{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T20:25:15Z","timestamp":1781036715363,"version":"3.54.1"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL151737"],"award-info":[{"award-number":["HL151737"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL132401"],"award-info":[{"award-number":["HL132401"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R56HL165334-01"],"award-info":[{"award-number":["R56HL165334-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cancer Genomics Core"},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP180734"],"award-info":[{"award-number":["RP180734"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Mutations in the DSP gene encoding desmoplakin, a constituent of the desmosomes at the intercalated discs (IDs), cause a phenotype that spans arrhythmogenic cardiomyopathy (ACM) and dilated cardiomyopathy. It is typically characterized by biventricular enlargement and dysfunction, myocardial fibrosis, cell death, and arrhythmias. The canonical wingless-related integration (cWNT)\/\u03b2-catenin pathway is implicated in the pathogenesis of ACM. The \u03b2-catenin is an indispensable co-transcriptional regulator of the cWNT pathway and a member of the IDs. We genetically inactivated or activated \u03b2-catenin to determine its role in the pathogenesis of desmoplakin cardiomyopathy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The Dsp gene was conditionally deleted in the 2-week-old post-natal cardiac myocytes using tamoxifen-inducible MerCreMer mice (Myh6-McmTam:DspF\/F). The cWNT\/\u03b2-catenin pathway was markedly dysregulated in the Myh6-McmTam:DspF\/F cardiac myocytes, as indicated by a concomitant increase in the expression of cWNT\/\u03b2-catenin target genes, isoforms of its key co-effectors, and the inhibitors of the pathway. The \u03b2-catenin was inactivated or activated upon inducible deletion of its transcriptional or degron domain, respectively, in the Myh6-McmTam:DspF\/F cardiac myocytes. Genetic inactivation of \u03b2-catenin in the Myh6-McmTam:DspF\/F mice prolonged survival, improved cardiac function, reduced cardiac arrhythmias, and attenuated myocardial fibrosis, and cell death caused by apoptosis, necroptosis, and pyroptosis, i.e. PANoptosis. In contrast, activation of \u03b2-catenin had the opposite effects. The deleterious and the salubrious effects were independent of changes in the expression levels of the cWNT target genes and were associated with changes in several molecular and biological pathways, including cell death programmes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The cWNT\/\u03b2-catenin was markedly dysregulated in the cardiac myocytes in a mouse model of desmoplakin cardiomyopathy. Inactivation of \u03b2-catenin attenuated, whereas its activation aggravated the phenotype, through multiple molecular pathways, independent of the cWNT transcriptional activity. Thus, suppression but not activation of \u03b2-catenin might be beneficial in desmoplakin cardiomyopathy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvad137","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T23:40:51Z","timestamp":1693006851000},"page":"2712-2728","source":"Crossref","is-referenced-by-count":20,"title":["Genetic inactivation of \u03b2-catenin is salubrious, whereas its activation is deleterious in desmoplakin cardiomyopathy"],"prefix":"10.1093","volume":"119","author":[{"given":"Melis","family":"Olcum","sequence":"first","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"},{"name":"The Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyang","family":"Fan","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"},{"name":"The Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Rouhi","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"},{"name":"The Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirisha","family":"Cheedipudi","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"},{"name":"The Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Cathcart","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"},{"name":"The Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Hwan","family":"Jeong","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"},{"name":"The Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongming","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"},{"name":"The Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyatansh","family":"Gurha","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"},{"name":"The Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1252-7120","authenticated-orcid":false,"given":"Ali J","family":"Marian","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"},{"name":"The Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"2024042021300146300_cvad137-B1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/CIRCRESAHA.116.309396","article-title":"Dilated