"Hatem","year":"2016","journal-title":"Cardiovasc Res"},{"key":"2021122415330310500_cvab080-B60","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1161\/CIRCEP.111.000104","article-title":"Role of leptin signaling in the pathogenesis of angiotensin II-mediated atrial fibrosis and fibrillation","volume":"6","author":"Fukui","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2021122415330310500_cvab080-B61","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/j.1550-8528.1999.tb00418.x","article-title":"Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women","volume":"7","author":"Goodfriend","year":"1999","journal-title":"Obes Res"},{"key":"2021122415330310500_cvab080-B62","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1136\/heartjnl-2015-308927","article-title":"The associations of leptin, adiponectin and resistin with incident atrial fibrillation in women","volume":"102","author":"Ermakov","year":"2016","journal-title":"Heart"},{"key":"2021122415330310500_cvab080-B63","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1161\/CIRCULATIONAHA.117.032474","article-title":"Leptin-aldosterone-neprilysin axis: identification of its distinctive role in the pathogenesis of the three phenotypes of heart failure in people with obesity","volume":"137","author":"Packer","year":"2018","journal-title":"Circulation"},{"key":"2021122415330310500_cvab080-B64","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/ijo.2010.227","article-title":"Neprilysin, obesity and the metabolic syndrome","volume":"35","author":"Standeven","year":"2011","journal-title":"Int J Obes"},{"key":"2021122415330310500_cvab080-B65","doi-asserted-by":"crossref","first-page":"48066","DOI":"10.1074\/jbc.M204058200","article-title":"Human adipose tissue cells keep tight control on the angiotensin II levels in their vicinity","volume":"277","author":"Schling","year":"2002","journal-title":"J Biol Chem"},{"key":"2021122415330310500_cvab080-B66","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1210\/jc.2007-1088","article-title":"Body mass index predicts aldosterone production in normotensive adults on a high-salt diet","volume":"92","author":"Bentley-Lewis","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122415330310500_cvab080-B67","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jacc.2012.03.042","article-title":"Electrophysiological and hemodynamic characteristics associated with obesity in patients with atrial fibrillation","volume":"60","author":"Munger","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2021122415330310500_cvab080-B68","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41371-019-0279-7","article-title":"Invited review: hypertension and atrial fibrillation: epidemiology, pathophysiology, and implications for management","volume":"33","author":"Gumprecht","year":"2019","journal-title":"J Hum Hypertens"},{"key":"2021122415330310500_cvab080-B69","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.hroo.2020.05.002","article-title":"Atrial remodeling and atrial fibrillation in acquired forms of cardiovascular disease","volume":"1","author":"Jansen","year":"2020","journal-title":"Heart Rhythm"},{"key":"2021122415330310500_cvab080-B70","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1161\/CIRCRESAHA.114.302226","article-title":"Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression","volume":"114","author":"Heijman","year":"2014","journal-title":"Circ Res"},{"key":"2021122415330310500_cvab080-B71","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1161\/CIRCRESAHA.120.316340","article-title":"Epidemiology of atrial fibrillation in the 21st century: novel methods and new insights","volume":"127","author":"Kornej","year":"2020","journal-title":"Circ Res"},{"key":"2021122415330310500_cvab080-B72","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol Rev"},{"key":"2021122415330310500_cvab080-B73","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijcard.2016.01.007","article-title":"Atrial fibrillation and arterial hypertension: a common duet with dangerous consequences where the renin angiotensin-aldosterone system plays an important role","volume":"206","author":"Seccia","year":"2016","journal-title":"Int J Cardiol"},{"key":"2021122415330310500_cvab080-B74","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0002-8703(00)90012-7","article-title":"Clinical study to investigate the predictive parameters for the onset of atrial fibrillation in patients with essential hypertension","volume":"139","author":"Ciaroni","year":"2000","journal-title":"Am Heart J"},{"key":"2021122415330310500_cvab080-B75","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.yjmcc.2018.09.011","article-title":"Distinct patterns of atrial electrical and structural remodeling in angiotensin II mediated atrial fibrillation","volume":"124","author":"Jansen","year":"2018","journal-title":"J Mol Cell Cardiol"},{"key":"2021122415330310500_cvab080-B76","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jacbts.2018.08.004","article-title":"Natriuretic peptide receptor-C protects against angiotensin II-mediated sinoatrial node disease in mice","volume":"3","author":"Mackasey","year":"2018","journal-title":"JACC Basic Transl Sci"},{"key":"2021122415330310500_cvab080-B77","doi-asserted-by":"crossref","first-page":"e006863","DOI":"10.1161\/CIRCEP.118.006863","article-title":"NPR-C (natriuretic peptide receptor-C) modulates the progression of angiotensin II-mediated atrial fibrillation and atrial remodeling in mice","volume":"12","author":"Jansen","year":"2019","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2021122415330310500_cvab080-B78","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1161\/CIRCULATIONAHA.113.003313","article-title":"Oxidized Ca2+\/calmodulin-dependent protein kinase II triggers atrial fibrillation","volume":"128","author":"Purohit","year":"2013","journal-title":"Circulation"},{"key":"2021122415330310500_cvab080-B79","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1161\/HYPERTENSIONAHA.117.10390","article-title":"Novel role for the immunoproteasome subunit PSMB10 in angiotensin ii-induced atrial fibrillation in mice","volume":"71","author":"Li","year":"2018","journal-title":"Hypertension"},{"key":"2021122415330310500_cvab080-B80","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1161\/01.HYP.0000257123.95372.ab","article-title":"Increased susceptibility to atrial tachyarrhythmia in spontaneously hypertensive rat hearts","volume":"49","author":"Choisy","year":"2007","journal-title":"Hypertension"},{"key":"2021122415330310500_cvab080-B81","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/cvr\/cvv045","article-title":"Early subcellular Ca2+ remodelling and increased propensity for Ca2+ alternans in left atrial myocytes from hypertensive rats","volume":"106","author":"Pluteanu","year":"2015","journal-title":"Cardiovasc