{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:56:19Z","timestamp":1793141779897,"version":"4.5.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C12\/16\/023"],"award-info":[{"award-number":["C12\/16\/023"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C14\/19\/095"],"award-info":[{"award-number":["C14\/19\/095"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["ID-N19\/031"],"award-info":[{"award-number":["ID-N19\/031"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program Financing","award":["PF\/10\/014"],"award-info":[{"award-number":["PF\/10\/014"]}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["FP7-StG-IMAGINED203291"],"award-info":[{"award-number":["FP7-StG-IMAGINED203291"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cosmetics Europe\/European Commission FP7 Grant","award":["FP7-Health-HemiBio266777"],"award-info":[{"award-number":["FP7-Health-HemiBio266777"]}],"id":[{"id":"https:\/\/ror.org\/00k4n6c32","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Interuniversity Attraction Poles grant","award":["IUAP\/P7\/07"],"award-info":[{"award-number":["IUAP\/P7\/07"]}]},{"name":"Fonds voor Wetenschappelijk Onderzoek [FWO]","award":["G.0A3116"],"award-info":[{"award-number":["G.0A3116"]}]},{"name":"Fonds voor Wetenschappelijk Onderzoek [FWO]","award":["W001420N"],"award-info":[{"award-number":["W001420N"]}]},{"name":"ZONMW OffRoad program","award":["2018\/23115|ZONMW"],"award-info":[{"award-number":["2018\/23115|ZONMW"]}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["17K09896"],"award-info":[{"award-number":["17K09896"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marie Sklodowska-Curie Actions post-doctoral fellowship","award":["H2020-MSCA-IF-REZONABLE658666"],"award-info":[{"award-number":["H2020-MSCA-IF-REZONABLE658666"]}]},{"name":"Horizon 2020 Marie Sk\u0142odowska-Curie Actions-Innovative Training Network grant","award":["H2020-MSCA-ITN-RenalToolBox813839"],"award-info":[{"award-number":["H2020-MSCA-ITN-RenalToolBox813839"]}]},{"name":"FWO fellowship","award":["1157318N"],"award-info":[{"award-number":["1157318N"]}]},{"name":"FWO fellowship","award":["12N5419N LV"],"award-info":[{"award-number":["12N5419N LV"]}]},{"name":"Inserm Technology Research Accelerator"},{"name":"Biomedical Ultrasound"},{"name":"Dutch Cancer Society [KWF","award":["10339"],"award-info":[{"award-number":["10339"]}],"id":[{"id":"https:\/\/ror.org\/0368jnd28","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Hepatic capillaries are lined with specialized liver sinusoidal endothelial cells (LSECs) which support macromolecule passage to hepatocytes and prevent fibrosis by keeping hepatic stellate cells (HSCs) quiescent. LSEC specialization is co-determined by transcription factors. The zinc-finger E-box-binding homeobox (Zeb)2 transcription factor is enriched in LSECs. Here, we aimed to elucidate the endothelium-specific role of Zeb2 during maintenance of the liver and in liver fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>To study the role of Zeb2 in liver endothelium we generated EC-specific Zeb2 knock-out (ECKO) mice. Sequencing of liver EC RNA revealed that deficiency of Zeb2 results in prominent expression changes in angiogenesis-related genes. Accordingly, the vascular area was expanded and the presence of pillars inside ECKO liver vessels indicated that this was likely due to increased intussusceptive angiogenesis. LSEC marker expression was not profoundly affected and fenestrations were preserved upon Zeb2 deficiency. However, an increase in continuous EC markers suggested that Zeb2-deficient LSECs are more prone to dedifferentiation, a process called \u2018capillarization\u2019. Changes in the endothelial expression of ligands that may be involved in HSC quiescence together with significant changes in the expression profile of HSCs showed that Zeb2 regulates LSEC\u2013HSC communication and HSC activation. Accordingly, upon exposure to the hepatotoxin carbon tetrachloride (CCl4), livers of ECKO mice showed increased capillarization, HSC activation, and fibrosis compared to livers from wild-type littermates. The vascular maintenance and anti-fibrotic role of endothelial Zeb2 was confirmed in mice with EC-specific overexpression of Zeb2, as the latter resulted in reduced vascularity and attenuated CCl4-induced liver fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Endothelial Zeb2 preserves liver angioarchitecture and protects against liver fibrosis. Zeb2 and Zeb2-dependent genes in liver ECs may be exploited to design novel therapeutic strategies to attenuate hepatic fibrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvab148","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T07:59:42Z","timestamp":1619423982000},"page":"1262-1275","source":"Crossref","is-referenced-by-count":45,"title":["Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5034-7905","authenticated-orcid":false,"given":"Willeke","family":"de