{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:53:50Z","timestamp":1793904830091,"version":"4.8.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170326"],"award-info":[{"award-number":["82170326"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700332"],"award-info":[{"award-number":["81700332"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770328"],"award-info":[{"award-number":["81770328"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>CD4+ T cells are the major drivers of cardiac-specific autoimmunity in myocarditis, specifically Th1, Treg, and most significant Th17 cells. But the molecular mechanisms of their activation remain unclear. We aimed to elucidate the regulatory role of phosphoglycerate kinase 1 (PGK1) in CD4+ T cells and experimental autoimmune myocarditis (EAM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>EAM was induced in BALB\/c mice by subcutaneous injections with alpha myosin heavy chain peptide emulsified in complete Freund\u2019s adjuvant. Single-cell sequencing analysis found that glycolysis and PGK1 expression were elevated in cardiac CD4+ T and Th17 cells from myocarditis mice. Mice treated with PGK1 inhibitor NG52 showed less cardiac inflammation and fibrosis and better contractile function, as well as reduced cardiac infiltrating Th17 and Th1 cells and increased proportion of Treg. NG52 suppressed CD4+ T cell activation and differentiation of mice and myocarditis patients in vitro. Mechanistically, inhibition of PGK1 suppressed glycolytic activity and decreased pyruvate dehydrogenase kinase 1 (PDHK1) phosphorylation, thereby increasing reactive oxygen species (ROS) production in mitochondria and thus preventing Th17 cell differentiation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>PGK1 may act as a key metabolic regulator of CD4+ T cell differentiation and regulates Th17 cell differentiation by regulating glycolysis and the PDHK1-ROS axis. Targeting PGK1 might be a promising strategy for the treatment of myocarditis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvad029","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T22:57:34Z","timestamp":1675292254000},"page":"1377-1389","source":"Crossref","is-referenced-by-count":67,"title":["Inhibition of phosphoglycerate kinase 1 attenuates autoimmune myocarditis by reprogramming CD4+ T cell metabolism"],"prefix":"10.1093","volume":"119","author":[{"given":"Yang","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"},{"name":"Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Avenue 1277, 430022 Wuhan , China"},{"name":"Key Lab for Biological Targeted Therapy of Education Ministry and Hubei Province, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"},{"name":"Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Avenue 1277, 430022 Wuhan , China"},{"name":"Key Lab for Biological Targeted Therapy of Education Ministry and Hubei Province, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"},{"name":"Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Avenue 1277, 430022 Wuhan , China"},{"name":"Key Lab for Biological Targeted Therapy of Education Ministry and Hubei Province, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaitao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"},{"name":"Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Avenue 1277, 430022 Wuhan , China"},{"name":"Key Lab for Biological Targeted Therapy of Education Ministry and Hubei Province, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"},{"name":"Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Avenue 1277, 430022 Wuhan , China"},{"name":"Key Lab for Biological Targeted Therapy of Education Ministry and Hubei Province, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"},{"name":"Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Avenue 1277, 430022 Wuhan , China"},{"name":"Key Lab for Biological Targeted Therapy of Education Ministry and Hubei Province, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1125-0294","authenticated-orcid":false,"given":"Yimei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"},{"name":"Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Avenue 1277, 430022 Wuhan , China"},{"name":"Key Lab for Biological Targeted Therapy of Education Ministry and Hubei Province, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 430022 Wuhan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"2023061309582722000_cvad029-B1","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1093\/eurheartj\/ehn296","article-title":"Acute viral