{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:20:41Z","timestamp":1790734841790,"version":"4.1.0"},"reference-count":148,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>NADPH oxidases (NOXs), enzymes whose primary function is to generate reactive oxygen species, are important regulators of the heart\u2019s physiological function and response to pathological insults. The role of NOX-driven redox signalling in pathophysiological myocardial remodelling, including processes such as interstitial fibrosis, contractile dysfunction, cellular hypertrophy, and cell survival, is well recognized. While the NOX2 isoform promotes many detrimental effects, the NOX4 isoform has attracted considerable attention as a driver of adaptive stress responses both during pathology and under physiological states such as exercise. Recent studies have begun to define some of the NOX4-modulated mechanisms that may underlie these adaptive responses. In particular, novel functions of NOX4 in driving cellular metabolic changes have emerged. Alterations in cellular metabolism are a recognized hallmark of the heart\u2019s response to physiological and pathological stresses. In this review, we highlight the emerging roles of NOX enzymes as important modulators of cellular intermediary metabolism in the heart, linking stress responses not only to myocardial energetics but also other functions. The novel interplay of NOX-modulated redox signalling pathways and intermediary metabolism in the heart is unravelling a new aspect of the fascinating biology of these enzymes which will inform a better understanding of how they drive adaptive responses. We also discuss the implications of these new findings for therapeutic approaches that target metabolism in cardiac disease.<\/jats:p>","DOI":"10.1093\/cvr\/cvac030","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T20:12:36Z","timestamp":1647375156000},"page":"3305-3319","source":"Crossref","is-referenced-by-count":45,"title":["The regulation of cardiac intermediary metabolism by NADPH oxidases"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1600-1492","authenticated-orcid":false,"given":"Adam A","family":"Nabeebaccus","sequence":"first","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London British Heart Foundation Centre of Excellence, James Black Centre , 125 Coldharbour Lane, London SE5 9NU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M","family":"Reumiller","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London British Heart Foundation Centre of Excellence, James Black Centre , 125 Coldharbour Lane, London SE5 9NU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5339-5638","authenticated-orcid":false,"given":"Jie","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London British Heart Foundation Centre of Excellence, James Black Centre , 125 Coldharbour Lane, London SE5 9NU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zoccarato","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London British Heart Foundation Centre of Excellence, James Black Centre , 125 Coldharbour Lane, London SE5 9NU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celio X C","family":"Santos","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London British Heart Foundation Centre of Excellence, James Black Centre , 125 Coldharbour Lane, London SE5 9NU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6547-0631","authenticated-orcid":false,"given":"Ajay M","family":"Shah","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London British Heart Foundation Centre of Excellence, James Black Centre , 125 Coldharbour Lane, London SE5 9NU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"2023011816300169600_cvac030-B1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/CIRCRESAHA.118.312017","article-title":"Metabolic coordination of physiological and pathological cardiac remodeling","volume":"123","author":"Gibb","year":"2018","journal-title":"Circ Res"},{"key":"2023011816300169600_cvac030-B2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/CIRCRESAHA.113.300376","article-title":"Cardiac metabolism in heart failure: implications beyond ATP production","volume":"113","author":"Doenst","year":"2013","journal-title":"Circ Res"},{"key":"2023011816300169600_cvac030-B3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1161\/CIRCRESAHA.113.302095","article-title":"Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes","volume":"113","author":"Kolwicz","year":"2013","journal-title":"Circ Res"},{"key":"2023011816300169600_cvac030-B4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/cvr\/cvx017","article-title":"Metabolism in cardiomyopathy: every substrate matters","volume":"113","author":"Ritterhoff","year":"2017","journal-title":"Cardiovasc Res"},{"key":"2023011816300169600_cvac030-B5","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJMra063052","article-title":"The failing heart\u2014an engine out of fuel","volume":"356","author":"Neubauer","year":"2007","journal-title":"N Engl J Med"},{"key":"2023011816300169600_cvac030-B6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol Rev"},{"key":"2023011816300169600_cvac030-B7","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1161\/CIRCRESAHA.111.243972","article-title":"Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system","volume":"110","author":"Lass\u00e8gue","year":"2012","journal-title":"Circ Res"},{"key":"2023011816300169600_cvac030-B8","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.freeradbiomed.2014.07.046","article-title":"Nox family NADPH oxidases: molecular mechanisms of activation","volume":"76","author":"Brandes","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"2023011816300169600_cvac030-B9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cardiores.2006.03.016","article-title":"NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure","volume":"71","author":"Murdoch","year":"2006","journal-title":"Cardiovasc