Res"},{"key":"2021122415330310500_cvab080-B82","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1093\/eurheartj\/ehp046","article-title":"Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles","volume":"30","author":"Goette","year":"2009","journal-title":"Eur Heart J"},{"key":"2021122415330310500_cvab080-B83","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1161\/CIRCRESAHA.111.243956","article-title":"Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias","volume":"110","author":"Swaminathan","year":"2012","journal-title":"Circ Res"},{"key":"2021122415330310500_cvab080-B84","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.pbiomolbio.2015.12.001","article-title":"Electrophysiological effects of natriuretic peptides in the heart are mediated by multiple receptor subtypes","volume":"120","author":"Moghtadaei","year":"2016","journal-title":"Prog Biophys Mol Biol"},{"key":"2021122415330310500_cvab080-B85","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.hrthm.2011.11.019","article-title":"The role of atrial natriuretic peptide in modulating cardiac electrophysiology","volume":"9","author":"Perrin","year":"2012","journal-title":"Heart Rhythm"},{"key":"2021122415330310500_cvab080-B86","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.yjmcc.2012.01.018","article-title":"The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors","volume":"52","author":"Springer","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"2021122415330310500_cvab080-B87","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1113\/jphysiol.2013.265405","article-title":"Effects of natriuretic peptides on electrical conduction in the sinoatrial node and atrial myocardium of the heart","volume":"592","author":"Azer","year":"2014","journal-title":"J Physiol"},{"key":"2021122415330310500_cvab080-B88","doi-asserted-by":"crossref","first-page":"H2454","DOI":"10.1152\/ajpheart.00388.2003","article-title":"Inhibition of L-type Ca2+ current by C-type natriuretic peptide in bullfrog atrial myocytes: an NPR-C-mediated effect","volume":"285","author":"Rose","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2021122415330310500_cvab080-B89","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1210\/er.2005-0014","article-title":"Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions","volume":"27","author":"Potter","year":"2006","journal-title":"Endocr Rev"},{"key":"2021122415330310500_cvab080-B90","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1113\/jphysiol.2007.144253","article-title":"Natriuretic peptide C receptor signalling in the heart and vasculature","volume":"586","author":"Rose","year":"2008","journal-title":"J Physiol"},{"key":"2021122415330310500_cvab080-B91","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.peptides.2004.09.023","article-title":"Natriuretic peptide receptor-C signaling and regulation","volume":"26","author":"Anand-Srivastava","year":"2005","journal-title":"Peptides"},{"key":"2021122415330310500_cvab080-B92","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1113\/jphysiol.2014.283135","article-title":"Impaired sinoatrial node function and increased susceptibility to atrial fibrillation in mice lacking natriuretic peptide receptor C","volume":"593","author":"Egom","year":"2015","journal-title":"J Physiol"},{"key":"2021122415330310500_cvab080-B93","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1161\/01.CIR.0000141802.29945.34","article-title":"Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia\/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide","volume":"110","author":"Hobbs","year":"2004","journal-title":"Circulation"},{"key":"2021122415330310500_cvab080-B94","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/eurheartj\/ehz093","article-title":"C-type natriuretic peptide co-ordinates cardiac structure and function","volume":"41","author":"Moyes","year":"2020","journal-title":"Eur Heart J"},{"key":"2021122415330310500_cvab080-B95","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1172\/JCI74281","article-title":"Endothelial C-type natriuretic peptide maintains vascular homeostasis","volume":"124","author":"Moyes","year":"2014","journal-title":"J Clin Invest"},{"key":"2021122415330310500_cvab080-B96","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/cvr\/cvy224","article-title":"Absence of natriuretic peptide clearance receptor attenuates TGF-beta1-induced selective atrial fibrosis and atrial fibrillation","volume":"115","author":"Rahmutula","year":"2019","journal-title":"Cardiovasc Res"},{"key":"2021122415330310500_cvab080-B97","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.yjmcc.2009.07.020","article-title":"Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation","volume":"48","author":"Abraham","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"2021122415330310500_cvab080-B98","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1056\/NEJMoa0706300","article-title":"Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation","volume":"359","author":"Hodgson-Zingman","year":"2008","journal-title":"N Engl J Med"},{"key":"2021122415330310500_cvab080-B99","doi-asserted-by":"crossref","first-page":"19196","DOI":"10.1074\/jbc.M109.010777","article-title":"A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation","volume":"284","author":"Dickey","year":"2009","journal-title":"J Biol Chem"},{"key":"2021122415330310500_cvab080-B100","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.cardiores.2004.03.004","article-title":"Atrial natriuretic peptide modulates the hyperpolarization-activated current (If) in human atrial myocytes","volume":"63","author":"Lonardo","year":"2004","journal-title":"Cardiovasc Res"},{"key":"2021122415330310500_cvab080-B101","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1161\/CIRCEP.115.002896","article-title":"Effects of wild-type and mutant forms of atrial natriuretic peptide on atrial electrophysiology and arrhythmogenesis","volume":"8","author":"Hua","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2021122415330310500_cvab080-B102","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1056\/NEJMra1110560","article-title":"The past 200 years in diabetes","volume":"367","author":"Polonsky","year":"2012","journal-title":"N Engl J Med"},{"key":"2021122415330310500_cvab080-B103","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cmet.2019.11.017","article-title":"New frontiers in the treatment of type 1 diabetes","volume":"31","author":"Warshauer","year":"2020","journal-title":"Cell Metab"},{"key":"2021122415330310500_cvab080-B104","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/S0140-6736(13)62154-6","article-title":"Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future","volume":"383","author":"Kahn","year":"2014","journal-title":"Lancet"},{"key":"2021122415330310500_cvab080-B105","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fphys.2019.00135","article-title":"The association between diabetes mellitus and atrial fibrillation: clinical and mechanistic