{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:24:53Z","timestamp":1792794293752,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation","doi-asserted-by":"publisher","award":["G-17-0017612"],"award-info":[{"award-number":["G-17-0017612"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Career Investigator Award","award":["StSB CI-7432"],"award-info":[{"award-number":["StSB CI-7432"]}]},{"name":"Mid-Career Investigator Awards"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["450152"],"award-info":[{"award-number":["450152"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["450171"],"award-info":[{"award-number":["450171"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CIHR-funded Sleep and Biological Rhythms Team Grant"},{"name":"Heart and Stroke Richard Lewar Centre of Excellence","id":[{"id":"https:\/\/ror.org\/00qbpyp73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Canadian Foundation for Innovation and Ontario Research Fund","award":["11810"],"award-info":[{"award-number":["11810"]}],"id":[{"id":"https:\/\/ror.org\/000az4664","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Qanatpharma AG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Circadian rhythms orchestrate important functions in the cardiovascular system: the contribution of microvascular rhythms to cardiovascular disease progression\/severity is unknown. This study hypothesized that (i) myogenic reactivity in skeletal muscle resistance arteries is rhythmic and (ii) disrupting this rhythmicity would alter cardiac injury post-myocardial infarction (MI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Cremaster skeletal muscle resistance arteries were isolated and assessed using standard pressure myography. Circadian rhythmicity was globally disrupted with the Clock\u039419\/\u039419 mutation or discretely through smooth muscle cell-specific Bmal1 deletion (Sm-Bmal1 KO). Cardiac structure and function were determined by echocardiographic, hemodynamic and histological assessments. Myogenic reactivity in cremaster muscle resistance arteries is rhythmic. This rhythm is putatively mediated by the circadian modulation of a mechanosensitive signalosome incorporating tumour necrosis factor and casein kinase 1. Following left anterior descending coronary artery ligation, myogenic responsiveness is locked at the circadian maximum, although circadian molecular clock gene expression cycles normally. Disrupting the molecular clock abolishes myogenic rhythmicity: myogenic tone is suspended at the circadian minimum and is no longer augmented by MI. The reduced myogenic tone in Clock\u039419\/\u039419 mice and Sm-Bmal1 KO mice associates with reduced total peripheral resistance (TPR), improved cardiac function and reduced infarct expansion post-MI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Augmented microvascular constriction aggravates cardiac injury post-MI. Following MI, skeletal muscle resistance artery myogenic reactivity increases specifically within the rest phase, when TPR would normally decline. Disrupting the circadian clock interrupts the MI-induced augmentation in myogenic reactivity: therapeutics targeting the molecular clock, therefore, may be useful for improving MI outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvac174","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T09:41:00Z","timestamp":1668850860000},"page":"1403-1415","source":"Crossref","is-referenced-by-count":16,"title":["Disrupting circadian control of peripheral myogenic reactivity mitigates cardiac injury following myocardial infarction"],"prefix":"10.1093","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9638-3816","authenticated-orcid":false,"given":"Jeffrey T","family":"Kroetsch","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Toronto , Toronto , Canada"},{"name":"Toronto Centre for Microvascular Medicine at The Ted Rogers Centre for Heart Research Translational Biology and Engineering 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University of Toronto , Toronto , Canada"},{"name":"Toronto Centre for Microvascular Medicine at The Ted Rogers Centre for Heart Research Translational Biology and Engineering Program, University of Toronto , 661 University Avenue, 14th Floor, Toronto, Ontario M5G 1M1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarak N","family":"Khatua","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Investigations, Department of Biomedical Sciences, University of Guelph , Guelph , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott P","family":"Heximer","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Toronto , Toronto , Canada"},{"name":"Heart & Stroke\/Richard Lewar Centre of Excellence for Cardiovascular Research, University of Toronto , Toronto , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tami 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