Res"},{"key":"2023011816300169600_cvac030-B10","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1161\/CIRCRESAHA.111.255216","article-title":"Redox signaling in cardiac physiology and pathology","volume":"111","author":"Burgoyne","year":"2012","journal-title":"Circ Res"},{"key":"2023011816300169600_cvac030-B11","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1126\/science.1202768","article-title":"X-ROS signaling: rapid mechano-chemo transduction in heart","volume":"333","author":"Prosser","year":"2011","journal-title":"Science"},{"key":"2023011816300169600_cvac030-B12","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1128\/MCB.01445-09","article-title":"Nox4-derived H2O2 mediates endoplasmic reticulum signaling through local Ras activation","volume":"30","author":"Wu","year":"2010","journal-title":"Mol Cell Biol"},{"key":"2023011816300169600_cvac030-B13","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1161\/CIRCRESAHA.113.301787","article-title":"Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase\/eukaryotic initiation factor 2\u03b1\/activating transcription factor 4 pathway","volume":"113","author":"Sciarretta","year":"2013","journal-title":"Circ Res"},{"key":"2023011816300169600_cvac030-B14","doi-asserted-by":"crossref","first-page":"e103530","DOI":"10.15252\/embj.2019103530","article-title":"Nox4 regulates InsP(3) receptor-dependent Ca(2+) release into mitochondria to promote cell survival","volume":"39","author":"Beretta","year":"2020","journal-title":"EMBO J"},{"key":"2023011816300169600_cvac030-B15","doi-asserted-by":"crossref","first-page":"8977","DOI":"10.1074\/jbc.M110.193821","article-title":"Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4","volume":"286","author":"Spencer","year":"2011","journal-title":"J Biol Chem"},{"key":"2023011816300169600_cvac030-B16","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/s41467-017-01106-1","article-title":"NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance","volume":"8","author":"Shanmugasundaram","year":"2017","journal-title":"Nat Commun"},{"key":"2023011816300169600_cvac030-B17","doi-asserted-by":"crossref","first-page":"18121","DOI":"10.1073\/pnas.1009700107","article-title":"NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis","volume":"107","author":"Zhang","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023011816300169600_cvac030-B18","doi-asserted-by":"crossref","first-page":"15565","DOI":"10.1073\/pnas.1002178107","article-title":"NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart","volume":"107","author":"Kuroda","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023011816300169600_cvac030-B19","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/ATVBAHA.108.181610","article-title":"NADPH oxidases: functions and pathologies in the vasculature","volume":"30","author":"Lass\u00e8gue","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023011816300169600_cvac030-B20","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1091\/mbc.e09-12-1003","article-title":"The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1","volume":"21","author":"Diebold","year":"2010","journal-title":"Mol Biol Cell"},{"key":"2023011816300169600_cvac030-B21","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.freeradbiomed.2008.05.019","article-title":"Positive regulation of the NADPH oxidase NOX4 promoter in vascular smooth muscle cells by E2F","volume":"45","author":"Zhang","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"2023011816300169600_cvac030-B22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00395-012-0283-3","article-title":"Transcriptional regulation of Nox4 by histone deacetylases in human endothelial cells","volume":"107","author":"Siuda","year":"2012","journal-title":"Basic Res Cardiol"},{"key":"2023011816300169600_cvac030-B23","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1161\/CIRCRESAHA.109.193722","article-title":"Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells","volume":"105","author":"Lyle","year":"2009","journal-title":"Circ Res"},{"key":"2023011816300169600_cvac030-B24","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1074\/jbc.M115.710772","article-title":"The endoplasmic reticulum chaperone calnexin is a NADPH oxidase NOX4 interacting protein","volume":"291","author":"Prior","year":"2016","journal-title":"J Biol Chem"},{"key":"2023011816300169600_cvac030-B25","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1091\/mbc.e07-10-0995","article-title":"The subcellular distribution of calnexin is mediated by PACS-2","volume":"19","author":"Myhill","year":"2008","journal-title":"Mol Biol Cell"},{"key":"2023011816300169600_cvac030-B26","doi-asserted-by":"crossref","first-page":"13304","DOI":"10.1074\/jbc.M110.192138","article-title":"The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4","volume":"286","author":"Takac","year":"2011","journal-title":"J Biol Chem"},{"key":"2023011816300169600_cvac030-B27","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1021\/bi500331y","article-title":"Nox4: a hydrogen peroxide-generating oxygen sensor","volume":"53","author":"Nisimoto","year":"2014","journal-title":"Biochemistry"},{"key":"2023011816300169600_cvac030-B28","doi-asserted-by":"crossref","first-page":"319","DOI":"10.15252\/embj.201592394","article-title":"Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2\u03b1-mediated stress signaling","volume":"35","author":"Santos","year":"2016","journal-title":"EMBO J"},{"key":"2023011816300169600_cvac030-B29","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1242\/jcs.02798","article-title":"Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1alpha and intracellular reactive oxygen species","volume":"119","author":"Ateghang","year":"2006","journal-title":"J Cell