insights","volume":"10","author":"Bohne","year":"2019","journal-title":"Front Physiol"},{"key":"2021122415330310500_cvab080-B106","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1161\/01.RES.0000266449.37396.1f","article-title":"Recipes for creating animal models of diabetic cardiovascular disease","volume":"100","author":"Hsueh","year":"2007","journal-title":"Circ Res"},{"key":"2021122415330310500_cvab080-B107","doi-asserted-by":"crossref","first-page":"7990","DOI":"10.1073\/pnas.1914853117","article-title":"Loss of insulin signaling may contribute to atrial fibrillation and atrial electrical remodeling in type 1 diabetes","volume":"117","author":"Polina","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021122415330310500_cvab080-B108","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/cvr\/cvu176","article-title":"Glucose fluctuations increase the incidence of atrial fibrillation in diabetic rats","volume":"104","author":"Saito","year":"2014","journal-title":"Cardiovasc Res"},{"key":"2021122415330310500_cvab080-B109","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1085\/jgp.201812293","article-title":"Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling","volume":"151","author":"Lin","year":"2019","journal-title":"J Gen Physiol"},{"key":"2021122415330310500_cvab080-B110","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.yjmcc.2015.02.024","article-title":"Altered parasympathetic nervous system regulation of the sinoatrial node in Akita diabetic mice","volume":"82","author":"Krishnaswamy","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"2021122415330310500_cvab080-B111","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1540-8167.2007.01037.x","article-title":"AGEs-RAGE system mediates atrial structural remodeling in the diabetic rat","volume":"19","author":"Kato","year":"2008","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2021122415330310500_cvab080-B112","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jjcc.2011.06.003","article-title":"Angiotensin II type 1 receptor blocker attenuates diabetes-induced atrial structural remodeling","volume":"58","author":"Kato","year":"2011","journal-title":"J Cardiol"},{"key":"2021122415330310500_cvab080-B113","doi-asserted-by":"crossref","first-page":"H86","DOI":"10.1152\/ajpheart.00010.2012","article-title":"Conduction and refractory disorders in the diabetic atrium","volume":"303","author":"Watanabe","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2021122415330310500_cvab080-B114","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.005945","article-title":"Alogliptin, a dipeptidyl peptidase-4 inhibitor, alleviates atrial remodeling and improves mitochondrial function and biogenesis in diabetic rabbits","volume":"6","author":"Zhang","year":"2017","journal-title":"Jaha"},{"key":"2021122415330310500_cvab080-B115","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","article-title":"IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045","volume":"138","author":"Cho","year":"2018","journal-title":"Diabetes Res Clin Pract"},{"key":"2021122415330310500_cvab080-B116","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/dom.13512","article-title":"Atrial fibrillation and type 2 diabetes: prevalence, etiology, pathophysiology and effect of anti-diabetic therapies","volume":"21","author":"Bell","year":"2019","journal-title":"Diabetes Obes Metab"},{"key":"2021122415330310500_cvab080-B117","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11010-007-9622-3","article-title":"Sarcoplasmic Ca2+ release is prolonged in nonfailing myocardium of diabetic patients","volume":"308","author":"Reuter","year":"2008","journal-title":"Mol Cell Biochem"},{"key":"2021122415330310500_cvab080-B118","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1475-2840-13-72","article-title":"Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction","volume":"13","author":"Lamberts","year":"2014","journal-title":"Cardiovasc Diabetol"},{"key":"2021122415330310500_cvab080-B119","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.carpath.2014.03.004","article-title":"Investigating inherent functional differences between human cardiac fibroblasts cultured from nondiabetic and Type 2 diabetic donors","volume":"23","author":"Sedgwick","year":"2014","journal-title":"Cardiovasc Pathol"},{"key":"2021122415330310500_cvab080-B120","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.3389\/fphys.2018.01482","article-title":"Arrhythmogenic substrates for atrial fibrillation in obesity","volume":"9","author":"Lubbers","year":"2018","journal-title":"Front Physiol"},{"key":"2021122415330310500_cvab080-B121","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fcvm.2018.00076","article-title":"Indexed left atrial adipose tissue area is associated with severity of atrial fibrillation and atrial fibrillation recurrence among patients undergoing catheter ablation","volume":"5","author":"Sanghai","year":"2018","journal-title":"Front Cardiovasc Med"},{"key":"2021122415330310500_cvab080-B122","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/cvr\/cvu045","article-title":"Epicardial adipose tissue and atrial fibrillation","volume":"102","author":"Hatem","year":"2014","journal-title":"Cardiovasc Res"},{"key":"2021122415330310500_cvab080-B123","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/eurheartj\/ehv625","article-title":"Atrial fibrillation is associated with the fibrotic remodelling of adipose tissue in the subepicardium of human and sheep atria","volume":"38","author":"Haemers","year":"2017","journal-title":"Eur Heart J"},{"key":"2021122415330310500_cvab080-B124","doi-asserted-by":"crossref","DOI":"10.1172\/JCI95747","article-title":"Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms","volume":"131","author":"Mesubi","year":"2021","journal-title":"J Clin Investig"},{"key":"2021122415330310500_cvab080-B125","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.hrthm.2020.08.019","article-title":"Electrical and structural remodeling contribute to atrial fibrillation in type 2 diabetic db\/db mice","volume":"18","author":"Bohne","year":"2021","journal-title":"Heart Rhythm"},{"key":"2021122415330310500_cvab080-B126","doi-asserted-by":"crossref","first-page":"116903","DOI":"10.1016\/j.lfs.2019.116903","article-title":"Mechanism of electrical remodeling of atrial myocytes and its influence on susceptibility to atrial fibrillation in diabetic rats","volume":"239","author":"Fu","year":"2019","journal-title":"Life Sci"},{"key":"2021122415330310500_cvab080-B127","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/cvr\/cvw071","article-title":"Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats","volume":"110","author":"Linz","year":"2016","journal-title":"Cardiovasc Res"},{"key":"2021122415330310500_cvab080-B128","doi-asserted-by":"crossref","first-page":"e006040","DOI":"10.1161\/CIRCEP.117.006040","article-title":"Interleukin 10 treatment