Haan","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, Box 911, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Dheedene","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, Box 911, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-1752","authenticated-orcid":false,"given":"Katerina","family":"Apelt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (Nephrology), Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2633-2903","authenticated-orcid":false,"given":"Sofiane","family":"D\u00e9combas-Deschamps","sequence":"additional","affiliation":[{"name":"Physics for Medicine Paris, Inserm, CNRS, ESPCI Paris, Paris Sciences et Lettres University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Vinckier","sequence":"additional","affiliation":[{"name":"Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism, KU Leuven, Leuven, Belgium"},{"name":"Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6566-6071","authenticated-orcid":false,"given":"Stefaan","family":"Verhulst","sequence":"additional","affiliation":[{"name":"Liver Cell Biology Research Group, Vrije Universiteit Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-1732","authenticated-orcid":false,"given":"Andrea","family":"Conidi","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Deffieux","sequence":"additional","affiliation":[{"name":"Physics for Medicine Paris, Inserm, CNRS, ESPCI Paris, Paris Sciences et Lettres University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W","family":"Staring","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, Box 911, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Vandervoort","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, Box 911, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Caluw\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, Box 911, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen","family":"Lox","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, Box 911, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2235-2555","authenticated-orcid":false,"given":"Inge","family":"Mannaerts","sequence":"additional","affiliation":[{"name":"Liver Cell Biology Research Group, Vrije Universiteit Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Disease Model, Institute of Developmental Research, Aichi Developmental Disability Center, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5101-4574","authenticated-orcid":false,"given":"Joris","family":"Jaekers","sequence":"additional","affiliation":[{"name":"Abdominal Surgery, UZ Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5770-2458","authenticated-orcid":false,"given":"Geert","family":"Berx","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Oncology Laboratory, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium"},{"name":"Cancer Research Institute Ghent (CRIG), Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody","family":"Haigh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Research Institute in Oncology and Hematology, Cancer Care Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0421-8301","authenticated-orcid":false,"given":"Baki","family":"Topal","sequence":"additional","affiliation":[{"name":"Abdominal Surgery, UZ Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8583-1721","authenticated-orcid":false,"given":"An","family":"Zwijsen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, Box 911, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7729-4594","authenticated-orcid":false,"given":"Yujiro","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Disease Model, Institute of Developmental Research, Aichi Developmental Disability Center, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0990-7034","authenticated-orcid":false,"given":"Leo A","family":"van Grunsven","sequence":"additional","affiliation":[{"name":"Liver Cell Biology Research Group, Vrije Universiteit Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfred F J","family":"van IJcken","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands"},{"name":"Center for Biomics-Genomics, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4045-4835","authenticated-orcid":false,"given":"Eskeatnaf","family":"Mulugeta","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickael","family":"Tanter","sequence":"additional","affiliation":[{"name":"Physics for Medicine Paris, Inserm, CNRS, ESPCI Paris, Paris Sciences et Lettres University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck P G","family":"Lebrin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (Nephrology), Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Physics for Medicine Paris, Inserm, CNRS, ESPCI Paris, Paris Sciences et Lettres University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4862-1079","authenticated-orcid":false,"given":"Danny","family":"Huylebroeck","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands"},{"name":"Department