myocarditis","volume":"29","author":"Dennert","year":"2008","journal-title":"Eur Heart J"},{"key":"2023061309582722000_cvad029-B2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41569-020-00435-x","article-title":"Myocarditis and inflammatory cardiomyopathy: current evidence and future directions","volume":"18","author":"Tsch\u00f6pe","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"2023061309582722000_cvad029-B3","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.2174\/1381612821666150316123711","article-title":"Mouse models of autoimmune diseases\u2014autoimmune myocarditis","volume":"21","author":"Muller","year":"2015","journal-title":"Curr Pharm Des"},{"key":"2023061309582722000_cvad029-B4","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.4049\/jimmunol.147.7.2141","article-title":"Myosin-induced acute myocarditis is a T cell-mediated disease","volume":"147","author":"Smith","year":"1991","journal-title":"J Immunol"},{"key":"2023061309582722000_cvad029-B5","doi-asserted-by":"crossref","first-page":"4396351","DOI":"10.1155\/2018\/4396351","article-title":"Regulatory role of CD4(+) T cells in myocarditis","volume":"2018","author":"Vdovenko","year":"2018","journal-title":"J Immunol Res"},{"key":"2023061309582722000_cvad029-B6","doi-asserted-by":"crossref","first-page":"e85851","DOI":"10.1172\/jci.insight.85851","article-title":"Cardiac myosin-Th17 responses promote heart failure in human myocarditis","volume":"1","author":"Myers","year":"2016","journal-title":"JCI Insight"},{"key":"2023061309582722000_cvad029-B7","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.intimp.2009.11.010","article-title":"Neutralization of IL-17 inhibits the production of anti-ANT autoantibodies in CVB3-induced acute viral myocarditis","volume":"10","author":"Yuan","year":"2010","journal-title":"Int Immunopharmacol"},{"key":"2023061309582722000_cvad029-B8","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.4049\/jimmunol.1001718","article-title":"Th17 cells contribute to viral replication in coxsackievirus B3-induced acute viral myocarditis","volume":"185","author":"Yuan","year":"2010","journal-title":"J Immunol"},{"key":"2023061309582722000_cvad029-B9","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1161\/CIRCRESAHA.109.213157","article-title":"Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy","volume":"106","author":"Baldeviano","year":"2010","journal-title":"Circ Res"},{"key":"2023061309582722000_cvad029-B10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0065-2776(08)00604-4","article-title":"Pathogenesis of myocarditis and dilated cardiomyopathy","volume":"99","author":"Cihakova","year":"2008","journal-title":"Adv Immunol"},{"key":"2023061309582722000_cvad029-B11","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1161\/CIRCULATIONAHA.109.893248","article-title":"Regulatory T cells protect mice against coxsackievirus-induced myocarditis through the transforming growth factor beta-coxsackie-adenovirus receptor pathway","volume":"121","author":"Shi","year":"2010","journal-title":"Circulation"},{"key":"2023061309582722000_cvad029-B12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41577-019-0203-y","article-title":"Metabolic coordination of T cell quiescence and activation","volume":"20","author":"Chapman","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"2023061309582722000_cvad029-B13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2567.2012.03583.x","article-title":"Molecular mechanisms of metabolic reprogramming in proliferating cells: implications for T-cell-mediated immunity","volume":"136","author":"Marelli-Berg","year":"2012","journal-title":"Immunology"},{"key":"2023061309582722000_cvad029-B14","doi-asserted-by":"crossref","first-page":"240","DOI":"10.15698\/cst2019.08.194","article-title":"Immunometabolic cross-talk in the inflamed heart","volume":"3","author":"Marelli-Berg","year":"2019","journal-title":"Cell Stress"},{"key":"2023061309582722000_cvad029-B15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fimmu.2012.00173","article-title":"T cell immunity and cardiovascular metabolic disorders: does metabolism fuel inflammation?","volume":"3","author":"Mauro","year":"2012","journal-title":"Front Immunol"},{"key":"2023061309582722000_cvad029-B16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev-immunol-032712-095956","article-title":"Metabolic regulation of T lymphocytes","volume":"31","author":"MacIver","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"2023061309582722000_cvad029-B17","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.20110278","article-title":"HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells","volume":"208","author":"Shi","year":"2011","journal-title":"J