cardiomyopathy: genetic determinants and mechanisms","volume":"121","author":"McNally","year":"2017","journal-title":"Circ Res"},{"key":"2024042021300146300_cvad137-B2","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1161\/CIRCRESAHA.121.318346","article-title":"Molecular genetic basis of hypertrophic cardiomyopathy","volume":"128","author":"Marian","year":"2021","journal-title":"Circ Res"},{"key":"2024042021300146300_cvad137-B3","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/ejhf.1534","article-title":"Definition and treatment of arrhythmogenic cardiomyopathy: an updated expert panel report","volume":"21","author":"Elliott","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"2024042021300146300_cvad137-B4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0140-6736(99)06187-5","article-title":"Pathogenesis of diverse clinical and pathological phenotypes in hypertrophic cardiomyopathy","volume":"355","author":"Marian","year":"2000","journal-title":"Lancet"},{"key":"2024042021300146300_cvad137-B5","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.hrthm.2022.04.015","article-title":"Clinical profile and long-term follow-up of a cohort of patients with desmoplakin cardiomyopathy","volume":"19","author":"Bariani","year":"2022","journal-title":"Heart Rhythm"},{"key":"2024042021300146300_cvad137-B6","doi-asserted-by":"crossref","first-page":"e001914","DOI":"10.1136\/openhrt-2021-001914","article-title":"Clinical presentations leading to arrhythmogenic left ventricular cardiomyopathy","volume":"9","author":"Graziosi","year":"2022","journal-title":"Open Heart"},{"key":"2024042021300146300_cvad137-B7","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1161\/CIRCULATIONAHA.119.044934","article-title":"Desmoplakin cardiomyopathy, a fibrotic and inflammatory form of cardiomyopathy distinct from typical dilated or arrhythmogenic right ventricular cardiomyopathy","volume":"141","author":"Smith","year":"2020","journal-title":"Circulation"},{"key":"2024042021300146300_cvad137-B8","doi-asserted-by":"crossref","first-page":"107749","DOI":"10.1016\/j.jsb.2021.107749","article-title":"Desmosomal protein structure and function and the impact of disease-causing mutations","volume":"213","author":"Mohammed","year":"2021","journal-title":"J Struct Biol"},{"key":"2024042021300146300_cvad137-B9","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.280.5364.750","article-title":"Actin mutations in dilated cardiomyopathy, a heritable form of heart failure","volume":"280","author":"Olson","year":"1998","journal-title":"Science"},{"key":"2024042021300146300_cvad137-B10","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.3390\/ijms24032490","article-title":"DSP-related cardiomyopathy as a distinct clinical entity? Emerging evidence from an Italian cohort","volume":"24","author":"Di Lorenzo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2024042021300146300_cvad137-B11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.20517\/jca.2022.34","article-title":"PANoptosis is a prominent feature of desmoplakin cardiomyopathy","volume":"3","author":"Olcum","year":"2023","journal-title":"J Cardiovasc Aging"},{"key":"2024042021300146300_cvad137-B12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/joa.13634","article-title":"Structure and regulation of desmosomes in intercalated discs: lessons from epithelia","volume":"242","author":"Yeruva","year":"2023","journal-title":"J Anat"},{"key":"2024042021300146300_cvad137-B13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/cvr\/cvw259","article-title":"Refining the molecular organization of the cardiac intercalated disc","volume":"113","author":"Vermij","year":"2017","journal-title":"Cardiovasc Res"},{"key":"2024042021300146300_cvad137-B14","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1152\/physrev.00021.2022","article-title":"The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes","volume":"103","author":"Nielsen","year":"2023","journal-title":"Physiol Rev"},{"key":"2024042021300146300_cvad137-B15","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/CIRCRESAHA.114.302810","article-title":"The Hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy","volume":"114","author":"Chen","year":"2014","journal-title":"Circ Res"},{"key":"2024042021300146300_cvad137-B16","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1172\/JCI27751","article-title":"Suppression of canonical Wnt\/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy","volume":"116","author":"Garcia-Gras","year":"2006","journal-title":"J Clin Invest"},{"key":"2024042021300146300_cvad137-B17","doi-asserted-by":"crossref","first-page":"1254211","DOI":"10.1126\/science.1254211","article-title":"Cell adhesion. The minimal cadherin-catenin complex binds to actin filaments under