{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:34:49Z","timestamp":1792085689675,"version":"4.4.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000968","name":"AHA","doi-asserted-by":"publisher","award":["23CDA1052548 (D.Y.C.)"],"award-info":[{"award-number":["23CDA1052548 (D.Y.C.)"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"AHA","doi-asserted-by":"publisher","award":["19CDA34760010 (Z.K.)"],"award-info":[{"award-number":["19CDA34760010 (Z.K.)"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"AHA","doi-asserted-by":"publisher","award":["16SDG30130015 (J.F.G.)"],"award-info":[{"award-number":["16SDG30130015 (J.F.G.)"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P01HL129941 (K.E.B.)"],"award-info":[{"award-number":["P01HL129941 (K.E.B.)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01AI134714 (K.E.B.)"],"award-info":[{"award-number":["R01AI134714 (K.E.B.)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01AI164519 (K.E.B.)"],"award-info":[{"award-number":["R01AI164519 (K.E.B.)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HL142672 (J.F.G.)"],"award-info":[{"award-number":["R01HL142672 (J.F.G.)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30DK063491 (J.F.G.)"],"award-info":[{"award-number":["P30DK063491 (J.F.G.)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K99HL141638 (D.O.-D.)"],"award-info":[{"award-number":["K99HL141638 (D.O.-D.)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R35 GM138003 (A.S.D.)"],"award-info":[{"award-number":["R35 GM138003 (A.S.D.)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30 DK063491 (A.S.D.)"],"award-info":[{"award-number":["P30 DK063491 (A.S.D.)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The metabolic failure of macrophages to adequately process lipid is central to the aetiology of atherosclerosis. Here, we examine the role of macrophage angiotensin-converting enzyme (ACE) in a mouse model of PCSK9-induced atherosclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Atherosclerosis in mice was induced with AAV-PCSK9 and a high-fat diet. Animals with increased macrophage ACE (ACE 10\/10 mice) have a marked reduction in atherosclerosis vs. WT mice. Macrophages from both the aorta and peritoneum of ACE 10\/10 express increased PPAR\u03b1 and have a profoundly altered phenotype to process lipids characterized by higher levels of the surface scavenger receptor CD36, increased uptake of lipid, increased capacity to transport long chain fatty acids into mitochondria, higher oxidative metabolism and lipid \u03b2-oxidation as determined using 13C isotope tracing, increased cell ATP, increased capacity for efferocytosis, increased concentrations of the lipid transporters ABCA1 and ABCG1, and increased cholesterol efflux. These effects are mostly independent of angiotensin II. Human THP-1 cells, when modified to express more ACE, increase expression of PPAR\u03b1, increase cell ATP and acetyl-CoA, and increase cell efferocytosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Increased macrophage ACE expression enhances macrophage lipid metabolism, cholesterol efflux, efferocytosis, and it reduces atherosclerosis. This has implications for the treatment of cardiovascular disease with angiotensin II receptor antagonists vs. ACE inhibitors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvad082","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T19:01:23Z","timestamp":1684954883000},"page":"1825-1841","source":"Crossref","is-referenced-by-count":61,"title":["Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor \u03b1 and fundamentally changing lipid metabolism"],"prefix":"10.1093","volume":"119","author":[{"given":"DuoYao","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakir","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]},{"name":"Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen A","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron R","family":"Victor","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faizan","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoi O","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana C","family":"Veiras","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingtian","family":"Che","sequence":"additional","affiliation":[{"name":"Biobank and Pathology Shared Resource, Cedars-Sinai Medical Center , Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cai","sequence":"additional","affiliation":[{"name":"Saha Cardiovascular Research Center and Department of Physiology, University of Kentucky , Lexington, KY 40536 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michifumi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Saha Cardiovascular Research Center and Department of Physiology, University of Kentucky , Lexington, KY 40536 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan E","family":"Temel","sequence":"additional","affiliation":[{"name":"Saha Cardiovascular Research Center and Department of Physiology, University of Kentucky , Lexington, KY 40536 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge F","family":"Giani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]},{"name":"Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Luthringer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit S","family":"Divakaruni","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine , Los Angeles, CA 90095 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derick","family":"Okwan-Duodu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]},{"name":"Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5435-8663","authenticated-orcid":false,"given":"Kenneth