{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:27:35Z","timestamp":1792445255912,"version":"4.5.0"},"reference-count":205,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL136431"],"award-info":[{"award-number":["R01HL136431"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL147095"],"award-info":[{"award-number":["R01HL147095"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL141917 to E.A."],"award-info":[{"award-number":["R01HL141917 to E.A."]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Calcific aortic valve disease (CAVD), and its clinical manifestation that is calcific aortic valve stenosis, is the leading cause for valve disease within the developed world, with no current pharmacological treatment available to delay or halt its progression. Characterized by progressive fibrotic remodelling and subsequent pathogenic mineralization of the valve leaflets, valve disease affects 2.5% of the western population, thus highlighting the need for urgent intervention. Whilst the pathobiology of valve disease is complex, involving genetic factors, lipid infiltration, and oxidative damage, the immune system is now being accepted to play a crucial role in pathogenesis and disease continuation. No longer considered a passive degenerative disease, CAVD is understood to be an active inflammatory process, involving a multitude of pro-inflammatory mechanisms, with both the adaptive and the innate immune system underpinning these complex mechanisms. Within the valve, 15% of cells evolve from haemopoietic origin, and this number greatly expands following inflammation, as macrophages, T lymphocytes, B lymphocytes, and innate immune cells infiltrate the valve, promoting further inflammation. Whether chronic immune infiltration or pathogenic clonal expansion of immune cells within the valve or a combination of the two is responsible for disease progression, it is clear that greater understanding of the immune systems role in valve disease is required to inform future treatment strategies for control of CAVD development.<\/jats:p>","DOI":"10.1093\/cvr\/cvab273","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T19:12:46Z","timestamp":1629486766000},"source":"Crossref","is-referenced-by-count":51,"title":["Innate and adaptive immunity: the understudied driving force of heart valve disease"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7436-3873","authenticated-orcid":false,"given":"Francesca","family":"Bartoli-Leonard","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2543-9576","authenticated-orcid":false,"given":"Jonas","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7835-2135","authenticated-orcid":false,"given":"Elena","family":"Aikawa","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Center for Excellence in Vascular Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Human Pathology, Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"2021090917145860400_cvab273-B1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"2021090917145860400_cvab273-B2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4065\/mcp.2009.0706","article-title":"Valvular heart disease: diagnosis and management","volume":"85","author":"Maganti","year":"2010","journal-title":"Mayo Clin Proc"},{"key":"2021090917145860400_cvab273-B3","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1161\/CIRCOUTCOMES.112.966002","article-title":"Five-year clinical and economic outcomes among patients with medically managed severe aortic stenosis: results from a Medicare claims analysis","volume":"5","author":"Clark","year":"2012","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2021090917145860400_cvab273-B4","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/CIRCULATIONAHA.110.006767","article-title":"Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: calcific aortic valve disease-2011 update","volume":"124","author":"Rajamannan","year":"2011","journal-title":"Circulation"},{"key":"2021090917145860400_cvab273-B5","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1161\/ATVBAHA.114.302523","article-title":"Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease","volume":"34","author":"Yutzey","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B6","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1161\/CIRCULATIONAHA.104.486738","article-title":"Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies","volume":"111","author":"Freeman","year":"2005","journal-title":"Circulation"},{"key":"2021090917145860400_cvab273-B7","doi-asserted-by":"crossref","first-page":"100193","DOI":"10.1074\/jbc.RA120.015700","article-title":"ApoC-III is a novel inducer of calcification in human aortic valves","volume":"296","author":"Schlotter","year":"2021","journal-title":"J Biol Chem"},{"key":"2021090917145860400_cvab273-B8","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.1038\/nrdp.2016.6","article-title":"Calcific aortic stenosis","volume":"2","author":"Lindman","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2021090917145860400_cvab273-B9","doi-asserted-by":"crossref","first-page":"196037","DOI":"10.1155\/2012\/196037","article-title":"Bicuspid aortic valve disease: a Comprehensive Review","volume":"2012","author":"Mordi","year":"2012","journal-title":"Cardiol Res Pract"},{"key":"2021090917145860400_cvab273-B10","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0140-6736(11)61171-9","article-title":"Rheumatic heart disease","volume":"379","author":"Marijon","year":"2012","journal-title":"Lancet"},{"key":"2021090917145860400_cvab273-B11","doi-asserted-by":"crossref","first-page":"15084","DOI":"10.1038\/nrdp.2015.84","article-title":"Acute rheumatic fever and rheumatic heart disease","volume":"2","author":"Carapetis","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2021090917145860400_cvab273-B12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.atherosclerosis.2014.11.024","article-title":"The interdependence between cardiovascular calcifications in different arterial beds and vascular risk factors in patients at high cardiovascular risk","volume":"238","author":"Takx","year":"2015","journal-title":"Atherosclerosis"},{"key":"2021090917145860400_cvab273-B13","first-page":"290","article-title":"Age-related changes in the aortic valve affect leaflet stress distributions: implications for aortic valve degeneration","volume":"17","author":"Singh","year":"2008","journal-title":"J Heart Valve Dis"},{"key":"2021090917145860400_cvab273-B14","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1016\/j.ajpath.2013.01.037","article-title":"Side-specific endothelial-dependent regulation of aortic valve calcification: interplay of hemodynamics and nitric oxide signaling","volume":"182","author":"Richards","year":"2013","journal-title":"Am J Pathol"},{"key":"2021090917145860400_cvab273-B15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.atherosclerosis.2015.07.008","article-title":"Valvular interstitial cells suppress calcification of valvular endothelial cells","volume":"242","author":"Hjortnaes","year":"2015","journal-title":"Atherosclerosis"},{"key":"2021090917145860400_cvab273-B16","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1089\/ten.2006.12.905","article-title":"Valvular endothelial cells regulate the phenotype of interstitial cells in co-culture: effects of steady shear stress","volume":"12","author":"Butcher","year":"2006","journal-title":"Tissue Eng"},{"key":"2021090917145860400_cvab273-B17","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1089\/ars.2015.6554","article-title":"Shear-sensitive genes in aortic valve endothelium","volume":"25","author":"Fern\u00e1ndez Esmerats","year":"2016","journal-title":"Antioxid Redox Signal"},{"key":"2021090917145860400_cvab273-B18","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1152\/physrev.1995.75.3.519","article-title":"Flow-mediated endothelial mechanotransduction","volume":"75","author":"Davies","year":"1995","journal-title":"Physiol Rev"},{"key":"2021090917145860400_cvab273-B19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fcvm.2016.00044","article-title":"Quantification of calcified particles in human valve tissue reveals