of Development and Regeneration, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7902-9524","authenticated-orcid":false,"given":"Aernout","family":"Luttun","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, Box 911, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"2022032513474112900_cvab148-B1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1161\/01.RES.0000255690.03436.ae","article-title":"Phenotypic heterogeneity of the endothelium: II. Representative vascular beds","volume":"100","author":"Aird","year":"2007","journal-title":"Circ Res"},{"key":"2022032513474112900_cvab148-B2","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1161\/CIRCULATIONAHA.114.013721","article-title":"Meox2\/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake","volume":"131","author":"Coppiello","year":"2015","journal-title":"Circulation"},{"key":"2022032513474112900_cvab148-B3","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1172\/JCI90086","article-title":"GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis","volume":"127","author":"Geraud","year":"2017","journal-title":"J Clin Invest"},{"key":"2022032513474112900_cvab148-B4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jhep.2016.07.009","article-title":"Liver sinusoidal endothelial cells: physiology and role in liver diseases","volume":"66","author":"Poisson","year":"2017","journal-title":"J Hepatol"},{"key":"2022032513474112900_cvab148-B5","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jhep.2016.04.018","article-title":"Sinusoidal communication in liver fibrosis and regeneration","volume":"65","author":"Marrone","year":"2016","journal-title":"J Hepatol"},{"key":"2022032513474112900_cvab148-B6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1055\/s-0037-1617455","article-title":"Liver sinusoidal endothelial cell: an update","volume":"37","author":"DeLeve","year":"2017","journal-title":"Semin Liver Dis"},{"key":"2022032513474112900_cvab148-B7","doi-asserted-by":"crossref","first-page":"4097205","DOI":"10.1155\/2017\/4097205","article-title":"SECs (Sinusoidal Endothelial Cells), liver microenvironment, and fibrosis","volume":"2017","author":"Natarajan","year":"2017","journal-title":"Biomed Res Int"},{"key":"2022032513474112900_cvab148-B8","doi-asserted-by":"crossref","first-page":"G803","DOI":"10.1152\/ajpgi.00215.2019","article-title":"Unraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization","volume":"318","author":"de Haan","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2022032513474112900_cvab148-B9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cytogfr.2011.11.006","article-title":"Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFbeta\/BMP signaling in vivo","volume":"22","author":"Conidi","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"key":"2022032513474112900_cvab148-B10","doi-asserted-by":"crossref","first-page":"dev184861","DOI":"10.1242\/dev.184861","article-title":"Multifaceted actions of Zeb2 in postnatal neurogenesis from the ventricular-subventricular zone to the olfactory bulb","volume":"147","author":"Deryckere","year":"2020","journal-title":"Development"},{"key":"2022032513474112900_cvab148-B11","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/nn.4321","article-title":"Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair","volume":"19","author":"Quintes","year":"2016","journal-title":"Nat Neurosci"},{"key":"2022032513474112900_cvab148-B12","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nn.4322","article-title":"Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination","volume":"19","author":"Wu","year":"2016","journal-title":"Nat Neurosci"},{"key":"2022032513474112900_cvab148-B13","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S1097-2765(01)00260-X","article-title":"The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion","volume":"7","author":"Comijn","year":"2001","journal-title":"Mol Cell"},{"key":"2022032513474112900_cvab148-B14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.molimm.2016.05.018","article-title":"MicroRNA-145 inhibits hepatic stellate cell activation and proliferation by targeting ZEB2 through Wnt\/beta-catenin pathway","volume":"75","author":"Zhou","year":"2016","journal-title":"Mol Immunol"},{"key":"2022032513474112900_cvab148-B15","doi-asserted-by":"crossref","first-page":"980","DOI":"10.3389\/fphar.2017.00980","article-title":"MicroRNA-145 increases the apoptosis of activated hepatic stellate cells induced by TRAIL through NF-kappaB signaling pathway","volume":"8","author":"Yang","year":"2017","journal-title":"Front Pharmacol"},{"key":"2022032513474112900_cvab148-B16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.immuni.2018.07.004","article-title":"The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages","volume":"49","author":"Scott","year":"2018","journal-title":"Immunity"},{"key":"2022032513474112900_cvab148-B17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.biomaterials.2017.05.047","article-title":"Functionality