E","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]},{"name":"Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"2026041420141486600_cvad082-B1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nri3520","article-title":"Macrophages in atherosclerosis: a dynamic balance","volume":"13","author":"Moore","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"2026041420141486600_cvad082-B2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/ATVBAHA.119.312802","article-title":"Macrophages in atherosclerosis regression","volume":"40","author":"Barrett","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026041420141486600_cvad082-B3","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/HYPERTENSIONAHA.120.16667","article-title":"Comparative first-line effectiveness and safety of ACE (angiotensin-converting enzyme) inhibitors and angiotensin receptor blockers: a multinational cohort study","volume":"78","author":"Chen","year":"2021","journal-title":"Hypertension"},{"key":"2026041420141486600_cvad082-B4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s11658-020-00225-w","article-title":"Role of angiotensin-converting enzyme in myeloid cell immune responses","volume":"25","author":"Cao","year":"2020","journal-title":"Cell Mol Biol Lett"},{"key":"2026041420141486600_cvad082-B5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2018.15","article-title":"Angiotensin-converting enzyme in innate and adaptive immunity","volume":"14","author":"Bernstein","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"2026041420141486600_cvad082-B6","doi-asserted-by":"crossref","first-page":"170769","DOI":"10.1016\/j.peptides.2022.170769","article-title":"The non-cardiovascular actions of ACE","volume":"152","author":"Cao","year":"2022","journal-title":"Peptides"},{"key":"2026041420141486600_cvad082-B7","doi-asserted-by":"crossref","first-page":"39051","DOI":"10.1074\/jbc.M110.163782","article-title":"Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus","volume":"285","author":"Okwan-Duodu","year":"2010","journal-title":"J Biol Chem"},{"key":"2026041420141486600_cvad082-B8","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.2353\/ajpath.2007.061205","article-title":"Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma","volume":"170","author":"Shen","year":"2007","journal-title":"Am J Pathol"},{"key":"2026041420141486600_cvad082-B9","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/brain\/awz364","article-title":"Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease","volume":"143","author":"Koronyo-Hamaoui","year":"2020","journal-title":"Brain"},{"key":"2026041420141486600_cvad082-B10","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1172\/JCI66541","article-title":"Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer\u2019s-like cognitive decline","volume":"124","author":"Bernstein","year":"2014","journal-title":"J Clin Invest"},{"key":"2026041420141486600_cvad082-B11","doi-asserted-by":"crossref","first-page":"eabj2138","DOI":"10.1126\/scitranslmed.abj2138","article-title":"An ACE inhibitor reduces bactericidal activity of human neutrophils in vitro and impairs mouse neutrophil activity in vivo","volume":"13","author":"Cao","year":"2021","journal-title":"Sci Transl Med"},{"key":"2026041420141486600_cvad082-B12","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1161\/01.CIR.94.11.2756","article-title":"Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease","volume":"94","author":"Diet","year":"1996","journal-title":"Circulation"},{"key":"2026041420141486600_cvad082-B13","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1097\/00004872-199715110-00014","article-title":"Enhanced expression of angiotensin-converting enzyme is associated with progression of coronary atherosclerosis in humans","volume":"15","author":"Ohishi","year":"1997","journal-title":"J Hypertens"},{"key":"2026041420141486600_cvad082-B14","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/S0021-9258(17)49895-4","article-title":"ACE Overexpression in myeloid cells increases oxidative metabolism and cellular","volume":"295","author":"Cao","year":"2020","journal-title":"J Biol Chem"},{"key":"2026041420141486600_cvad082-B15","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fcvm.2019.00046","article-title":"Mouse models for atherosclerosis research-which is my line?","volume":"6","author":"Oppi","year":"2019","journal-title":"Front Cardiovasc Med"},{"key":"2026041420141486600_cvad082-B16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.atherosclerosis.2016.06.011","article-title":"A single injection of gain-of- function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification","volume":"251","author":"Goettsch","year":"2016","journal-title":"Atherosclerosis"},{"key":"2026041420141486600_cvad082-B17","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/labinvest.2017.47","article-title":"Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation","volume":"97","author":"Kumar","year":"2017","journal-title":"Lab Invest"},{"key":"2026041420141486600_cvad082-B18","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bbrc.2019.10.078","article-title":"Overexpression of myeloid angiotensin-converting enzyme (ACE) reduces atherosclerosis","volume":"520","author":"Okwan-Duodu","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"2026041420141486600_cvad082-B19","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1194\/jlr.M500232-JLR200","article-title":"Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2","volume":"46","author":"Temel","year":"2005","journal-title":"J