asymmetry of calcific aortic valve disease development","volume":"3","author":"Yabusaki","year":"2016","journal-title":"Front Cardiovasc Med"},{"key":"2021090917145860400_cvab273-B20","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2174\/1574888X09666140213154144","article-title":"The endothelial-mesenchymal transition (EndMT) and tissue regeneration","volume":"9","author":"Yu","year":"2014","journal-title":"Curr Stem Cell Res Ther"},{"key":"2021090917145860400_cvab273-B21","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jacc.2018.09.089","article-title":"Endothelial to mesenchymal transition in cardiovascular disease: JACC State-of-the-Art Review","volume":"73","author":"Kovacic","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2021090917145860400_cvab273-B22","doi-asserted-by":"crossref","first-page":"19943","DOI":"10.1073\/pnas.1106954108","article-title":"Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve","volume":"108","author":"Balachandran","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021090917145860400_cvab273-B23","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1161\/01.RES.0000245188.41002.2c","article-title":"Human pulmonary valve progenitor cells exhibit endothelial\/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2","volume":"99","author":"Paruchuri","year":"2006","journal-title":"Circ Res"},{"key":"2021090917145860400_cvab273-B24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1161\/ATVBAHA.112.300504","article-title":"Inflammatory cytokines promote mesenchymal transformation in embryonic and adult valve endothelial cells","volume":"33","author":"Mahler","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B25","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.cyto.2019.01.009","article-title":"Differential expression patterns of Toll like receptors and Interleukin-37 between calcific aortic and mitral valve cusps in humans","volume":"116","author":"Kapelouzou","year":"2019","journal-title":"Cytokine"},{"key":"2021090917145860400_cvab273-B26","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jacc.2008.09.052","article-title":"Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2","volume":"53","author":"Fullerton","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2021090917145860400_cvab273-B27","doi-asserted-by":"crossref","first-page":"C29","DOI":"10.1152\/ajpcell.00137.2007","article-title":"Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis","volume":"294","author":"Meng","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"2021090917145860400_cvab273-B28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ijcard.2010.12.089","article-title":"Viral and bacterial patterns induce TLR-mediated sustained inflammation and calcification in aortic valve interstitial cells","volume":"158","author":"L\u00f3pez","year":"2012","journal-title":"Int J Cardiol"},{"key":"2021090917145860400_cvab273-B29","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jacc.2008.09.052","article-title":"Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2","volume":"53","author":"Yang","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2021090917145860400_cvab273-B30","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1093\/cvr\/cvaa134","article-title":"Loss of SIRT1 in diabetes accelerates DNA damage-induced vascular calcification","volume":"117","author":"Bartoli-Leonard","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2021090917145860400_cvab273-B31","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1161\/ATVBAHA.112.300177","article-title":"Antioxidant enzymes reduce DNA damage and early activation of valvular interstitial cells in aortic valve sclerosis","volume":"33","author":"Branchetti","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B32","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1161\/ATVBAHA.116.308615","article-title":"Biomarkers of calcific aortic valve disease","volume":"37","author":"Small","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B33","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/HCO.0000000000000300","article-title":"Lipoprotein(a) and oxidized phospholipids in calcific aortic valve stenosis","volume":"31","author":"Yeang","year":"2016","journal-title":"Curr Opin Cardiol"},{"key":"2021090917145860400_cvab273-B34","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa1109034","article-title":"Genetic associations with valvular calcification and aortic stenosis","volume":"368","author":"Thanassoulis","year":"2013","journal-title":"N Engl J Med"},{"key":"2021090917145860400_cvab273-B35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10558-009-9089-9","article-title":"Hemodynamic environments from opposing sides of human aortic valve leaflets evoke distinct endothelial phenotypes in vitro","volume":"10","author":"Weinberg","year":"2010","journal-title":"Cardiovasc Eng"},{"key":"2021090917145860400_cvab273-B36","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1161\/CIRCULATIONAHA.117.032291","article-title":"Spatiotemporal multi-omics mapping generates a molecular atlas of the aortic valve and reveals networks driving disease","volume":"138","author":"Schlotter","year":"2018","journal-title":"Circulation"},{"key":"2021090917145860400_cvab273-B37","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijcard.2019.04.063","article-title":"Circulating cytokines predict severity of rheumatic heart disease","volume":"289","author":"Diamantino Soares","year":"2019","journal-title":"Int J Cardiol"},{"key":"2021090917145860400_cvab273-B38","doi-asserted-by":"crossref","first-page":"761","DOI":"10.21037\/atm-20-4463","article-title":"Antibody microarray analysis of serum inflammatory cytokines in patients with calcific aortic valve disease","volume":"8","author":"Fu","year":"2020","journal-title":"Ann Transl Med"},{"key":"2021090917145860400_cvab273-B39","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/S0002-9440(10)63415-3","article-title":"Rheumatic heart disease: proinflammatory cytokines play a role in the progression and maintenance of valvular lesions","volume":"165","author":"Guilherme","year":"2004","journal-title":"Am J Pathol"},{"key":"2021090917145860400_cvab273-B40","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1515\/cclm-2013-0606","article-title":"Interleukin-6 receptor Asp358Ala gene polymorphism is associated with plasma C-reactive protein levels and severity of aortic valve stenosis","volume":"52","author":"Wypasek","year":"2014","journal-title":"Clin Chem Lab Med"},{"key":"2021090917145860400_cvab273-B41","doi-asserted-by":"crossref","first-page":"875363","DOI":"10.1155\/2013\/875363","article-title":"The role of TNF-\u03b1 and TNF superfamily members in the pathogenesis of calcific aortic valvular disease","volume":"2013","author":"Galeone","year":"2013","journal-title":"Sci World J"},{"key":"2021090917145860400_cvab273-B42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ijcard.2013.09.012","article-title":"Aortic valvular interstitial cells apoptosis and calcification are mediated by TNF-related apoptosis-inducing ligand","volume":"169","author":"Galeone","year":"2013","journal-title":"Int J Cardiol"},{"key":"2021090917145860400_cvab273-B43","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0003-4975(02)04312-6","article-title":"Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis","volume":"75","author":"Jian","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"2021090917145860400_cvab273-B44","doi-asserted-by":"crossref","first-page":"e003688","DOI":"10.1161\/CIRCHEARTFAILURE.116.003688","article-title":"Activated T lymphocytes are essential drivers of pathological remodeling in ischemic heart failure","volume":"10","author":"Bansal","year":"2017","journal-title":"Circ Heart Fail"},{"key":"2021090917145860400_cvab273-B45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jjcc.2017.11.007","article-title":"Mechanisms of aortic stenosis","volume":"71","author":"Akahori","year":"2018","journal-title":"J Cardiol"},{"key":"2021090917145860400_cvab273-B46","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.yjmcc.2014.02.014","article-title":"P2Y2 