Sci"},{"key":"2023011816300169600_cvac030-B30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbrc.2005.01.089","article-title":"Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells","volume":"329","author":"Goyal","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"2023011816300169600_cvac030-B31","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1161\/ATVBAHA.112.300956","article-title":"A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells","volume":"33","author":"Anilkumar","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023011816300169600_cvac030-B32","doi-asserted-by":"crossref","first-page":"935","DOI":"10.3389\/fphys.2017.00935","article-title":"Alternative splicing of NOX4 in the failing human heart","volume":"8","author":"Varga","year":"2017","journal-title":"Front Physiol"},{"key":"2023011816300169600_cvac030-B33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.yjmcc.2018.05.068","article-title":"The role of cardiomyocyte Nox4D, a redox-active splice variant of NADPH oxidase-4","volume":"120","author":"Savage","year":"2018","journal-title":"J Mol Cell Cardiol"},{"issue":"S1","key":"2023011816300169600_cvac030-B34","doi-asserted-by":"crossref","first-page":"815.11","DOI":"10.1096\/fasebj.2019.33.1_supplement.815.11","article-title":"Expression of Nox4 NADPH oxidase splice variants generate hydrogen peroxide and modify the cell cycle","volume":"33","author":"Scott","year":"2019","journal-title":"FASEB J"},{"key":"2023011816300169600_cvac030-B35","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1089\/ars.2012.4550","article-title":"NADPH oxidases in heart failure: poachers or gamekeepers?","volume":"18","author":"Zhang","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"2023011816300169600_cvac030-B36","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/cvr\/cvx204","article-title":"Both cardiomyocyte and endothelial cell Nox4 mediate protection against hemodynamic overload-induced remodelling","volume":"114","author":"Zhang","year":"2018","journal-title":"Cardiovasc Res"},{"key":"2023011816300169600_cvac030-B37","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1161\/CIRCRESAHA.112.267054","article-title":"Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase","volume":"110","author":"Schr\u00f6der","year":"2012","journal-title":"Circ Res"},{"key":"2023011816300169600_cvac030-B38","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/HYPERTENSIONAHA.114.04208","article-title":"Nicotinamide adenine dinucleotide phosphate oxidase-4-dependent upregulation of nuclear factor erythroid-derived 2-like 2 protects the heart during chronic pressure overload","volume":"65","author":"Smyrnias","year":"2015","journal-title":"Hypertension"},{"key":"2023011816300169600_cvac030-B39","doi-asserted-by":"crossref","first-page":"e41044","DOI":"10.7554\/eLife.41044","article-title":"Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise","volume":"7","author":"Hancock","year":"2018","journal-title":"eLife"},{"key":"2023011816300169600_cvac030-B40","doi-asserted-by":"crossref","first-page":"e13474","DOI":"10.14814\/phy2.13474","article-title":"Cardiac and renal upregulation of Nox2 and NF-\u03baB and repression of Nox4 and Nrf2 in season- and diabetes-mediated models of vascular oxidative stress in guinea-pig and rat","volume":"5","author":"Gajos-Draus","year":"2017","journal-title":"Physiol Rep"},{"key":"2023011816300169600_cvac030-B41","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.freeradbiomed.2011.04.022","article-title":"Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo","volume":"51","author":"Brewer","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"2023011816300169600_cvac030-B42","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2018.01.024","article-title":"ROS and redox signaling in myocardial ischemia\u2013reperfusion injury and cardioprotection","volume":"117","author":"Cadenas","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"2023011816300169600_cvac030-B43","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1089\/ars.2013.5607","article-title":"NADPH oxidases in vascular pathology","volume":"20","author":"Konior","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"2023011816300169600_cvac030-B44","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s11906-011-0238-3","article-title":"The Nox family of NADPH oxidases: friend or foe of the vascular system?","volume":"14","author":"Takac","year":"2012","journal-title":"Curr Hypertens Rep"},{"key":"2023011816300169600_cvac030-B45","doi-asserted-by":"crossref","first-page":"e96184","DOI":"10.1172\/jci.insight.96184","article-title":"Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation","volume":"2","author":"Nabeebaccus","year":"2017","journal-title":"JCI Insight"},{"key":"2023011816300169600_cvac030-B46","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature05815","article-title":"Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins","volume":"446","author":"Hart","year":"2007","journal-title":"Nature"},{"key":"2023011816300169600_cvac030-B47","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1083\/jcb.201501101","article-title":"A little sugar goes a long way: the cell biology of O-GlcNAc","volume":"208","author":"Bond","year":"2015","journal-title":"J Cell Biol"},{"key":"2023011816300169600_cvac030-B48","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/cvr\/cvv105","article-title":"Good and bad consequences of altered fatty acid metabolism in heart failure: evidence from mouse models","volume":"106","author":"Abdurrachim","year":"2015","journal-title":"Cardiovasc Res"},{"key":"2023011816300169600_cvac030-B49","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/cvr\/cvp414","article-title":"Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload","volume":"86","author":"Doenst","year":"2010","journal-title":"Cardiovasc