force","volume":"346","author":"Buckley","year":"2014","journal-title":"Science"},{"key":"2024042021300146300_cvad137-B18","doi-asserted-by":"crossref","first-page":"H1252","DOI":"10.1152\/ajpheart.00515.2010","article-title":"Cardiac myocyte remodeling mediated by N-cadherin-dependent mechanosensing","volume":"300","author":"Chopra","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2024042021300146300_cvad137-B19","doi-asserted-by":"crossref","first-page":"240ra274","DOI":"10.1126\/scitranslmed.3008008","article-title":"Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy","volume":"6","author":"Asimaki","year":"2014","journal-title":"Sci Transl Med"},{"key":"2024042021300146300_cvad137-B20","doi-asserted-by":"crossref","first-page":"e85923","DOI":"10.1172\/jci.insight.85923","article-title":"Central role for GSK3beta in the pathogenesis of arrhythmogenic cardiomyopathy","volume":"1","author":"Chelko","year":"2016","journal-title":"JCI Insight"},{"key":"2024042021300146300_cvad137-B21","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1161\/CIRCULATIONAHA.119.040366","article-title":"Severe cardiac dysfunction and death caused by arrhythmogenic right ventricular cardiomyopathy type 5 are improved by inhibition of glycogen synthase kinase-3beta","volume":"140","author":"Padron-Barthe","year":"2019","journal-title":"Circulation"},{"key":"2024042021300146300_cvad137-B22","article-title":"Pharmacological suppression of the WNT signaling pathway attenuates age-dependent expression of the phenotype in a mouse model of arrhythmogenic cardiomyopathy","volume":"1","author":"Cheedipudi","year":"2021","journal-title":"J Cardiovasc Aging"},{"key":"2024042021300146300_cvad137-B23","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1161\/CIRCRESAHA.111.255075","article-title":"Nuclear plakoglobin is essential for differentiation of cardiac progenitor cells to adipocytes in arrhythmogenic right ventricular cardiomyopathy","volume":"109","author":"Lombardi","year":"2011","journal-title":"Circ Res"},{"key":"2024042021300146300_cvad137-B24","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1093\/cvr\/cvab197","article-title":"The EP300\/TP53 pathway, a suppressor of the Hippo and canonical WNT pathways, is activated in human hearts with arrhythmogenic cardiomyopathy in the absence of overt heart failure","volume":"118","author":"Rouhi","year":"2022","journal-title":"Cardiovasc Res"},{"key":"2024042021300146300_cvad137-B25","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/cvr\/cvy253","article-title":"A novel murine model for arrhythmogenic cardiomyopathy points to a pathogenic role of Wnt signalling and miRNA dysregulation","volume":"115","author":"Calore","year":"2019","journal-title":"Cardiovasc Res"},{"key":"2024042021300146300_cvad137-B26","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1093\/cvr\/cvy057","article-title":"Loss of cardiac Wnt\/beta-catenin signalling in desmoplakin-deficient AC8 zebrafish models is rescuable by genetic and pharmacological intervention","volume":"114","author":"Giuliodori","year":"2018","journal-title":"Cardiovasc Res"},{"key":"2024042021300146300_cvad137-B27","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1172\/JCI125538","article-title":"Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy","volume":"129","author":"Roberts","year":"2019","journal-title":"J Clin Invest"},{"key":"2024042021300146300_cvad137-B28","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pharmthera.2014.11.016","article-title":"Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases","volume":"148","author":"Beurel","year":"2015","journal-title":"Pharmacol Ther"},{"key":"2024042021300146300_cvad137-B29","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/med.21867","article-title":"Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases","volume":"42","author":"Wang","year":"2022","journal-title":"Med Res Rev"},{"key":"2024042021300146300_cvad137-B30","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.jacbts.2022.04.007","article-title":"Acute glycogen synthase kinase-3 inhibition modulates human cardiac conduction","volume":"7","author":"Li","year":"2022","journal-title":"JACC Basic Transl Sci"},{"key":"2024042021300146300_cvad137-B31","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/beta-catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"2024042021300146300_cvad137-B32","first-page":"15","article-title":"The WNT\/beta-catenin pathway regulates expression of the genes involved in cell cycle progression and mitochondrial oxidative phosphorylation in the postmitotic cardiac myocytes","volume":"2","author":"Olcum","year":"2022","journal-title":"J Cardiovasc Aging"},{"key":"2024042021300146300_cvad137-B33","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0092-8674(02)00685-2","article-title":"Control