receptor represses IL-6 expression by valve interstitial cells through Akt: implication for calcific aortic valve disease","volume":"72","author":"El Husseini","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"2021090917145860400_cvab273-B47","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1161\/ATVBAHA.120.314143","article-title":"A role for MMP-10 (matrix metalloproteinase-10) in calcific aortic valve stenosis","volume":"40","author":"Matilla","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B48","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1161\/ATVBAHA.109.201749","article-title":"Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in BALB\/c mice","volume":"30","author":"Isoda","year":"2010","journal-title":"ATVB"},{"key":"2021090917145860400_cvab273-B49","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1517\/14728222.12.10.1209","article-title":"Association between plasma levels and immunolocalization of cytokines in heart valve lesions: a possible target for treatment?","volume":"12","author":"Toli","year":"2008","journal-title":"Expert Opin Ther Targets"},{"key":"2021090917145860400_cvab273-B50","doi-asserted-by":"crossref","first-page":"12343","DOI":"10.18632\/oncotarget.23901","article-title":"Meta-analysis of the relationship between single nucleotide polymorphism of IL-10-1082G\/A and rheumatic heart disease","volume":"9","author":"Dai","year":"2018","journal-title":"Oncotarget"},{"key":"2021090917145860400_cvab273-B51","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1073\/pnas.1619667114","article-title":"Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice","volume":"114","author":"Zeng","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021090917145860400_cvab273-B52","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/echo.12534","article-title":"The relationship between neutrophil\/lymphocyte ratio and calcific aortic stenosis","volume":"31","author":"Avci","year":"2014","journal-title":"Echocardiography"},{"key":"2021090917145860400_cvab273-B53","doi-asserted-by":"crossref","first-page":"12010","DOI":"10.1073\/pnas.96.21.12010","article-title":"Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils","volume":"96","author":"Leitinger","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021090917145860400_cvab273-B54","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3389\/fimmu.2014.00508","article-title":"Neutrophil-derived cytokines: facts beyond expression","volume":"5","author":"Tecchio","year":"2014","journal-title":"Front Immunol"},{"key":"2021090917145860400_cvab273-B55","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1126\/science.aaa8064","article-title":"Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis","volume":"349","author":"Warnatsch","year":"2015","journal-title":"Science"},{"key":"2021090917145860400_cvab273-B56","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijcard.2019.03.047","article-title":"NETosis is associated with the severity of aortic stenosis: links with inflammation","volume":"286","author":"Kopytek","year":"2019","journal-title":"Int J Cardiol"},{"key":"2021090917145860400_cvab273-B57","doi-asserted-by":"crossref","first-page":"e018243","DOI":"10.1161\/JAHA.120.018243","article-title":"Basophil blood cell count is associated with enhanced factor II plasma coagulant activity and increased risk of mortality in patients with stable coronary artery disease: not only neutrophils as prognostic marker in ischemic heart disease","volume":"10","author":"Pizzolo","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2021090917145860400_cvab273-B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/5584_2021_640","article-title":"Eosinophils as major player in type 2 inflammation: autoimmunity and beyond","author":"Folci","year":"2021","journal-title":"Adv Exp Med Biol"},{"key":"2021090917145860400_cvab273-B59","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.atherosclerosis.2011.12.034","article-title":"Lymphangiogenesis in aortic valve stenosis\u2013novel regulatory roles for valvular myofibroblasts and mast cells","volume":"221","author":"Syv\u00e4ranta","year":"2012","journal-title":"Atherosclerosis"},{"key":"2021090917145860400_cvab273-B60","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.it.2020.06.006","article-title":"Cardiac mast cells: underappreciated immune cells in cardiovascular homeostasis and disease","volume":"41","author":"Varricchi","year":"2020","journal-title":"Trends Immunol"},{"key":"2021090917145860400_cvab273-B61","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.jacc.2004.07.054","article-title":"Induction of local angiotensin II-producing systems in stenotic aortic valves","volume":"44","author":"Helske","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2021090917145860400_cvab273-B62","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.atherosclerosis.2012.10.055","article-title":"Angiotensin II promotes aortic valve thickening independent of elevated blood pressure in apolipoprotein-E deficient mice","volume":"226","author":"Fujisaka","year":"2013","journal-title":"Atherosclerosis"},{"key":"2021090917145860400_cvab273-B63","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10753-012-9565-z","article-title":"Mast cells in human stenotic aortic valves are associated with the severity of stenosis","volume":"36","author":"Wypasek","year":"2013","journal-title":"Inflammation"},{"key":"2021090917145860400_cvab273-B64","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.prp.2017.07.016","article-title":"Mast cells in calcific aortic stenosis","volume":"214","author":"\u0160teiner","year":"2018","journal-title":"Pathol Res Pract"},{"key":"2021090917145860400_cvab273-B65","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/ATVBAHA.109.198267","article-title":"Vascular endothelial growth factor\u2014secreting mast cells and myofibroblasts: a novel self-perpetuating angiogenic pathway in aortic valve stenosis","volume":"30","author":"Syv\u00e4ranta","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B66","doi-asserted-by":"crossref","first-page":"H141","DOI":"10.1152\/ajpheart.00100.2019","article-title":"Adaptive immune cells in calcific aortic valve disease","volume":"317","author":"Raddatz","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2021090917145860400_cvab273-B67","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1084\/jem.20082129","article-title":"Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves","volume":"206","author":"Choi","year":"2009","journal-title":"J Exp Med"},{"key":"2021090917145860400_cvab273-B68","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.3389\/fimmu.2019.02035","article-title":"Human monocyte subsets and phenotypes in major chronic inflammatory diseases","volume":"10","author":"Kapellos","year":"2019","journal-title":"Front Immunol"},{"key":"2021090917145860400_cvab273-B69","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1182\/blood.V86.3.1184.1184","article-title":"Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages","volume":"86","author":"Weinberg","year":"1995","journal-title":"Blood"},{"key":"2021090917145860400_cvab273-B70","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1161\/ATVBAHA.114.304650","article-title":"Nonclassical patrolling monocyte function in the vasculature","volume":"35","author":"Thomas","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B71","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/j.1538-7836.2011.04603.x","article-title":"The CD14++CD16+ monocyte subset and monocyte-platelet interactions in patients with ST-elevation myocardial infarction","volume":"10","author":"Tapp","year":"2012","journal-title":"J Thromb Haemost"},{"key":"2021090917145860400_cvab273-B72","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1155\/2010\/236405","article-title":"CD14CD16 monocyte subset levels in heart failure patients","volume":"28","author":"Barisione","year":"2010","journal-title":"Dis Markers"},{"key":"2021090917145860400_cvab273-B73","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12265-016-9726-9","article-title":"Severe aortic valve stenosis in