Exp Med"},{"key":"2023061309582722000_cvad029-B18","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1084\/jem.20151159","article-title":"T cell metabolism drives immunity","volume":"212","author":"Buck","year":"2015","journal-title":"J Exp Med"},{"key":"2023061309582722000_cvad029-B19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fimmu.2017.00311","article-title":"Immunometabolic regulation of interleukin-17-producing T helper cells: uncoupling new targets for autoimmunity","volume":"8","author":"Binger","year":"2017","journal-title":"Front Immunol"},{"key":"2023061309582722000_cvad029-B20","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.immuni.2021.04.008","article-title":"Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses","volume":"54","author":"Xu","year":"2021","journal-title":"Immunity"},{"key":"2023061309582722000_cvad029-B21","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.yjmcc.2019.08.002","article-title":"Metabolic reprogramming orchestrates CD4+ T-cell immunological status and restores cardiac dysfunction in autoimmune induced-dilated cardiomyopathy mice","volume":"135","author":"Wu","year":"2019","journal-title":"J Mol Cell Cardiol"},{"key":"2023061309582722000_cvad029-B22","doi-asserted-by":"crossref","first-page":"117863","DOI":"10.1016\/j.lfs.2020.117863","article-title":"Phosphoglycerate kinase 1 (PGK1) in cancer: a promising target for diagnosis and therapy","volume":"256","author":"Fu","year":"2020","journal-title":"Life Sci"},{"key":"2023061309582722000_cvad029-B23","first-page":"2280","article-title":"PGK1-mediated cancer progression and drug resistance","volume":"9","author":"He","year":"2019","journal-title":"Am J Cancer Res"},{"key":"2023061309582722000_cvad029-B24","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00011-016-0965-7","article-title":"PGK1, a glucose metabolism enzyme, may play an important role in rheumatoid arthritis","volume":"65","author":"Zhao","year":"2016","journal-title":"Inflamm Res"},{"key":"2023061309582722000_cvad029-B25","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1161\/CIRCULATIONAHA.119.043545","article-title":"Single-cell RNA sequencing to dissect the immunological network of autoimmune myocarditis","volume":"142","author":"Hua","year":"2020","journal-title":"Circulation"},{"key":"2023061309582722000_cvad029-B26","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1038\/s41467-020-15851-3","article-title":"Deep learning enables accurate clustering with batch effect removal in single-cell RNA-seq analysis","volume":"11","author":"Li","year":"2020","journal-title":"Nat Commun"},{"key":"2023061309582722000_cvad029-B27","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41401-020-0465-8","article-title":"Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52","volume":"42","author":"Wang","year":"2021","journal-title":"Acta Pharmacol Sin"},{"key":"2023061309582722000_cvad029-B28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/bph.13682","article-title":"The neuropeptide cortistatin attenuates experimental autoimmune myocarditis via inhibition of cardiomyogenic T cell-driven inflammatory responses","volume":"174","author":"Delgado-Maroto","year":"2017","journal-title":"Br J Pharmacol"},{"key":"2023061309582722000_cvad029-B29","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1172\/JCI76012","article-title":"Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation","volume":"125","author":"Gerriets","year":"2015","journal-title":"J Clin Invest"},{"key":"2023061309582722000_cvad029-B30","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.molcel.2016.02.009","article-title":"Mitochondria-translocated PGK1 functions as a protein kinase to coordinate glycolysis and the TCA cycle in tumorigenesis","volume":"61","author":"Li","year":"2016","journal-title":"Mol Cell"},{"key":"2023061309582722000_cvad029-B31","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.smim.2016.10.009","article-title":"Metabolic pathways in T cell activation and lineage differentiation","volume":"28","author":"Almeida","year":"2016","journal-title":"Semin Immunol"},{"key":"2023061309582722000_cvad029-B32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cmet.2019.10.015","article-title":"Pharmacological activation of pyruvate kinase M2 inhibits CD4(+) T cell pathogenicity and suppresses autoimmunity","volume":"31","author":"Angiari","year":"2020","journal-title":"Cell