Res"},{"key":"2023011816300169600_cvac030-B50","doi-asserted-by":"crossref","first-page":"12035","DOI":"10.1038\/s41598-018-30616-1","article-title":"Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure","volume":"8","author":"Umbarawan","year":"2018","journal-title":"Sci Rep"},{"key":"2023011816300169600_cvac030-B51","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/cvr\/cvn001","article-title":"Cardiac hypertrophy is enhanced in PPAR alpha\u2212\/\u2212 mice in response to chronic pressure overload","volume":"78","author":"Smeets","year":"2008","journal-title":"Cardiovasc Res"},{"key":"2023011816300169600_cvac030-B52","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1161\/CIRCRESAHA.112.268128","article-title":"Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy","volume":"111","author":"Kolwicz","year":"2012","journal-title":"Circ Res"},{"issue":"Suppl 1","key":"2023011816300169600_cvac030-B53","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/S0140-6736(15)60388-9","article-title":"Cardiac-targeted NADPH oxidase 4 in the adaptive cardiac remodelling of the murine heart","volume":"385","author":"Nabeebaccus","year":"2015","journal-title":"Lancet"},{"key":"2023011816300169600_cvac030-B54","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/nm.4153","article-title":"NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages","volume":"22","author":"Moon","year":"2016","journal-title":"Nat Med"},{"key":"2023011816300169600_cvac030-B55","doi-asserted-by":"crossref","first-page":"101160","DOI":"10.1016\/j.molmet.2020.101160","article-title":"Nox4 mediates skeletal muscle metabolic responses to exercise","volume":"45","author":"Specht","year":"2021","journal-title":"Mol Metab"},{"key":"2023011816300169600_cvac030-B56","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1038\/ijo.2011.279","article-title":"Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity","volume":"36","author":"Li","year":"2012","journal-title":"Int J Obes"},{"key":"2023011816300169600_cvac030-B57","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/CIRCRESAHA.111.300171","article-title":"Broad suppression of NADPH oxidase activity exacerbates ischemia\/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1\u03b1 and upregulation of peroxisome proliferator-activated receptor-\u03b1","volume":"112","author":"Matsushima","year":"2013","journal-title":"Circ Res"},{"key":"2023011816300169600_cvac030-B58","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.3390\/ijms21124406","article-title":"Downregulation of PPAR\u03b1 during experimental left ventricular hypertrophy is critically dependent on Nox2 NADPH oxidase signalling","volume":"21","author":"Harvey","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2023011816300169600_cvac030-B59","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41569-021-00569-6","article-title":"PPAR control of metabolism and cardiovascular functions","volume":"18","author":"Montaigne","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"2023011816300169600_cvac030-B60","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41467-017-00664-8","article-title":"Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling","volume":"8","author":"Liu","year":"2017","journal-title":"Nat Commun"},{"key":"2023011816300169600_cvac030-B61","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1038\/s41467-019-12523-9","article-title":"Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise","volume":"10","author":"Henr\u00edquez-Olguin","year":"2019","journal-title":"Nat Commun"},{"key":"2023011816300169600_cvac030-B62","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1161\/CIRCULATIONAHA.119.045033","article-title":"Implications of altered ketone metabolism and therapeutic ketosis in heart failure","volume":"141","author":"Selvaraj","year":"2020","journal-title":"Circulation"},{"key":"2023011816300169600_cvac030-B63","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/cvr\/cvab068","article-title":"Ketone therapy for heart failure: current evidence for clinical use","volume":"118","author":"Takahara","year":"2022","journal-title":"Cardiovasc Res"},{"issue":"171","key":"2023011816300169600_cvac030-B64","article-title":"NADPH oxidase 2 mediates myocardial oxygen wasting in obesity","volume":"9","author":"Hafstad","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"2023011816300169600_cvac030-B65","doi-asserted-by":"crossref","first-page":"e0145750","DOI":"10.1371\/journal.pone.0145750","article-title":"Inhibition of NAPDH oxidase 2 (NOX2) prevents oxidative stress and mitochondrial abnormalities caused by saturated fat in cardiomyocytes","volume":"11","author":"Joseph","year":"2016","journal-title":"PLoS One"},{"key":"2023011816300169600_cvac030-B66","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.bbrc.2020.05.162","article-title":"Nox2 dependent redox-regulation of Akt and ERK1\/2 to promote left ventricular hypertrophy in dietary obesity of mice","volume":"528","author":"Bhatti","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"2023011816300169600_cvac030-B67","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1194\/jlr.M055152","article-title":"Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity","volume":"56","author":"Jaishy","year":"2015","journal-title":"J Lipid Res"},{"key":"2023011816300169600_cvac030-B68","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1111\/jcmm.15318","article-title":"Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2-related programmed cell death in an AMPK-dependent manner","volume":"24","author":"Wang","year":"2020","journal-title":"J Cell Mol Med"},{"key":"2023011816300169600_cvac030-B69","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1161\/CIRCRESAHA.119.316288","article-title":"Hyperglycemia acutely increases cytosolic reactive oxygen species via O-linked GlcNAcylation and CaMKII activation