adults is associated with increased levels of circulating intermediate monocytes","volume":"10","author":"Hewing","year":"2017","journal-title":"J Cardiovasc Transl Res"},{"key":"2021090917145860400_cvab273-B74","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/heart.88.4.348","article-title":"T lymphocyte infiltration in non-rheumatic aortic stenosis: a comparative descriptive study between tricuspid and bicuspid aortic valves","volume":"88","author":"Wallby","year":"2002","journal-title":"Heart"},{"key":"2021090917145860400_cvab273-B75","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1161\/CIRCULATIONAHA.106.654913","article-title":"Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease","volume":"115","author":"Aikawa","year":"2007","journal-title":"Circulation"},{"key":"2021090917145860400_cvab273-B76","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cell.2011.04.005","article-title":"Macrophages in the pathogenesis of atherosclerosis","volume":"145","author":"Moore","year":"2011","journal-title":"Cell"},{"key":"2021090917145860400_cvab273-B77","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1161\/01.CIR.90.2.844","article-title":"Characterization of the early lesion of \u2018degenerative\u2019 valvular aortic stenosis. Histological and immunohistochemical studies","volume":"90","author":"Otto","year":"1994","journal-title":"Circulation"},{"key":"2021090917145860400_cvab273-B78","doi-asserted-by":"crossref","first-page":"341308","DOI":"10.1155\/2015\/341308","article-title":"Current concept and update of the macrophage plasticity concept: intracellular mechanisms of reprogramming and M3 macrophage \u201cSwitch\u201d phenotype","volume":"2015","author":"Malyshev","year":"2015","journal-title":"BioMed Res Int"},{"key":"2021090917145860400_cvab273-B79","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3389\/fcvm.2018.00187","article-title":"Roles and regulation of extracellular vesicles in cardiovascular mineral metabolism","volume":"5","author":"Blaser","year":"2018","journal-title":"Front Cardiovasc Med"},{"key":"2021090917145860400_cvab273-B80","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1161\/ATVBAHA.118.314087","article-title":"S100A9-RAGE axis accelerates formation of macrophage-mediated extracellular vesicle microcalcification in diabetes mellitus","volume":"40","author":"Kawakami","year":"2020","journal-title":"ATVB"},{"key":"2021090917145860400_cvab273-B81","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/jcb.25088","article-title":"Oncostatin M promotes osteoblastic differentiation of human vascular smooth muscle cells through JAK3-STAT3 pathway","volume":"116","author":"Kakutani","year":"2015","journal-title":"J Cell Biochem"},{"key":"2021090917145860400_cvab273-B82","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.7150\/ijms.49533","article-title":"IL-21 promotes osteoblastic differentiation of human valvular interstitial cells through the JAK3\/STAT3 pathway","volume":"17","author":"Liu","year":"2020","journal-title":"Int J Med Sci"},{"key":"2021090917145860400_cvab273-B83","doi-asserted-by":"crossref","first-page":"154141","DOI":"10.1016\/j.cyto.2017.08.021","article-title":"CXCL4-induced macrophages in human atherosclerosis","volume":"122","author":"Domschke","year":"2019","journal-title":"Cytokine"},{"key":"2021090917145860400_cvab273-B84","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/ATVBAHA.119.312802","article-title":"Macrophages in atherosclerosis regression","volume":"40","author":"Barrett","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B85","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/MOL.0b013e3283309848","article-title":"Macrophage heterogeneity in atherosclerotic plaques","volume":"20","author":"Johnson","year":"2009","journal-title":"Curr Opin Lipidol"},{"key":"2021090917145860400_cvab273-B86","doi-asserted-by":"crossref","first-page":"472","DOI":"10.5551\/jat.No1248","article-title":"Ubiquitin-positive foam cells are identified in the aortic and mitral valves with atherosclerotic involvement","volume":"16","author":"Yamada","year":"2009","journal-title":"J Atheroscler Thromb"},{"key":"2021090917145860400_cvab273-B87","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00011-013-0667-3","article-title":"OxLDL-induced IL-1 beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation","volume":"63","author":"Liu","year":"2014","journal-title":"Inflammation Res"},{"key":"2021090917145860400_cvab273-B88","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1161\/01.ATV.16.12.1573","article-title":"Human monocytes\/macrophages release TNF-alpha in response to Ox-LDL","volume":"16","author":"Jovinge","year":"1996","journal-title":"ATVB"},{"key":"2021090917145860400_cvab273-B89","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1161\/ATVBAHA.114.303887","article-title":"Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes","volume":"34","author":"Bekkering","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B90","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0092-8674(00)81574-3","article-title":"Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma","volume":"93","author":"Nagy","year":"1998","journal-title":"Cell"},{"key":"2021090917145860400_cvab273-B91","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/CIRCRESAHA.116.310262","article-title":"Human alternative macrophages populate calcified areas of atherosclerotic lesions and display impaired RANKL-induced osteoclastic bone resorption activity","volume":"121","author":"Chinetti-Gbaguidi","year":"2017","journal-title":"Circ Res"},{"key":"2021090917145860400_cvab273-B92","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1093\/eurheartj\/ehq237","article-title":"Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation","volume":"31","author":"Hjortnaes","year":"2010","journal-title":"Eur Heart J"},{"key":"2021090917145860400_cvab273-B93","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.ajpath.2017.02.012","article-title":"Interferon-\u03b3 released by activated CD8(+) T lymphocytes impairs the calcium resorption potential of osteoclasts in calcified human aortic valves","volume":"187","author":"Nagy","year":"2017","journal-title":"Am J Pathol"},{"key":"2021090917145860400_cvab273-B94","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCRESAHA.114.302761","article-title":"Adaptive (T and B cells) immunity and control by dendritic cells in atherosclerosis","volume":"114","author":"Ait-Oufella","year":"2014","journal-title":"Circ Res"},{"key":"2021090917145860400_cvab273-B95","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1161\/CIRCULATIONAHA.114.011090","article-title":"MHC Class II\u2013restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity","volume":"130","author":"Sage","year":"2014","journal-title":"Circulation"},{"key":"2021090917145860400_cvab273-B96","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.atherosclerosis.2009.01.002","article-title":"oxLDL uptake by dendritic cells induces upregulation of scavenger-receptors, maturation and differentiation","volume":"205","author":"Nickel","year":"2009","journal-title":"Atherosclerosis"},{"key":"2021090917145860400_cvab273-B97","doi-asserted-by":"crossref","first-page":"eaaw8151","DOI":"10.1126\/scisignal.aaw8151","article-title":"CD45 functions as a signaling gatekeeper in T cells","volume":"12","author":"Courtney","year":"2019","journal-title":"Sci Signal"},{"key":"2021090917145860400_cvab273-B98","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.prp.2012.02.009","article-title":"Calcific aortic valve stenosis: immunohistochemical analysis of inflammatory infiltrate","volume":"208","author":"Steiner","year":"2012","journal-title":"Pathol Res Pract"},{"key":"2021090917145860400_cvab273-B99","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/0735-1097(94)90606-8","article-title":"Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves","volume":"23","author":"Olsson","year":"1994","journal-title":"J Am Coll Cardiol"},{"key":"2021090917145860400_cvab273-B100","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.jacc.2003.12.041","article-title":"Neoangiogenesis, T-lymphocyte