{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:35:48Z","timestamp":1792798548433,"version":"4.5.0"},"reference-count":110,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL135060"],"award-info":[{"award-number":["HL135060"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UAB-Department of Medicine-CVD startup funding"},{"name":"American Heart Association to P.R.","award":["826859"],"award-info":[{"award-number":["826859"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Among several known RNA modifications, N6-methyladenosine (m6A) is the most studied RNA epitranscriptomic modification and controls multiple cellular functions during development, differentiation, and disease. Current research advancements have made it possible to examine the regulatory mechanisms associated with RNA methylation and reveal its functional consequences in the pathobiology of many diseases, including heart failure. m6A methylation has been described both on coding (mRNA) and non-coding RNA species including rRNA, tRNA, small nuclear RNA and circular RNAs. The protein components which catalyze the m6A methylation are termed methyltransferase or \u2018m6A writers\u2019. The family of proteins that recognize this methylation are termed \u2018m6A readers\u2019 and finally the enzymes involved in the removal of a methyl group from RNA are known as demethylases or \u2018m6A erasers\u2019. At the cellular level, different components of methylation machinery are tightly regulated by many factors to maintain the m6A methylation dynamics. The m6A methylation process impacts different stages of mRNA metabolism and the biogenesis of long non-coding RNA and miRNA. Although, mRNA methylation was initially described in the 1970s, its regulatory roles in various diseases, including cardiovascular diseases are broadly unexplored. Recent investigations suggest the important role of m6A mRNA methylation in both hypertrophic and ischaemic heart diseases. In the present review, we evaluate the significance of m6A methylation in the cardiovascular system, in cardiac homeostasis and disease, all of which may help to improve therapeutic intervention for the treatment of heart failure. RNA methylation in cardiovascular diseases: altered m6A RNA (coding and non-coding RNA) methylation is identified during different cardiovascular diseases. Increased cardiac hypertrophy is observed following METTL3 overexpression. In contrast, reduced FTO level was seen in mice following myocardial infarction. Increased cardiac fibroblasts activation or increased atherosclerotic plaques were also co-related with m6A RNA methylation.<\/jats:p>","DOI":"10.1093\/cvr\/cvab160","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T17:21:11Z","timestamp":1620148871000},"page":"1680-1692","source":"Crossref","is-referenced-by-count":210,"title":["mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification"],"prefix":"10.1093","volume":"118","author":[{"given":"Rajesh","family":"Kumari","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Disease, The University of Alabama at Birmingham \u00a0 703 19th St. South, ZRB-302, Birmingham, AL 35233 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhat","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Disease, The University of Alabama at Birmingham \u00a0 703 19th St. South, ZRB-302, Birmingham, AL 35233 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6607-143X","authenticated-orcid":false,"given":"Zainab Gbongbo","family":"Suleiman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The University of Alabama at Birmingham , Birmingham, AL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumanta Kumar","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Disease, The University of Alabama at Birmingham \u00a0 703 19th St. South, ZRB-302, Birmingham, AL 35233 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Disease, The University of Alabama at Birmingham \u00a0 703 19th St. South, ZRB-302, Birmingham, AL 35233 , 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