based method for simultaneous isolation of rodent hepatic sinusoidal cells","volume":"139","author":"Stradiot","year":"2017","journal-title":"Biomaterials"},{"key":"2022032513474112900_cvab148-B18","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1053\/j.gastro.2011.12.017","article-title":"Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats","volume":"142","author":"Xie","year":"2012","journal-title":"Gastroenterology"},{"key":"2022032513474112900_cvab148-B19","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.neuroimage.2015.11.014","article-title":"4D microvascular imaging based on ultrafast Doppler tomography","volume":"127","author":"Demene","year":"2016","journal-title":"Neuroimage"},{"key":"2022032513474112900_cvab148-B20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.neuroimage.2007.08.022","article-title":"Modelling vascular reactivity to investigate the basis of the relationship between cerebral blood volume and flow under CO2 manipulation","volume":"39","author":"Piechnik","year":"2008","journal-title":"Neuroimage"},{"key":"2022032513474112900_cvab148-B21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.prp.2016.02.015","article-title":"Deletion of SIP1 promotes liver regeneration and lipid accumulation","volume":"212","author":"Yang","year":"2016","journal-title":"Pathol Res Pract"},{"key":"2022032513474112900_cvab148-B22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/hep.1840140122","article-title":"Differences in the lectin-binding patterns of the periportal and perivenous endothelial domains in the liver sinusoids","volume":"14","author":"Barbera-Guillem","year":"1991","journal-title":"Hepatology"},{"key":"2022032513474112900_cvab148-B23","doi-asserted-by":"crossref","first-page":"17238","DOI":"10.1038\/s41598-017-17574-w","article-title":"GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury","volume":"7","author":"Chung","year":"2017","journal-title":"Sci Rep"},{"key":"2022032513474112900_cvab148-B24","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.3168\/jds.2013-7505","article-title":"Lactoferrin protects against chemical-induced rat liver fibrosis by inhibiting stellate cell activation","volume":"97","author":"Tung","year":"2014","journal-title":"J Dairy Sci"},{"key":"2022032513474112900_cvab148-B25","doi-asserted-by":"crossref","first-page":"34605","DOI":"10.1038\/srep34605","article-title":"IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner","volume":"6","author":"Nishizawa","year":"2016","journal-title":"Sci Rep"},{"key":"2022032513474112900_cvab148-B26","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1172\/JCI92823","article-title":"Building discontinuous liver sinusoidal vessels","volume":"127","author":"Griffin","year":"2017","journal-title":"J Clin Invest"},{"key":"2022032513474112900_cvab148-B27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1748-1716.2011.02321.x","article-title":"Intussusceptive angiogenesis: pillars against the blood flow","volume":"202","author":"Styp-Rekowska","year":"2011","journal-title":"Acta Physiol (Oxf)"},{"key":"2022032513474112900_cvab148-B28","doi-asserted-by":"crossref","first-page":"E4111","DOI":"10.1073\/pnas.1721403115","article-title":"Glucagon contributes to liver zonation","volume":"115","author":"Cheng","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022032513474112900_cvab148-B29","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.celrep.2015.10.049","article-title":"The angiocrine factor Rspondin3 is a key determinant of liver zonation","volume":"13","author":"Rocha","year":"2015","journal-title":"Cell Rep"},{"key":"2022032513474112900_cvab148-B30","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature14863","article-title":"Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver","volume":"524","author":"Wang","year":"2015","journal-title":"Nature"},{"key":"2022032513474112900_cvab148-B31","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1158\/0008-5472.CAN-18-1752","article-title":"Hepatic endothelial notch activation protects against liver metastasis by regulating endothelial-tumor cell adhesion independent of angiocrine signaling","volume":"79","author":"Wohlfeil","year":"2019","journal-title":"Cancer Res"},{"key":"2022032513474112900_cvab148-B32","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jhep.2020.08.033","article-title":"Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling","volume":"74","author":"Winkler","year":"2021","journal-title":"J Hepatol"},{"key":"2022032513474112900_cvab148-B33","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1007\/s12026-017-8946-7","article-title":"Von Willebrand factor protects against acute CCl4-induced hepatotoxicity through phospho-p38 MAPK signaling