{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:14Z","timestamp":1792785854539,"version":"4.5.0"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG, VO 1568\/3-1, VO 1568\/4-1, IRTG1816 project 12, SFB1002"],"award-info":[{"award-number":["DFG, VO 1568\/3-1, VO 1568\/4-1, IRTG1816 project 12, SFB1002"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["2067\/1-390729940"],"award-info":[{"award-number":["2067\/1-390729940"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["STR 1411\/7-1"],"award-info":[{"award-number":["STR 1411\/7-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"German Center for Cardiovascular Research","doi-asserted-by":"publisher","award":["81X2300189 and 81X4300102"],"award-info":[{"award-number":["81X2300189 and 81X4300102"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"German Center for Cardiovascular Research","doi-asserted-by":"publisher","award":["81X4300114"],"award-info":[{"award-number":["81X4300114"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"BMBF","doi-asserted-by":"publisher","award":["01GM1902D"],"award-info":[{"award-number":["01GM1902D"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"BMBF","doi-asserted-by":"publisher","award":["161L0250A"],"award-info":[{"award-number":["161L0250A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"G\u00f6ttingen Promotionskolleg f\u00fcr Medizinstudierende"},{"name":"Jacob-Henle-Programm"},{"DOI":"10.13039\/501100003042","name":"Else-Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"DZHK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["20CVD04"],"award-info":[{"award-number":["20CVD04"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["EXC 2067\/1"],"award-info":[{"award-number":["EXC 2067\/1"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) is associated with tachycardia-induced cellular electrophysiology alterations which promote AF chronification and treatment resistance. Development of novel antiarrhythmic therapies is hampered by the absence of scalable experimental human models that reflect AF-associated electrical remodelling. Therefore, we aimed to assess if AF-associated remodelling of cellular electrophysiology can be simulated in human atrial-like cardiomyocytes derived from induced pluripotent stem cells in the presence of retinoic acid (iPSC-aCM), and atrial-engineered human myocardium (aEHM) under short term (24 h) and chronic (7 days) tachypacing (TP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>First, 24-h electrical pacing at 3 Hz was used to investigate whether AF-associated remodelling in iPSC-aCM and aEHM would ensue. Compared to controls (24 h, 1 Hz pacing) TP-stimulated iPSC-aCM presented classical hallmarks of AF-associated remodelling: (i) decreased L-type Ca2+ current (ICa,L) and (ii) impaired activation of acetylcholine-activated inward-rectifier K+ current (IK,ACh). This resulted in action potential shortening and an absent response to the M-receptor agonist carbachol in both iPSC-aCM and aEHM subjected to TP. Accordingly, mRNA expression of the channel-subunit Kir3.4 was reduced. Selective IK,ACh blockade with tertiapin reduced basal inward-rectifier K+ current only in iPSC-aCM subjected to TP, thereby unmasking an agonist-independent constitutively active IK,ACh. To allow for long-term TP, we developed iPSC-aCM and aEHM expressing the light-gated ion-channel f-Chrimson. The same hallmarks of AF-associated remodelling were observed after optical-TP. In addition, continuous TP (7 days) led to (i) increased amplitude of inward-rectifier K+ current (IK1), (ii) hyperpolarization of the resting membrane potential, (iii) increased action potential-amplitude and upstroke velocity as well as (iv) reversibly impaired contractile function in aEHM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Classical hallmarks of AF-associated remodelling were mimicked through TP of iPSC-aCM and aEHM. The use of the ultrafast f-Chrimson depolarizing ion channel allowed us to model the time-dependence of AF-associated remodelling in vitro for the first time. The observation of electrical remodelling with associated reversible contractile dysfunction offers a novel platform for human-centric discovery of antiarrhythmic therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvad143","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T16:18:39Z","timestamp":1693930719000},"page":"2623-2637","source":"Crossref","is-referenced-by-count":44,"title":["Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development"],"prefix":"10.1093","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8554-5186","authenticated-orcid":false,"given":"Fitzwilliam","family":"Seibertz","sequence":"first","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen , Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"},{"name":"Cluster of Excellence \u2018Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells\u2019 (MBExC), University of G\u00f6ttingen , G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Rubio","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen , Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Springer","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen , Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5248-3273","authenticated-orcid":false,"given":"Fiona","family":"Popp","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen , Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Ritter","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen , Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiste","family":"Liutkute","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen , Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Bartelt","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen , Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Stelzer","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen , Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Haghighi","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery, Georg-August-University G\u00f6ttingen , G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Pietras","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery, Georg-August-University G\u00f6ttingen , G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Windel","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery, Georg-August-University G\u00f6ttingen , G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria D\u00edaz i","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen , Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9917-9922","authenticated-orcid":false,"given":"Markus","family":"Rapedius","sequence":"additional","affiliation":[{"name":"Nanion Technologies GmbH , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannic","family":"Doering","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen , Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7608-6099","authenticated-orcid":false,"given":"Richard","family":"Solano","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen , Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery, Georg-August-University G\u00f6ttingen , G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Hindmarsh","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"},{"name":"Clinic for Cardiology and Pneumology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runzhu","family":"Shi","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"},{"name":"Institute for Cardiovascular Physiology, University Medical Center G\u00f6ttingen , G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Tiburcy","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen , Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6930-9634","authenticated-orcid":false,"given":"Tobias","family":"Bruegmann","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"},{"name":"Cluster of Excellence \u2018Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells\u2019 (MBExC), University of G\u00f6ttingen , G\u00f6ttingen , Germany"},{"name":"Institute for Cardiovascular Physiology, University Medical Center G\u00f6ttingen , G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7358-3513","authenticated-orcid":false,"given":"Ingo","family":"Kutschka","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery, Georg-August-University G\u00f6ttingen , G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5137-7228","authenticated-orcid":false,"given":"Katrin","family":"Streckfuss-B\u00f6meke","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"},{"name":"Clinic for Cardiology and Pneumology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Germany"},{"name":"Institute of Pharmacology and Toxicology, University of W\u00fcrzburg , W\u00fcrzburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0219-8279","authenticated-orcid":false,"given":"George","family":"Kensah","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery, Georg-August-University G\u00f6ttingen , G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9120-1382","authenticated-orcid":false,"given":"Lukas","family":"Cyganek","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"},{"name":"Cluster of Excellence \u2018Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells\u2019 (MBExC), University of G\u00f6ttingen , G\u00f6ttingen , Germany"},{"name":"Clinic for Cardiology and Pneumology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-4040","authenticated-orcid":false,"given":"Wolfram H","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen , Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"},{"name":"Cluster of Excellence \u2018Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells\u2019 (MBExC), University of G\u00f6ttingen , G\u00f6ttingen , Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) , G\u00f6ttingen , Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP) , G\u00f6ttingen , Germany"},{"name":"Campus-Institute Data Science (CIDAS), University of G\u00f6ttingen , G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8230-2341","authenticated-orcid":false,"given":"Niels","family":"Voigt","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Georg-August University G\u00f6ttingen , Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen , Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen , Germany"},{"name":"Cluster of Excellence \u2018Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells\u2019 (MBExC), University of G\u00f6ttingen , G\u00f6ttingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"2023121923005695900_cvad143-B1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/CIRCRESAHA.120.316363","article-title":"Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective","volume":"127","author":"Nattel","year":"2020","journal-title":"Circ Res"},{"key":"2023121923005695900_cvad143-B2","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1161\/CIRCRESAHA.114.302226","article-title":"Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression","volume":"114","author":"Heijman","year":"2014","journal-title":"Circ Res"},{"key":"2023121923005695900_cvad143-B3","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1161\/CIRCULATIONAHA.111.067306","article-title":"Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation","volume":"125","author":"Voigt","year":"2012","journal-title":"Circulation"},{"key":"2023121923005695900_cvad143-B4","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/01.RES.85.5.428","article-title":"Atrial L-type Ca2+ currents and human atrial fibrillation","volume":"85","author":"Van Wagoner","year":"1999","journal-title":"Circ Res"},{"key":"2023121923005695900_cvad143-B5","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1161\/01.CIR.0000145659.80212.6A","article-title":"L-type ca2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases","volume":"110","author":"Christ","year":"2004","journal-title":"Circulation"},{"key":"2023121923005695900_cvad143-B6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.120.316366","article-title":"Animal models of atrial fibrillation","volume":"127","author":"Sch\u00fcttler","year":"2020","journal-title":"Circ Res"},{"key":"2023121923005695900_cvad143-B7","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/europace\/eup328","article-title":"Animal models for atrial fibrillation: clinical insights and scientific opportunities","volume":"12","author":"Nishida","year":"2010","journal-title":"Europace"},{"key":"2023121923005695900_cvad143-B8","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1093\/cvr\/cvac044","article-title":"Not the classical serendipity: does doxapram treat atrial fibrillation?","volume":"118","author":"Liutkute","year":"2022","journal-title":"Cardiovasc Res"},{"key":"2023121923005695900_cvad143-B9","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3389\/fphys.2018.01227","article-title":"Axial tubule junctions activate atrial Ca2+ release across Species","volume":"9","author":"Brandenburg","year":"2018","journal-title":"Front Physiol"},{"key":"2023121923005695900_cvad143-B10","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.cell.2018.11.042","article-title":"A platform for generation of chamber-specific cardiac tissues and disease modeling","volume":"176","author":"Zhao","year":"2019","journal-title":"Cell"},{"key":"2023121923005695900_cvad143-B11","doi-asserted-by":"crossref","first-page":"e99941","DOI":"10.1172\/jci.insight.99941","article-title":"Deep phenotyping of human induced pluripotent stem cell-derived atrial and ventricular cardiomyocytes","volume":"3","author":"Cyganek","year":"2018","journal-title":"JCI Insight"},{"key":"2023121923005695900_cvad143-B12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.stem.2017.07.003","article-title":"Human pluripotent stem cell-derived atrial and ventricular cardiomyocytes develop from distinct mesoderm populations","volume":"21","author":"Lee","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2023121923005695900_cvad143-B13","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/s42003-022-03871-2","article-title":"A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes","volume":"5","author":"Seibertz","year":"2022","journal-title":"Commun Biol"},{"key":"2023121923005695900_cvad143-B14","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.stemcr.2018.10.008","article-title":"Atrial-like engineered heart tissue: an in vitro model of the human atrium","volume":"11","author":"Lemme","year":"2018","journal-title":"Stem Cell Rep"},{"key":"2023121923005695900_cvad143-B15","doi-asserted-by":"crossref","first-page":"e19406","DOI":"10.7554\/eLife.19406","article-title":"Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells","volume":"6","author":"Stillitano","year":"2017","journal-title":"Elife"},{"key":"2023121923005695900_cvad143-B16","first-page":"1008","article-title":"Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells","volume":"144","author":"Giacomelli","year":"2017","journal-title":"Development"},{"key":"2023121923005695900_cvad143-B17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.coph.2013.11.004","article-title":"Cardiac safety assays","volume":"15","author":"Heijman","year":"2014","journal-title":"Curr Opin Pharmacol"},{"key":"2023121923005695900_cvad143-B18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cardiores.2005.02.019","article-title":"Consequences of atrial electrical remodeling for the anti-arrhythmic action of class IC and