{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:04:36Z","timestamp":1769123076793,"version":"3.49.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Interdisciplinary Centre for Clinical Research W\u00fcrzburg"},{"name":"European Research Area Network\u2014Cardiovascular Diseases","award":["ERANET-CVD JCT2018, AIR-MI Consortium grant 01KL1902 to G.C.R."],"award-info":[{"award-number":["ERANET-CVD JCT2018, AIR-MI Consortium grant 01KL1902 to G.C.R."]}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["DFG grant 411619907"],"award-info":[{"award-number":["DFG grant 411619907"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"German Ministry of Research and Education","award":["BMBF 01EO1504 to C.C. and A.E.S."],"award-info":[{"award-number":["BMBF 01EO1504 to C.C. and A.E.S."]}]},{"DOI":"10.13039\/501100003042","name":"Else-Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010578","name":"German Cardiac Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010578","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Recent studies have revealed that B cells and antibodies can influence inflammation and remodelling following a myocardial infarction (MI) and culminating in heart failure\u2014but the mechanisms underlying these observations remain elusive. We therefore conducted in mice a deep phenotyping of the post-MI B-cell responses in infarcted hearts and mediastinal lymph nodes, which drain the myocardium. Thereby, we sought to dissect the mechanisms controlling B-cell mobilization and activity in situ.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Histological, flow cytometry, and single-cell RNA-sequencing (scRNA-seq) analyses revealed a rapid accumulation of diverse B-cell subsets in infarcted murine hearts, paralleled by mild clonal expansion of germinal centre B cells in the mediastinal lymph nodes. The repertoire of cardiac B cells was largely polyclonal and showed no sign of antigen-driven clonal expansion. Instead, it included a distinct subset exclusively found in the heart, herein termed \u2018heart-associated B cells\u2019 (hB) that expressed high levels of Cd69 as an activation marker, C-C-chemokine receptor type 7 (Ccr7), CXC-chemokine receptor type 5 (Cxcr5), and transforming growth factor beta 1 (Tgfb1). This distinct signature was not shared with any other cell population in the healing myocardium. Moreover, we detected a myocardial gradient of CXC-motif chemokine ligand 13 (CXCL13, the ligand of CXCR5) on Days 1 and 5 post-MI. When compared with wild-type controls, mice treated with a neutralizing CXCL13-specific antibody as well as CXCR5-deficient mice showed reduced post-MI infiltration of B cells and reduced local Tgfb1 expression but no differences in contractile function nor myocardial morphology were observed between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our study reveals that polyclonal B cells showing no sign of antigen-specificity readily infiltrate the heart after MI via the CXCL13-CXCR5 axis and contribute to local TGF-\u00df1 production. The local B-cell responses are paralleled by mild antigen-driven germinal centre reactions in the mediastinal lymph nodes that might ultimately lead to the production of specific antibodies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvab181","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T21:47:58Z","timestamp":1622152078000},"source":"Crossref","is-referenced-by-count":34,"title":["The healing myocardium mobilizes a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism"],"prefix":"10.1093","author":[{"given":"Margarete","family":"Heinrichs","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078 W\u00fcrzburg, Germany"},{"name":"Comprehensive Heart Failure Centre, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DiyaaElDin","family":"Ashour","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078 W\u00fcrzburg, Germany"},{"name":"Comprehensive Heart Failure Centre, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Siegel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078 W\u00fcrzburg, Germany"},{"name":"Comprehensive Heart Failure Centre, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotte","family":"B\u00fcchner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078 W\u00fcrzburg, Germany"},{"name":"Comprehensive Heart Failure Centre, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1145-5129","authenticated-orcid":false,"given":"Georg","family":"Wedekind","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078 W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2372-6800","authenticated-orcid":false,"given":"Katrin G","family":"Heinze","sequence":"additional","affiliation":[{"name":"Rudolf Virchow Centre for Integrative and Translational Bioimaging, University of W\u00fcrzburg, Am Schwarzenberg 15, 97078, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7925-8984","authenticated-orcid":false,"given":"Panagiota","family":"Arampatzi","sequence":"additional","affiliation":[{"name":"Core Unit Systems Medicine, University of W\u00fcrzburg, Am Schwarzenberg 15, 97078, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine-Emmanuel","family":"Saliba","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Am Schwarzenberg 15, 97078, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-1745","authenticated-orcid":false,"given":"Clement","family":"Cochain","sequence":"additional","affiliation":[{"name":"Comprehensive Heart Failure Centre, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078, W\u00fcrzburg, Germany"},{"name":"Institute of Experimental Biomedicine, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078 W\u00fcrzburg, Germany"},{"name":"Comprehensive Heart Failure Centre, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-6185","authenticated-orcid":false,"given":"Stefan","family":"Frantz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078 W\u00fcrzburg, Germany"},{"name":"Comprehensive Heart Failure Centre, University Hospital W\u00fcrzburg, Am Schwarzenberg 15, 97078, W\u00fcrzburg, 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