ameliorates high-fat diet-induced inflammatory atrial remodeling and fibrillation","volume":"11","author":"Kondo","year":"2018","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2021122415330310500_cvab080-B129","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12933-019-0928-8","article-title":"Atrial fibrillation and its arrhythmogenesis associated with insulin resistance","volume":"18","author":"Chan","year":"2019","journal-title":"Cardiovasc Diabetol"},{"key":"2021122415330310500_cvab080-B130","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00395-019-0771-9","article-title":"Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart","volume":"115","author":"Fender","year":"2020","journal-title":"Basic Res Cardiol"},{"key":"2021122415330310500_cvab080-B131","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/jce.13200","article-title":"Hyperleptinemia exacerbates high-fat diet-mediated atrial fibrosis and fibrillation","volume":"28","author":"Fukui","year":"2017","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2021122415330310500_cvab080-B132","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrcardio.2016.174","article-title":"Thyroid hormones and cardiovascular disease","volume":"14","author":"Jabbar","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"2021122415330310500_cvab080-B133","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1056\/NEJM199411103311901","article-title":"Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons","volume":"331","author":"Sawin","year":"1994","journal-title":"N Engl J Med"},{"key":"2021122415330310500_cvab080-B134","first-page":"98","article-title":"Subclinical hyperthyroidism and atrial fibrillation","volume":"30","author":"Auer","year":"2003","journal-title":"Acta Med Austriaca"},{"key":"2021122415330310500_cvab080-B135","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1001\/archinte.167.9.928","article-title":"Association between serum free thyroxine concentration and atrial fibrillation","volume":"167","author":"Gammage","year":"2007","journal-title":"Arch Intern Med"},{"key":"2021122415330310500_cvab080-B136","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1001\/archinte.1996.00440180083010","article-title":"How useful is thyroid function testing in patients with recent-onset atrial fibrillation? The Canadian Registry of Atrial Fibrillation Investigators","volume":"156","author":"Krahn","year":"1996","journal-title":"Arch Internal Med"},{"key":"2021122415330310500_cvab080-B137","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nrendo.2009.225","article-title":"Effects of amiodarone therapy on thyroid function","volume":"6","author":"Cohen-Lehman","year":"2010","journal-title":"Nat Rev Endocrinol"},{"key":"2021122415330310500_cvab080-B138","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/0002-9149(89)90142-2","article-title":"Cardiac arrhythmias and heart rate in hyperthyroidism","volume":"63","author":"von Olshausen","year":"1989","journal-title":"Am J Cardiol"},{"key":"2021122415330310500_cvab080-B139","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1210\/jc.2008-0092","article-title":"Activation of electrical triggers of atrial fibrillation in hyperthyroidism","volume":"93","author":"Wustmann","year":"2008","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"2021122415330310500_cvab080-B140","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/00005344-199111000-00008","article-title":"Hypothyroidism renders protection against lethal ventricular arrhythmias in a conscious canine model of sudden death","volume":"18","author":"Venkatesh","year":"1991","journal-title":"J Cardiovasc Pharmacol"},{"key":"2021122415330310500_cvab080-B141","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.jacc.2018.02.045","article-title":"Thyroid hormones and cardiovascular function and diseases","volume":"71","author":"Razvi","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2021122415330310500_cvab080-B142","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrendo.2015.205","article-title":"Nongenomic actions of thyroid hormone","volume":"12","author":"Davis","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"2021122415330310500_cvab080-B143","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1530\/EJE-12-0627","article-title":"Mechanisms in endocrinology: heart failure and thyroid dysfunction","volume":"167","author":"Biondi","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"2021122415330310500_cvab080-B144","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/01.RES.26.5.575","article-title":"Atrial electrophysiology in experimental hyperthyroidism in rabbits","volume":"26","author":"Arnsdorf","year":"1970","journal-title":"Circ Res"},{"key":"2021122415330310500_cvab080-B145","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000169643","article-title":"Action of thyroid hormone on the transmembrane potentials from sinoatrial node cells and atrial muscle cells in isolated atria of rabbits","volume":"58","author":"Johnson","year":"1973","journal-title":"Cardiology"},{"key":"2021122415330310500_cvab080-B146","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1113\/jphysiol.1970.sp009066","article-title":"The effect of altered thyroid state on atrial intracellular potentials","volume":"207","author":"Freedberg","year":"1970","journal-title":"J Physiol"},{"key":"2021122415330310500_cvab080-B147","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0022-2828(85)80015-8","article-title":"Influence of thyroid hormone levels on the electrical and mechanical properties of rabbit papillary muscle","volume":"17","author":"Sharp","year":"1985","journal-title":"J Mol Cell Cardiol"},{"key":"2021122415330310500_cvab080-B148","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/BF00584774","article-title":"Effects of thyroid hormone on the action potential and membrane currents of guinea pig ventricular myocytes","volume":"409","author":"Binah","year":"1987","journal-title":"Pflugers Arch"},{"key":"2021122415330310500_cvab080-B149","first-page":"H211","article-title":"Electrophysiological mechanisms by which hypothyroidism delays repolarization in guinea pig hearts","volume":"277","author":"Bosch","year":"1999","journal-title":"Am J Physiol"},{"key":"2021122415330310500_cvab080-B150","doi-asserted-by":"crossref","first-page":"E302","DOI":"10.1152\/ajpendo.2000.278.2.E302","article-title":"Effects of thyroid hormone on action potential and repolarizing currents in rat ventricular myocytes","volume":"278","author":"Sun","year":"2000","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2021122415330310500_cvab080-B151","doi-asserted-by":"crossref","first-page":"H1448","DOI":"10.1152\/ajpheart.00828.2004","article-title":"Effects of hyperthyroidism on delayed rectifier K+ currents in left and right murine atria","volume":"289","author":"Hu","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2021122415330310500_cvab080-B152","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/BF00717748","article-title":"Thyroid