in mouse ventricular myocytes","volume":"126","author":"Lu","year":"2020","journal-title":"Circ Res"},{"key":"2023011816300169600_cvac030-B70","doi-asserted-by":"crossref","first-page":"C597","DOI":"10.1152\/ajpcell.00331.2011","article-title":"Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes","volume":"302","author":"Maalouf","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"issue":"Suppl","key":"2023011816300169600_cvac030-B71","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.yjmcc.2018.05.082","article-title":"Adverse cardiac remodelling in experimental diabetes is regulated by endothelial Nox4 NADPH oxidase-derived reactive oxygen species","volume":"120","author":"Edgar","year":"2018","journal-title":"J Mol Cell Cardiol"},{"key":"2023011816300169600_cvac030-B72","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/j.bbadis.2017.07.025","article-title":"The role of NADPH oxidases in diabetic cardiomyopathy","volume":"1864","author":"Hansen","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2023011816300169600_cvac030-B73","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1042\/CS20170063","article-title":"Phosphoinositide 3-kinase (p110\u03b1) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction","volume":"131","author":"Prakoso","year":"2017","journal-title":"Clin Sci"},{"key":"2023011816300169600_cvac030-B74","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.yjmcc.2013.05.009","article-title":"MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative\/nitrative stress and subsequent dysfunction in the heart","volume":"62","author":"Varga","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"2023011816300169600_cvac030-B75","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/cvr\/cvv238","article-title":"Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy","volume":"108","author":"Kyrychenko","year":"2015","journal-title":"Cardiovasc Res"},{"key":"2023011816300169600_cvac030-B76","doi-asserted-by":"crossref","first-page":"H1002","DOI":"10.1152\/ajpheart.00685.2016","article-title":"High-throughput screening identifies microRNAs that target Nox2 and improve function after acute myocardial infarction","volume":"312","author":"Yang","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2023011816300169600_cvac030-B77","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12933-020-01107-3","article-title":"MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy","volume":"19","author":"Ait-Aissa","year":"2020","journal-title":"Cardiovasc Diabet"},{"key":"2023011816300169600_cvac030-B78","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1161\/HYPERTENSIONAHA.118.10824","article-title":"Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension","volume":"72","author":"Camargo","year":"2018","journal-title":"Hypertension"},{"key":"2023011816300169600_cvac030-B79","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1161\/ATVBAHA.116.307922","article-title":"RasGRF couples Nox4-dependent endoplasmic reticulum signaling to Ras","volume":"37","author":"Wu","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023011816300169600_cvac030-B80","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1128\/MCB.24.24.10703-10717.2004","article-title":"NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells","volume":"24","author":"Pedruzzi","year":"2004","journal-title":"Mol Cell Biol"},{"key":"2023011816300169600_cvac030-B81","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1089\/ars.2009.2625","article-title":"Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase","volume":"11","author":"Santos","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"2023011816300169600_cvac030-B82","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2023011816300169600_cvac030-B83","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI0216886","article-title":"Orchestrating the unfolded protein response in health and disease","volume":"110","author":"Kaufman","year":"2002","journal-title":"J Clin Invest"},{"key":"2023011816300169600_cvac030-B84","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41569-021-00511-w","article-title":"Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases","volume":"18","author":"Ren","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"2023011816300169600_cvac030-B85","doi-asserted-by":"crossref","first-page":"a012278","DOI":"10.1101\/cshperspect.a012278","article-title":"New insights into translational regulation in the endoplasmic reticulum unfolded protein response","volume":"4","author":"Pavitt","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2023011816300169600_cvac030-B86","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3945\/an.112.002113","article-title":"Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism","volume":"3","author":"Baird","year":"2012","journal-title":"Adv Nutr"},{"key":"2023011816300169600_cvac030-B87","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1074\/jbc.M115.685578","article-title":"Transcriptional regulation of cystathionine-\u03b3-lyase in endothelial cells by NADPH oxidase 4-dependent signaling","volume":"291","author":"Mistry","year":"2016","journal-title":"J Biol Chem"},{"key":"2023011816300169600_cvac030-B88","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.freeradbiomed.2015.09.015","article-title":"NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice","volume":"89","author":"Murray","year":"2015","journal-title":"Free Radic Biol Med"},{"key":"2023011816300169600_cvac030-B89","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1161\/CIRCRESAHA.109.206607","article-title":"Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart","volume":"105","author":"Endo","year":"2009","journal-title":"Circ Res"},{"key":"2023011816300169600_cvac030-B90","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cmet.2015.01.016","article-title":"Protein