{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:22:39Z","timestamp":1791015759268,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["397484323"],"award-info":[{"award-number":["397484323"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["WA 3533\/3-1"],"award-info":[{"award-number":["WA 3533\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["EL 651\/6-1"],"award-info":[{"award-number":["EL 651\/6-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["EL 651\/8-1"],"award-info":[{"award-number":["EL 651\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Abdominal aortic aneurysm (AAA) is a highly lethal disease with progressive dilatation of the abdominal aorta accompanied by degradation and remodelling of the vessel wall due to chronic inflammation. Platelets play an important role in cardiovascular diseases, but their role in AAA is poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The present study revealed that platelets play a crucial role in promoting AAA through modulation of inflammation and degradation of the extracellular matrix (ECM). They are responsible for the up-regulation of SPP1 (osteopontin, OPN) gene expression in macrophages and aortic tissue, which triggers inflammation and remodelling and also platelet adhesion and migration into the abdominal aortic wall and the intraluminal thrombus (ILT). Further, enhanced platelet activation and pro-coagulant activity result in elevated gene expression of various cytokines, Mmp9 and Col1a1 in macrophages and Il-6 and Mmp9 in fibroblasts. Enhanced platelet activation and pro-coagulant activity were also detected in AAA patients. Further, we detected platelets and OPN in the vessel wall and in the ILT of patients who underwent open repair of AAA. Platelet depletion in experimental murine AAA reduced inflammation and ECM remodelling, with reduced elastin fragmentation and aortic diameter expansion. Of note, OPN co-localized with platelets, suggesting a potential role of OPN for the recruitment of platelets into the ILT and the aortic wall.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, our data strongly support the potential relevance of anti-platelet therapy to reduce AAA progression and rupture in AAA patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvad168","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T13:30:34Z","timestamp":1700227834000},"page":"417-432","source":"Crossref","is-referenced-by-count":84,"title":["Crosstalk of platelets with macrophages and fibroblasts aggravates inflammation, aortic wall stiffening, and osteopontin release in abdominal aortic aneurysm"],"prefix":"10.1093","volume":"120","author":[{"given":"Markus U","family":"Wagenh\u00e4user","sequence":"first","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf, Heinrich-Heine University , Moorenstrasse 5, 40225 D\u00fcsseldorf , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joscha","family":"Mulorz","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf, Heinrich-Heine University , Moorenstrasse 5, 40225 D\u00fcsseldorf , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim J","family":"Krott","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf, Heinrich-Heine University , Moorenstrasse 5, 40225 D\u00fcsseldorf , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Bosbach","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf, Heinrich-Heine University , Moorenstrasse 5, 40225 D\u00fcsseldorf , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Feige","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf, Heinrich-Heine University , Moorenstrasse 5, 40225 D\u00fcsseldorf , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yae H","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf, Heinrich-Heine University , Moorenstrasse 5, 40225 D\u00fcsseldorf , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3428-4107","authenticated-orcid":false,"given":"Madhumita","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Experimental Therapy and Toxicology, University Hospital T\u00fcbingen , Wilhelmstrasse 5, 72074 T\u00fcbingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Petzold","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf, Heinrich-Heine University , Moorenstrasse 5, 40225 D\u00fcsseldorf , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"B\u00f6ddeker","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf, Heinrich-Heine University , Moorenstrasse 5, 40225 D\u00fcsseldorf , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Ibing","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf, Heinrich-Heine University , Moorenstrasse 5, 40225 D\u00fcsseldorf , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf, Heinrich-Heine University , Moorenstrasse 5, 40225 D\u00fcsseldorf , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M","family":"Popovic","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf, Heinrich-Heine University , Moorenstrasse 5, 40225 D\u00fcsseldorf , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Roseman","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System , Palo Alto, 3801 Miranda Avenue, 94304 CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M","family":"Spin","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System , Palo Alto, 3801 Miranda Avenue, 94304 CA , USA"},{"name":"Department of Cardiovascular Medicine, Stanford