hormone modulates membrane currents in guinea-pig ventricular myocytes","volume":"340","author":"Rubinstein","year":"1989","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2021122415330310500_cvab080-B153","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1006\/jmcc.1994.1110","article-title":"Effects of thyroid hormone on the calcium current and isoprenaline-induced background current in rabbit ventricular myocytes","volume":"26","author":"Han","year":"1994","journal-title":"J Mol Cell Cardiol"},{"key":"2021122415330310500_cvab080-B154","first-page":"H1875","article-title":"Thyroxine effects on temperature dependence of ionic currents in single rabbit cardiac myocytes","volume":"265","author":"Shimoni","year":"1993","journal-title":"Am J Physiol"},{"key":"2021122415330310500_cvab080-B155","doi-asserted-by":"crossref","first-page":"6597","DOI":"10.1073\/pnas.85.18.6597","article-title":"Translational control of anionic trypsinogen and amylase synthesis in rat pancreas in response to caerulein stimulation","volume":"85","author":"Steinhilber","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122415330310500_cvab080-B156","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0006-291X(03)01420-7","article-title":"Thyroid hormone regulates mRNA expression and currents of ion channels in rat atrium","volume":"308","author":"Watanabe","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"2021122415330310500_cvab080-B157","doi-asserted-by":"crossref","first-page":"4744","DOI":"10.1210\/endo.137.11.8895342","article-title":"Acute effects of thyroid hormone on inward rectifier potassium channel currents in guinea pig ventricular myocytes","volume":"137","author":"Sakaguchi","year":"1996","journal-title":"Endocrinology"},{"key":"2021122415330310500_cvab080-B158","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1113\/jphysiol.1992.sp019383","article-title":"Hyperthyroidism selectively modified a transient potassium current in rabbit ventricular and atrial myocytes","volume":"457","author":"Shimoni","year":"1992","journal-title":"J Physiol"},{"key":"2021122415330310500_cvab080-B159","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/bbrc.1998.8411","article-title":"Thyroid hormone regulates expression of shaker-related potassium channel mRNA in rat heart","volume":"245","author":"Abe","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"2021122415330310500_cvab080-B160","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0008-6363(98)00135-7","article-title":"Effects of thyroid status on expression of voltage-gated potassium channels in rat left ventricle","volume":"40","author":"Nishiyama","year":"1998","journal-title":"Cardiovascular Research"},{"key":"2021122415330310500_cvab080-B161","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1536\/jhj.44.101","article-title":"Different gene expression of potassium channels by thyroid hormone and an antithyroid drug between the atrium and ventricle of rats","volume":"44","author":"Ma","year":"2003","journal-title":"Jpn Heart J"},{"key":"2021122415330310500_cvab080-B162","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/01.RES.75.2.245","article-title":"Thyroid hormone-induced alterations in phospholamban protein expression. Regulatory effects on sarcoplasmic reticulum Ca2+ transport and myocardial relaxation","volume":"75","author":"Kiss","year":"1994","journal-title":"Circ Res"},{"key":"2021122415330310500_cvab080-B163","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0735-1097(01)01731-4","article-title":"Effects of thyroid hormone on the arrhythmogenic activity of pulmonary vein cardiomyocytes","volume":"39","author":"Chen","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2021122415330310500_cvab080-B164","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/jmcc.1996.0004","article-title":"Upregulation of collagen type I gene expression in the ventricular myocardium of thyroidectomized male and female rats","volume":"28","author":"Klein","year":"1996","journal-title":"J Mol Cell Cardiol"},{"key":"2021122415330310500_cvab080-B165","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1161\/01.RES.71.4.831","article-title":"Decreased collagen gene expression and absence of fibrosis in thyroid hormone-induced myocardial hypertrophy. Response of cardiac fibroblasts to thyroid hormone in vitro","volume":"71","author":"Yao","year":"1992","journal-title":"Circ Res"},{"key":"2021122415330310500_cvab080-B166","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1023\/A:1024153003249","article-title":"The expression of mRNA of cytokines and of extracellular matrix proteins in triiodothyronine-treated rat hearts","volume":"247","author":"Ziegelhoffer-Mihalovicova","year":"2003","journal-title":"Mol Cell Biochem"},{"key":"2021122415330310500_cvab080-B167","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.matbio.2006.12.005","article-title":"Thyroid hormone induces myocardial matrix degradation by activating matrix metalloproteinase-1","volume":"26","author":"Ghose Roy","year":"2007","journal-title":"Matrix Biol"},{"key":"2021122415330310500_cvab080-B168","doi-asserted-by":"crossref","first-page":"900","DOI":"10.2119\/molmed.2015.00140","article-title":"Early and short-term triiodothyronine supplementation prevents adverse postischemic cardiac remodeling: role of transforming growth factor-beta1 and antifibrotic miRNA signaling","volume":"21","author":"Nicolini","year":"2016","journal-title":"Mol Med"},{"key":"2021122415330310500_cvab080-B169","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1006\/bbrc.1993.1394","article-title":"The thyroid hormone receptor interferes with transcriptional activation via the AP-1 complex","volume":"192","author":"Schmidt","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"2021122415330310500_cvab080-B170","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1006\/jmcc.1998.0811","article-title":"An activator protein-1 (AP-1) response element on pro alpha1(l) collagen gene is necessary for thyroid hormone-induced inhibition of promoter activity in cardiac fibroblasts","volume":"30","author":"Lee","year":"1998","journal-title":"J Mol Cell Cardiol"},{"key":"2021122415330310500_cvab080-B171","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1677\/joe.0.1600043","article-title":"Local renin-angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy","volume":"160","author":"Kobori","year":"1999","journal-title":"J Endocrinol"},{"key":"2021122415330310500_cvab080-B172","doi-asserted-by":"crossref","first-page":"R1473","DOI":"10.1152\/ajpregu.00269.2003","article-title":"Thyroxine-induced cardiac hypertrophy: influence of adrenergic nervous system versus renin-angiotensin system on myocyte remodeling","volume":"285","author":"Hu","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2021122415330310500_cvab080-B173","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.3390\/ijms20153758","article-title":"Cardiac Cx43 and ECM responses to altered thyroid status are blunted in spontaneously hypertensive versus normotensive rats","volume":"20","author":"Sykora","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2021122415330310500_cvab080-B174","doi-asserted-by":"crossref","first-page":"e46655","DOI":"10.1371\/journal.pone.0046655","article-title":"Longstanding hyperthyroidism is associated with normal or enhanced intrinsic cardiomyocyte function despite decline in global cardiac function","volume":"7","author":"Weltman","year":"2012","journal-title":"PLoS One"},{"key":"2021122415330310500_cvab080-B175","doi-asserted-by":"crossref","first-page":"e109753","DOI":"10.1371\/journal.pone.0109753","article-title":"Hypothyroidism and its rapid correction alter cardiac remodeling","volume":"9","author":"Hajje","year":"2014","journal-title":"PLoS One"},{"key":"2021122415330310500_cvab080-B176","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1093\/nar\/gki280","article-title":"A critical role for the Sp1-binding sites in the transforming growth factor-beta-mediated inhibition of lipoprotein lipase gene expression in macrophages","volume":"33","author":"Irvine","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"2021122415330310500_cvab080-B177","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/jcp.20228","article-title":"TGF-beta-induced expression of tissue inhibitor of metalloproteinases-3 gene in chondrocytes is mediated by extracellular signal-regulated kinase pathway and Sp1 transcription factor","volume":"203","author":"Qureshi","year":"2005","journal-title":"J Cell Physiol"},{"key":"2021122415330310500_cvab080-B178","doi-asserted-by":"crossref","first-page":"F16","DOI":"10.1152\/ajprenal.00318.2003","article-title":"Both Sp1 and Smad participate in mediating TGF-beta1-induced HGF receptor expression in renal epithelial cells","volume":"288","author":"Zhang","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"2021122415330310500_cvab080-B179","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0303-7207(00)00203-3","article-title":"Molecular characterization of myocardial fibrosis during hypothyroidism: evidence for negative regulation of the pro-alpha1(I) collagen gene expression by thyroid hormone receptor","volume":"162","author":"Chen","year":"2000","journal-title":"Mol Cell Endocrinol"},{"key":"2021122415330310500_cvab080-B180","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.yjmcc.2006.09.017","article-title":"Hypothyroidism leads to increased collagen-based stiffness and re-expression of large cardiac titin isoforms with high compliance","volume":"42","author":"Wu","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"2021122415330310500_cvab080-B181","first-page":"57","article-title":"Experimental hypothyroidism increases content of collagen and glycosaminoglycans in the heart","volume":"60","author":"Drobnik","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"2021122415330310500_cvab080-B182","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1161\/CIRCEP.113.000502","article-title":"Both hypothyroidism and hyperthyroidism increase atrial fibrillation inducibility in rats","volume":"6","author":"Zhang","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2021122415330310500_cvab080-B183","doi-asserted-by":"crossref","first-page":"554762","DOI":"10.3389\/fendo.2020.554762","article-title":"Impact of hypothyroidism on echocardiographic characteristics of patients with heart valve disease: a single-center propensity score-based study","volume":"11","author":"Zhai","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2021122415330310500_cvab080-B184","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.cardfail.2014.05.002","article-title":"The prevalence and prognostic effects of subclinical thyroid dysfunction in dilated cardiomyopathy patients: a single-center cohort study","volume":"20","author":"Li","year":"2014","journal-title":"J Card Fail"},{"key":"2021122415330310500_cvab080-B185","doi-asserted-by":"crossref","first-page":"596","DOI":"10.20452\/pamw.1970","article-title":"Assessment of left atrial mechanical functions in thyroid dysfunction","volume":"123","author":"Karabag","year":"2013","journal-title":"Pol Arch Med Wewn"},{"key":"2021122415330310500_cvab080-B186","first-page":"286","article-title":"Evaluation of atrial conduction abnormalities and left atrial mechanical functions in patients with subclinical thyroid disorders","volume":"63","author":"Ozturk","year":"2012","journal-title":"Endokrynol Pol"},{"key":"2021122415330310500_cvab080-B187","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/jocs.12513","article-title":"Preoperative hypothyroidism is a risk factor for postoperative atrial fibrillation in cardiac surgical patients","volume":"30","author":"Worku","year":"2015","journal-title":"J Card Surg"},{"key":"2021122415330310500_cvab080-B188","first-page":"427","article-title":"Subclinical hypothyroidism might increase the risk of postoperative atrial fibrillation after aortic valve replacement","volume":"64","author":"Martinez-Comendador","year":"2016","journal-title":"Thorac Cardiovasc Surg"},{"key":"2021122415330310500_cvab080-B189","first-page":"475","article-title":"Hypothyroidism is a risk factor for atrial fibrillation after coronary artery bypass graft","volume":"32","author":"Jaimes","year":"2017","journal-title":"Braz J Cardiovasc Surg"},{"key":"2021122415330310500_cvab080-B190","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00424-006-0192-0","article-title":"Angiotensin type 1 (AT1) and type 2 (AT2) receptors mediate the increase in TGF-beta1 in thyroid hormone-induced cardiac hypertrophy","volume":"454","author":"Diniz","year":"2007","journal-title":"Pflugers Arch"},{"key":"2021122415330310500_cvab080-B191","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1161\/01.RES.43.5.688","article-title":"Synthesis and degradation of myocardial protein during the development and regression of thyroxine-induced cardiac hypertrophy in rats","volume":"43","author":"Sanford","year":"1978","journal-title":"Circ Res"},{"key":"2021122415330310500_cvab080-B192","doi-asserted-by":"crossref","first-page":"C309","DOI":"10.1152\/ajpcell.1985.248.3.C309","article-title":"Faster protein and ribosome synthesis in thyroxine-induced hypertrophy of rat heart","volume":"248","author":"Siehl","year":"1985","journal-title":"Am J Physiol"},{"key":"2021122415330310500_cvab080-B193","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.110.1.1","article-title":"Sorting within the regulated secretory pathway occurs in the trans-Golgi network","volume":"110","author":"Sossin","year":"1990","journal-title":"J Cell Biol"},{"key":"2021122415330310500_cvab080-B194","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3389\/fphys.2018.01249","article-title":"The role of calcitonin gene related peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects","volume":"9","author":"Kee","year":"2018","journal-title":"Front Physiol"},{"key":"2021122415330310500_cvab080-B195","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s00198-008-0603-5","article-title":"The effects of oral calcitonin on bone collagen maturation: implications for bone turnover and quality","volume":"19","author":"Karsdal","year":"2008","journal-title":"Osteoporos Int"},{"key":"2021122415330310500_cvab080-B196","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/ki.1991.203","article-title":"Calcitonin, an important factor in the calcemic response to parathyroid hormone in the rat","volume":"40","author":"Rodriguez","year":"1991","journal-title":"Kidney Int"},{"key":"2021122415330310500_cvab080-B197","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1152\/physrev.00066.2017","article-title":"The activity of peptides of the calcitonin family in bone","volume":"99","author":"Naot","year":"2019","journal-title":"Physiol Rev"},{"key":"2021122415330310500_cvab080-B198","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1046\/j.1365-2613.2000.00176.x","article-title":"Calcitonin and calcitonin receptors: bone and beyond","volume":"81","author":"Pondel","year":"2000","journal-title":"Int J Exp Pathol"},{"key":"2021122415330310500_cvab080-B199","author":"Moreira","year":"2020"},{"key":"2021122415330310500_cvab080-B200","first-page":"117","article-title":"Calcitonin and calcitonin receptors","volume":"4","author":"Masi","year":"2007","journal-title":"Clin Cases Miner Bone Metab"},{"key":"2021122415330310500_cvab080-B201","doi-asserted-by":"crossref","first-page":"19927","DOI":"10.1016\/S0021-9258(20)80674-7","article-title":"A recombinant human calcitonin receptor functions as an extracellular calcium sensor","volume":"268","author":"Stroop","year":"1993","journal-title":"J Biol Chem"},{"key":"2021122415330310500_cvab080-B202","doi-asserted-by":"crossref","first-page":"19809","DOI":"10.1074\/jbc.273.31.19809","article-title":"The calcitonin receptor stimulates Shc tyrosine phosphorylation and Erk1\/2 activation. Involvement of Gi, protein kinase C, and calcium","volume":"273","author":"Chen","year":"1998","journal-title":"J Biol Chem"},{"key":"2021122415330310500_cvab080-B203","first-page":"265","article-title":"Expression cloning and characterization of a porcine renal calcitonin receptor","volume":"104","author":"Lin","year":"1991","journal-title":"Trans Assoc Am Physicians"},{"key":"2021122415330310500_cvab080-B204","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1172\/JCI112584","article-title":"Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization","volume":"78","author":"Nicholson","year":"1986","journal-title":"J Clin Invest"},{"key":"2021122415330310500_cvab080-B205","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.1210\/endo.136.12.7588285","article-title":"Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene","volume":"136","author":"Albrandt","year":"1995","journal-title":"Endocrinology"},{"key":"2021122415330310500_cvab080-B206","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1373\/clinchem.2003.026963","article-title":"Reference intervals for serum calcitonin in men, women, and children","volume":"50","author":"Basuyau","year":"2004","journal-title":"Clin Chem"},{"key":"2021122415330310500_cvab080-B207","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature14177","article-title":"Genetic studies of body mass index yield new insights for obesity biology","volume":"518","author":"Locke","year":"2015","journal-title":"Nature"},{"key":"2021122415330310500_cvab080-B208","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","article-title":"Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study","volume":"129","author":"Chugh","year":"2014","journal-title":"Circulation"},{"key":"2021122415330310500_cvab080-B209","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1161\/CIRCRESAHA.117.311081","article-title":"Translational challenges in atrial fibrillation","volume":"122","author":"Heijman","year":"2018","journal-title":"Circ Res"},{"key":"2021122415330310500_cvab080-B210","first-page":"555","article-title":"Effect of calcitonin on certain experimental models of arrhythmia","author":"Cuparencu","year":"1975","journal-title":"Therapie"},{"key":"2021122415330310500_cvab080-B211","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1536\/ihj.18.214","article-title":"Effects of salmon calcitonin on SA nodal pacemaker activity and contractility in isolated, blood-perfused atrial and papillary muscle preparations of dogs","volume":"18","author":"Chiba","year":"1977","journal-title":"Jpn Heart J"},{"key":"2021122415330310500_cvab080-B212","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.brainresbull.2011.02.006","article-title":"Additive inhibitory effects of calcitonin and capsaicin on voltage activated calcium channel currents in nociceptive neurones of rat","volume":"85","author":"Hagenacker","year":"2011","journal-title":"Brain Res Bull"},{"key":"2021122415330310500_cvab080-B213","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1038\/ki.1997.271","article-title":"Effect of calcitonin on calcium transport by the luminal and basolateral membranes of the rabbit nephron","volume":"51","author":"Zuo","year":"1997","journal-title":"Kidney Int"},{"key":"2021122415330310500_cvab080-B214","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1113\/jphysiol.1990.sp018329","article-title":"Membrane depolarization and intracellular Ca2+ increase caused by high external Ca2+ in a rat calcitonin-secreting cell line","volume":"431","author":"Yamashita","year":"1990","journal-title":"J Physiol"},{"key":"2021122415330310500_cvab080-B215","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1748-1716.1986.tb07803.x","article-title":"Electrophysiological properties of calcitonin-secreting cells derived from human medullary thyroid carcinoma","volume":"126","author":"Sand","year":"1986","journal-title":"Acta Physiol Scand"},{"key":"2021122415330310500_cvab080-B216","doi-asserted-by":"crossref","first-page":"11427","DOI":"10.1038\/srep11427","article-title":"Mitochondrial oxidative stress promotes atrial fibrillation","volume":"5","author":"Xie","year":"2015","journal-title":"Sci Rep"},{"key":"2021122415330310500_cvab080-B217","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF01941066","article-title":"Regulation of cellular calcium metabolism and calcium transport by calcitonin","volume":"21","author":"Borle","year":"1975","journal-title":"J Membr Biol"},{"key":"2021122415330310500_cvab080-B218","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1744-8069-8-42","article-title":"Anti-hyperalgesic effects of calcitonin on neuropathic pain interacting with its peripheral receptors","volume":"8","author":"Ito","year":"2012","journal-title":"Mol