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Autophagy dysregulation has been observed and linked with the development and progression of several pathologies, including cardiovascular diseases, the leading cause of death in the developed world. In this review, we aim to provide a broad understanding of the different molecular factors that govern autophagy regulation and how these mechanisms are involved in the development of specific cardiovascular pathologies, including ischemic and reperfusion injury, myocardial infarction, cardiac hypertrophy, cardiac remodelling, and heart failure.<\/jats:p>","DOI":"10.1093\/cvr\/cvab158","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T15:11:55Z","timestamp":1619795515000},"page":"934-950","source":"Crossref","is-referenced-by-count":97,"title":["The role of autophagy in cardiovascular pathology"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5052-3131","authenticated-orcid":false,"given":"Dami\u00e1n","family":"Gatica","sequence":"first","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology, Life Sciences Institute, University of Michigan, 210 Washtenaw Ave, Ann Arbor, MI 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Santiago 7860201, Chile"},{"name":"Department of Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390-8573, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7828-8118","authenticated-orcid":false,"given":"Daniel J","family":"Klionsky","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology, Life Sciences Institute, University of Michigan, 210 Washtenaw Ave, Ann Arbor, MI 48109-2216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"2022031721055069100_cvab158-B1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.cmet.2019.03.003","article-title":"Watch what you (self-) eat: autophagic mechanisms that modulate metabolism","volume":"29","author":"Lahiri","year":"2019","journal-title":"Cell 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