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Here, we show through parallel clinical and integrative preclinical studies the significance of the protease cathepsin-L on cardiac function during reperfusion injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We found that direct cardiac release of cathepsin-L in STEMI patients (n\u2009=\u200976) immediately post-PPCI leads to elevated serum cathepsin-L levels and that serum levels of cathepsin-L in the first 24\u2009h post-reperfusion are associated with reduced cardiac contractile function and increased infarct size. Preclinical studies demonstrate that inhibition of cathepsin-L release following reperfusion injury with CAA0225 reduces infarct size and improves cardiac contractile function by limiting abnormal cardiomyocyte calcium handling and apoptosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that cathepsin-L is a novel therapeutic target that could be exploited clinically to counteract the deleterious effects of acute reperfusion injury after an acute STEMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvab204","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T15:11:21Z","timestamp":1623683481000},"page":"1535-1547","source":"Crossref","is-referenced-by-count":15,"title":["Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4712-1777","authenticated-orcid":false,"given":"Weihong","family":"He","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, Glasgow Cardiovascular Research Centre, University of Glasgow, University Place, Glasgow G12 8TA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte S","family":"McCarroll","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, Glasgow Cardiovascular Research Centre, University of Glasgow, University Place, Glasgow G12 8TA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Nather","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life 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