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A large body of experimental data links HIF activity to protection against multiple disorders affecting the cardiovascular system: ischemic cardiovascular disease (including coronary artery disease and peripheral artery disease), through collateral blood vessel formation and preconditioning phenomena; emphysema; lymphedema; and lung transplant rejection. In these disorders, strategies to increase the expression of one or both HIFs may be of therapeutic utility. Conversely, extensive data link HIFs to the pathogenesis of pulmonary arterial hypertension and drugs that inhibit one or both HIFs may be useful in treating this disease.<\/jats:p>","DOI":"10.1093\/cvr\/cvac089","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T13:38:31Z","timestamp":1654868311000},"page":"371-380","source":"Crossref","is-referenced-by-count":38,"title":["Hypoxia-inducible factors: roles in cardiovascular disease progression, prevention, and treatment"],"prefix":"10.1093","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0913-211X","authenticated-orcid":false,"given":"Gregg L","family":"Semenza","sequence":"first","affiliation":[{"name":"Armstrong Oxygen Biology Research Center, Vascular Program, Institute for Cell Engineering; and Departments of Genetic Medicine, Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, Johns Hopkins University School of Medicine , Baltimore, MD 21205 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,11]]},"reference":[{"key":"2023033112404789100_","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-physiol-021113-170322","article-title":"Hypoxia-inducible factor 1 and cardiovascular disease","volume":"76","author":"Semenza","year":"2014","journal-title":"Ann Rev Physiol"},{"key":"2023033112404789100_","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/s41467-021-21687-2","article-title":"Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response","volume":"12","author":"Andrysik","year":"2021","journal-title":"Nat Commun"},{"key":"2023033112404789100_","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/embr.201337642","article-title":"Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2","volume":"15","author":"Choudhry","year":"2014","journal-title":"EMBO Rep"},{"key":"2023033112404789100_","doi-asserted-by":"crossref","first-page":"eabe3771","DOI":"10.1126\/sciadv.abe3771","article-title":"Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization","volume":"7","author":"Wang","year":"2021","journal-title":"Sci Adv"},{"key":"2023033112404789100_","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"1995. 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