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Although best understood following cardiac transplantation, similar forms of allograft vasculopathy occur in other vascularized organ grafts and some features of CAV may be shared with other immune-mediated vasculopathies. Here, we describe the incidence and diagnosis, the nature of the vascular remodelling, immune and non-immune contributions to pathogenesis, current therapies, and future areas of research in CAV.<\/jats:p>","DOI":"10.1093\/cvr\/cvab259","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T11:13:55Z","timestamp":1627643635000},"source":"Crossref","is-referenced-by-count":47,"title":["Cardiac allograft vasculopathy: current review and future research directions"],"prefix":"10.1093","author":[{"given":"Jordan S","family":"Pober","sequence":"first","affiliation":[{"name":"Department of Immunobiology, Pathology and Dermatology, Yale School of Medicine, 10 Amistad Street, New Haven CT 06520-8089, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Chih","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-3172","authenticated-orcid":false,"given":"Jon","family":"Kobashigawa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joren C","family":"Madsen","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery and Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-8190","authenticated-orcid":false,"given":"George","family":"Tellides","sequence":"additional","affiliation":[{"name":"Department of Surgery (Cardiac Surgery), Yale School of Medicine, New Haven, CT, 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