University , 291 Campus Drive Stanford, 94305 CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S","family":"Tsao","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System , Palo Alto, 3801 Miranda Avenue, 94304 CA , USA"},{"name":"Department of Cardiovascular Medicine, Stanford University , 291 Campus Drive Stanford, 94305 CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Schelzig","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf, Heinrich-Heine University , Moorenstrasse 5, 40225 D\u00fcsseldorf , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3234-9341","authenticated-orcid":false,"given":"Margitta","family":"Elvers","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf, Heinrich-Heine University , Moorenstrasse 5, 40225 D\u00fcsseldorf , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"2024033018254289500_cvad168-B1","first-page":"657","article-title":"Ultrasonographic screening for the detection of abdominal aortic aneurysms","volume":"106","author":"Eckstein","year":"2009","journal-title":"Dtsch Arztebl Int"},{"key":"2024033018254289500_cvad168-B2","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1182\/blood-2017-08-743237","article-title":"Antithrombotic therapy in abdominal aortic aneurysm: beneficial or detrimental?","volume":"132","author":"Cameron","year":"2018","journal-title":"Blood"},{"key":"2024033018254289500_cvad168-B3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejvs.2018.07.035","article-title":"Editor\u2019s choice\u2014metformin prescription is associated with a reduction in the combined incidence of surgical repair and rupture related mortality in patients with abdominal aortic aneurysm","volume":"57","author":"Golledge","year":"2019","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2024033018254289500_cvad168-B4","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.2310\/JIM.0b013e31823548e8","article-title":"Statin therapy reduces growth of abdominal aortic aneurysms","volume":"59","author":"Karrowni","year":"2011","journal-title":"J Investig Med"},{"key":"2024033018254289500_cvad168-B5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jvssci.2020.11.031","article-title":"Inhibition of angiotensin-induced aortic aneurysm by metformin in apolipoprotein E-deficient mice","volume":"2","author":"Kunath","year":"2021","journal-title":"JVS Vasc Sci"},{"key":"2024033018254289500_cvad168-B6","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1136\/jim-2019-001177","article-title":"Association between metformin and abdominal aortic aneurysm in diabetic and non-diabetic US veterans","volume":"68","author":"Sutton","year":"2020","journal-title":"J Investig Med"},{"key":"2024033018254289500_cvad168-B7","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(05)66459-8","article-title":"Abdominal aortic aneurysm","volume":"365","author":"Sakalihasan","year":"2005","journal-title":"Lancet"},{"key":"2024033018254289500_cvad168-B8","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.ATV.0000214999.12921.4f","article-title":"Inflammation and cellular immune responses in abdominal aortic aneurysms","volume":"26","author":"Shimizu","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024033018254289500_cvad168-B9","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/S0741-5214(03)00791-2","article-title":"Influence of intraluminal thrombus on structural and cellular composition of abdominal aortic aneurysm wall","volume":"38","author":"Kazi","year":"2003","journal-title":"J Vasc Surg"},{"key":"2024033018254289500_cvad168-B10","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1067\/mva.2002.126087","article-title":"Effect of intraluminal thrombus on wall stress in patient-specific models of abdominal aortic aneurysm","volume":"36","author":"Wang","year":"2002","journal-title":"J Vasc Surg"},{"key":"2024033018254289500_cvad168-B11","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.jbiomech.2014.01.041","article-title":"The biaxial mechanical behaviour of abdominal aortic aneurysm intraluminal thrombus: classification of morphology and the determination of layer and region specific properties","volume":"47","author":"O\u2019Leary","year":"2014","journal-title":"J Biomech"},{"key":"2024033018254289500_cvad168-B12","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0967-2109(96)00008-7","article-title":"Potential influence of intraluminal thrombus on abdominal aortic aneurysm as assessed by a new non-invasive method","volume":"4","author":"Vorp","year":"1996","journal-title":"Cardiovasc Surg"},{"key":"2024033018254289500_cvad168-B13","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.2174\/1381612822666160607064118","article-title":"The role of platelets in cardiovascular disease: molecular mechanisms","volume":"22","author":"Papapanagiotou","year":"2016","journal-title":"Curr Pharm Des"},{"key":"2024033018254289500_cvad168-B14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jvssci.2021.01.002","article-title":"Translating mouse models of abdominal aortic aneurysm to the translational needs of vascular surgery","volume":"2","author":"Busch","year":"2021","journal-title":"JVS Vasc Sci"},{"key":"2024033018254289500_cvad168-B15","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/ATVBAHA.115.305537","article-title":"Platelet inhibitors reduce rupture in a mouse model of established abdominal