Pain"},{"key":"2021122415330310500_cvab080-B219","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.joca.2004.08.005","article-title":"Treatment with calcitonin prevents the net loss of collagen, hyaluronan and proteoglycan aggregates from cartilage in the early stages of canine experimental osteoarthritis","volume":"12","author":"El Hajjaji","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"2021122415330310500_cvab080-B220","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.celrep.2015.08.083","article-title":"Calcitonin receptor signaling inhibits muscle stem cells from escaping the quiescent state and the niche","volume":"13","author":"Yamaguchi","year":"2015","journal-title":"Cell Rep"},{"key":"2021122415330310500_cvab080-B221","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1161\/CIRCULATIONAHA.119.044183","article-title":"Effect of dapagliflozin on atrial fibrillation in patients with type 2 diabetes mellitus: insights from the DECLARE-TIMI 58 trial","volume":"141","author":"Zelniker","year":"2020","journal-title":"Circulation"},{"key":"2021122415330310500_cvab080-B222","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s40618-017-0698-7","article-title":"Glucagon-like peptide-1 receptor agonists and atrial fibrillation: a systematic review and meta-analysis of randomised controlled trials","volume":"40","author":"Monami","year":"2017","journal-title":"J Endocrinol Invest"},{"key":"2021122415330310500_cvab080-B223","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.numecd.2020.03.013","article-title":"Major cardiovascular events, heart failure, and atrial fibrillation in patients treated with glucagon-like peptide-1 receptor agonists: an updated meta-analysis of randomized controlled trials","volume":"30","author":"Nreu","year":"2020","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2021122415330310500_cvab080-B224","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/s42255-019-0145-5","article-title":"Inter-organ cross-talk in metabolic syndrome","volume":"1","author":"Priest","year":"2019","journal-title":"Nat Metab"},{"key":"2021122415330310500_cvab080-B225","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.4022\/jafib.1604","article-title":"D. Use of oral steroid and its effects on atrial fibrillation recurrence and inflammatory cytokines post ablation - the steroid AF study","volume":"9","author":"Iskandar","year":"2017","journal-title":"J Atr Fibrillation"},{"key":"2021122415330310500_cvab080-B226","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jsha.2016.03.005","article-title":"Use of short-term steroids in the prophylaxis of atrial fibrillation after cardiac surgery","volume":"29","author":"Al-Shawabkeh","year":"2017","journal-title":"J Saudi Heart Assoc"},{"key":"2021122415330310500_cvab080-B227","doi-asserted-by":"crossref","first-page":"e3721","DOI":"10.1097\/MD.0000000000003721","article-title":"Angiotensin-receptor blocker, angiotensin-converting enzyme inhibitor, and risks of atrial fibrillation: a nationwide cohort study","volume":"95","author":"Hsieh","year":"2016","journal-title":"Medicine"},{"key":"2021122415330310500_cvab080-B228","doi-asserted-by":"crossref","first-page":"e013267","DOI":"10.1161\/JAHA.119.013267","article-title":"Effects of mineralocorticoid receptor antagonists on atrial fibrillation occurrence: a systematic review, meta-analysis, and meta-regression to identify modifying factors","volume":"8","author":"Alexandre","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2021122415330310500_cvab080-B229","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mayocpiqo.2017.05.003","article-title":"Normalization of testosterone levels after testosterone replacement therapy is not associated with reduced myocardial infarction in smokers","volume":"1","author":"Oni","year":"2017","journal-title":"Mayo Clin Proc Innov Qual Outcomes"},{"key":"2021122415330310500_cvab080-B230","doi-asserted-by":"crossref","first-page":"e51580","DOI":"10.1371\/journal.pone.0051580","article-title":"Hormone replacement therapy and risk of new-onset atrial fibrillation after myocardial infarction \u2013 a nationwide cohort study","volume":"7","author":"Bretler","year":"2012","journal-title":"PLoS One"},{"key":"2021122415330310500_cvab080-B231","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0008-6363(01)00449-7","article-title":"Effects of gonadal steroids on gender-related differences in transmural dispersion of L-type calcium current","volume":"53","author":"Pham","year":"2002","journal-title":"Cardiovascular Research"},{"key":"2021122415330310500_cvab080-B232","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1093\/europace\/euy067","article-title":"Sex differences in cardiac arrhythmia: a consensus document of the European Heart Rhythm Association, endorsed by the Heart Rhythm Society and Asia Pacific Heart Rhythm Society","volume":"20","author":"Linde","year":"2018","journal-title":"Europace"},{"key":"2021122415330310500_cvab080-B233","doi-asserted-by":"crossref","first-page":"e0151413","DOI":"10.1371\/journal.pone.0151413","article-title":"Safe oral triiodo-L-thyronine therapy protects from post-infarct cardiac dysfunction and arrhythmias without cardiovascular adverse effects","volume":"11","author":"Rajagopalan","year":"2016","journal-title":"PLoS One"},{"key":"2021122415330310500_cvab080-B234","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/ncpendmet0590","article-title":"Potential therapeutic applications of thyroid hormone analogs","volume":"3","author":"Brenta","year":"2007","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"2021122415330310500_cvab080-B235","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1172\/JCI107044","article-title":"An evaluation of antibodies and clinical resistance to salmon calcitonin","volume":"51","author":"Singer","year":"1972","journal-title":"J Clin Invest"},{"key":"2021122415330310500_cvab080-B236","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.cjca.2020.09.001","article-title":"The 2020 Canadian Cardiovascular Society\/Canadian Heart Rhythm Society Comprehensive Guidelines for the Management of Atrial Fibrillation","volume":"36","author":"Andrade","year":"2020","journal-title":"Can J Cardiol"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvab080\/36781299\/cvab080.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/117\/7\/1645\/41927599\/cvab080.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/117\/7\/1645\/41927599\/cvab080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T17:31:54Z","timestamp":1724607114000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/117\/7\/1645\/6173397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,16]]},"references-count":236,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,3,16]]},"published-print":{"date-parts":[[2021,6,16]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvab080","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,6,15]]},"published":{"date-parts":[[2021,3,16]]}}}