{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:11:40Z","timestamp":1792080700931,"version":"4.4.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1062671"],"award-info":[{"award-number":["1062671"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We investigated the association of fasting triglycerides with cardiovascular disease (CVD) mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This cohort study included US adults from the National Health and Nutrition Examination Surveys from 1988 to 2014. CVD mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of triglycerides for CVD mortality. The cohort included 26 570 adult participants, among which 3978 had diabetes. People with higher triglycerides had a higher prevalence of diabetes at baseline. The cohort was followed up for a mean of 12.0 years with 1492 CVD deaths recorded. A 1-natural-log-unit higher triglyceride was associated with a 30% higher multivariate-adjusted risk of CVD mortality in participants with diabetes (HR, 1.30; 95% CI, 1.08\u20131.56) but not in those without diabetes (HR, 0.95; 95% CI, 0.83\u20131.07). In participants with diabetes, people with high triglycerides (200\u2013499 mg\/dL) had a 44% (HR, 1.44; 95% CI, 1.12\u20131.85) higher multivariate-adjusted risk of CVD mortality compared with those with normal triglycerides (&amp;lt;150 mg\/dL). The findings remained significant when diabetes was defined by fasting glucose levels alone, or after further adjustment for the use of lipid-lowering medications, or after the exclusion of those who took lipid-lowering medications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study demonstrates that fasting triglycerides of \u2265200 mg\/dL are associated with an increased risk of CVD mortality in patients with diabetes but not in those without diabetes. Future clinical trials of new treatments to lower triglycerides should focus on patients with diabetes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvac124","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T17:09:11Z","timestamp":1659114551000},"page":"826-834","source":"Crossref","is-referenced-by-count":33,"title":["Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes"],"prefix":"10.1093","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-6443","authenticated-orcid":false,"given":"Yutang","family":"Wang","sequence":"first","affiliation":[{"name":"Discipline of Life Science, School of Science, Psychology and Sport, Federation University Australia , University Drive, Mt Helen, Ballarat, VIC, 3350 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Fang","sequence":"additional","affiliation":[{"name":"Discipline of Life Science, School of Science, Psychology and Sport, Federation University Australia , University Drive, Mt Helen, Ballarat, VIC, 3350 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna J","family":"Magliano","sequence":"additional","affiliation":[{"name":"Diabetes and Population Health, Baker Heart and Diabetes Institute , Melbourne, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-9941","authenticated-orcid":false,"given":"Fadi J","family":"Charchar","sequence":"additional","affiliation":[{"name":"Discipline of Life Science, School of Science, Psychology and Sport, Federation University Australia , University Drive, Mt Helen, Ballarat, VIC, 3350 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G","family":"Sobey","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Biology and Disease Research and Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University , Melbourne, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant R","family":"Drummond","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Biology and Disease Research and Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University , Melbourne, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-8848","authenticated-orcid":false,"given":"Jonathan","family":"Golledge","sequence":"additional","affiliation":[{"name":"Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University , Townsville, QLD , Australia"},{"name":"Department of Vascular and Endovascular Surgery, The Townsville University Hospital , Townsville, QLD , 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