Lipid Res"},{"key":"2026041420141486600_cvad082-B20","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1161\/ATVBAHA.120.315255","article-title":"Local M-CSF (macrophage colony-stimulating factor) expression regulates macrophage proliferation and apoptosis in atherosclerosis","volume":"41","author":"Sinha","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026041420141486600_cvad082-B21","first-page":"102535","article-title":"Streptococcus pneumoniae pneumolysin and neuraminidase A convert high-density lipoproteins into pro- atherogenic particles","volume-title":"iScience","author":"Syed","year":"2021"},{"key":"2026041420141486600_cvad082-B22","doi-asserted-by":"crossref","first-page":"6139107","DOI":"10.1155\/2017\/6139107","article-title":"New transcriptional reporters to quantify and monitor PPARgamma activity","volume":"2017","author":"Degrelle","year":"2017","journal-title":"PPAR Res"},{"key":"2026041420141486600_cvad082-B23","doi-asserted-by":"crossref","first-page":"e1832","DOI":"10.21769\/BioProtoc.1832","article-title":"Preparation of single cell suspensions from mouse aorta","volume":"6","author":"Hu","year":"2016","journal-title":"Bio Protoc"},{"key":"2026041420141486600_cvad082-B24","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/bs.mie.2015.05.017","article-title":"Analysis of fatty acid metabolism using stable isotope tracers and mass spectrometry","volume":"561","author":"Tumanov","year":"2015","journal-title":"Methods Enzymol"},{"key":"2026041420141486600_cvad082-B25","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.molcel.2014.09.024","article-title":"Regulation of substrate utilization by the mitochondrial pyruvate carrier","volume":"56","author":"Vacanti","year":"2014","journal-title":"Mol Cell"},{"key":"2026041420141486600_cvad082-B26","first-page":"C80","article-title":"Forces, fluxes, and fuels: tracking mitochondrial metabolism by integrating measurements of membrane potential, respiration, and metabolites","volume":"320","author":"Jones","year":"2021","journal-title":"Am J Physiol Cell Physiol"},{"key":"2026041420141486600_cvad082-B27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1186\/s12859-016-1360-7","article-title":"Fluxfix: automatic isotopologue normalization for metabolic tracer analysis","volume":"17","author":"Trefely","year":"2016","journal-title":"BMC Bioinformatics"},{"key":"2026041420141486600_cvad082-B28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/B978-0-12-801415-8.00016-3","article-title":"Analysis and interpretation of microplate-based oxygen consumption and pH data","volume":"547","author":"Divakaruni","year":"2014","journal-title":"Methods Enzymol"},{"key":"2026041420141486600_cvad082-B29","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.tiv.2012.11.002","article-title":"A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays","volume":"27","author":"Hynes","year":"2013","journal-title":"Toxicol In Vitro"},{"key":"2026041420141486600_cvad082-B30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-physiol-021115-105045","article-title":"The biochemistry and physiology of mitochondrial fatty acid beta-oxidation and its genetic disorders","volume":"78","author":"Houten","year":"2016","journal-title":"Annu Rev Physiol"},{"key":"2026041420141486600_cvad082-B31","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fphys.2014.00282","article-title":"Mitochondrial and cellular mechanisms for managing lipid excess","volume":"5","author":"Aon","year":"2014","journal-title":"Front Physiol"},{"key":"2026041420141486600_cvad082-B32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fmed.2020.00065","article-title":"Defective mitochondrial fatty acid oxidation and lipotoxicity in kidney diseases","volume":"7","author":"Jang","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"2026041420141486600_cvad082-B33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1476-511X-10-53","article-title":"Oleic acid induces smooth muscle foam cell formation and enhances atherosclerotic lesion development via CD36","volume":"10","author":"Ma","year":"2011","journal-title":"Lipids Health Dis"},{"key":"2026041420141486600_cvad082-B34","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3389\/fmicb.2020.01394","article-title":"Foam cells control mycobacterium tuberculosis infection","volume":"11","author":"Agarwal","year":"2020","journal-title":"Front Microbiol"},{"key":"2026041420141486600_cvad082-B35","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/415813a","article-title":"Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha","volume":"415","author":"Xu","year":"2002","journal-title":"Nature"},{"key":"2026041420141486600_cvad082-B36","first-page":"476","article-title":"The role of efferocytosis in atherosclerosis","volume-title":"Circulation","author":"Kojima","year":"2017"},{"key":"2026041420141486600_cvad082-B37","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.cmet.2020.01.001","article-title":"Macrophage metabolism of apoptotic cell-derived arginine promotes continual efferocytosis and resolution of injury","volume":"31","author":"Yurdagul A","year":"2020","journal-title":"Cell Metab"},{"key":"2026041420141486600_cvad082-B38","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1161\/01.HYP.35.1.353","article-title":"Angiotensin-converting enzyme expression in human carotid artery