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Associations of specific antibody levels and defined B-cell subsets with cardiovascular disease activity in humans as well as mounting evidence from preclinical models demonstrate a role of B cells and humoral immunity in atherosclerotic cardiovascular disease. These include all aspects of B-cell immunity, the generation of antigen-specific antibodies, antigen presentation and co-stimulation of T cells, as well as production of cytokines. Through their impact on adaptive and innate immune responses and the regulation of many other immune cells, B cells mediate both protective and detrimental effects in cardiovascular disease. Several antigens derived from (oxidized) lipoproteins, the vascular wall and classical autoantigens have been identified. The unique antibody responses they trigger and their relationship with atherosclerotic cardiovascular disease are reviewed. In particular, we focus on the different effector functions of specific IgM, IgG, and IgE antibodies and the cellular responses they trigger and highlight potential strategies to target B-cell functions for therapy.<\/jats:p>","DOI":"10.1093\/cvr\/cvab285","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T22:44:09Z","timestamp":1630104249000},"source":"Crossref","is-referenced-by-count":41,"title":["Humoral immunity in atherosclerosis and myocardial infarction: from B cells to antibodies"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2633-6632","authenticated-orcid":false,"given":"Florentina","family":"Porsch","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Medical University of Vienna, Lazarettgasse 14, AKH BT25.2, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0443-7878","authenticated-orcid":false,"given":"Ziad","family":"Mallat","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U970, Paris Cardiovascular Research Centre, H\u00f4pital Europ\u00e9en Georges Pompidou, 56 Rue Leblanc, 75015 Paris, France"},{"name":"Unversit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8313-7050","authenticated-orcid":false,"given":"Christoph J","family":"Binder","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Medical University of Vienna, Lazarettgasse 14, AKH BT25.2, 1090 Vienna, 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