Metab"},{"key":"2023061309582722000_cvad029-B33","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.cell.2020.06.014","article-title":"Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancy","volume":"182","author":"Wu","year":"2020","journal-title":"Cell"},{"key":"2023061309582722000_cvad029-B34","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.cmet.2019.10.004","article-title":"Lactate buildup at the site of chronic inflammation promotes disease by inducing CD4(+) T cell metabolic rewiring","volume":"30","author":"Pucino","year":"2019","journal-title":"Cell Metab"},{"key":"2023061309582722000_cvad029-B35","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.cell.2015.08.012","article-title":"Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses","volume":"162","author":"Ho","year":"2015","journal-title":"Cell"},{"key":"2023061309582722000_cvad029-B36","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.4049\/jimmunol.1502581","article-title":"NADPH oxidase-derived superoxide provides a third signal for CD4 T cell effector responses","volume":"197","author":"Padgett","year":"2016","journal-title":"J Immunol"},{"key":"2023061309582722000_cvad029-B37","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.immuni.2019.08.001","article-title":"High glucose intake exacerbates autoimmunity through reactive-oxygen-species-mediated TGF-\u03b2 cytokine activation","volume":"51","author":"Zhang","year":"2019","journal-title":"Immunity"},{"key":"2023061309582722000_cvad029-B38","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1084\/jem.20161120","article-title":"Suppression of Th17 cell differentiation by misshapen\/NIK-related kinase MINK1","volume":"214","author":"Fu","year":"2017","journal-title":"J Exp Med"},{"key":"2023061309582722000_cvad029-B39","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.cmet.2019.01.019","article-title":"Calcium signaling controls pathogenic Th17 cell-mediated inflammation by regulating mitochondrial function","volume":"29","author":"Kaufmann","year":"2019","journal-title":"Cell Metab"},{"key":"2023061309582722000_cvad029-B40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"2023061309582722000_cvad029-B41","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nature06878","article-title":"TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function","volume":"453","author":"Zhou","year":"2008","journal-title":"Nature"},{"key":"2023061309582722000_cvad029-B42","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.4049\/jimmunol.1003613","article-title":"Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets","volume":"186","author":"Michalek","year":"2011","journal-title":"J Immunol"},{"key":"2023061309582722000_cvad029-B43","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1182\/blood-2010-09-307041","article-title":"Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress","volume":"117","author":"Mougiakakos","year":"2011","journal-title":"Blood"},{"key":"2023061309582722000_cvad029-B44","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1182\/blood-2008-09-181040","article-title":"Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress-induced cell death","volume":"113","author":"Mougiakakos","year":"2009","journal-title":"Blood"},{"key":"2023061309582722000_cvad029-B45","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1002\/eji.201142209","article-title":"Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy","volume":"42","author":"Nindl","year":"2012","journal-title":"Eur J Immunol"},{"key":"2023061309582722000_cvad029-B46","doi-asserted-by":"crossref","first-page":"10785","DOI":"10.1128\/JVI.76.21.10785-10790.2002","article-title":"Vgamma4(+) T cells promote autoimmune CD8(+) cytolytic T-lymphocyte activation in coxsackievirus B3-induced myocarditis in mice: role for CD4(+) Th1 cells","volume":"76","author":"Huber","year":"2002","journal-title":"J Virol"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvad029\/49228757\/cvad029.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/119\/6\/1377\/50578250\/cvad029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/119\/6\/1377\/50578250\/cvad029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T09:59:12Z","timestamp":1686650352000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/119\/6\/1377\/7023060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,2]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,2,2]]},"published-print":{"date-parts":[[2023,6,13]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvad029","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5]]},"published":{"date-parts":[[2023,2,2]]}}}