{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:05:40Z","timestamp":1773885940210,"version":"3.50.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although coronavirus disease 2019 seems to be the leading topic in research number of outstanding studies have been published in the field of aorta and peripheral vascular diseases likely affecting our clinical practice in the near future. This review article highlights key research on vascular diseases published in 2020. Some studies have shed light in the pathophysiology of aortic aneurysm and dissection suggesting a potential role for kinase inhibitors as new therapeutic options. A first proteogenomic study on fibromuscular dysplasia (FMD) revealed a promising novel disease gene and provided proof-of-concept for a protein\/lipid-based FMD blood test. The role of NADPH oxidases in vascular physiology, and particularly endothelial cell differentiation, is highlighted with potential for cell therapy development. Imaging of vulnerable plaque has been an intense field of research. Features of plaque vulnerability on magnetic resonance imaging as an under-recognized cause of stroke are discussed. Major clinical trials on lower extremity peripheral artery disease have shown added benefit of dual antithrombotic (aspirin plus rivaroxaban) treatment.<\/jats:p>","DOI":"10.1093\/cvr\/cvab144","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T07:36:36Z","timestamp":1619076996000},"page":"2045-2053","source":"Crossref","is-referenced-by-count":6,"title":["Progress in aorta and peripheral cardiovascular disease research"],"prefix":"10.1093","volume":"117","author":[{"given":"Lucia","family":"Mazzolai","sequence":"first","affiliation":[{"name":"Division of Angiology, Heart and Vessel Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Alatri","sequence":"additional","affiliation":[{"name":"Division of Angiology, Heart and Vessel Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7469-2407","authenticated-orcid":false,"given":"Alessandra Bura","family":"Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine, Heart, Vessels and Metabolisms Department, Toulouse University Hospital, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5763-9804","authenticated-orcid":false,"given":"Marco","family":"De Carlo","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3212-8995","authenticated-orcid":false,"given":"Christian","family":"Heiss","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Faculty of Health and Medical Sciences, University 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Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Staub","sequence":"additional","affiliation":[{"name":"Division of Angiology, University Hospital Basel, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7229-9780","authenticated-orcid":false,"given":"Jos\u00e9 F","family":"Rodriguez-Palomares","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital General Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Research Institute (VHIR), CIBER-CV, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4740-8014","authenticated-orcid":false,"given":"Aline","family":"Verstraeten","sequence":"additional","affiliation":[{"name":"Centre of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, Antwerp, 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