{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:33:52Z","timestamp":1769276032822,"version":"3.49.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We undertook a propensity match-weighted cohort study to investigate whether statin treatment recommendations for statins translate into improved cardiovascular (CV) outcomes in the current routine clinical care of the elderly.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We included in our analysis (ISACS Archives -NCT04008173) a total of 5619 Caucasian patients with no known prior history of CV disease who presented to hospital with a first manifestation of CV disease with age of 65\u2009years or older. The risk of ST-segment elevation myocardial infarction (STEMI) was much lower in statin users than in non-users in both patients aged 65\u201375\u2009years [14.7% absolute risk reduction; relative risk (RR): 0.55, 95% CI 0.45\u20130.66] and those aged 76\u2009years and older (13.3% absolute risk reduction; RR: 0.58, 95% CI 0.46\u20130.72). Estimates were similar in patients with and without history of hypercholesterolaemia (interaction test; P-values = 0.24 and 0.35). Proportional reductions in STEMI diminished with female sex in the old (P for interaction\u2009= 0.002), but not in the very old age (P for interaction\u2009= 0.26). We also observed a remarkable reduction in the risk of 30 day mortality from STEMI with statin therapy in both age groups (10.2% absolute risk reduction; RR: 0.39; 95% CI 0.23\u20130.68 for patients aged 76 or over and 3.8% absolute risk reduction; RR 0.37; 95% CI 0.17\u20130.82 for patients aged 65\u201375\u2009years old; interaction test, P-value\u2009= 0.46).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Preventive statin therapy in the elderly reduces the risk of STEMI with benefits in mortality from STEMI, irrespective of the presence of a history of hypercholesterolaemia. This effect persists after the age of 76\u2009years. Benefits are less pronounced in women. Randomized clinical trials may contribute to more definitively determine the role of statin therapy in the elderly.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvab348","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T20:17:17Z","timestamp":1637785037000},"page":"3000-3009","source":"Crossref","is-referenced-by-count":10,"title":["Statins for primary prevention among elderly men and women"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1389-0597","authenticated-orcid":false,"given":"Maria","family":"Bergami","sequence":"first","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna , Policlinico Sant\u2019Orsola Malpighi, Padiglione 11, Via Massarenti 9, 40138 Bologna , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8102-3324","authenticated-orcid":false,"given":"Edina","family":"Cenko","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna , Policlinico Sant\u2019Orsola Malpighi, Padiglione 11, Via Massarenti 9, 40138 Bologna , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5481-5171","authenticated-orcid":false,"given":"Jinsung","family":"Yoon","sequence":"additional","affiliation":[{"name":"Google Cloud AI , Sunnyvale, CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6652-9036","authenticated-orcid":false,"given":"Guiomar","family":"Mendieta","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) , C. de Melchor Fern\u00e1ndez Almagro, 3, 28029, Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasko","family":"Kedev","sequence":"additional","affiliation":[{"name":"University Clinic of Cardiology, Medical Faculty, University \u2018Ss. Cyril and Methodius\u2019 , Skopje 1000, Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Zdravkovic","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Clinical Hospital Center Bezanijska Kosa are two separate words , Belgrade 11080 , Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zorana","family":"Vasiljevic","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Belgrade , Dr Subotica 8, 11000, Belgrade , Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davor","family":"Mili\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department for Cardiovascular Diseases, University Hospital Center Zagreb, University of Zagreb , Kispaticeva 12, HR-10000, Zagreb , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Manfrini","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna , Policlinico Sant\u2019Orsola Malpighi, Padiglione 11, Via Massarenti 9, 40138 Bologna , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"van der Schaar","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of California 56-125B Engineering IV Building 420 Westwood Plaza , Los Angeles, CA 90095-1594 USA"},{"name":"Cambridge Centre for Artificial Intelligence in Medicine, Department of Applied Mathematics and Theoretical Physics and Department of Population Health, University of Cambridge , Trinity Ln, Cambridge CB2 1TN , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4732-382X","authenticated-orcid":false,"given":"Chris P","family":"Gale","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Woodhouse, Leeds LS2 9JT , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9162-2459","authenticated-orcid":false,"given":"Lina","family":"Badimon","sequence":"additional","affiliation":[{"name":"Cardiovascular Program (ICCC), IR-IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, CiberCV-Institute Carlos III , C\/ Sant Antoni Maria Claret, 167, 08025, Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6819-6818","authenticated-orcid":false,"given":"Raffaele","family":"Bugiardini","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna , Policlinico Sant\u2019Orsola Malpighi, Padiglione 11, Via Massarenti 9, 40138 Bologna , 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