of beta-catenin phosphorylation\/degradation by a dual-kinase mechanism","volume":"108","author":"Liu","year":"2002","journal-title":"Cell"},{"key":"2024042021300146300_cvad137-B34","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.1093\/emboj\/18.21.5931","article-title":"Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene","volume":"18","author":"Harada","year":"1999","journal-title":"EMBO J"},{"key":"2024042021300146300_cvad137-B35","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1242\/dev.133439","article-title":"-catenin-mediated adhesion is required for successful preimplantation mouse embryo development","volume":"143","author":"Messerschmidt","year":"2016","journal-title":"Development"},{"key":"2024042021300146300_cvad137-B36","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1083\/jcb.143.7.2009","article-title":"Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage","volume":"143","author":"Gallicano","year":"1998","journal-title":"J Cell Biol"},{"key":"2024042021300146300_cvad137-B37","first-page":"H2183","article-title":"Cardiomyocyte DNA synthesis and binucleation during murine development","volume":"271","author":"Soonpaa","year":"1996","journal-title":"Am J Physiol"},{"key":"2024042021300146300_cvad137-B38","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.scr.2014.09.003","article-title":"Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation","volume":"13","author":"Senyo","year":"2014","journal-title":"Stem Cell Res"},{"key":"2024042021300146300_cvad137-B39","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1093\/cvr\/cvz199","article-title":"Exercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathy","volume":"116","author":"Cheedipudi","year":"2020","journal-title":"Cardiovasc Res"},{"key":"2024042021300146300_cvad137-B40","first-page":"8","article-title":"Effects of tamoxifen inducible MerCreMer on gene expression in cardiac myocytes in mice","volume":"2","author":"Rouhi","year":"2022","journal-title":"J Cardiovasc Aging"},{"key":"2024042021300146300_cvad137-B41","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1172\/JCI135922","article-title":"BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific lamin A\/C-deficient mice","volume":"130","author":"Auguste","year":"2020","journal-title":"J Clin Invest"},{"key":"2024042021300146300_cvad137-B42","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1093\/cvr\/cvaa300","article-title":"Haploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy","volume":"117","author":"Rouhi","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2024042021300146300_cvad137-B43","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1161\/CIRCRESAHA.117.312052","article-title":"Suppression of activated FOXO transcription factors in the heart prolongs survival in a mouse model of laminopathies","volume":"122","author":"Auguste","year":"2018","journal-title":"Circ Res"},{"key":"2024042021300146300_cvad137-B44","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/CIRCRESAHA.118.314238","article-title":"DNA damage response\/TP53 pathway is activated and contributes to the pathogenesis of dilated cardiomyopathy associated with LMNA (lamin A\/C) mutations","volume":"124","author":"Chen","year":"2019","journal-title":"Circ Res"},{"key":"2024042021300146300_cvad137-B45","doi-asserted-by":"crossref","first-page":"30","DOI":"10.20517\/jca.2022.14","article-title":"Deletion of the lmna gene in fibroblasts causes senescence-associated dilated cardiomyopathy by activating the double-stranded DNA damage response and induction of senescence-associated secretory phenotype","volume":"2","author":"Rouhi","year":"2022","journal-title":"J Cardiovasc Aging"},{"key":"2024042021300146300_cvad137-B46","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.yexcr.2010.08.017","article-title":"Identification of cardiomyocyte nuclei and assessment of ploidy for the analysis of cell turnover","volume":"317","author":"Bergmann","year":"2011","journal-title":"Exp Cell Res"},{"key":"2024042021300146300_cvad137-B47","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2024042021300146300_cvad137-B48","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/nbt.2931","article-title":"Normalization of RNA-seq data using factor analysis of control genes or samples","volume":"32","author":"Risso","year":"2014","journal-title":"Nat Biotechnol"},{"key":"2024042021300146300_cvad137-B49","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-Seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2024042021300146300_cvad137-B50","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jacbts.2022.06.015","article-title":"Genetic ablation of the DNA damage response pathway attenuates lamin-associated dilated cardiomyopathy in mice","volume":"7","author":"Cheedipudi","year":"2022","journal-title":"JACC