{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:36:52Z","timestamp":1784266612906,"version":"3.55.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL078825"],"award-info":[{"award-number":["P01 HL078825"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 HL113530"],"award-info":[{"award-number":["UM1 HL113530"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cardiovascular Cell Therapy Research Network","award":["UM1 HL087318"],"award-info":[{"award-number":["UM1 HL087318"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Exogenous cell-based therapy has emerged as a promising new strategy to facilitate repair of hearts damaged by acute or chronic injury. However, the field of cell-based therapy is handicapped by the lack of standardized definitions and terminology, making comparisons across studies challenging. Even the term \u2018stem cell therapy\u2019 is misleading because only a small percentage of cells derived from adult bone marrow, peripheral blood, or adipose tissue meets the accepted haematopoietic or developmental definition of stem cells. Furthermore, cells (stem or otherwise) are dynamic biological products, meaning that their surface-marker expression, phenotypic and functional characteristics, and the products they secrete in response to their microenvironment can change. It is also important to point out that most surface markers are seldom specific for a cell type. In this article, we discuss the lack of consistency in the descriptive terminology used in cell-based therapies and offer guidelines aimed at standardizing nomenclature and definitions to improve communication among investigators and the general public.<\/jats:p>","DOI":"10.1093\/cvr\/cvab270","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T03:11:39Z","timestamp":1628651499000},"page":"2428-2436","source":"Crossref","is-referenced-by-count":8,"title":["Recommendations for nomenclature and definition of cell products intended for human cardiovascular use"],"prefix":"10.1093","volume":"118","author":[{"given":"Doris A","family":"Taylor","sequence":"first","affiliation":[{"name":"Regenerative Medicine Research, Texas Heart Institute , 6770 Bertner Ave, Houston, TX 77030 , USA"},{"name":"RegenMedix Consulting LLC , 1301 McKinney St. STE 3700, Houston, TX 77010 , 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson C","family":"Perin","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Research, Texas Heart Institute , 6770 Bertner Ave, Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda C P","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Research, Texas Heart Institute , 6770 Bertner Ave, Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1123-0533","authenticated-orcid":false,"given":"Timothy D","family":"Henry","sequence":"additional","affiliation":[{"name":"The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital , Cincinnati, 2123 Auburn Ave #424, Cincinnati, OH 45219 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2108-0252","authenticated-orcid":false,"given":"Jay H","family":"Traverse","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, and University of Minnesota School of Medicine , 800 E 28th St, Minneapolis, MN 55407 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J","family":"Pepine","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Florida College of Medicine , 1600 SW Archer Road, Gainesville, FL 32610 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7751-5032","authenticated-orcid":false,"given":"Joshua M","family":"Hare","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami School of Medicine , 1475 NW 12th Ave, Miami, FL 33136 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Murphy","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine , 340 W 10th St, Indianapolis, IN 46202 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip C","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiovascular Medicine), Stanford University School of Medicine , 300 Pasteur Drive #H2157, Stanford, CA 94305 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-0379","authenticated-orcid":false,"given":"Keith L","family":"March","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Florida College of Medicine , 1600 SW Archer Road, Gainesville, FL 32610 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel W","family":"Vojvodic","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston School of Public Health , 7000 Fannin St. #1200, Houston, TX 77030 , 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