pathway inhibition","volume":"65","author":"Sun","year":"2017","journal-title":"Immunol Res"},{"key":"2022032513474112900_cvab148-B34","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1182\/blood-2010-08-300236","article-title":"The EMT regulator Zeb2\/Sip1 is essential for murine embryonic hematopoietic stem\/progenitor cell differentiation and mobilization","volume":"117","author":"Goossens","year":"2011","journal-title":"Blood"},{"key":"2022032513474112900_cvab148-B35","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1128\/MCB.01237-09","article-title":"Regulation of the expression and activity of the antiangiogenic homeobox gene GAX\/MEOX2 by ZEB2 and microRNA-221","volume":"30","author":"Chen","year":"2010","journal-title":"Mol Cell Biol"},{"key":"2022032513474112900_cvab148-B36","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.12659\/MSM.904678","article-title":"Zinc finger E-box binding protein 2 (ZEB2) suppress apoptosis of vascular endothelial cells induced by high glucose through mitogen-activated protein kinases (MAPK) pathway activation","volume":"23","author":"Wang","year":"2017","journal-title":"Med Sci Monit"},{"key":"2022032513474112900_cvab148-B37","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s10456-018-9634-5","article-title":"PDGF-BB regulates splitting angiogenesis in skeletal muscle by limiting VEGF-induced endothelial proliferation","volume":"21","author":"Gianni-Barrera","year":"2018","journal-title":"Angiogenesis"},{"key":"2022032513474112900_cvab148-B38","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1053\/j.gastro.2011.12.052","article-title":"Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice","volume":"142","author":"Dill","year":"2012","journal-title":"Gastroenterology"},{"key":"2022032513474112900_cvab148-B39","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.3390\/ijms19103207","article-title":"The functional role of zinc finger E box-binding homeobox 2 (Zeb2) in promoting cardiac fibroblast activation","volume":"19","author":"Jahan","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2022032513474112900_cvab148-B40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/jcm5040045","article-title":"Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of human fibrotic diseases","volume":"5","author":"Piera-Velazquez","year":"2016","journal-title":"J Clin Med"},{"key":"2022032513474112900_cvab148-B41","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/s41467-017-01169-0","article-title":"Dynamic regulation of canonical TGFbeta signalling by endothelial transcription factor ERG protects from liver fibrogenesis","volume":"8","author":"Dufton","year":"2017","journal-title":"Nat Commun"},{"key":"2022032513474112900_cvab148-B42","doi-asserted-by":"crossref","first-page":"G492","DOI":"10.1152\/ajpgi.00428.2016","article-title":"small population of liver endothelial cells undergoes endothelial-to-mesenchymal transition in response to chronic liver injury","volume":"313","author":"Ribera","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2022032513474112900_cvab148-B43","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/stem.2521","article-title":"Zeb2 regulates cell fate at the exit from epiblast state in mouse embryonic stem cells","volume":"35","author":"Stryjewska","year":"2017","journal-title":"Stem Cells"},{"key":"2022032513474112900_cvab148-B44","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1182\/blood-2016-05-714659","article-title":"The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling","volume":"129","author":"Li","year":"2017","journal-title":"Blood"},{"key":"2022032513474112900_cvab148-B45","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/nn.2409","article-title":"Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors","volume":"12","author":"Seuntjens","year":"2009","journal-title":"Nat Neurosci"},{"key":"2022032513474112900_cvab148-B46","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuron.2012.11.009","article-title":"Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1","volume":"77","author":"van den Berghe","year":"2013","journal-title":"Neuron"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvab148\/37949300\/cvab148.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/118\/5\/1262\/43027652\/cvab148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/118\/5\/1262\/43027652\/cvab148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T15:53:16Z","timestamp":1648223596000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/118\/5\/1262\/6257433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,28]]},"references-count":46,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,4,28]]},"published-print":{"date-parts":[[2022,3,25]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvab148","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,4,1]]},"published":{"date-parts":[[2021,4,28]]}}}