class III drugs","volume":"67","author":"Duytschaever","year":"2005","journal-title":"Cardiovasc Res"},{"key":"2023121923005695900_cvad143-B19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.hrthm.2004.11.014","article-title":"Does flecainide regain its antiarrhythmic activity after electrical cardioversion of persistent atrial fibrillation?","volume":"2","author":"Tieleman","year":"2005","journal-title":"Hear Rhythm"},{"key":"2023121923005695900_cvad143-B20","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1172\/JCI62185","article-title":"MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation","volume":"123","author":"Luo","year":"2013","journal-title":"J Clin Invest"},{"key":"2023121923005695900_cvad143-B21","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1161\/CIRCRESAHA.108.175463","article-title":"Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current","volume":"103","author":"Qi","year":"2008","journal-title":"Circ Res"},{"key":"2023121923005695900_cvad143-B22","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/cvr\/cvz245","article-title":"Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue","volume":"116","author":"Lemme","year":"2020","journal-title":"Cardiovasc Res"},{"key":"2023121923005695900_cvad143-B23","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.116.024145","article-title":"Defined engineered human myocardium with advanced maturation for applications in heart failure modeling and repair","volume":"135","author":"Tiburcy","year":"2017","journal-title":"Circulation"},{"key":"2023121923005695900_cvad143-B24","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cardiores.2007.02.009","article-title":"Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK, ACh channels in patients with chronic atrial fibrillation","volume":"74","author":"Voigt","year":"2007","journal-title":"Cardiovasc Res"},{"key":"2023121923005695900_cvad143-B25","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1161\/CIRCULATIONAHA.105.575332","article-title":"The G protein-gated potassium current IK, ACh is constitutively active in patients with chronic atrial fibrillation","volume":"112","author":"Dobrev","year":"2005","journal-title":"Circulation"},{"key":"2023121923005695900_cvad143-B26","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1038\/s41467-018-04146-3","article-title":"High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics","volume":"9","author":"Mager","year":"2018","journal-title":"Nat Commun"},{"key":"2023121923005695900_cvad143-B27","doi-asserted-by":"crossref","first-page":"100026","DOI":"10.1016\/j.xpro.2020.100026","article-title":"Subtype-Directed differentiation of human iPSCs into atrial and ventricular cardiomyocytes","volume":"1","author":"Kleinsorge","year":"2020","journal-title":"STAR Protoc"},{"key":"2023121923005695900_cvad143-B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2020.101944"},{"key":"2023121923005695900_cvad143-B29","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.stemcr.2015.08.015","article-title":"CGMP-manufactured human induced pluripotent stem cells are available for pre-clinical and clinical applications","volume":"5","author":"Baghbaderani","year":"2015","journal-title":"Stem Cell Rep"},{"key":"2023121923005695900_cvad143-B30","doi-asserted-by":"crossref","first-page":"100032","DOI":"10.1016\/j.xpro.2020.100032","article-title":"Generation of engineered human myocardium in a multi-well format","volume":"1","author":"Tiburcy","year":"2020","journal-title":"STAR Protoc"},{"key":"2023121923005695900_cvad143-B31","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1093\/eurheartj\/ehs349","article-title":"Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro","volume":"34","author":"Kensah","year":"2013","journal-title":"Eur Heart J"},{"key":"2023121923005695900_cvad143-B32","first-page":"e61890","article-title":"Single-cell optical action potential measurement in human induced pluripotent stem cell-derived cardiomyocytes","volume":"2020","author":"Seibertz","year":"2020","journal-title":"J Vis Exp"},{"key":"2023121923005695900_cvad143-B33","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/CIRCEP.110.954636","article-title":"Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation","volume":"3","author":"Voigt","year":"2010","journal-title":"Circ Arrhythmia Electrophysiol"},{"key":"2023121923005695900_cvad143-B34","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.yjmcc.2013.03.011","article-title":"Impaired Na+-dependent regulation of acetylcholine-activated inward-rectifier K+ current modulates action potential rate dependence in patients with chronic atrial fibrillation","volume":"61","author":"Voigt","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"2023121923005695900_cvad143-B35","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1161\/01.CIR.0000145155.60288.71","article-title":"Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation","volume":"110","author":"Wettwer","year":"2004","journal-title":"Circulation"},{"key":"2023121923005695900_cvad143-B36","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1161\/CIRCRESAHA.111.251843","article-title":"Terminal