quality control and metabolism: bidirectional control in the heart","volume":"21","author":"Wang","year":"2015","journal-title":"Cell Metab"},{"key":"2023011816300169600_cvac030-B91","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1093\/nar\/gkt563","article-title":"The eIF2\u03b1\/ATF4 pathway is essential for stress-induced autophagy gene expression","volume":"41","author":"B\u2019Chir","year":"2013","journal-title":"Nucl Acid Res"},{"key":"2023011816300169600_cvac030-B92","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1042\/BJ20120972","article-title":"Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival","volume":"449","author":"Pike","year":"2013","journal-title":"Biochem J"},{"key":"2023011816300169600_cvac030-B93","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.2337\/db09-1800","article-title":"Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes","volume":"59","author":"Li","year":"2010","journal-title":"Diabetes"},{"key":"2023011816300169600_cvac030-B94","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.bbadis.2015.01.010","article-title":"Activation of NADPH oxidase mediates increased endoplasmic reticulum stress and left ventricular remodeling after myocardial infarction in rabbits","volume":"1852","author":"Li","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"2023011816300169600_cvac030-B95","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1159\/000478960","article-title":"Nobiletin, a polymethoxy flavonoid, protects against cardiac hypertrophy induced by pressure-overload via inhibition of NAPDH oxidases and endoplasmic reticulum stress","volume":"42","author":"Zhang","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"2023011816300169600_cvac030-B96","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1083\/jcb.201006121","article-title":"NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis","volume":"191","author":"Li","year":"2010","journal-title":"J Cell Biol"},{"key":"2023011816300169600_cvac030-B97","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0014-5793(03)01179-7","article-title":"Hypoxic regulation of the 6-phosphofructo-2-kinase\/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo","volume":"554","author":"Minchenko","year":"2003","journal-title":"FEBS Lett"},{"key":"2023011816300169600_cvac030-B98","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/CIRCULATIONAHA.109.922427","article-title":"Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy","volume":"122","author":"Moslehi","year":"2010","journal-title":"Circulation"},{"key":"2023011816300169600_cvac030-B99","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/cdd.2008.13","article-title":"Role of hypoxia-inducible factor in cell survival during myocardial ischemia\u2013reperfusion","volume":"15","author":"Loor","year":"2008","journal-title":"Cell Death Diff"},{"key":"2023011816300169600_cvac030-B100","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cmet.2009.05.005","article-title":"Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy","volume":"9","author":"Krishnan","year":"2009","journal-title":"Cell Metab"},{"key":"2023011816300169600_cvac030-B101","doi-asserted-by":"crossref","first-page":"8019","DOI":"10.1074\/jbc.M611569200","article-title":"NAD(P)H oxidases regulate HIF-2alpha protein expression","volume":"282","author":"Block","year":"2007","journal-title":"J Biol Chem"},{"key":"2023011816300169600_cvac030-B102","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.freeradbiomed.2014.01.027","article-title":"NADPH oxidase 4 promotes cardiac microvascular angiogenesis after hypoxia\/reoxygenation in vitro","volume":"69","author":"Wang","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"2023011816300169600_cvac030-B103","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1161\/01.ATV.0000258979.92828.bc","article-title":"Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site","volume":"27","author":"Bonello","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023011816300169600_cvac030-B104","doi-asserted-by":"crossref","first-page":"e00268-18","DOI":"10.1128\/MCB.00268-18","article-title":"Reactive oxygen species signaling promotes hypoxia-inducible factor 1\u03b1 stabilization in sonic hedgehog-driven cerebellar progenitor cell proliferation","volume":"39","author":"Eyrich","year":"2019","journal-title":"Mol Cell Biol"},{"key":"2023011816300169600_cvac030-B105","doi-asserted-by":"crossref","first-page":"e25217","DOI":"10.7554\/eLife.25217","article-title":"HIF-1\u03b1 is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium","volume":"6","author":"Wu","year":"2017","journal-title":"eLife"},{"key":"2023011816300169600_cvac030-B106","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/cvr\/cvu050","article-title":"ROS signalling between endothelial cells and cardiac cells","volume":"102","author":"Zhang","year":"2014","journal-title":"Cardiovasc Res"},{"key":"2023011816300169600_cvac030-B107","doi-asserted-by":"crossref","first-page":"646","DOI":"10.7150\/ijms.15177","article-title":"NOX2 antisense attenuates hypoxia-induced oxidative stress and apoptosis in cardiomyocyte","volume":"13","author":"Yu","year":"2016","journal-title":"Int J Med Sci"},{"key":"2023011816300169600_cvac030-B108","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.redox.2017.01.023","article-title":"Redox regulation in metabolic programming and inflammation","volume":"12","author":"Griffiths","year":"2017","journal-title":"Redox Biol"},{"key":"2023011816300169600_cvac030-B109","doi-asserted-by":"crossref","first-page":"e00236-16","DOI":"10.1128\/MCB.00236-16","article-title":"PHD2 is a regulator for glycolytic reprogramming in macrophages","volume":"37","author":"Guentsch","year":"2016","journal-title":"Mol Cell Biol"},{"key":"2023011816300169600_cvac030-B110","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1242\/jcs.094060","article-title":"The