{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:54:39Z","timestamp":1791345279975,"version":"4.3.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Canadian Foundation for Innovation","award":["42228"],"award-info":[{"award-number":["42228"]}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["16-00012708"],"award-info":[{"award-number":["16-00012708"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["G-22-0031958"],"award-info":[{"award-number":["G-22-0031958"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Recent studies suggest that bioactive mediators called resolvins promote an active resolution of inflammation. Inflammatory signalling is involved in the development of the substrate for atrial fibrillation (AF). The aim of this study is to evaluate the effects of resolvin-D1 on atrial arrhythmogenic remodelling resulting from left ventricular (LV) dysfunction induced by myocardial infarction (MI) in rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>MI was produced by left anterior descending coronary artery ligation. Intervention groups received daily intraperitoneal resolvin-D1, beginning before MI surgery (early-RvD1) or Day 7 post-MI (late-RvD1) and continued until Day 21 post-MI. AF vulnerability was evaluated by performing an electrophysiological study. Atrial conduction was analysed by using optical mapping. Fibrosis was quantified by Masson\u2019s trichrome staining and gene expression by quantitative polymerase chain reaction and RNA sequencing. Investigators were blinded to group identity. Early-RvD1 significantly reduced MI size (17 \u00b1 6%, vs. 39 \u00b1 6% in vehicle-MI) and preserved LV ejection fraction; these were unaffected by late-RvD1. Transoesophageal pacing induced atrial tachyarrhythmia in 2\/18 (11%) sham-operated rats, vs. 18\/18 (100%) MI-only rats, in 5\/18 (28%, P &amp;lt; 0.001 vs. MI) early-RvD1 MI rats, and in 7\/12 (58%, P &amp;lt; 0.01) late-RvD1 MI rats. Atrial conduction velocity significantly decreased post-MI, an effect suppressed by RvD1 treatment. Both early-RvD1 and late-RvD1 limited MI-induced atrial fibrosis and prevented MI-induced increases in the atrial expression of inflammation-related and fibrosis-related biomarkers and pathways.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>RvD1 suppressed MI-related atrial arrhythmogenic remodelling. Early-RvD1 had MI sparing and atrial remodelling suppressant effects, whereas late-RvD1 attenuated atrial remodelling and AF promotion without ventricular protection, revealing atrial-protective actions unrelated to ventricular function changes. These results point to inflammation resolution\u2013promoting compounds as novel cardio-protective interventions with a particular interest in attenuating AF substrate development.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvad175","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T23:28:27Z","timestamp":1702510107000},"page":"345-359","source":"Crossref","is-referenced-by-count":34,"title":["An inflammation resolution\u2013promoting intervention prevents atrial fibrillation caused by left ventricular dysfunction"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4291-8314","authenticated-orcid":false,"given":"Roddy","family":"Hiram","sequence":"first","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute (MHI), Universit\u00e9 de Montr\u00e9al , 5000 Belanger Street, Montreal, Quebec , Canada H1T 1C8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute (MHI), Universit\u00e9 de Montr\u00e9al , 5000 Belanger Street, Montreal, Quebec , Canada H1T 1C8"},{"name":"Department of Pharmacology and Therapeutics, McGill University , 3655 Prom. Sir William Osler, Montreal , Canada H3G 1Y6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Naud","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute (MHI), Universit\u00e9 de Montr\u00e9al , 5000 Belanger Street, Montreal, Quebec , Canada H1T 1C8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiening","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute (MHI), Universit\u00e9 de Montr\u00e9al , 5000 Belanger Street, Montreal, Quebec , Canada H1T 1C8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna K","family":"Sosnowski","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute (MHI), Universit\u00e9 de Montr\u00e9al , 5000 Belanger Street, Montreal, Quebec , Canada H1T 1C8"},{"name":"Department of Pharmacology and Therapeutics, McGill University , 3655 Prom. 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Box 2177, Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issam H","family":"Abu-Taha","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen , Hufelandstr 55, Essen , Germany D-45122"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Kamler","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, West German Heart and Vascular Center Essen, University Hospital Essen , Hufelanstr 55, Essen , Germany 45122"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles-Alexandre","family":"LeBlanc","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute (MHI), Universit\u00e9 de Montr\u00e9al , 5000 Belanger Street, Montreal, Quebec , Canada H1T 1C8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doa\u2019a G F","family":"Al-U\u2019Datt","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology , P.O. Box 3030 Irbid , Jordan 22110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G","family":"Sirois","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute (MHI), Universit\u00e9 de Montr\u00e9al , 5000 Belanger Street, Montreal, Quebec , Canada H1T 1C8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence E","family":"Hebert","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, McGill University , 3655 Prom. Sir William Osler, Montreal , Canada H3G 1Y6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Tanguay","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute (MHI), Universit\u00e9 de Montr\u00e9al , 5000 Belanger Street, Montreal, Quebec , Canada H1T 1C8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-8983","authenticated-orcid":false,"given":"Jean-Claude","family":"Tardif","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute (MHI), Universit\u00e9 de Montr\u00e9al , 5000 Belanger Street, Montreal, Quebec , Canada H1T 1C8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-117X","authenticated-orcid":false,"given":"Dobromir","family":"Dobrev","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute (MHI), Universit\u00e9 de Montr\u00e9al , 5000 Belanger Street, Montreal, Quebec , Canada H1T 1C8"},{"name":"Department of Pharmacology and Therapeutics, McGill University , 3655 Prom. 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