differentiation, advanced organotypic maturation, and modeling of hypertrophic growth in engineered heart tissue","volume":"109","author":"Tiburcy","year":"2011","journal-title":"Circ Res"},{"key":"2023121923005695900_cvad143-B37","doi-asserted-by":"crossref","first-page":"H66","DOI":"10.1152\/ajpheart.00029.2013","article-title":"Tissue-specific effects of acetylcholine in the canine heart","volume":"305","author":"Calloe","year":"2013","journal-title":"Am J Physiol Hear Circ Physiol"},{"key":"2023121923005695900_cvad143-B38","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/CIRCRESAHA.111.253120","article-title":"Differential protein kinase c isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling","volume":"109","author":"Makary","year":"2011","journal-title":"Circ Res"},{"key":"2023121923005695900_cvad143-B39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/cvr\/cvm051","article-title":"Changes in IK, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes","volume":"77","author":"Voigt","year":"2008","journal-title":"Cardiovasc Res"},{"key":"2023121923005695900_cvad143-B40","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1124\/jpet.113.207266","article-title":"NSC23766, A widely used inhibitor of rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors","volume":"347","author":"Levay","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"key":"2023121923005695900_cvad143-B41","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1161\/01.CIR.98.22.2422","article-title":"Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle","volume":"98","author":"Wang","year":"1998","journal-title":"Circulation"},{"key":"2023121923005695900_cvad143-B42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1748-1716.1993.tb09605.x","article-title":"Potassium currents in isolated human atrial and ventricular cardiocytes","volume":"149","author":"Varr\u00f3","year":"1993","journal-title":"Acta Physiol Scand"},{"key":"2023121923005695900_cvad143-B43","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00395-022-00912-z","article-title":"Increased cytosolic calcium buffering contributes to a cellular arrhythmogenic substrate in iPSC-cardiomyocytes from patients with dilated cardiomyopathy","volume":"117","author":"Jung","year":"2022","journal-title":"Basic Res Cardiol"},{"key":"2023121923005695900_cvad143-B44","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijcard.2017.12.050","article-title":"Muscarinic type-1 receptors contribute to IK, ACh in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation","volume":"255","author":"Heijman","year":"2018","journal-title":"Int J Cardiol"},{"key":"2023121923005695900_cvad143-B45","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European association for cardio-thoracic surgery (EACTS)","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart J"},{"key":"2023121923005695900_cvad143-B46","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00392-018-1377-1","article-title":"German Cardiac Society Working Group on cellular electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management","volume":"108","author":"Thomas","year":"2019","journal-title":"Clin Res Cardiol"},{"key":"2023121923005695900_cvad143-B47","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1161\/01.CIR.92.7.1954","article-title":"Atrial fibrillation begets atrial fibrillation: a study in awake chronically instrumented goats","volume":"92","author":"Wijffels","year":"1995","journal-title":"Circulation"},{"key":"2023121923005695900_cvad143-B48","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1161\/CIRCULATIONAHA.114.012657","article-title":"Upregulation of K2P3.1 K+ current causes action potential shortening in patients with chronic atrial fibrillation","volume":"132","author":"Schmidt","year":"2015","journal-title":"Circulation"},{"key":"2023121923005695900_cvad143-B49","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1113\/JP271404","article-title":"Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation","volume":"594","author":"Heijman","year":"2016","journal-title":"J Physiol"},{"key":"2023121923005695900_cvad143-B50","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/01.RES.0000258428.09589.1a","article-title":"Contrasting gene expression profiles in two canine models of atrial fibrillation","volume":"100","author":"Cardin","year":"2007","journal-title":"Circ Res"},{"key":"2023121923005695900_cvad143-B51","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/europace\/eut012","article-title":"Role of nitric oxide and oxidative stress in a sheep model of persistent atrial fibrillation","volume":"15","author":"Lenaerts","year":"2013","journal-title":"Europace"},{"key":"2023121923005695900_cvad143-B52","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1161\/CIRCRESAHA.109.206276","article-title":"Ultrastructural and functional remodeling of the coupling between Ca2+ influx and sarcoplasmic reticulum Ca2+ release in right atrial myocytes from experimental persistent atrial fibrillation","volume":"105","author":"Lenaerts","year":"2009","journal-title":"Circ Res"},{"key":"2023121923005695900_cvad143-B53","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1172\/JCI70102","article-title":"Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes","volume":"124","author":"Greiser","year":"2014","journal-title":"J Clin Invest"},{"key":"2023121923005695900_cvad143-B54","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.lfs.2013.12.006","article-title":"Cardiac expression and atrial fibrillation-associated remodeling of K2P2.1 (TREK-1) K+ channels in a porcine model","volume":"97","author":"Schmidt","year":"2014","journal-title":"Life Sci"},{"key":"2023121923005695900_cvad143-B55","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ccep.2016.02.005","article-title":"Atrial-Selective potassium channel blockers","volume":"8","author":"Voigt","year":"2016","journal-title":"Card Electrophysiol Clin"},{"key":"2023121923005695900_cvad143-B56","doi-asserted-by":"crossref","first-page":"15187","DOI":"10.1038\/srep15187","article-title":"Constitutively active acetylcholine-dependent potassium current increases atrial defibrillation threshold by favoring post-shock Re-initiation","volume":"5","author":"Bingen","year":"2015","journal-title":"Sci Rep"},{"key":"2023121923005695900_cvad143-B57","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1161\/CIRCULATIONAHA.119.044127","article-title":"Attenuation of oxidative injury with targeted expression of NADPH oxidase 2 short hairpin RNA prevents onset and maintenance of electrical remodeling in the canine atrium","volume":"142","author":"Yoo","year":"2020","journal-title":"Circulation"},{"key":"2023121923005695900_cvad143-B58","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00395-020-00827-7","article-title":"Cellular and mitochondrial mechanisms of atrial fibrillation","volume":"115","author":"Mason","year":"2020","journal-title":"Basic Res Cardiol"},{"key":"2023121923005695900_cvad143-B59","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/cr.2010.163","article-title":"Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals","volume":"21","author":"Zhang","year":"2011","journal-title":"Cell Res"},{"key":"2023121923005695900_cvad143-B60","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.1038\/s41598-017-05652-y","article-title":"Modeling atrial fibrillation using human embryonic stem cell-derived atrial tissue","volume":"7","author":"Laksman","year":"2017","journal-title":"Sci Rep"},{"key":"2023121923005695900_cvad143-B61","doi-asserted-by":"crossref","first-page":"394","DOI":"10.15252\/emmm.201404757","article-title":"Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology","volume":"7","author":"Devalla","year":"2015","journal-title":"EMBO Mol Med"},{"key":"2023121923005695900_cvad143-B62","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/FJC.0000000000000951","article-title":"Intermittent optogenetic tachypacing of atrial engineered heart tissue induces only limited electrical remodelling","volume":"77","author":"Lemoine","year":"2020","journal-title":"J Cardiovasc Pharmacol"},{"key":"2023121923005695900_cvad143-B63","doi-asserted-by":"crossref","first-page":"dmm037994","DOI":"10.1242\/dmm.037994","article-title":"Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (IK, ACh)","volume":"12","author":"Veerman","year":"2019","journal-title":"DMM Dis Model Mech"},{"key":"2023121923005695900_cvad143-B64","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1113\/jphysiol.2006.126714","article-title":"Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart","volume":"582","author":"Gaborit","year":"2007","journal-title":"J Physiol"},{"key":"2023121923005695900_cvad143-B65","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41467-019-13868-x","article-title":"Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes","volume":"11","author":"Goldfracht","year":"2020","journal-title":"Nat Commun"},{"key":"2023121923005695900_cvad143-B66","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.watres.2017.10.024","article-title":"Faradaic reactions in capacitive deionization (CDI)\u2014problems and possibilities: a review","volume":"128","author":"Zhang","year":"2018","journal-title":"Water Res"},{"key":"2023121923005695900_cvad143-B67","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1113\/jphysiol.2004.061119","article-title":"Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium","volume":"557","author":"Ehrlich","year":"2004","journal-title":"J Physiol"},{"key":"2023121923005695900_cvad143-B68","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1093\/eurheartj\/ehad086","article-title":"Phosphodiesterase 8 governs cAMP\/PKA-dependent reduction of L-type calcium current in human atrial fibrillation: a novel arrhythmogenic mechanism","volume":"44","author":"Grammatika Pavlidou","year":"2023","journal-title":"Eur Heart J"},{"key":"2023121923005695900_cvad143-B69","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.RES.81.4.512","article-title":"Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation","volume":"81","author":"Yue","year":"1997","journal-title":"Circ Res"},{"key":"2023121923005695900_cvad143-B70","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0735-1097(02)02922-4","article-title":"Molecular mechanisms of early electrical remodeling: transcriptional downregulation of ion channel subunits reduces I(Ca, L) and I(to) in rapid atrial pacing in rabbits","volume":"41","author":"Bosch","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2023121923005695900_cvad143-B71","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0008-6363(99)00036-X","article-title":"Dihydropyridine and beta adrenergic receptor binding in dogs with tachycardia-induced atrial fibrillation","volume":"42","author":"Gaspo","year":"1999","journal-title":"Cardiovasc Res"},{"key":"2023121923005695900_cvad143-B72","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/cvr\/cvz217","article-title":"Human iPSC modelling of a familial form of atrial fibrillation reveals a gain of function of if and ICaL in patient-derived cardiomyocytes","volume":"116","author":"Benzoni","year":"2020","journal-title":"Cardiovasc Res"},{"key":"2023121923005695900_cvad143-B73","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/CIRCRESAHA.120.316575","article-title":"Genetics of atrial fibrillation in 2020","volume":"127","author":"Roselli","year":"2020","journal-title":"Circ Res"},{"key":"2023121923005695900_cvad143-B74","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1093\/cvr\/cvab153","article-title":"Genetics of atrial fibrillation-practical applications for clinical management: if not now, when and how?","volume":"117","author":"Kany","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2023121923005695900_cvad143-B75","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1161\/CIRCULATIONAHA.113.006641","article-title":"Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation","volume":"129","author":"Voigt","year":"2014","journal-title":"Circulation"},{"key":"2023121923005695900_cvad143-B76","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/cvr\/cvaa162","article-title":"Altered atrial cytosolic calcium handling contributes to the development of postoperative atrial fibrillation","volume":"117","author":"Fakuade","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2023121923005695900_cvad143-B77","first-page":"1764","article-title":"Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy","volume":"38","author":"Schmidt","year":"2017","journal-title":"Eur Heart J"},{"key":"2023121923005695900_cvad143-B78","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10557-017-6735-0","article-title":"Human iPSC-derived cardiomyocytes for investigation of disease mechanisms and therapeutic strategies in inherited arrhythmia syndromes: strengths and limitations","volume":"31","author":"Casini","year":"2017","journal-title":"Cardiovasc Drugs Ther"},{"key":"2023121923005695900_cvad143-B79","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s12015-011-9273-3","article-title":"Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes","volume":"7","author":"Lee","year":"2011","journal-title":"Stem Cell Rev Rep"},{"key":"2023121923005695900_cvad143-B80","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/j.biomaterials.2012.11.055","article-title":"The effect of microgrooved culture substrates on calcium cycling of cardiac myocytes derived from human induced pluripotent stem cells","volume":"34","author":"Rao","year":"2013","journal-title":"Biomaterials"},{"key":"2023121923005695900_cvad143-B81","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3389\/fcell.2020.00536","article-title":"Ultrarapid delayed rectifier K(+) channelopathies in human induced pluripotent stem cell-derived cardiomyocytes","volume":"8","author":"Hilderink","year":"2020","journal-title":"Front cell Dev Biol"},{"key":"2023121923005695900_cvad143-B82","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/FJC.0b013e31828780eb","article-title":"Human electrophysiological and pharmacological properties of XEN-D0101: a novel atrial-selective Kv1.5\/IKur inhibitor","volume":"61","author":"Ford","year":"2013","journal-title":"J Cardiovasc Pharmacol"},{"key":"2023121923005695900_cvad143-B83","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/bjp.2008.209","article-title":"Pathology-specific effects of the IKur\/Ito\/IK, ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation","volume":"154","author":"Christ","year":"2008","journal-title":"Br J Pharmacol"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvad143\/51772733\/cvad143.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/119\/16\/2623\/54643184\/cvad143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/119\/16\/2623\/54643184\/cvad143.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T18:01:59Z","timestamp":1703008919000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/119\/16\/2623\/7263227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,7]]},"references-count":83,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2023,9,7]]},"published-print":{"date-parts":[[2023,12,19]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvad143","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,11]]},"published":{"date-parts":[[2023,9,7]]}}}