{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:17:57Z","timestamp":1792595877767,"version":"4.5.0"},"reference-count":131,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01HL1379"],"award-info":[{"award-number":["R01HL1379"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R21AG063197"],"award-info":[{"award-number":["R21AG063197"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Diabetes Fonds - Diabetes Onderzoek Nederland","award":["2020.10.002"],"award-info":[{"award-number":["2020.10.002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neutrophils, the most abundant of all leucocytes and the first cells to arrive at the sites of sterile inflammation\/injury act as a double-edged sword. On one hand, they inflict a significant collateral damage to the tissues and on the other hand, they help facilitate wound healing by a number of mechanisms. Recent studies have drastically changed the perception of neutrophils from being simple one-dimensional cells with an unrestrained mode of action to a cell type that display maturity and complex behaviour. It is now recognized that neutrophils are transcriptionally active and respond to plethora of signals by deploying a wide variety of cargo to influence the activity of other cells in the vicinity. Neutrophils can regulate macrophage behaviour, display innate immune memory, and play a major role in the resolution of inflammation in a context-dependent manner. In this review, we provide an update on the factors that regulate neutrophil production and the emerging dichotomous role of neutrophils in the context of cardiovascular diseases, particularly in atherosclerosis and the ensuing complications, myocardial infarction, and heart failure. Deciphering the complex behaviour of neutrophils during inflammation and resolution may provide novel insights and in turn facilitate the development of potential therapeutic strategies to manage cardiovascular disease.<\/jats:p>","DOI":"10.1093\/cvr\/cvab302","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T19:55:03Z","timestamp":1631649303000},"page":"2596-2609","source":"Crossref","is-referenced-by-count":78,"title":["Neutrophils in cardiovascular disease: warmongers, peacemakers, or both?"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4616-8397","authenticated-orcid":false,"given":"Gopalkrishna","family":"Sreejit","sequence":"first","affiliation":[{"name":"Department of Surgery, The Ohio State University Wexner Medical Center , 473 W, 12th Ave, DHLRI 611A , Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1559-3377","authenticated-orcid":false,"given":"Jillian","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Ohio State University Wexner Medical Center , 473 W, 12th Ave, DHLRI 611A , Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9539-5065","authenticated-orcid":false,"given":"Robert M","family":"Jaggers","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Ohio State University Wexner Medical Center , 473 W, 12th Ave, DHLRI 611A , Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9122-6990","authenticated-orcid":false,"given":"Albert","family":"Dahdah","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Ohio State University Wexner Medical Center , 473 W, 12th Ave, DHLRI 611A , Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-7777","authenticated-orcid":false,"given":"Andrew J","family":"Murphy","sequence":"additional","affiliation":[{"name":"Division of Immunometabolism, Baker Heart and Diabetes Institute , 75 Commercial Road, Melbourne, VIC 3004 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9541-7244","authenticated-orcid":false,"given":"Nordin M J","family":"Hanssen","sequence":"additional","affiliation":[{"name":"Amsterdam Diabetes Centrum, Amsterdam University Medical Centre, Location Academic Medical Centre Meibergdreef 9, 1105 AZ Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0294-641X","authenticated-orcid":false,"given":"Prabhakara R","family":"Nagareddy","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Ohio State University Wexner Medical Center , 473 W, 12th Ave, DHLRI 611A , Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"2023020110462869500_cvab302-B1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41586-019-1167-6","article-title":"Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death","volume":"569","author":"Silvestre-Roig","year":"2019","journal-title":"Nature"},{"key":"2023020110462869500_cvab302-B2","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1160\/TH11-02-0096","article-title":"Neutrophils and clinical outcomes in patients with acute coronary syndromes and\/or cardiac revascularisation. 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