HIF1 target gene NOX2 promotes angiogenesis through urotensin-II","volume":"125","author":"Diebold","year":"2012","journal-title":"J Cell Sci"},{"key":"2023011816300169600_cvac030-B111","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.niox.2011.02.007","article-title":"The Keap1-Nrf2 system as an in vivo sensor for electrophiles","volume":"25","author":"Uruno","year":"2011","journal-title":"Nitric Oxide"},{"key":"2023011816300169600_cvac030-B112","doi-asserted-by":"crossref","first-page":"13291","DOI":"10.1074\/jbc.R900010200","article-title":"The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress","volume":"284","author":"Nguyen","year":"2009","journal-title":"J Biol Chem"},{"key":"2023011816300169600_cvac030-B113","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","article-title":"The Nrf2 regulatory network provides an interface between redox and intermediary metabolism","volume":"39","author":"Hayes","year":"2014","journal-title":"Trends Biochem Sci"},{"key":"2023011816300169600_cvac030-B114","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.abb.2015.11.040","article-title":"Keap1\/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet","volume":"591","author":"Slocum","year":"2016","journal-title":"Arch Biochem Biophys"},{"key":"2023011816300169600_cvac030-B115","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1128\/MCB.00677-14","article-title":"Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance","volume":"34","author":"Meakin","year":"2014","journal-title":"Mol Cell Biol"},{"key":"2023011816300169600_cvac030-B116","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1038\/s41467-019-12164-y","article-title":"Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma","volume":"10","author":"Best","year":"2019","journal-title":"Nat Commun"},{"key":"2023011816300169600_cvac030-B117","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ccr.2012.05.016","article-title":"Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming","volume":"22","author":"Mitsuishi","year":"2012","journal-title":"Cancer Cell"},{"key":"2023011816300169600_cvac030-B118","doi-asserted-by":"crossref","first-page":"38598","DOI":"10.1038\/srep38598","article-title":"NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury","volume":"6","author":"Nlandu-Khodo","year":"2016","journal-title":"Sci Rep"},{"key":"2023011816300169600_cvac030-B119","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1074\/jbc.M116.752261","article-title":"NADPH oxidase 4 (Nox4) suppresses mitochondrial biogenesis and bioenergetics in lung fibroblasts via a nuclear factor erythroid-derived 2-like 2 (Nrf2)-dependent pathway","volume":"292","author":"Bernard","year":"2017","journal-title":"J Biol Chem"},{"key":"2023011816300169600_cvac030-B120","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1152\/japplphysiol.00201.2019","article-title":"Aerobic exercise modulates cardiac NAD(P)H oxidase and the NRF2\/KEAP1 pathway in a mouse model of chronic fructose consumption","volume":"128","author":"Alves","year":"2020","journal-title":"J Appl Physiol"},{"key":"2023011816300169600_cvac030-B121","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.abb.2018.12.018","article-title":"Mitochondria-associated endoplasmic reticulum membranes in the heart","volume":"662","author":"Wu","year":"2019","journal-title":"Arch Biochem Biophys"},{"key":"2023011816300169600_cvac030-B122","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1161\/CIRCRESAHA.109.213116","article-title":"Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes","volume":"106","author":"Ago","year":"2010","journal-title":"Circ Res"},{"key":"2023011816300169600_cvac030-B123","doi-asserted-by":"crossref","first-page":"e94248","DOI":"10.1172\/jci.insight.94248","article-title":"Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function","volume":"2","author":"Joseph","year":"2017","journal-title":"JCI Insight"},{"key":"2023011816300169600_cvac030-B124","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation","volume":"62","author":"Paulus","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2023011816300169600_cvac030-B125","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1093\/eurheartj\/ehy529","article-title":"Systemic microvascular dysfunction in microvascular and vasospastic angina","volume":"39","author":"Ford","year":"2018","journal-title":"Eur Heart J"},{"key":"2023011816300169600_cvac030-B126","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41569-020-0339-2","article-title":"Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence","volume":"17","author":"Tan","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"2023011816300169600_cvac030-B127","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1089\/ars.2005.7.308","article-title":"Expression and localization of NOX2 and NOX4 in primary human endothelial cells","volume":"7","author":"Van Buul","year":"2005","journal-title":"Antioxid Redox Signal"},{"key":"2023011816300169600_cvac030-B128","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1365-2443.2005.00907.x","article-title":"The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells","volume":"10","author":"Kuroda","year":"2005","journal-title":"Genes Cells"},{"key":"2023011816300169600_cvac030-B129","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.cmet.2013.08.001","article-title":"Role of endothelial cell metabolism in vessel sprouting","volume":"18","author":"De Bock","year":"2013","journal-title":"Cell Metab"},{"key":"2023011816300169600_cvac030-B130","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nature14362","article-title":"Fatty acid carbon is essential for dNTP synthesis in endothelial cells","volume":"520","author":"Schoors","year":"2015","journal-title":"Nature"},{"key":"2023011816300169600_cvac030-B131","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1089\/ars.2006.8.1473","article-title":"NOX2 