infiltration, and heat shock protein-60 are biological hallmarks of an immunomediated inflammatory process in end-stage calcified aortic valve stenosis","volume":"43","author":"Mazzone","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2021090917145860400_cvab273-B101","doi-asserted-by":"crossref","first-page":"21763","DOI":"10.1074\/jbc.M501759200","article-title":"Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis","volume":"280","author":"Li","year":"2005","journal-title":"J Biol Chem"},{"key":"2021090917145860400_cvab273-B102","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1161\/01.ATV.14.7.1210","article-title":"Diversity of T-cell antigen receptor V beta gene utilization in advanced human atheroma","volume":"14","author":"Swanson","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"2021090917145860400_cvab273-B103","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1161\/01.CIR.101.25.2883","article-title":"Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes","volume":"101","author":"Liuzzo","year":"2000","journal-title":"Circulation"},{"key":"2021090917145860400_cvab273-B104","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1161\/CIRCULATIONAHA.105.537712","article-title":"Patients with acute coronary syndrome show oligoclonal T-cell recruitment within unstable plaque: evidence for a local, intracoronary immunologic mechanism","volume":"113","author":"De Palma","year":"2006","journal-title":"Circulation"},{"key":"2021090917145860400_cvab273-B105","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1073\/pnas.92.9.3893","article-title":"T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein","volume":"92","author":"Stemme","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021090917145860400_cvab273-B106","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ijcard.2009.01.022","article-title":"Increased interleukin-18 expression in nonrheumatic aortic valve stenosis","volume":"144","author":"Naito","year":"2010","journal-title":"Int J Cardiol"},{"key":"2021090917145860400_cvab273-B107","doi-asserted-by":"crossref","first-page":"e296","DOI":"10.1161\/ATVBAHA.120.315261","article-title":"Secreted factors from proinflammatory macrophages promote an osteoblast-like phenotype in valvular interstitial cells","volume":"40","author":"Grim","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B108","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s12026-017-8978-z","article-title":"T cell subsets: an integral component in pathogenesis of rheumatic heart disease","volume":"66","author":"Toor","year":"2018","journal-title":"Immunol Res"},{"key":"2021090917145860400_cvab273-B109","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nri.2017.118","article-title":"T(H)2 cell development and function","volume":"18","author":"Walker","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"2021090917145860400_cvab273-B110","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jjcc.2019.06.011","article-title":"IL-33 promotes the progression of nonrheumatic aortic valve stenosis via inducing differential phenotypic transition in valvular interstitial cells","volume":"75","author":"He","year":"2020","journal-title":"J Cardiol"},{"key":"2021090917145860400_cvab273-B111","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1084\/jem.20071868","article-title":"IL-33 reduces the development of atherosclerosis","volume":"205","author":"Miller","year":"2008","journal-title":"J Exp Med"},{"key":"2021090917145860400_cvab273-B112","doi-asserted-by":"crossref","first-page":"i101","DOI":"10.1136\/annrheumdis-2011-200589","article-title":"IL-33: a Janus cytokine","volume":"71 (Suppl. 2","author":"Liew","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"2021090917145860400_cvab273-B113","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1161\/HYPERTENSIONAHA.109.145094","article-title":"Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction","volume":"55","author":"Madhur","year":"2010","journal-title":"Hypertension"},{"key":"2021090917145860400_cvab273-B114","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/path.4133","article-title":"Macrophage plasticity and polarization in tissue repair and remodelling","volume":"229","author":"Mantovani","year":"2013","journal-title":"J Pathol"},{"key":"2021090917145860400_cvab273-B115","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1161\/CIRCULATIONAHA.117.030414","article-title":"Proteomic biomarkers for incident aortic stenosis requiring valvular replacement","volume":"138","author":"Ljungberg","year":"2018","journal-title":"Circulation"},{"key":"2021090917145860400_cvab273-B116","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/01.hdx.0000089834.97829.5e","article-title":"Valvular heart disease and systemic lupus erythematosus: therapeutic implications","volume":"5","author":"Fluture","year":"2003","journal-title":"Heart Dis"},{"key":"2021090917145860400_cvab273-B117","doi-asserted-by":"crossref","first-page":"12885","DOI":"10.1073\/pnas.0812530106","article-title":"IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells","volume":"106","author":"Elyaman","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021090917145860400_cvab273-B118","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-020-0352-5","article-title":"T cell subsets and functions in atherosclerosis","volume":"17","author":"Saigusa","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"2021090917145860400_cvab273-B119","doi-asserted-by":"crossref","first-page":"635672","DOI":"10.1155\/2013\/635672","article-title":"Circulating Th22 and Th9 levels in patients with acute coronary syndrome","volume":"2013","author":"Lin","year":"2013","journal-title":"Mediators Inflammation"},{"key":"2021090917145860400_cvab273-B120","doi-asserted-by":"crossref","first-page":"5697149","DOI":"10.1155\/2018\/5697149","article-title":"Circulating Th1, Th2, Th9, Th17, Th22, and Treg levels in aortic dissection patients","volume":"2018","author":"Ye","year":"2018","journal-title":"Mediators Inflammation"},{"key":"2021090917145860400_cvab273-B121","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/cvr\/cvv110","article-title":"IL-9 aggravates the development of atherosclerosis in ApoE-\/- mice","volume":"106","author":"Zhang","year":"2015","journal-title":"Cardiovasc Res"},{"key":"2021090917145860400_cvab273-B122","doi-asserted-by":"crossref","first-page":"e71466","DOI":"10.1371\/journal.pone.0071466","article-title":"Elevated frequencies of circulating Th22 cell in addition to Th17 cell and Th17\/Th1 cell in patients with acute coronary syndrome","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"2021090917145860400_cvab273-B123","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1111\/jcmm.14967","article-title":"IL-22 produced by Th22 cells aggravates atherosclerosis development in ApoE\u2212\/\u2212 mice by enhancing DC-induced Th17 cell proliferation","volume":"24","author":"Shi","year":"2020","journal-title":"J Cell Mol Med"},{"key":"2021090917145860400_cvab273-B124","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cca.2017.10.033","article-title":"Increased levels of interleukin-22 in thoracic aorta and plasma from patients with acute thoracic aortic dissection","volume":"486","author":"Ye","year":"2018","journal-title":"Clin Chim Acta"},{"key":"2021090917145860400_cvab273-B125","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.immuni.2018.09.011","article-title":"An interleukin-23-interleukin-22 axis regulates intestinal microbial homeostasis to protect from diet-induced atherosclerosis","volume":"49","author":"Fatkhullina","year":"2018","journal-title":"Immunity"},{"key":"2021090917145860400_cvab273-B126","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1182\/blood-2004-11-4494","article-title":"Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help","volume":"106","author":"Hardtke","year":"2005","journal-title":"Blood"},{"key":"2021090917145860400_cvab273-B127","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/eji.201545760","article-title":"T follicular helper (Tfh) cells in lupus: activation and involvement in SLE pathogenesis","volume":"46","author":"Blanco","year":"2016","journal-title":"Eur J Immunol"},{"key":"2021090917145860400_cvab273-B128","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.3389\/fimmu.2019.02709","article-title":"T-follicular regulatory cells: potential therapeutic targets in rheumatoid arthritis","volume":"10","author":"Ding","year":"2019","journal-title":"Front Immunol"},{"key":"2021090917145860400_cvab273-B129","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/s41467-018-03493-5","article-title":"Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis","volume":"9","author":"Gaddis","year":"2018","journal-title":"Nat Commun"},{"key":"2021090917145860400_cvab273-B130","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1161\/ATVBAHA.117.310678","article-title":"Follicular B cells promote atherosclerosis via T cell\u2013mediated differentiation into plasma cells and secreting pathogenic immunoglobulin G","volume":"38","author":"Tay","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B131","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/sj.embor.7401099","article-title":"Interleukin 2: from immunostimulation to immunoregulation and back again","volume":"8","author":"Bachmann","year":"2007","journal-title":"EMBO Rep"},{"key":"2021090917145860400_cvab273-B132","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3389\/fimmu.2017.00195","article-title":"Expansions of cytotoxic CD4(+)CD28(-) T cells drive excess cardiovascular mortality in rheumatoid arthritis and other chronic inflammatory conditions and are triggered by CMV infection","volume":"8","author":"Broadley","year":"2017","journal-title":"Front Immunol"},{"key":"2021090917145860400_cvab273-B133","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1161\/CIRCRESAHA.111.261933","article-title":"High levels of costimulatory receptors OX40 and 4-1BB characterize CD4+CD28null T cells in patients with acute coronary syndrome","volume":"110","author":"Dumitriu","year":"2012","journal-title":"Circ Res"},{"key":"2021090917145860400_cvab273-B134","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3109\/07853890.2015.1059955","article-title":"MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease","volume":"47","author":"Ohukainen","year":"2015","journal-title":"Ann Med"},{"key":"2021090917145860400_cvab273-B135","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/CIRCULATIONAHA.114.013710","article-title":"Proteasome-mediated reduction in proapoptotic molecule Bim renders CD4+CD28null T cells resistant to apoptosis in acute coronary syndrome","volume":"131","author":"Kovalcsik","year":"2015","journal-title":"Circulation"},{"key":"2021090917145860400_cvab273-B136","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/cvr\/cvq211","article-title":"OX40 ligand plays an important role in the development of atherosclerosis through vasa vasorum neovascularization","volume":"88","author":"Nakano","year":"2010","journal-title":"Cardiovasc Res"},{"key":"2021090917145860400_cvab273-B137","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1161\/01.ATV.0000029720.59649.50","article-title":"Role of heat shock proteins in atherosclerosis","volume":"22","author":"Xu","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B138","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.3389\/fimmu.2018.01869","article-title":"Natural killer cells: development, maturation, and clinical utilization","volume":"9","author":"Abel","year":"2018","journal-title":"Front Immunol"},{"key":"2021090917145860400_cvab273-B139","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1177\/039463200902200406","article-title":"Beta glycosphingolipids suppress rank expression and inhibit natural killer T cell and CD8+ accumulation in alleviating aortic valve calcification","volume":"22","author":"Shuvy","year":"2009","journal-title":"Int J Immunopathol Pharmacol"},{"key":"2021090917145860400_cvab273-B140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carpath.2018.03.004","article-title":"Lymphocyte and monocyte subpopulations in severe aortic stenosis at the time of surgical intervention","volume":"35","author":"Mazur","year":"2018","journal-title":"Cardiovasc Pathol"},{"key":"2021090917145860400_cvab273-B141","doi-asserted-by":"crossref","first-page":"e109416","DOI":"10.1371\/journal.pone.0109416","article-title":"\u03b3\u03b4T cells are prevalent in the proximal aorta and drive nascent atherosclerotic lesion progression and neutrophilia in hypercholesterolemic mice","volume":"9","author":"Vu","year":"2014","journal-title":"Plos One"},{"key":"2021090917145860400_cvab273-B142","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.atherosclerosis.2014.03.007","article-title":"Gammadelta (\u03b3\u03b4) T lymphocytes do not impact the development of early atherosclerosis","volume":"234","author":"Cheng","year":"2014","journal-title":"Atherosclerosis"},{"key":"2021090917145860400_cvab273-B143","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1161\/CIRCULATIONAHA.116.027058","article-title":"\u03b3\u03b4 T cells mediate angiotensin II-induced hypertension and vascular injury","volume":"135","author":"Caillon","year":"2017","journal-title":"Circulation"},{"key":"2021090917145860400_cvab273-B144","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrcardio.2015.169","article-title":"Regulatory T cells in cardiovascular diseases","volume":"13","author":"Meng","year":"2016","journal-title":"Nat Rev Cardiol"},{"key":"2021090917145860400_cvab273-B145","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijcard.2016.05.039","article-title":"Circulating regulatory T cells in patients with aortic valve stenosis: association with disease progression and aortic valve intervention","volume":"218","author":"Shimoni","year":"2016","journal-title":"Int J Cardiol"},{"key":"2021090917145860400_cvab273-B146","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3389\/fgene.2019.00604","article-title":"CD73 rather than CD39 is mainly involved in controlling purinergic signaling in calcified aortic valve disease","volume":"10","author":"Kudryavtsev","year":"2019","journal-title":"Front Genet"},{"key":"2021090917145860400_cvab273-B147","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/CIRCRESAHA.119.316461","article-title":"Regulatory T cells license macrophage pro-resolving functions during atherosclerosis regression","volume":"127","author":"Sharma","year":"2020","journal-title":"Circ Res"},{"key":"2021090917145860400_cvab273-B148","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/ATVBAHA.114.303568","article-title":"Treating atherosclerosis with regulatory T cells","volume":"35","author":"Foks","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B149","doi-asserted-by":"crossref","first-page":"E4002","DOI":"10.1073\/pnas.1524845114","article-title":"SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors","volume":"114","author":"Taracanova","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021090917145860400_cvab273-B150","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/all.12143","article-title":"IgE-mediated basophil tumour necrosis factor alpha induces matrix metalloproteinase-9 from monocytes","volume":"68","author":"Falkencrone","year":"2013","journal-title":"Allergy"},{"key":"2021090917145860400_cvab273-B151","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1161\/ATVBAHA.119.313744","article-title":"IgE contributes to atherosclerosis and obesity by affecting macrophage polarization, macrophage protein network, and foam cell formation","volume":"40","author":"Zhang","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B152","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nri3839","article-title":"Perforin and granzymes: function, dysfunction and human pathology","volume":"15","author":"Voskoboinik","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"2021090917145860400_cvab273-B153","doi-asserted-by":"crossref","first-page":"726","DOI":"10.4049\/jimmunol.1600253","article-title":"Osteoclast-primed Foxp3+ CD8 T cells induce T-bet, eomesodermin, and IFN-\u03b3 to regulate bone resorption","volume":"197","author":"Shashkova","year":"2016","journal-title":"J