aortic aneurysm","volume":"35","author":"Owens","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024033018254289500_cvad168-B16","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jvs.2008.09.057","article-title":"Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model","volume":"49","author":"Dai","year":"2009","journal-title":"J Vasc Surg"},{"key":"2024033018254289500_cvad168-B17","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.2353\/ajpath.2006.050868","article-title":"Renewal of mural thrombus releases plasma markers and is involved in aortic abdominal aneurysm evolution","volume":"168","author":"Touat","year":"2006","journal-title":"Am J Pathol"},{"key":"2024033018254289500_cvad168-B18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2174\/1570161111311030005","article-title":"Anti-platelet treatment of middle-sized abdominal aortic aneurysms","volume":"11","author":"Lindholt","year":"2013","journal-title":"Curr Vasc Pharmacol"},{"key":"2024033018254289500_cvad168-B19","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1161\/ATVBAHA.107.158576","article-title":"Dilation-dependent activation of platelets and prothrombin in human thoracic ascending aortic aneurysm","volume":"28","author":"Touat","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024033018254289500_cvad168-B20","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3390\/diagnostics12040871","article-title":"Adventitial fibroblasts in aortic aneurysm: unraveling pathogenic contributions to vascular disease","volume":"12","author":"Mackay","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"2024033018254289500_cvad168-B21","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3390\/ph12030118","article-title":"Matrix metalloproteinase in abdominal aortic aneurysm and aortic dissection","volume":"12","author":"Maguire","year":"2019","journal-title":"Pharmaceuticals"},{"key":"2024033018254289500_cvad168-B22","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0735-1097(97)00510-X","article-title":"Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease","volume":"31","author":"Furman","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"2024033018254289500_cvad168-B23","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1056\/NEJM199005313222201","article-title":"Platelet hyperreactivity and prognosis in survivors of myocardial infarction","volume":"322","author":"Trip","year":"1990","journal-title":"N Engl J Med"},{"key":"2024033018254289500_cvad168-B24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1055\/s-0037-1614480","article-title":"Circulating platelets show increased activation in patients with acute cerebral ischemia","volume":"81","author":"Zeller","year":"1999","journal-title":"Thromb Haemost"},{"key":"2024033018254289500_cvad168-B25","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.3390\/cells11213500","article-title":"Only acute but not chronic thrombocytopenia protects mice against left ventricular dysfunction after acute myocardial infarction","volume":"11","author":"Reusswig","year":"2022","journal-title":"Cells"},{"key":"2024033018254289500_cvad168-B26","doi-asserted-by":"crossref","first-page":"e152373","DOI":"10.1172\/JCI152373","article-title":"Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms","volume":"132","author":"Morrell","year":"2022","journal-title":"J Clin Invest"},{"key":"2024033018254289500_cvad168-B27","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1053\/ejvs.2002.1794","article-title":"Increased platelet aggregation and activation in peripheral arterial disease","volume":"25","author":"Robless","year":"2003","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2024033018254289500_cvad168-B28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/stem.5530130106","article-title":"Dynamic regulation of integrins","volume":"13","author":"Faull","year":"1995","journal-title":"Stem Cells"},{"key":"2024033018254289500_cvad168-B29","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1053\/ejvs.1998.0790","article-title":"Effects of asymptomatic abdominal aortic aneurysm on the soluble coagulation system, platelet count and platelet activation","volume":"17","author":"Milne","year":"1999","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2024033018254289500_cvad168-B30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1177\/1708538115596911","article-title":"Platelet activation after endovascular repair of abdominal aortic aneurysm","volume":"24","author":"Arnaoutoglou","year":"2016","journal-title":"Vascular"},{"key":"2024033018254289500_cvad168-B31","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s11239-020-02342-x","article-title":"Inflammatory cytokines enhance procoagulant activity of platelets and endothelial cells through phosphatidylserine exposure in patients with essential hypertension","volume":"51","author":"Li","year":"2021","journal-title":"J Thromb Thrombolysis"},{"key":"2024033018254289500_cvad168-B32","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1182\/bloodadvances.2017013359","article-title":"Prognostic value of D-dimer and markers of coagulation for stratification of abdominal aortic aneurysm growth","volume":"2","author":"Sundermann","year":"2018","journal-title":"Blood Adv"},{"key":"2024033018254289500_cvad168-B33","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.thromres.2009.01.016","article-title":"Haemostatic