and NOX4 mediate proliferative response in endothelial cells","volume":"8","author":"Petry","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"2023011816300169600_cvac030-B132","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.tem.2014.06.012","article-title":"Endothelial NADPH oxidases: which NOX to target in vascular disease?","volume":"25","author":"Drummond","year":"2014","journal-title":"Trends Endocrinol Metab"},{"key":"2023011816300169600_cvac030-B133","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1161\/CIRCRESAHA.116.302855","article-title":"Endothelial cell metabolism in normal and diseased vasculature","volume":"116","author":"Eelen","year":"2015","journal-title":"Circ Res"},{"key":"2023011816300169600_cvac030-B134","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1152\/physrev.00001.2017","article-title":"Endothelial cell metabolism","volume":"98","author":"Eelen","year":"2018","journal-title":"Physiol Rev"},{"key":"2023011816300169600_cvac030-B135","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1126\/science.1144318","article-title":"Cysteine redox sensor in PKGIa enables oxidant-induced activation","volume":"317","author":"Burgoyne","year":"2007","journal-title":"Science"},{"key":"2023011816300169600_cvac030-B136","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1161\/ATVBAHA.110.219238","article-title":"Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo","volume":"31","author":"Ray","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023011816300169600_cvac030-B137","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1093\/eurheartj\/ehv460","article-title":"The NADPH oxidase Nox4 has anti-atherosclerotic functions","volume":"36","author":"Sch\u00fcrmann","year":"2015","journal-title":"Eur Heart J"},{"key":"2023011816300169600_cvac030-B138","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1161\/ATVBAHA.115.307012","article-title":"Reactive oxygen species can provide atheroprotection via NOX4-dependent inhibition of inflammation and vascular remodeling","volume":"36","author":"Gray","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023011816300169600_cvac030-B139","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1016\/j.jacc.2014.02.572","article-title":"Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through proinflammatory effects and endothelial-mesenchymal transition","volume":"63","author":"Murdoch","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2023011816300169600_cvac030-B140","first-page":"3264858","article-title":"The NADPH oxidase Nox4 controls macrophage polarization in an NF\u03baB-dependent manner","author":"Helfinger","year":"2019","journal-title":"Oxidat Med Cell Longev"},{"key":"2023011816300169600_cvac030-B141","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jacbts.2017.06.006","article-title":"NADPH oxidase-4 driven cardiac macrophage polarization protects against myocardial infarction-induced remodeling","volume":"2","author":"Mongue-Din","year":"2017","journal-title":"JACC Basic Transl Sci"},{"key":"2023011816300169600_cvac030-B142","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1113\/JP276758","article-title":"Endothelial cell-cardiomyocyte crosstalk in heart development and disease","volume":"598","author":"Colliva","year":"2020","journal-title":"J Physiol"},{"key":"2023011816300169600_cvac030-B143","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/cvr\/cvw159","article-title":"Endothelial cell-cardiomyocyte crosstalk in diabetic cardiomyopathy","volume":"111","author":"Wan","year":"2016","journal-title":"Cardiovasc Res"},{"key":"2023011816300169600_cvac030-B144","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jgg.2013.05.002","article-title":"Regulatory roles of metabolites in cell signaling networks","volume":"40","author":"Li","year":"2013","journal-title":"J Genet Genomics"},{"key":"2023011816300169600_cvac030-B145","doi-asserted-by":"crossref","first-page":"90","DOI":"10.12703\/P6-90","article-title":"Rethinking cardiac metabolism: metabolic cycles to refuel and rebuild the failing heart","volume":"6","author":"Taegtmeyer","year":"2014","journal-title":"F1000 Prime Rep"},{"key":"2023011816300169600_cvac030-B146","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1016\/j.bbadis.2016.08.012","article-title":"O-GlcNAcylation, enemy or ally during cardiac hypertrophy development?","volume":"1862","author":"Mailleux","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"2023011816300169600_cvac030-B147","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.freeradbiomed.2016.10.500","article-title":"NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells","volume":"101","author":"Zeng","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"2023011816300169600_cvac030-B148","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.trecan.2016.11.001","article-title":"Nutrient exploitation within the tumor-stroma metabolic crosstalk","volume":"2","author":"Morandi","year":"2016","journal-title":"Trends Cancer"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvac030\/43374861\/cvac030.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/118\/17\/3305\/48758307\/cvac030.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/118\/17\/3305\/48758307\/cvac030.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T16:32:34Z","timestamp":1674059554000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/118\/17\/3305\/6553925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,24]]},"references-count":148,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,3,24]]},"published-print":{"date-parts":[[2023,1,18]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvac030","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,12,1]]},"published":{"date-parts":[[2022,3,24]]}}}