Immunol"},{"key":"2021090917145860400_cvab273-B154","doi-asserted-by":"crossref","first-page":"5329","DOI":"10.4049\/jimmunol.178.8.5329","article-title":"The lymphocytic infiltration in calcific aortic stenosis predominantly consists of clonally expanded T cells","volume":"178","author":"Wu","year":"2007","journal-title":"J Immunol"},{"key":"2021090917145860400_cvab273-B155","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.4049\/jimmunol.1003521","article-title":"Circulating activated and effector memory T cells are associated with calcification and clonal expansions in bicuspid and tricuspid valves of calcific aortic stenosis","volume":"187","author":"Winchester","year":"2011","journal-title":"J Immunol"},{"key":"2021090917145860400_cvab273-B156","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.it.2009.03.013","article-title":"CD28-T cells: their role in the age-associated decline of immune function","volume":"30","author":"Weng","year":"2009","journal-title":"Trends Immunol"},{"key":"2021090917145860400_cvab273-B157","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1084\/jem.20100155","article-title":"B cell depletion reduces the development of atherosclerosis in mice","volume":"207","author":"Ait-Oufella","year":"2010","journal-title":"J Exp Med"},{"key":"2021090917145860400_cvab273-B158","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1084\/jem.20101499","article-title":"Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70","volume":"208","author":"Griffin","year":"2011","journal-title":"J Exp Med"},{"key":"2021090917145860400_cvab273-B159","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1161\/CIRCRESAHA.117.306044","article-title":"B-1b cells secrete atheroprotective IgM and attenuate atherosclerosis","volume":"117","author":"Rosenfeld","year":"2015","journal-title":"Circ Res"},{"key":"2021090917145860400_cvab273-B160","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fimmu.2012.00373","article-title":"B cell subsets in atherosclerosis","volume":"3","author":"Perry","year":"2012","journal-title":"Front Immunol"},{"key":"2021090917145860400_cvab273-B161","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jjcc.2015.05.002","article-title":"Presence of B cells within aortic valves in patients with aortic stenosis: relation to severity of the disease","volume":"67","author":"Natorska","year":"2016","journal-title":"J Cardiol"},{"key":"2021090917145860400_cvab273-B162","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","author":"Jaiswal","year":"2014","journal-title":"N Engl J Med"},{"key":"2021090917145860400_cvab273-B163","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1701719","article-title":"Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease","volume":"377","author":"Jaiswal","year":"2017","journal-title":"N Engl J Med"},{"key":"2021090917145860400_cvab273-B164","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/eurheartj\/ehz591","article-title":"Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation","volume":"41","author":"Mas-Peiro","year":"2020","journal-title":"Eur Heart J"},{"key":"2021090917145860400_cvab273-B165","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.cell.2021.01.049","article-title":"Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis","volume":"184","author":"Heyde","year":"2021","journal-title":"Cell"},{"key":"2021090917145860400_cvab273-B166","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1126\/science.aag1381","article-title":"Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice","volume":"355","author":"Fuster","year":"2017","journal-title":"Science"},{"key":"2021090917145860400_cvab273-B167","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/CIRCRESAHA.118.313225","article-title":"CRISPR-mediated gene editing to assess the roles of Tet2 and Dnmt3a in clonal hematopoiesis and cardiovascular disease","volume":"123","author":"Sano","year":"2018","journal-title":"Circ Res"},{"key":"2021090917145860400_cvab273-B168","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/CIRCRESAHA.117.312115","article-title":"Somatic mutations and clonal hematopoiesis: unexpected potential new drivers of age-related cardiovascular disease","volume":"122","author":"Fuster","year":"2018","journal-title":"Circ Res"},{"key":"2021090917145860400_cvab273-B169","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.jacc.2020.12.052","article-title":"Outcomes 2 years after transcatheter aortic valve replacement in patients at low surgical risk","volume":"77","author":"Leon","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2021090917145860400_cvab273-B170","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1093\/eurheartj\/ehy310","article-title":"Modulation of the interleukin-6 signalling pathway and incidence rates of atherosclerotic events and all-cause mortality: analyses from the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS)","volume":"39","author":"Ridker","year":"2018","journal-title":"Eur Heart J"},{"key":"2021090917145860400_cvab273-B171","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1056\/NEJMoa043876","article-title":"A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis","volume":"352","author":"Cowell","year":"2005","journal-title":"N Engl J Med"},{"key":"2021090917145860400_cvab273-B172","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1053\/j.ajkd.2008.02.298","article-title":"A 1-year randomized trial of calcium acetate versus sevelamer on progression of coronary artery calcification in hemodialysis patients with comparable lipid control: the Calcium Acetate Renagel Evaluation-2 (CARE-2) study","volume":"51","author":"Qunibi","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"2021090917145860400_cvab273-B173","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1161\/ATVBAHA.115.306683","article-title":"Lipoprotein(a) levels are associated with subclinical calcific aortic valve disease in white and black individuals: the multi-ethnic study of atherosclerosis","volume":"36","author":"Cao","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B174","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1161\/CIRCRESAHA.121.319149","article-title":"Old drugs for an old pathology? Drug repurposing for calcific aortic valve disease","volume":"128","author":"Bartoli-Leonard","year":"2021","journal-title":"Circ Res"},{"key":"2021090917145860400_cvab273-B175","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1161\/CIRCRESAHA.120.318503","article-title":"KPT-330 prevents aortic valve calcification via a novel C\/EBP\u03b2 signaling pathway","volume":"128","author":"Dutta","year":"2021","journal-title":"Circ Res"},{"key":"2021090917145860400_cvab273-B176","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.cjca.2011.03.012","article-title":"Lipid lowering on progression of mild to moderate aortic stenosis: meta-analysis of the randomized placebo-controlled clinical trials on 2344 patients","volume":"27","author":"Teo","year":"2011","journal-title":"Can J Cardiol"},{"key":"2021090917145860400_cvab273-B177","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1161\/CIRCRESAHA.116.309692","article-title":"Neutrophil extracellular traps in atherosclerosis and atherothrombosis","volume":"120","author":"D\u00f6ring","year":"2017","journal-title":"Circ Res"},{"key":"2021090917145860400_cvab273-B178","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2020.12.016","article-title":"The association of serum lipid and lipoprotein levels with total and differential leukocyte counts: results of a cross-sectional and longitudinal analysis of the UK Biobank","volume":"319","author":"Tucker","year":"2021","journal-title":"Atherosclerosis"},{"key":"2021090917145860400_cvab273-B179","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.jacl.2019.07.003","article-title":"The association of plasma lipids with white blood cell counts: results from the Multi-Ethnic Study of Atherosclerosis","volume":"13","author":"Lai","year":"2019","journal-title":"J Clin Lipidol"},{"key":"2021090917145860400_cvab273-B180","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/S0003-4975(03)00689-1","article-title":"Hypereosinophilic