Basic Transl Sci"},{"key":"2024042021300146300_cvad137-B51","doi-asserted-by":"crossref","first-page":"e137689","DOI":"10.1172\/JCI137689","article-title":"Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"131","author":"Liang","year":"2021","journal-title":"J Clin Invest"},{"key":"2024042021300146300_cvad137-B52","doi-asserted-by":"crossref","first-page":"a015081","DOI":"10.1101\/cshperspect.a015081","article-title":"Secreted and transmembrane Wnt inhibitors and activators","volume":"5","author":"Cruciat","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2024042021300146300_cvad137-B53","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1146\/annurev-biochem-040320-103615","article-title":"The Wnt pathway: from signaling mechanisms to synthetic modulators","volume":"91","author":"Rim","year":"2022","journal-title":"Annu Rev Biochem"},{"key":"2024042021300146300_cvad137-B54","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.cellsig.2008.04.014","article-title":"Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-catenin","volume":"20","author":"Jin","year":"2008","journal-title":"Cell Signal"},{"key":"2024042021300146300_cvad137-B55","doi-asserted-by":"crossref","first-page":"9096","DOI":"10.1038\/s41598-021-88618-5","article-title":"Inhibition of Wnt signalling by Notch via two distinct mechanisms","volume":"11","author":"Acar","year":"2021","journal-title":"Sci Rep"},{"key":"2024042021300146300_cvad137-B56","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1126\/science.257.5073.1142.b","article-title":"Plakoglobin and beta-catenin: distinct but closely related","volume":"257","author":"Butz","year":"1992","journal-title":"Science"},{"key":"2024042021300146300_cvad137-B57","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1242\/dev.126.2.371","article-title":"Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice","volume":"126","author":"Bierkamp","year":"1999","journal-title":"Development"},{"key":"2024042021300146300_cvad137-B58","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/dvdy.22019","article-title":"Regulation of Wnt\/beta-catenin signaling by protein kinases","volume":"239","author":"Verheyen","year":"2010","journal-title":"Dev Dyn"},{"key":"2024042021300146300_cvad137-B59","doi-asserted-by":"crossref","first-page":"dev193417","DOI":"10.1242\/dev.193417","article-title":"-Catenin drives distinct transcriptional networks in proliferative and nonproliferative cardiomyocytes","volume":"147","author":"Quaife-Ryan","year":"2020","journal-title":"Development"},{"key":"2024042021300146300_cvad137-B60","doi-asserted-by":"crossref","first-page":"e13912","DOI":"10.1111\/apha.13912","article-title":"WNT\/beta-catenin pathway is a key regulator of cardiac function and energetic metabolism","volume":"237","author":"Balatskyi","year":"2023","journal-title":"Acta Physiol (Oxf)"},{"key":"2024042021300146300_cvad137-B61","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1093\/hmg\/9.18.2761","article-title":"Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma","volume":"9","author":"Norgett","year":"2000","journal-title":"Hum Mol Genet"},{"key":"2024042021300146300_cvad137-B62","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0735-1097(03)00628-4","article-title":"A recessive mutation in desmoplakin causes arrhythmogenic right ventricular dysplasia, skin disorder, and woolly hair","volume":"42","author":"Alcalai","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2024042021300146300_cvad137-B63","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/S0140-6736(00)02379-5","article-title":"Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease)","volume":"355","author":"McKoy","year":"2000","journal-title":"Lancet"},{"key":"2024042021300146300_cvad137-B64","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mito.2021.07.005","article-title":"Cardiac-specific beta-catenin deletion dysregulates energetic metabolism and mitochondrial function in perinatal cardiomyocytes","volume":"60","author":"Balatskyi","year":"2021","journal-title":"Mitochondrion"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvad137\/53689163\/cvad137.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/119\/17\/2712\/57293919\/cvad137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/119\/17\/2712\/57293919\/cvad137.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T21:31:00Z","timestamp":1713648660000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/119\/17\/2712\/7251435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,25]]},"references-count":64,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2023,8,25]]},"published-print":{"date-parts":[[2023,12,30]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvad137","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12]]},"published":{"date-parts":[[2023,8,25]]}}}