atherosclerosis","volume":"35","author":"Fukuhara","year":"2000","journal-title":"Hypertension"},{"key":"2026041420141486600_cvad082-B39","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ymgme.2018.02.007","article-title":"ACE Phenotyping in Gaucher disease","volume":"123","author":"Danilov","year":"2018","journal-title":"Mol Genet Metab"},{"key":"2026041420141486600_cvad082-B40","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cmet.2018.12.004","article-title":"Efferocytosis fuels requirements of fatty acid oxidation and the electron transport chain to polarize macrophages for tissue repair","volume":"29","author":"Zhang","year":"2019","journal-title":"Cell Metab"},{"key":"2026041420141486600_cvad082-B41","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S1471-4914(02)02289-X","article-title":"Molecular basis of cholesterol homeostasis: lessons from Tangier disease and ABCA1","volume":"8","author":"Oram","year":"2002","journal-title":"Trends Mol Med"},{"key":"2026041420141486600_cvad082-B42","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1073\/pnas.092327399","article-title":"Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues","volume":"99","author":"van Eck","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026041420141486600_cvad082-B43","first-page":"3900","article-title":"Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice","volume":"117","author":"Yvan-Charvet","year":"2007","journal-title":"J Clin Invest"},{"key":"2026041420141486600_cvad082-B44","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/ATVBAHA.107.156935","article-title":"Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels","volume":"28","author":"Out","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026041420141486600_cvad082-B45","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1161\/CIRCRESAHA.113.301086","article-title":"Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice","volume":"112","author":"Westerterp","year":"2013","journal-title":"Circ Res"},{"key":"2026041420141486600_cvad082-B46","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.3390\/jpm12061010","article-title":"Role of ABCA1 in cardiovascular disease","volume":"12","author":"Wang","year":"2022","journal-title":"J Pers Med"},{"key":"2026041420141486600_cvad082-B47","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/bs.acc.2015.06.005","article-title":"Peroxisome proliferator-activated receptor alpha in lipid metabolism and atherosclerosis","volume":"71","author":"Yu","year":"2015","journal-title":"Adv Clin Chem"},{"key":"2026041420141486600_cvad082-B48","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.bbalip.2007.04.021","article-title":"PPARalpha in atherosclerosis and inflammation","volume":"1771","author":"Zandbergen","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"2026041420141486600_cvad082-B49","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1172\/JCI18730","article-title":"Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta\/delta, and gamma","volume":"114","author":"Li","year":"2004","journal-title":"J Clin Invest"},{"key":"2026041420141486600_cvad082-B50","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1097\/00005344-200212000-00003","article-title":"Peroxisome proliferator-activated receptor activators inhibit oxidized low-density lipoprotein-induced endothelin-1 secretion in endothelial cells","volume":"40","author":"Martin-Nizard","year":"2002","journal-title":"J Cardiovasc Pharmacol"},{"key":"2026041420141486600_cvad082-B51","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.4049\/jimmunol.1601920","article-title":"PPAR-alpha activation mediates innate host defense through induction of TFEB and lipid catabolism","volume":"198","author":"Kim","year":"2017","journal-title":"J Immunol"},{"key":"2026041420141486600_cvad082-B52","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4093\/dmj.2020.0001","article-title":"Fibrates revisited: potential role in cardiovascular risk reduction","volume":"44","author":"Kim","year":"2020","journal-title":"Diabetes Metab J"},{"key":"2026041420141486600_cvad082-B53","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11883-006-0076-y","article-title":"Field of confusion: future prospects for fibrate therapy in cardiovascular disease","volume":"8","author":"Rosenson","year":"2006","journal-title":"Curr Atheroscler Rep"},{"key":"2026041420141486600_cvad082-B54","article-title":"The role of angiotensin antagonism in coronary plaque regression: insights from the glagovian model","volume":"2021","author":"Alkatiri","year":"2021","journal-title":"Int J Vasc Med"},{"key":"2026041420141486600_cvad082-B55","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1182\/blood-2016-11-752006","article-title":"Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils","volume":"130","author":"Khan","year":"2017","journal-title":"Blood"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvad082\/50562489\/cvad082.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/119\/9\/1825\/56541501\/cvad082.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/119\/9\/1825\/56541501\/cvad082.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:24:40Z","timestamp":1776212680000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/119\/9\/1825\/7177921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,24]]},"references-count":55,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,5,24]]},"published-print":{"date-parts":[[2023,8,7]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvad082","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,7]]},"published":{"date-parts":[[2023,5,24]]}}}