thrombus causing aortic stenosis and myocardial infarction","volume":"76","author":"D'Souza","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"2021090917145860400_cvab273-B181","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.atherosclerosis.2010.02.038","article-title":"Eosinophil cationic protein: A new biomarker of coronary atherosclerosis","volume":"211","author":"Niccoli","year":"2010","journal-title":"Atherosclerosis"},{"key":"2021090917145860400_cvab273-B182","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/hr.2011.191","article-title":"Eosinophil count is positively correlated with coronary artery calcification","volume":"35","author":"Tanaka","year":"2012","journal-title":"Hypertens Res"},{"key":"2021090917145860400_cvab273-B183","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1182\/blood.2019000518","article-title":"Eosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis with eosinophil extracellular traps","volume":"134","author":"Marx","year":"2019","journal-title":"Blood"},{"key":"2021090917145860400_cvab273-B184","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0046-8177(94)90271-2","article-title":"The association of mast cells and atherosclerosis: a morphologic study of early atherosclerotic lesions in young people","volume":"25","author":"Atkinson","year":"1994","journal-title":"Hum Pathol"},{"key":"2021090917145860400_cvab273-B185","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/ATVBAHA.114.303570","article-title":"Mast cells as effectors in atherosclerosis","volume":"35","author":"Bot","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B186","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1161\/CIRCULATIONAHA.107.698480","article-title":"Mast cells as mediators and modulators of atherogenesis","volume":"115","author":"Libby","year":"2007","journal-title":"Circulation"},{"key":"2021090917145860400_cvab273-B187","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000351034","article-title":"The CD1d-natural killer T cell axis in atherosclerosis","volume":"6","author":"Bondarenko","year":"2014","journal-title":"J Innate Immun"},{"key":"2021090917145860400_cvab273-B188","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejphar.2017.05.009","article-title":"Killer cells in atherosclerosis","volume":"816","author":"Kyaw","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"2021090917145860400_cvab273-B189","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nrcardio.2017.2","article-title":"Natural killer T cells in atherosclerosis","volume":"14","author":"Getz","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"2021090917145860400_cvab273-B190","first-page":"500","article-title":"Low circulating monocyte count is associated with severe aortic valve stenosis","volume":"15","author":"Schwartzenberg","year":"2013","journal-title":"Isr Med Assoc J"},{"key":"2021090917145860400_cvab273-B191","doi-asserted-by":"crossref","first-page":"935","DOI":"10.3892\/etm.2014.1529","article-title":"M1\/M2 macrophages and associated mechanisms in congenital bicuspid aortic valve stenosis","volume":"7","author":"Wang","year":"2014","journal-title":"Exp Ther Med"},{"key":"2021090917145860400_cvab273-B192","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1161\/ATVBAHA.120.314360","article-title":"Macrophages promote aortic valve cell calcification and alter STAT3 splicing","volume":"40","author":"Raddatz","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B193","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.atherosclerosis.2014.10.106","article-title":"Pro-inflammatory monocyte-macrophage polarization imbalance in human hypercholesterolemia and atherosclerosis","volume":"237","author":"Fadini","year":"2014","journal-title":"Atherosclerosis"},{"key":"2021090917145860400_cvab273-B194","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.3390\/cells9071710","article-title":"TLR7 expression is associated with M2 macrophage subset in calcific aortic valve stenosis","volume":"9","author":"Karadimou","year":"2020","journal-title":"Cells"},{"key":"2021090917145860400_cvab273-B195","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1161\/ATVBAHA.112.249334","article-title":"Thioredoxin-1 promotes anti-inflammatory macrophages of the M2 phenotype and antagonizes atherosclerosis","volume":"32","author":"Hadri","year":"2012","journal-title":"ATVB"},{"key":"2021090917145860400_cvab273-B196","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.it.2011.07.001","article-title":"How dendritic cells shape atherosclerosis","volume":"32","author":"Koltsova","year":"2011","journal-title":"Trends Immunol"},{"key":"2021090917145860400_cvab273-B197","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1161\/ATVBAHA.114.303566","article-title":"Dendritic cells in atherosclerosis: evidence in mice and humans","volume":"35","author":"Zernecke","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B198","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1161\/CIRCRESAHA.119.315248","article-title":"Impaired autophagy in CD11b(+) dendritic cells expands CD4(+) regulatory T cells and limits atherosclerosis in mice","volume":"125","author":"Clement","year":"2019","journal-title":"Circ Res"},{"key":"2021090917145860400_cvab273-B199","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1161\/ATVBAHA.117.310678","article-title":"Follicular B cells promote atherosclerosis via T Cell mediated differentiation into plasma cells and secreting pathogenic immunoglobulin G","volume":"38","author":"Tay","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021090917145860400_cvab273-B200","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cellimm.2013.01.007","article-title":"Characterization of CD4+CD28null T cells in patients with coronary artery disease and individuals with risk factors for atherosclerosis","volume":"281","author":"T\u00e9o","year":"2013","journal-title":"Cell Immunol"},{"key":"2021090917145860400_cvab273-B201","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1093\/cvr\/cvaa202","article-title":"Interleukin-7 and interleukin-15 drive CD4+CD28null T lymphocyte expansion and function in patients with acute coronary syndrome","volume":"117","author":"Bullenkamp","year":"2020","journal-title":"Cardiovasc Res"},{"key":"2021090917145860400_cvab273-B202","doi-asserted-by":"crossref","first-page":"578","DOI":"10.55563\/clinexprheumatol\/gs3o43","article-title":"Atherosclerosis in rheumatoid arthritis: associations between anti-cytomegalovirus IgG antibodies, CD4+CD28null T-cells, CD8+CD28null T-cells and intima-media thickness","volume":"39","author":"Wahlin","year":"2021","journal-title":"Clin Exp Rheumatol"},{"key":"2021090917145860400_cvab273-B203","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/MOL.0000000000000541","article-title":"The many faces of CD8+ T cells in atherosclerosis","volume":"29","author":"van Duijn","year":"2018","journal-title":"Curr Opin Lipidol"},{"key":"2021090917145860400_cvab273-B204","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/cvr\/cvy261","article-title":"CD8+ T-cells contribute to lesion stabilization in advanced atherosclerosis by limiting macrophage content and CD4+ T-cell responses","volume":"115","author":"van Duijn","year":"2019","journal-title":"Cardiovasc Res"},{"key":"2021090917145860400_cvab273-B205","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/cells10010037","article-title":"CD8(+) T cells in atherosclerosis","volume":"10","author":"Sch\u00e4fer","year":"2020","journal-title":"Cells"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvab273\/40341824\/cvab273.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvab273\/40341824\/cvab273.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T19:41:39Z","timestamp":1673120499000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article\/doi\/10.1093\/cvr\/cvab273\/6357700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,25]]},"references-count":205,"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvab273","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,25]]},"article-number":"cvab273"}}