markers in patients with abdominal aortic aneurysm and the impact of aneurysm size","volume":"124","author":"Wallinder","year":"2009","journal-title":"Thromb Res"},{"key":"2024033018254289500_cvad168-B34","doi-asserted-by":"crossref","first-page":"e51707","DOI":"10.1371\/journal.pone.0051707","article-title":"Clopidogrel, a platelet P2Y12 receptor inhibitor, reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"2024033018254289500_cvad168-B35","doi-asserted-by":"crossref","first-page":"111703","DOI":"10.1016\/j.exger.2022.111703","article-title":"Platelet protects angiotensin II-driven abdominal aortic aneurysm formation through inhibition of inflammation","volume":"159","author":"Liu","year":"2022","journal-title":"Exp Gerontol"},{"key":"2024033018254289500_cvad168-B36","doi-asserted-by":"crossref","first-page":"815","DOI":"10.7326\/0003-4819-159-12-201312170-00007","article-title":"Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial","volume":"159","author":"Meijer C","year":"2013","journal-title":"Ann Intern Med"},{"key":"2024033018254289500_cvad168-B37","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/bjs.9824","article-title":"Randomized clinical trial of mast cell inhibition in patients with a medium-sized abdominal aortic aneurysm","volume":"102","author":"Sillesen","year":"2015","journal-title":"Br J Surg"},{"key":"2024033018254289500_cvad168-B38","first-page":"450","article-title":"The effect of ticagrelor on growth of small abdominal aortic aneurysms-a randomized controlled trial","volume":"116","author":"Wanhainen","year":"2020","journal-title":"Cardiovasc Res"},{"key":"2024033018254289500_cvad168-B39","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1196\/annals.1383.014","article-title":"Attenuation of experimental aortic aneurysm formation in P-selectin knockout mice","volume":"1085","author":"Hannawa","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"2024033018254289500_cvad168-B40","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/ATVBAHA.118.311577","article-title":"Osteopontin in vascular disease","volume":"39","author":"Lok","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024033018254289500_cvad168-B41","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12079-009-0068-0","article-title":"The role of osteopontin in inflammatory processes","volume":"3","author":"Lund","year":"2009","journal-title":"J Cell Commun Signal"},{"key":"2024033018254289500_cvad168-B42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/01.RES.0000025268.10302.0C","article-title":"Osteopontin plays an important role in the development of medial thickening and neointimal formation","volume":"91","author":"Isoda","year":"2002","journal-title":"Circ Res"},{"key":"2024033018254289500_cvad168-B43","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/s11596-011-0568-z","article-title":"The elevated expression of osteopontin and NF-\u03baB in human aortic aneurysms and its implication","volume":"31","author":"Mi","year":"2011","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"2024033018254289500_cvad168-B44","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1172\/JCI200318141","article-title":"Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice","volume":"112","author":"Bruemmer","year":"2003","journal-title":"J Clin Invest"},{"key":"2024033018254289500_cvad168-B45","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1161\/ATVBAHA.109.202259","article-title":"Enhanced abdominal aortic aneurysm formation in thrombin-activatable procarboxypeptidase B-deficient mice","volume":"30","author":"Schultz","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024033018254289500_cvad168-B46","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1160\/TH13-02-0113","article-title":"Platelets and matrix metalloproteinases","volume":"110","author":"Seizer","year":"2013","journal-title":"Thromb Haemost"},{"key":"2024033018254289500_cvad168-B47","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1177\/1708538118762214","article-title":"Aspirin use is associated with decreased radiologically-determined thrombus sac volume in abdominal aortic aneurysms","volume":"26","author":"Balceniuk","year":"2018","journal-title":"Vascular"},{"key":"2024033018254289500_cvad168-B48","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2174\/1570161115666170413145705","article-title":"Pharmacological therapy of abdominal aortic aneurysm: an update","volume":"16","author":"Wang","year":"2018","journal-title":"Curr Vasc Pharmacol"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvad168\/56785174\/cvad168.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/120\/4\/417\/57128425\/cvad168.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/120\/4\/417\/57128425\/cvad168.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T14:26:09Z","timestamp":1711808769000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/120\/4\/417\/7425469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,17]]},"references-count":48,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,11,17]]},"published-print":{"date-parts":[[2024,3,30]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvad168","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.12.01.518674","asserted-by":"object"}]},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2023,11,17]]}}}