{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:17:47Z","timestamp":1787008667780,"version":"build-2736575974"},"reference-count":141,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Here, we review the highlights of cardiovascular basic science published in 2021 and early 2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular Science. We begin with non-coding RNAs which have emerged as central regulators cardiovascular biology, and then discuss how technological developments in single-cell \u2018omics are providing new insights into cardiovascular development, inflammation, and disease. We also review recent discoveries on the biology of extracellular vesicles in driving either protective or pathogenic responses. The Nobel Prize in Physiology or Medicine 2021 recognized the importance of the molecular basis of mechanosensing and here we review breakthroughs in cardiovascular sensing of mechanical force. We also summarize discoveries in the field of atherosclerosis including the role of clonal haematopoiesis of indeterminate potential, and new mechanisms of crosstalk between hyperglycaemia, lipid mediators, and inflammation. The past 12 months also witnessed major advances in the field of cardiac arrhythmia including new mechanisms of fibrillation. We also focus on inducible pluripotent stem cell technology which has demonstrated disease causality for several genetic polymorphisms in long-QT syndrome and aortic valve disease, paving the way for personalized medicine approaches. Finally, the cardiovascular community has continued to better understand COVID-19 with significant advancement in our knowledge of cardiovascular tropism, molecular markers, the mechanism of vaccine-induced thrombotic complications and new anti-viral therapies that protect the cardiovascular system.<\/jats:p>","DOI":"10.1093\/cvr\/cvac114","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T02:38:52Z","timestamp":1658975932000},"page":"2754-2767","source":"Crossref","is-referenced-by-count":11,"title":["From novel discovery tools and biomarkers to precision medicine\u2014basic cardiovascular science highlights of 2021\/22"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7975-681X","authenticated-orcid":false,"given":"Paul C","family":"Evans","sequence":"first","affiliation":[{"name":"Department of Infection, Immunity and Cardiovascular Disease and Insigneo Institute, University of Sheffield , Sheffield S10 2RX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M","family":"Davidson","sequence":"additional","affiliation":[{"name":"The Hatter Cardiovascular Institute, University College London , 67 Chenies Mews, London WC1E 6HX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1282-9276","authenticated-orcid":false,"given":"Johann","family":"Wojta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Medical University of Vienna , 1090 Vienna , Austria"},{"name":"Ludwig Boltzmann Institute for Cardiovascular Research , 1090 Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"B\u00e4ck","sequence":"additional","affiliation":[{"name":"Translational Cardiology, Karolinska Institutet and Karolinska University Hospital , 171 77 Stockholm , Sweden"},{"name":"INSERM U1116, University of Lorraine, U1116 Nancy University Hospital, Nancy , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sveva","family":"Bollini","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine (DIMES), University of Genova , L.go R. Benzi 10, 16132 Genova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3830-200X","authenticated-orcid":false,"given":"Mairi","family":"Brittan","sequence":"additional","affiliation":[{"name":"Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences, University of Edinburgh , Edinburgh EH16 4TJ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-2094","authenticated-orcid":false,"given":"Alberico L","family":"Catapano","sequence":"additional","affiliation":[{"name":"University of Milano and Multimedica IRCCS , 20149 Milano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bill","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University , Newcastle upon Tyne NE1 7RU , 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Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2012-1187","authenticated-orcid":false,"given":"Tomasz J","family":"Guzik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Jagiellonian University Medical College , 31-008 Krak\u00f3w , Poland"},{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow , Glasgow G12 8QQ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imo","family":"Hoefer","sequence":"additional","affiliation":[{"name":"Central Diagnostic Laboratory, UMC Utrecht , 3584 CX Utrecht , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6455-2777","authenticated-orcid":false,"given":"Rosalinda","family":"Madonna","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Molecular and Critical Care Area, Institute of Cardiology, University of Pisa , 56124 Pisa , Italy"},{"name":"Department of Internal Medicine, Cardiology Division, University of Texas Medical School , Houston, TX 77065 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o P","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences, University of Edinburgh , Edinburgh EH16 4TJ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Morawietz","sequence":"additional","affiliation":[{"name":"Division of Vascular Endothelium and Microcirculation, Department of Medicine III, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden , 01069 Dresden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8196-5696","authenticated-orcid":false,"given":"Elena","family":"Osto","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Department of Cardiology, Heart Center, University Hospital & University of Zurich , 8091 Z\u00fcric , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Padr\u00f3","sequence":"additional","affiliation":[{"name":"Cardiovascular Program-ICCC, IR-Hospital Santa Creu i Sant Pau, IIB-Sant Pau , 08041 Barcelona , Spain"},{"name":"CiberCV, Institute Carlos III , Madrid 28029 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith C","family":"Sluimer","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht, Maastricht University , 6200 MD Maastricht , the Netherlands"},{"name":"University\/BHF Centre for Cardiovascular Sciences, University of Edinburgh , Edinburgh EH16 4TJ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Gabriele","family":"Tocchetti","sequence":"additional","affiliation":[{"name":"Cardio-Oncology Unit, Department of Translational Medical Sciences, Center for Basic and Clinical Immunology (CISI), Interdepartmental Center of Clinical and Translational Sciences (CIRCET), Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University , 80131 Napoli , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6537-5992","authenticated-orcid":false,"given":"Kim","family":"Van der Heiden","sequence":"additional","affiliation":[{"name":"Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, 3015 GD Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Vilahur","sequence":"additional","affiliation":[{"name":"Cardiovascular Program-ICCC, IR-Hospital Santa Creu i Sant Pau, IIB-Sant Pau , 08041 Barcelona , Spain"},{"name":"CiberCV, Institute Carlos III , Madrid 28029 , 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